1.Evaluation of the extent of the stenosis in relation to the suture materials and methods after End-to-End anastomosis of the trachea.
Joo Chul PARK ; Dong Won KIM ; Seong Kuk AHN
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(12):972-979
No abstract available.
Constriction, Pathologic*
;
Sutures*
;
Trachea*
2.A Case Report of the Primary Lung Lymphoma.
Ye Ree KIM ; Seong Yuk YOUN ; Kwang Ha YOO ; Chul Min AHN ; Hyung Joong KIM ; Choon Jo JIN
Tuberculosis and Respiratory Diseases 1999;47(2):272-273
The primary lymphoma in the lung is very rare. Most of the primary pulmonary lymphomas, which represent 3-4 % of extra-nodal lymphomas, are low-grade B-cell lymphoma. The low-grade B-cell lymphomas progress slowly and the prognosis of these are more favorable than that of the nodal lymphomas. However, high-grade forms progress rapidly with more severe course. The diagnosis of primary pulmonary lymphomas generally relies on the histopathologic findings of lung specimens obtained by surgical excision of the lesions or open-lung biopsy. Recently, less aggressive biopsies(transbronchial, transthoracic) and/or immunocyto -chemical, immunochemical and gene rearrangement studies on materials obtained by bronchoalveolar lavage have been used occasionally. The treatment of the primary pulmonary lymphomas has not been precisely codified. Several clinical data suggest that limited surgery or non -aggressive chemotherapy can provide long-term survival in patients with such slowly developing neoplasm, and demonstrated the need for the development of noninvasive diagnostic methods. In this study, we report a case of high-grade B-cell lymphoma of the lung which was treated with combination chemotherapy.
B-Lymphocytes
;
Biopsy
;
Bronchoalveolar Lavage
;
Diagnosis
;
Drug Therapy
;
Drug Therapy, Combination
;
Gene Rearrangement
;
Humans
;
Lung*
;
Lymphoma*
;
Lymphoma, B-Cell
;
Prognosis
3.Dynamic study of the Pancreas with Spiral CT: Comparison of Amount of The Contrast Medium.
Kyung Jin NAM ; Seung Eon AHN ; Seong Kuk YOON ; Jae Ik KIM ; Jong Cheol CHOI ; Young Il LEE
Journal of the Korean Radiological Society 1998;38(2):285-289
PURPOSE: To determine the hemodynamics of the pancreas by investigating the enhancement patterns of pancreaticparenchyma, as seen on spiral CT, after the administration of various amounts of contrast medium, and to determineoptimal scan time by knowing the peak time of normal pancreatic parenchyma. MATERIALS AND METHODS: Between January1995 and April 1997 55 cases of normal abdominal CT with dynamic enhancement study on pancreas, the subject were38 cases(28 persons) with good image, aged 21-65 years, men were twenty-one and women were seven. Non-ioniccontrast medium, 30ml(n=15), 60ml(n=9), 990ml(n=7), and 120ml(n=7) were injected at a rate of 3ml/sec. From 20sec. after the start of injection, 15 images were obtained at 3-sec intervals. Before and after injection, R.O.I.was applied to each image, and for the aorta and pancreatic parenchyma, Hounsfield units(H.U.) were measured; timeof enhancement and maximal H.U. were also measured. RESULTS: After 30, 60, 90, and 120ml of contrast mediuminjection, mean maximal H.U. of pancreatic parenchyma was 36+/-7, 54+/-6, 68V13, and 92+/-8, respectively; mean valueat peak parenchymal enhancement of the pancreas was 27+/-3, 32+/-3, 42+/-3, and 52+/-3, respectively. Time intervalsof maximal enhancement of aorta and pancreatic parenchyma could not be obtained in 30ml injection, but 5,4+/-2.5,4.2+/-1.6, and 6.0+/-2.1sec in 60, 90, and 120ml injection, respectively. CONCLUSION: Maximal H.U. of parenchymalenhancement of the pancreas is directly proportional to the amount of injected contrast medium and the peak timeof parenchymal enhancement was 12sec after the injection of contrast material. Time interval of maximalenhancement of aorta and pancreatic parenchyma was 5.2+/-2.1sec.
Aorta
;
Contrast Media
;
Female
;
Hemodynamics
;
Humans
;
Male
;
Pancreas*
;
Tomography, Spiral Computed*
;
Tomography, X-Ray Computed
4.Genetic Diversity of Plasmodium vivax Causing Epidemic Malaria in the Republic of Korea
Young Yil BAHK ; Jeonga KIM ; Seong Kyu AHN ; Byoung Kuk NA ; Jong Yil CHAI ; Tong Soo KIM
The Korean Journal of Parasitology 2018;56(6):545-552
Plasmodium vivax is more challenging to control and eliminate than P. falciparum due to its more asymptomatic infections with low parasite densities making diagnosis more difficult, in addition to its unique biological characteristics. The potential re-introduction of incidence cases, either through borders or via human migrations, is another major hurdle to sustained control and elimination. The Republic of Korea has experienced re-emergence of vivax malaria in 1993 but is one of the 32 malaria-eliminating countries to-date. Despite achieving successful nationwide control and elimination of vivax malaria, the evolutionary characteristics of vivax malaria isolates in the Republic of Korea have not been fully understood. In this review, we present an overview of the genetic variability of such isolates to increase understanding of the epidemiology, diversity, and dynamics of vivax populations in the Republic of Korea.
Asymptomatic Infections
;
Diagnosis
;
Epidemiology
;
Genetic Variation
;
Human Migration
;
Incidence
;
Korea
;
Malaria
;
Malaria, Vivax
;
Parasites
;
Plasmodium vivax
;
Plasmodium
;
Population Characteristics
;
Republic of Korea
5.Vitamin E Potentiates the Anti-nociceptive Effects by Intraperitoneal Administration of Lidocaine in Rats.
Hye Jin KIM ; Hae Ji YANG ; Sun Hyong KIM ; Dan A KIM ; Seong Ju KIM ; Han na PARK ; Jin Sook JU ; Dong Kuk AHN
International Journal of Oral Biology 2016;41(4):191-197
The present study was to evaluate effects of vitamin E on intravenous administration of lidocaine-induced antinociception. Experiments were carried out using male Sprague-Dawley rats. Orofacial formalin-induced nociceptive behavioral responses were used as the orofacial animal pain model. Subcutaneous injection of formalin produced significant nociceptive scratching behavior. Intraperitoneal injection of 5 and 10 mg/kg of lidocaine attenuated formalin-induced nociceptive behavior in the 2nd phase, compared to the vehicle-treated group. Intraperitoneal injection of 1 g/kg of vitamin E also attenuated the formalin-induced nociceptive behavior in the 2nd phase, compared to the vehicle-treated group. However, low dose of vitamin E (0.5 g/kg) did not affect the nociceptive behavioral responses produced by subcutaneous injection of formalin. The present study also investigated effects of intraperitoneal injection of both vitamin E and lidocaine on orofacial formalin-induced behavioral responses. Vehicle treatment affected neither formalin-induced behavioral responses nor lidocaine-induced antinociceptive effects. However, intraperitoneal injection of 0.5 g/kg of vitamin E enhanced the lidocaine-induced antinociceptive effects in the 2nd phase compared to the vehicle-treated group. Intraperitoneal injection of naloxone, an opioid receptor antagonist, did not affect antinociception produced by intraperitoneal injections of both vitamin E and lidocaine. These results suggest that treatment with vitamin E enhances the systemic treatment with lidocaine-induced antinociception and reduces side effects when systemically treated with lidocaine. Therefore, the combined treatment with vitamin E and lidocaine is a potential therapeutic for chronic orofacial pain.
Administration, Intravenous
;
Animals
;
Facial Pain
;
Formaldehyde
;
Humans
;
Injections, Intraperitoneal
;
Injections, Subcutaneous
;
Lidocaine*
;
Male
;
Naloxone
;
Rats*
;
Rats, Sprague-Dawley
;
Receptors, Opioid
;
Vitamin E*
;
Vitamins*
6.The Effect of Zolpidem on the Psychomotor Performance in Healthy Volunteers.
Chang Yoon KIM ; Chang Hwa LEE ; Young Kuk YUN ; Joon Ho AHN ; Chul LEE ; Seong Yoon KIM ; Oh Su HAN
Journal of Korean Neuropsychiatric Association 1999;38(6):1459-1468
OBJECTIVES: Zolpidem is known to have fewer cognitive side effects than older hypnotics. To confirm this objectively, we compared the effects of zolpidem on the psychomotor performance with those of placebo in 10 healthy volunteers. METHOD: Zolpidem and placebo were administered orally in a double-blind, two-way, single dose, cross-over design. Assessments of psychomotor performances were carried out before (1 hour) and 1.5 and 6 hours after the administration of single dose of zolpidem (10mg) or placebo. Each treatment day was separated by 1 week of washout period. The psychomotor performances were measured using Vienna Determination Unit, Vienna Reaction Unit, Vienna Signal Detection, Grooved Pegboard Test and Finger Tapping Test. The data were analyzed using two-way, repeated measures ANOVA on a crossover model. RESULTS: The results showed that 1.5 hours after the administration, zolpidem 10mg produced markedly impaired psychomotor performance but 6 hours after, produced no significant psychomotor performance decrements on most of the psychomotor tests. CONCLUSION: This study confirmed previous findings that zolpidem is generally devoid of adverse side effects on psychomotor performance at the next day after administration.
Benzodiazepines
;
Cross-Over Studies
;
Fingers
;
Healthy Volunteers*
;
Hypnotics and Sedatives
;
Psychomotor Performance*
7.Seroprevalence of Plasmodium vivax Circumsporozoite Protein Antibody in High-Risk Malaria Areas in Korea
Jinyoung LEE ; Kyoung JIN ; Seong Kyu AHN ; Sung-Keun LEE ; Hyung Wook KWON ; Byoung-Kuk NA ; Tong-Soo KIM
The Korean Journal of Parasitology 2021;59(4):415-419
The circumsporozoite protein (CSP) of Plasmodium spp. is a diagnostic antigen and useful biomarker for monitoring short-term/seasonal changes to malaria transmission. Using P. vivax CSP antibody ELISA, epidemiological characteristics were analyzed in the residents of Ganghwa, Cheorwon, Paju, and Goseong from 2017 to 2018. In Ganghwa and Cheorwon, 1.6% and 1.2% of residents, respectively, were PvCSP-antibody-positive in 2018, which indicates a decrease of 0.4% in the positive rate compared to 2017. The annual parasite incidence (API) in Ganghwa and Cheorwon was 24.9 and 10.5 in 2017 and 20.3 and 10.7 in 2018, respectively. Although the changes were not significant, the API in Ganghwa decreased slightly by 4.5 in 2018 compared to the previous year. In Paju and Goseong, 3.9% and 2.0% of residents were positive for the PvCSP antibody. The API in Paju was 13.1 in 2017 and 16.0 in 2018, although no malaria patients were reported for the 2 years. Therefore, the results suggest that PvCSP is a useful antigen for confirming initial malaria infection. Additionally, considering that the antibody is relatively transient, it can be employed for sero-epidemiological studies to determine the extent of malaria transmission in the current year.
8.Antinociceptive Effects of Transcytosed Botulinum Neurotoxin Type A on Trigeminal Nociception in Rats.
Hye Jin KIM ; Geun Woo LEE ; Min Ji KIM ; Kui Ye YANG ; Seong Taek KIM ; Yong Cheol BAE ; Dong Kuk AHN
The Korean Journal of Physiology and Pharmacology 2015;19(4):349-355
We examined the effects of peripherally or centrally administered botulinum neurotoxin type A (BoNT-A) on orofacial inflammatory pain to evaluate the antinociceptive effect of BoNT-A and its underlying mechanisms. The experiments were carried out on male Sprague-Dawley rats. Subcutaneous (3 U/kg) or intracisternal (0.3 or 1 U/kg) administration of BoNT-A significantly inhibited the formalin-induced nociceptive response in the second phase. Both subcutaneous (1 or 3 U/kg) and intracisternal (0.3 or 1 U/kg) injection of BoNT-A increased the latency of head withdrawal response in the complete Freund's adjuvant (CFA)-treated rats. Intracisternal administration of N-methyl-D-aspartate (NMDA) evoked nociceptive behavior via the activation of trigeminal neurons, which was attenuated by the subcutaneous or intracisternal injection of BoNT-A. Intracisternal injection of NMDA up-regulated c-Fos expression in the trigeminal neurons of the medullary dorsal horn. Subcutaneous (3 U/kg) or intracisternal (1 U/kg) administration of BoNT-A significantly reduced the number of c-Fos immunoreactive neurons in the NMDA-treated rats. These results suggest that the central antinociceptive effects the peripherally or centrally administered BoNT-A are mediated by transcytosed BoNT-A or direct inhibition of trigeminal neurons. Our data suggest that central targets of BoNT-A might provide a new therapeutic tool for the treatment of orofacial chronic pain conditions.
Animals
;
Chronic Pain
;
Freund's Adjuvant
;
Head
;
Horns
;
Humans
;
Male
;
N-Methylaspartate
;
Neurons
;
Nociception*
;
Rats*
;
Rats, Sprague-Dawley
9.Botulinum toxin type A enhances the inhibitory spontaneous postsynaptic currents on the substantia gelatinosa neurons of the subnucleus caudalis in immature mice.
Seon Hui JANG ; Soo Joung PARK ; Chang Jin LEE ; Dong Kuk AHN ; Seong Kyu HAN
The Korean Journal of Physiology and Pharmacology 2018;22(5):539-546
Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc) receive orofacial nociceptive information from primary afferents and transmit the information to higher brain center. Although many studies have shown the analgesic effects of BoNT/A, the effects of BoNT/A at the central nervous system and the action mechanism are not well understood. Therefore, the effects of BoNT/A on the spontaneous postsynaptic currents (sPSCs) in the SG neurons were investigated. In whole cell voltage clamp mode, the frequency of sPSCs was increased in 18 (37.5%) neurons, decreased in 5 (10.4%) neurons and not affected in 25 (52.1%) of 48 neurons tested by BoNT/A (3 nM). Similar proportions of frequency variation of sPSCs were observed in 1 and 10 nM BoNT/A and no significant differences were observed in the relative mean frequencies of sPSCs among 1–10 nM BoNT/A. BoNT/A-induced frequency increase of sPSCs was not affected by pretreated tetrodotoxin (0.5 µM). In addition, the frequency of sIPSCs in the presence of CNQX (10 µM) and AP5 (20 µM) was increased in 10 (53%) neurons, decreased in 1 (5%) neuron and not affected in 8 (42%) of 19 neurons tested by BoNT/A (3 nM). These results demonstrate that BoNT/A increases the frequency of sIPSCs on SG neurons of the Vc at least partly and can provide an evidence for rapid action of BoNT/A at the central nervous system.
6-Cyano-7-nitroquinoxaline-2,3-dione
;
Animals
;
Botulinum Toxins*
;
Botulinum Toxins, Type A*
;
Brain
;
Central Nervous System
;
Cerebral Palsy
;
Dystonia
;
Hyperhidrosis
;
Mice*
;
Neurons*
;
Substantia Gelatinosa*
;
Synaptic Potentials*
;
Tetrodotoxin
10.Participation of central GABAA receptors in the trigeminal processing of mechanical allodynia in rats.
Min Ji KIM ; Young Hong PARK ; Kui Ye YANG ; Jin Sook JU ; Yong Chul BAE ; Seong Kyu HAN ; Dong Kuk AHN
The Korean Journal of Physiology and Pharmacology 2017;21(1):65-74
Here we investigated the central processing mechanisms of mechanical allodynia and found a direct excitatory link with low-threshold input to nociceptive neurons. Experiments were performed on male Sprague-Dawley rats weighing 230-280 g. Subcutaneous injection of interleukin 1 beta (IL-1β) (1 ng/10 µL) was used to produce mechanical allodynia and thermal hyperalgesia. Intracisternal administration of bicuculline, a gamma aminobutyric acid A (GABAA) receptor antagonist, produced mechanical allodynia in the orofacial area under normal conditions. However, intracisternal administration of bicuculline (50 ng) produced a paradoxical anti-allodynic effect under inflammatory pain conditions. Pretreatment with resiniferatoxin (RTX), which depletes capsaicin receptor protein in primary afferent fibers, did not alter the paradoxical anti-allodynic effects produced by the intracisternal injection of bicuculline. Intracisternal injection of bumetanide, an Na-K-Cl cotransporter (NKCC 1) inhibitor, reversed the IL-1β-induced mechanical allodynia. In the control group, application of GABA (100 µM) or muscimol (3 µM) led to membrane hyperpolarization in gramicidin perforated current clamp mode. However, in some neurons, application of GABA or muscimol led to membrane depolarization in the IL-1β-treated rats. These results suggest that some large myelinated Aβ fibers gain access to the nociceptive system and elicit pain sensation via GABA(A) receptors under inflammatory pain conditions.
Animals
;
Bicuculline
;
Bumetanide
;
Capsaicin
;
gamma-Aminobutyric Acid
;
Gramicidin
;
Humans
;
Hyperalgesia*
;
Injections, Subcutaneous
;
Interleukin-1beta
;
Male
;
Membranes
;
Muscimol
;
Myelin Sheath
;
Neurons
;
Nociceptors
;
Rats*
;
Rats, Sprague-Dawley
;
Receptors, GABA-A
;
Sensation