1.Epidemiological analysis of NDM-1-positive bacteria in China
Shengshu WANG ; Jinzhu SUN ; Wenli SU ; Zhi HU ; Jianpeng YANG ; Yong WANG
Military Medical Sciences 2015;(11):825-830
Objective To analyze the epidemiological characteristic of New Delhi metallo-β-lactamase (NDM)-1-positive bacteria in China and explore its mechanism of drug-resistance.Methods The published papers from 2010 to 2015 about domestic blaNDM-1 were collected and analyzed according to the bacteria species,regional distribution,NDM-1-positive bacteria,infectious source,drug-resistance spectra and transfer mechanism.Results NDM-1-positive bacteria were isola-ted from 25 provinces (municipalities)in China,Guangdong Province was predominant and accounted for 39.49%(P <0.05).The number of Klebsiella pneumoniae and Enterobacter cloacae were predominant in the NDM-1-positive bacteria (P <0.05).Number of patients under the age of ten and among 60 -80 years which infected by NDM-1-positive bacteria were predominant of all the reported patients(P <0.05).The most kinds of samples and diseases were sputum sample (P <0.05)and pulmonary diseases(P <0.05).NDM-1-positive bacteria which found in China had the lowest resistance to amikacin and tigecycline accounted for 7.69% and 2.33%(P <0.05).Conclusion Antibiotic resistant bacteria with NDM-1 resistant gene have become a global public health problem,and significant difference among age,districts and sources,which need active surveillance and more studies to find how it happens and epidemic in the future.
2.Evaluation of activities of daily living and related factors in community elderly people in urban and rural areas of Beijing
Miao LIU ; Jianhua WANG ; Shanshan YANG ; Yao YAO ; Shengshu WANG ; Yao HE
Chinese Journal of Epidemiology 2018;39(3):268-272
Objective To evaluate the activities of daily living (ADL) and related factors in community elderly people in urban and rural areas of Beijing.Methods A population-based cross-sectional study was conducted in Haidian and Miyun districts of Beijing using two-stage random cluster sampling method between 2011 and 2014.Results A total of 4 499 community elderly people (1 815 males,2 684 females) aged 60-95 years were included in the study.The mean age was (70.3 ±6.7) years.Compared with the participants from urban area,the participants from rural area had lower education level (85.2% had education level primary school),but higher level of smoking (22.8%) and drinking (43.1%).The ADL disability rate was higher in rural area than in urban area (12.4% vs.11.8%,P=0.039).And it increased significantly with age (P<0.05).Multivariate logistic regression showed besides urban-rural difference (P=0.031),age (P=0.013),education level (P=0.015),physical activity (P=0.001) and stroke (P<0.001) were related factors influencing ADL disability.Conclusions The ADL disability was relatively low in the community elderly people in Beijing,and there was significant difference between rural area and urban area.Older age,lower education level and physical inactivity and stroke were related factors.
3.Evaluation of activities of daily living and related factors in community elderly people in urban and rural areas of Beijing
Miao LIU ; Jianhua WANG ; Shanshan YANG ; Yao YAO ; Shengshu WANG ; Yao HE
Chinese Journal of Epidemiology 2018;39(3):268-272
Objective To evaluate the activities of daily living (ADL) and related factors in community elderly people in urban and rural areas of Beijing.Methods A population-based cross-sectional study was conducted in Haidian and Miyun districts of Beijing using two-stage random cluster sampling method between 2011 and 2014.Results A total of 4 499 community elderly people (1 815 males,2 684 females) aged 60-95 years were included in the study.The mean age was (70.3 ±6.7) years.Compared with the participants from urban area,the participants from rural area had lower education level (85.2% had education level primary school),but higher level of smoking (22.8%) and drinking (43.1%).The ADL disability rate was higher in rural area than in urban area (12.4% vs.11.8%,P=0.039).And it increased significantly with age (P<0.05).Multivariate logistic regression showed besides urban-rural difference (P=0.031),age (P=0.013),education level (P=0.015),physical activity (P=0.001) and stroke (P<0.001) were related factors influencing ADL disability.Conclusions The ADL disability was relatively low in the community elderly people in Beijing,and there was significant difference between rural area and urban area.Older age,lower education level and physical inactivity and stroke were related factors.
4. Blood pressure level, hypertension prevalence and control status in oldest old in China
Miao LIU ; Jianhua WANG ; Shengshu WANG ; Yao HE
Chinese Journal of Epidemiology 2019;40(3):290-295
Objective:
To investigate blood pressure level, hypertension prevalence and control status in the oldest old in China.
Methods:
A cross-sectional data set of Chinese Longitudinal and Health Longevity Study (CLHLS) in 2014 was used to investigate the blood pressure level and hypertension prevalence and control status in the oldest old.
Results:
A total of 4 587 elderly people aged ≥80 years were surveyed with mean age (91.3±7.8) years old, including 1 896 males (41.3
5. Association between hypertension and carotid plaque in a physical examination population: a cross-sectional study
Jian LIU ; Xuehua MA ; Leyuan YAN ; Miao LIU ; Shanshan YANG ; Shengshu WANG ; Yao HE
Chinese Journal of Health Management 2020;14(1):21-26
Objective:
This study aimed to assess the association between hypertension and carotid plaque in a research population in China.
Methods:
The subjects of this study were selected from a population undergoing physical examination at the Fourth Medical Center of PLA General Hospital in 2017. We collected information on physical examination, physiological index test, blood pressure indicators were analyzed according as continuous variables (systolic blood pressure, diastolic blood pressure, and pulse pressure) and categorical variables (hypertension and quartile of blood pressure pulse pressure). A multivariate logistic regression model was conducted to estimate the correlation between blood pressure and carotid plaque development.
Results:
A total of 716 individuals were surveyed, including 321 men (44.8%) and 395 women (55.2%), and the prevalence of hypertension and carotid plaque were 40.9%(293 cases) and 40.4% (289 cases), respectively. The prevalence of carotid plaque was higher in individuals aged ≥60 years, diabetes mellitus, hypertension and increased waist circumference, systolic blood pressure, fasting blood glucose and glycosylated hemoglobin. The prevalence of carotid plaque increased with the increase of the quartile of blood pressure and pulse pressure (
6. Association between dyslipidemia and carotid plaque incidence in a research group: a prospective cohort study
Jian LIU ; Xuehua MA ; Leyuan YAN ; Miao LIU ; Shengshu WANG ; Yao HE
Chinese Journal of Epidemiology 2019;40(3):341-345
Objective:
To assess the association and intensity of baseline dyslipidemia with the incidence of carotid plaque in a researchers group in China.
Methods:
A total of 716 researchers were enrolled in this prospective cohort study. Dyslipidemia was assessed in 2010. Follow-up study on carotid plaque was conducted in 2017.
Results:
Over 8 years’ follow-up, 289 carotid plaque patients were identified among 716 individuals who did not have carotid plaque at baseline survey, with cumulative incidence of 40.36
7. Epidemiological investigation of a family clustering of COVID-19
Qun GUAN ; Miao LIU ; Yingjie ZHUANG ; Yue YUAN ; Shengshu WANG ; Jin LI ; Zhu CHEN ; Xinglong YANG ; Zirong TANG ; Hongjun JIA ; Jingyi MA ; Xiaoxia WANG ; Penggang TAI ; Jing LI ; Yingjie ZHUANG ; Yao HE
Chinese Journal of Epidemiology 2020;41(5):629-633
Objective To investigate the epidemiological characteristics of a family clustering of COVID-19. Methods Field epidemiological survey was conducted. Result Case 1 of the long-term residents from Hubei province was the source of infection of this family clustering. There were 6 cases (from case 2 to case 7) infected in the whole incubation period. The incubation period was more than 14 days for 3 of the second-generation cases. Routes of transmission include respiratory droplets (from case 1 transmitted to case 6, from case 1 to her family members) and closecontact (from case 1 to other cases in her family). All the age groups were generally susceptible, while elderly were easier to progress to critically ill. Besides respiratory symptoms, there were also gastrointestinal symptoms, of which diarrhea was the most common one. Conclusion Family clustering had been an important part for COVID-19 cases.