Objective To explore the relationship between asymptomatic lacunar cerebral infarction and blood pressure variability (BPV) in senile patients with essential hypertension.Methods According to the results of the cranial magnetic resonance imaging (MRI),160 patients were divided into two groups:96 cases of hypertension combined with lacunar cerebral infarction group and 64 cases of simple hypertension group.Their levels and variability blood pressure were investigated by 24 hours ambulatory blood pressure monitoring.All markers included 24 h average systolic blood pressure variation (24 h SBPV),24 h average diastolic blood pressure variation (24 h DBPV),the day average systolic blood pressure variation (dSBPV),the night average systolic blood pressure variation (nSBPV),the day average diastolic blood pressure variation (dDBPV),the night average diastolic blood pressure variation (nDBPV),the standard deviation (SD)and variable coefficient (CV) of morning peak systolic blood pressure and diastolic blood pressure.Results 24 h SBPV,dSBPV,nSBPV,24 h DBPV,dDBPV,nDBPV was increased significantly in hypertension combined with lacunar cerebral infarction group compared with those in simple hypertension group (0.15±0.03 vs.0.11 ± 0.02,0.14 ± 0.02 vs.0.10 ± 0.03,0.14 ± 0.03 vs.0.10 ± 0.08,0.13 ± 0.08 vs.0.11 ±0.04,0.14 ±0.02 vs.0.11 ±0.07,0.14 ±0.05 vs.0.09 ±0.02),and there was significant difference (P ＜ 0.05).SD and CV of morning peak systolic blood pressure and diastolic blood pressure in hypertension combined with lacunar cerebral infarction group was higher than that in simple hypertension group [(15.37 ±4.55) mmHg (1 mmHg =0.133 kPa) vs.(13.53 ±2.26) mmHg,(13.64 ±4.95) mmHg vs.(9.80 ± 3.46) mmHg,0.141 ± 0.048 vs.0.113 ± 0.037,0.145 ± 0.056 vs.0.105 ± 0.036],and there was significant difference(P ＜ 0.05).Conclusion The BPV,especially morning blood pressure surge BPV are increased significantly in the hypertension combined with lacunar cerebral infarction group compared with that simple hypertension group,BPV increase is one of the important risk factors of cerebral infarction.

ObjectiveTo investigate the perioperative nursing experience in patients with renal cell carcinoma treated by cryoablation.Method The clinical data of 34 patients with renal cell carcinoma treated by cryoablation were retrospectively analyzed to summarize the perioperative nursing strategies.Results All the patients lived through the operations.The complications after the surgery occurred in 7 cases,with bleeding in 4 cases,urinary fistula in 1 case and wound infections in 2 cases.All the complications were cured by active treatment.After following up for 6 months,all the tumors showed liquefaction and necrosis and no one relapse. Conclusion Active and effective nursing intervention is the key point for the success of cryoablation.

Vitamin E succinate (VES) has been recently recognized as a neotype tumor suppressor.However, the molecular mechanisms that VES induces apoptosis in breast cancer cells have not been validated. Current studies have indicated that VES induces breast cancer cell apoptosis through TGF-β signaling transduction pathways, Fas signaling transduction pathways, and JNK signaling transduction pathways.Other signaling transduction pathways still need to be investigated further.

Objective To evaluate the accuracy of the index of consciousness (IoC) in monitoring the depth of anesthesia with sevoflurane inhalation in children,by comparing it with the bispectral index (BIS).Methods Forty-two ASA physical status Ⅰ or Ⅱ children,aged 8-12 yr,scheduled for elective abdominal surgery under general anesthesia,were studied.Anesthesia was induced with sevoflurane inhalation.The patients were endotracheally intubated.The concentration of sevoflurane was then adjusted to maintain the end-tidal concentration of sevoflurane (CETSev) at 1.6％,2.1％,2.6％,3.1％,3.6％,4.1％ and 4.6％ for5 min.The IoC and BIS values were recorded simultaneously.Results When CETSev ＜ 3.1％,CETSev was negatively correlated with IoC and BIS values,and the correlation coefficients between CETSev and IoC and BIS values were-0.927 (r1) and -0.869 (r2),respectively (P ＜ 0.01).When 3.1％ ≤ CETSev ≤ 4.6 ％,CET Sev was negatively correlated with IoC and BIS values,and the correlation coefficients between CETSev and IoC and BIS values were-0.808 (r3,P＜ 0.01) and-0.430 (r4,P ＜ 0.05),respectively.Comparison of the absolute value of correlation coefficients:there was no significant difference between r1,r2 and r3 (P ＞ 0.05) ; r1,r2 and r3 were significantly larger than r4 (P ＜ 0.01).Conclusion IoC can accurately reflect the depth of anesthesia with sevoflurane inhalation in children and when 3.1％ ≤ CET Sev ≤ 4.6 ％,the accuracy of IoC in monitoring the depth of anesthesia is superior to that of BIS.

Hyperglycemia has direct and indirect impact on the occurrence and develop-ment of stroke. At present, hyperglycemia is considered as an independent risk factor for stroke. Hyperglycemia directly involves in cellular and vascular injury through activating polyol pathway, forming advanced glycosylation end product, activating protein kinase C and the hexosamine pathway. Moreover, hyperglycemia involves in vascular injury through the indirectly pathway such as lipid metabolism, glycosylated hemoglobin and insulin. Controlling hyperglycemia may effectively reduce the incidence of stroke and improve the prognosis in patients with stroke.

Objective To build relationship model of personality, life style and mental health for medical students. Methods 869 medical students were surveyed with Eysenk Personality Questionnaire, Symptom Check List 90(SCL-90), common condition questionnaire, to describe the situation of medical students mental health and personality, and a relationship model was set up by structural equation modeling. Results The situation of mental health for medical students was well. Male students showed significantly higher lie than female students. The only children showed significant higher lie than those having siblings. Neuroticism, life style, lie, sleep time everyday, boarding and lodging in middle school, friends, only child, degree of parents attention had significant direct influence on mental health (β =0.508, 0.136, 0.100, 0.082, 0.076, -0.057, 0.057, 0.051 ). Neuroticism, friends and sleep time everyday affected mental health in an indirect way through life style (β = 0.044, - 0. 008, 0.007). Only child affected mental health in an indirect way through boarding and lodging in middle school (β = -0.026). Lie affected mental health in an indirect way through neuroticism (β =0. 195). Conclusion The important effects of personality, life style on mental health are further supported in this study.

Kawasaki disease, also known as infantile skin mucous membrane lymph node syndrome, is an acute vasculitis syndrome in pediatricdepartment. The lesion mainly involves medium and small arteries, particularly the coronary artery, being a major cause of pediatric coronary lesion and also a potential risk factor of coronary heart disease during later adulthood. Here the clinical data and treatment of one case of Kawasaki disease complicated with coronary aneurysm and 4 years later the occurrence of cardiocerebrovascular lesion (CCVL) were retrospectively analyzed, and the related literatures were reviewed and analyzed to approach the clinical characteristics of this disease complications. It is suggested that at early stage regular treatment should be applied and afterwards periodical follow-up should be performed; long-term monitoring coronary changes ought to be carried out to decrease the occurrence of CCVL accident.

Objective To evaluate the efficacy and safety of Levofloxacin combined triple viable bacteria tablets of Lactobacillus in the treatment of acute diarrhea.Methods65 cases of acute diarrhea patients were randomly divided into control group with 32 cases and experiment group of 33 cases.Patients were given antiemetic, fever and nutritional supplements and other symptomatic treatment,the control group was treated with ofloxacin injection 10mL+5% glucose solution 250mL for an intravenous injection, 3 days as a course of treatment;The experiment group was treated on the basis of triple viable bacteria tablets of Lactobacillus 4 tablets, 3 times a day, 3 days for a course of treatment.Clinical curative effect, adverse reaction rate, serum TNF-α, IL-6, CD4+, CD8+ and CD8+ CD4+/ level were compared.ResultsThe total effective rate in the experimental group was significantly higher than that in control group(P<0.05), there was no significant difference in the incidence of adverse reactions between the two groups.The levels of IL-6 and TNF-α were decreased in 2 groups (P<0.05), the levels of CD4+ in the two groups were decreased (P<0.05), and the CD4+ level was lower in the experiment group (P<0.05);the CD4+/CD8+ level was increased (P<0.05), and the CD4+/CD8+ level was higher in the experiment group (P<0.05).ConclusionThe clinical efficacy of levofloxacin combined with triple viable bacteria tablets of Lactobacillus in the treatment of acute diarrhea is significant, and the safety is high.

Background Atrial fibrillation (AF) is one of the most prevalent arrthythmias. Hypertension independently accounts for more AF cases than any other risk factors. Therefore,prevention of risk factors in patients with essential hypertensives(EH) is important for early prevention and diagnosis of AF. However,only a few data are available regarding left ventricle remodeling in essential hypertensive patients with atrial fibrillation(EH+AF). Objective To study the characteristics of left heart remodeling and function and its clinical significance in EH+AF,and predict some risk factors of AF. Methods All 561 patients were recruited which included EH+AF(n=224),EH alone(n=171),AF alone(n=166) with normal subjects as control(n=157). Interventricula septal thickness at end-diastole(IVSTd),posterior left ventricular wall thickness at end-diastole(LVPWTd),left ventricular end-diastolic dimension(LVEDD),left ventricular end-systolic dimension(LVESD),left atrial dimension (LAD),left ventricular ejection fraction stroke volume(LVEF),stroke volume(SV)cardiac output(CO)were measured with echocardiography. Left ventricular mass(LVM),left ventricular mass index(LVMI)and relative wall thickness(RWT)were calculated. Results LVM,LVMI,IVSTd,LVPWTd,LVESD,LVEDD,LAD,RWT in the EH+AF group were significantly greater than those in the AF alone or EH alone patients(P

Background Researches showed that aquaporin-1 (AQP1) is closely associated with corneal neovescularization(CNV).Carbonic anhydrase inhibitor has the inhibitory effect on the AQP1 and further suppresses the CNV.However,the systemic adverse effect of Carbonic anhydrase inhibitor limit its clinical application.Therefore,the influence of topical carbonic anhydrase inhibitor on CNV is concerned.Objective Present study was to investigate the effects of topical carbonic anhydrase inhibitors on the expression of AQP1 in rat cornea after alkali burn and explore its role in corneal neovascularization (CNV).Methods The alkali-burn animal models were established in 60 eyes of 30 clean Sprague Dawley rats by putting the filter paper soaked 1 mol/L NaOH solution at the central cornea for 40 seconds.1％ Brinzolamide was topically administered in the 30 eyes of 15 models (Brinzolamide group),and the normal saline solution was used at the same way in other 30 eyes of 15 rats (model group).The 10 eyes of 5 normal Sprague Dawley received the eye drops of normal saline solution as the normal control group.The corneal burning degree was graded on the Mahoney ' s criteria in the third day,and Ee ' s method was used to score the opacification of cornea and the CNV area was analyzed in 3,5,7,10 days under the slit lamp microscope.The cornea tissue was obtained in the tenth day after burning for the observation of the pathology under the light microscope and the ultrastructure under the transmission electron microscope.The expressions of AQP1 and vascular endothelial growth factor(VEGF) in cornea tissue were detected using immunohistochemistry.The use of animals complied with the Statement of ARVO.Results No significant difference was seen in the scores of rat corneal alkali burn between the model group and brinzolamide group( t=0.97,P＞0.05 ).The scores of corneal edema and opacification and neovascular area were lower in brinzolamide group compared with model group ( t =2.18,P＜0.05 ;t =6.58,P＜0.01 ).The pathological and ultrastructural examinations showed less CNV and inflammatory cells in rat corneal tissue of the brinzolamide group in comparison with model group.The grey values of VEGF were 84.92±9.49 and 78.18± 11.41,and those of AQP1 were 88.01 ± 11.03 and 58.10 ± 12.14 in the model group and brinzolamidegroup respectively,showing statistically significant differences ( VEGF:t =2.48,P =0.02 ; AQPI:t =9.99,P =0.00 ).Conclusions 1％ Brinzolamide suppresses alkali burn-induced CNV by downregulating the expressions of AQP1 and VEGF in cornea in rat.