1.Treatment of high-risk neuroblastoma.
Korean Journal of Pediatrics 2012;55(4):115-120
Although high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) have improved the prognosis for patients with high-risk neuroblastoma (NB), event-free survival rates remain in the range of 30 to 40%, which is unsatisfactory. To further improve outcomes, several clinical trials, including tandem HDCT/autoSCT, high-dose 131I-metaiodobenzylguanidine treatment, and immunotherapy with NB specific antibody, have been undertaken and pilot studies have reported encouraging results. Nonetheless, about half of high-risk NB patients still experience treatment failure and have no realistic chance for cure with conventional treatment options alone after relapse. Therefore, a new modality of treatment is warranted for these patients. In recent years, several groups of investigators have examined the feasibility and effectiveness of reduced-intensity allogeneic stem cell transplantation (RI alloSCT) for the treatment of relapsed/progressed NB. Although a graft-versus-tumor effect has not yet been convincingly demonstrated in the setting of relapsed NB, the strategy of employing RI alloSCT has provided hope that treatment-related mortality will be reduced and a therapeutic benefit will emerge. However, alloSCT for NB is still investigational and there remain many issues to be elucidated in many areas. At present, alloSCT is reserved for specific clinical trials testing the immunomodulatory effect against NB.
Disease-Free Survival
;
Humans
;
Immunotherapy
;
Neuroblastoma
;
Prognosis
;
Recurrence
;
Research Personnel
;
Stem Cell Transplantation
;
Treatment Failure
2.External Beam Radiotherapy Alone in Advanced Esophageal Cancer.
Sung Ja AHN ; Woong Ki CHUNG ; Byung Sik NAH ; Taek Keun NAM
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2000;18(1):11-16
PURPOSE: We performed the retrospective analysis to find the outcome of external beam radiotherapy alone in advanced esophageal cancer patients. METHODS AND MATERIALS: One hundred and six patients treated with external beam radiotherapy alone between July 1990 and December 1996 were analyzed retrospectively. We limited the site of the lesions to the thoracic esophagus and cell type to the squamous cell carcinoma. Follow-up was completed in 100 patients (9 4%) and ranged from 1 month to 92 months (median; 6 months). RESULTS: The median age was 62 years old and male to female ratio was 104:2. Fifty-three percent was the middle thorax lesion and curative radiotherapy was performed in 83%. Mean tumor dose delivered with curative aim was 58.6 Gy (55-70.8 Gy) and median duration o f the radiation therapy was 53 days. The median survival of all patients was 6 months and 1-year and 2-year overall survival rte was 27% and 12%, respectively. Improvement of dysphagia was obtained in most patients except fo 7 patients who underwent feeding gastrostomy. The complete response rate immediately after radiation therapy was 32% (34/106). The median survival and 2-year survival rate of the complete responder was 14 months and 30% respectively, while those of the nonresponder was 4 months and 0% respectively (p=0.000). The median survival and 2-year survival rate of the patients who could tolerate regular diet was 9 rnonths and 16% while those of the patients who could not tolerate regular diet was 3 months and 0%, respectively (p=0.004). The survival difference between the patients with 5 cm or less turnor length and those with more than 5 cm tumor length was rnarginally statistically significant (p=0.06). However, the survival difference according to the periesophageal invasion or mediastinal lymphadenopathy in the chest CT imaging study was not statistically significant in this study. In a multivariate analysis, the statistically significant covariates to the survival were complete response to radiotherapy, tumor length, and initial degree of dysphagia in a decreasing order. The complication was observed in 10 patients (9%). CONCLUSION: The survival outcome for advanced esophageal cancer patients treated by external be am radiotherapy alone was very poor, In the treatment of these patients, the brachytherapy and chemotherapy should be added to improve the treatment outcome.
Brachytherapy
;
Carcinoma, Squamous Cell
;
Deglutition Disorders
;
Diet
;
Drug Therapy
;
Esophageal Neoplasms*
;
Esophagus
;
Female
;
Follow-Up Studies
;
Gastrostomy
;
Humans
;
Lymphatic Diseases
;
Male
;
Middle Aged
;
Multivariate Analysis
;
Radiotherapy*
;
Retrospective Studies
;
Survival Rate
;
Thorax
;
Tomography, X-Ray Computed
;
Treatment Outcome
3.Influence of tumor size on chemosensitivity of FSa II in combination of cyclophosphamide and radiation.
Woong Ki CHUNG ; Hyon De CHUNG ; Sung Whan HA ; Charn Il PARK
Journal of the Korean Cancer Association 1992;24(1):109-124
No abstract available.
Cyclophosphamide*
4.Effect of Preoperative Chemotherapy.
Jae Kyung LEE ; Hyeong Soo CHOI ; Ki Woong SUNG ; Hee Young SHIN ; Hyo Seop AHN
Korean Journal of Pediatric Hematology-Oncology 1997;4(1):105-117
BACKGROUND: The survival rate of children with neuroblastoma has been improved over 20 years, excluding the metastatic disease, in which it does not exceed 20% so far. New treatment modalities have been developed to improve the outcome in metastatic disease. Preoperative chemotherapy reduce the size, the vascularity and the adhesiveness, so increase the resectability of the primary tumor. This retrospective clinical study was designed to review the survival rate in neuroblastoma and to analyze the effect of preoperative chemotherapy in the view point of neoadjuvant therapy on long-term survival in advanced disease. METHODS: One hundred and thirty-four cases were reviewed from 135 patients with neuroblastoma registered at the Department of Pediatrics in Seoul National University Children's Hospital from January, 1985 till December, 1995. The survival rate was reviewed according to the stage. The age, sex of the patients, the stage, anatomical site of the tumor, the level of serum ferritin and neuron-specific enolase were analyzed for the risk factors on survival. RESULTS: Ranges of age at diagnosis were from 1 month to 166 months with the median of 39 months. Five year survival rates and five year disease-free survival rates were 100%, 100% in stage 1(n=5), 90.9%, 90.9% in stage 2(n=13), 43.4%, 40.6% in stage 3(n=19), 27.1%, 19.8% in stage 4(n=95) and 100%, 100% in stage 4S(n=2), respectively. In stage 3, five year survival rate was 52.5% in group receiving neoadjuvant chemotherapy, 28.6% in control group(P=0.02). Five year disease-free survival rate was also noted as 48.6%, 28.6% in each group(P=0.02). In stage 4, five year and ten year survival rates were 27.6%, 23.6% in group receiving neoadjuvant chemotherapy, 26.9%, 0% in control group(P=0.02). Five year and ten year disease-free survival rates were 14.3%, 14.3% in group receiving neoadjuvant chemotherapy, 20%, 0% in control group (P=0.11). In univariate analysis, the age, the stage, and the site of primary tumor appeared to affect the long-term survival. CONCLUSION: Neoadjuvant chemotherapy and delayed primary surgery contribute for advance in survival in advanced neuroblastoma via increasing the resectability of the primary tumor.
Adhesiveness
;
Child
;
Diagnosis
;
Disease-Free Survival
;
Drug Therapy*
;
Ferritins
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Humans
;
Neoadjuvant Therapy
;
Neuroblastoma
;
Pediatrics
;
Phosphopyruvate Hydratase
;
Retrospective Studies
;
Risk Factors
;
Seoul
;
Survival Rate
5.A Case of Dermatomyofibroma on Inguinal Area in a Middle Aged Woman.
Sung Eun SONG ; Seung Gi HONG ; Sun Young JO ; Eun Phil HEO ; Ki Woong RO
Korean Journal of Dermatology 2018;56(10):640-641
No abstract available.
Female
;
Humans
;
Middle Aged*
;
Myofibroblasts
6.A Case of Diffuse Extramammary Paget's Disease of Vulva and Anus Showing a Good Response to Radiotherapy.
Sung eun SONG ; Seung gi HONG ; Ki woong RO ; Eun phil HEO
Korean Journal of Dermatology 2018;56(4):284-300
No abstract available.
Anal Canal*
;
Paget Disease, Extramammary*
;
Radiotherapy*
;
Vulva*
7.Allogeneic stem cell transplantation for neuroblastoma.
Korean Journal of Hematology 2012;47(1):3-5
No abstract available.
Neuroblastoma
;
Stem Cell Transplantation
;
Stem Cells
8.Differential diagnosis of abdominal masses in children.
Korean Journal of Pediatrics 2008;51(8):787-791
Enlargement of organs or other solid tissues usually presents as an abdominal mass. Often, abdominal masses in children are found by an unsuspected parent or by a physician during a routine examination. Most masses have no specific signs or symptoms. Abdominal masses in children require immediate attention. History and physical examination may provide clues to the diagnosis. Ultrasound examination is the most useful screening test in most cases and may identify the organ involved and clarify whether the mass is solid or cystic. CT may be necessary to make a more precise diagnosis, especially solid masses. MRI is occasionally is helpful for specific abnormalities.
Child
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Diagnosis, Differential
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Humans
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Mass Screening
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Parents
;
Physical Examination
9.A Case of Congenital Malaria due to Plasmodium vivax.
Gil Soon CHOE ; Ki Joong KIM ; Sung Hee OH ; Woong Soo LEE ; Hahng LEE
Korean Journal of Infectious Diseases 2001;33(3):223-226
No abstract available.
Malaria*
;
Plasmodium vivax*
;
Plasmodium*
10.The Use of Flexible Intramedullary Nails in Fracture of the Tibial Shaft
Jang Sung LEE ; Kyo Woong KIM ; Byung Guk KIM ; Seung Ki JEONG ; Sang Young KIM
The Journal of the Korean Orthopaedic Association 1990;25(1):70-77
Forty five cases of adult tibial shaft fractures were treated with flexible intramedullary nails under image intensifier at the department of orthopaedic surgery, Capital Armed Forces General Hospital during between April 1986 to July 1988. The results were summarized as follows: 1. 45 cases were all male, the average age was 24.3 years and the most common cause of fractures was sports injury(20 cases) and the second most common cause was traffic accident(18 cases). 2. 11 cases out of 45 cases were open fracture and 34 cases were closed fracture. Eight cases of open fraeture were grade I and three cases were grade II. Twenty eight cases were comminuted fracture. The most common level of the fracture was middle third of the tibial shaft. 3. Average interval from injury to Ender nailing was 13.5 days and the mean duration of permission to full weight bearing was 9.2 weeks. 4. Out of 2 cases of delayed union, the average time of clinical bone union was 9.7 weeks and that of roentgenological bone union was 14 weeks. 5. 11 cases of complication were noted among the 45 cases of tibial shaft fracture which were treated by PGP nailing such as angulation, rotation, ankle joint stiffness, delayed union, shortening, and soft tissue infection. 6. PGP nailing is considered to be a valuable method in treating tibial shaft fracture because of their relative ease of nailing, allowing early weight bearing and decreased complication.
Adult
;
Ankle Joint
;
Arm
;
Fractures, Closed
;
Fractures, Comminuted
;
Fractures, Open
;
Hospitals, General
;
Humans
;
Male
;
Methods
;
Soft Tissue Infections
;
Sports
;
Tibial Fractures
;
Weight-Bearing