1.The effect of azelaic acid and retinoic acid on epidermal melanocytes in UVB-irradiated black mice.
Kyung Won HAN ; Ki Hong LEE ; Ki Bum MYUNG
Korean Journal of Dermatology 1992;30(4):492-498
Increased melanin pigmentation following ultraviolet irradiat.ion is due to increasing tyrosinase activity and multiplicatian of functioning melanocytes. After UV-irradiation, the size of melanocytes increases, and melanocyte dendrites elongatc, and branch. In this experiment, we induced the activation of melanocyts in the epidermis of C57BL black mice by ultraviolet-B(UVB) irradiation and observcd ihe effect of azelaic acid and retinoic acid on the UVB activated epidermal melanocytes. Sixty C57BL black mice were irradiated by UVB 100mJ/cm daily for 10 days, and then azeiaic acid and retinoic acid were topically applied daily for 7 weeks. For the estimation of morphologic change of epidermal melanocytes, light microscopic observation with split DOPA stain was performed at the end of the 1st, 3rd, 5th and 7th week of topical application. The results are summerized as follows : 1. The number, size and circumference of DOPA-positive epidermal melanocytes were significantly decreased in 20% azelaic acid applied group and 30% azelaic acid and 0.05% retinoic acid applied group. 2. In 20% azelaic;i.cid and 0.05% retinoic acid applied group, the number, size and circumference of DOPA-positive epidermal melanocytes were nore significantly decreased than in 20% azelaic acid applied group. In summary, the present study suggets that azelaic acid act as a depigmenting agent on epidermal melanocyte; and such depigmenting effect of azelaic acid was increased by addition of retinoic acid.
Animals
;
Dendrites
;
Dihydroxyphenylalanine
;
Epidermis
;
Melanins
;
Melanocytes*
;
Mice*
;
Monophenol Monooxygenase
;
Pigmentation
;
Tretinoin*
2.Cystic Lesions in Os Calcis
Ki Ser KANG ; Han Koo LEE ; Sung Ho HAN
The Journal of the Korean Orthopaedic Association 1976;11(3):571-575
The authors experienced six patients who were admitted in Department of Orthopedic Surgery at Seoul National University Hospital during the period of March 1966 to February 1976 with cystic lesions in calcaneus by radiographic findings. The following results were obtained. Among the six patients, four were osteomyelitis, one was eosinophilic granuloma and the other was fibromyxoid sarcoma. They were all similar in radiographic findings, but were different each other in pathologic findings. 2. Diagnosis is very difficult only with the patients history, hematologic and radiographic findings and the pathologic findings is the most important in the final confirmative diagnosis from benign cystic lesions to malignant one. 3. We describe about the kinds and points of the differential diagnosis. of the other discases from the reported six cases.
Calcaneus
;
Diagnosis
;
Diagnosis, Differential
;
Eosinophilic Granuloma
;
Humans
;
Orthopedics
;
Osteomyelitis
;
Sarcoma
;
Seoul
3.Hemorrhagic Shock and Encephalopathy Syndrome as a Cause of Sudden Death in Infants.
Jong Won LEE ; Chang Han LEE ; Ki Sup CHUNG
Journal of the Korean Pediatric Society 2000;43(6):814-819
PURPOSE: To evaluate the clinical characteristics, treatments and outcome of patients with hemorrhagic shock and encephalopathy(HSE) syndrome. METHODS: We performed a clinical study on 14 patients who were diagnosed as hemorrhagic shock and having encephalopathy syndrome in the Department of Pediatrics, from 1984 to 1998. Age, sex, clinical symptoms and physical findings at admission, the most deranged laboratory findings, radiologic findings, treatments and outcome were analyzed. RESULTS: The age of onset was 1.0+/-0.9 years and the male to female ratio was 1: 1.8. At admission, clinical findings included dehydration in 85.7%, shock in 85.7%, fever in 71.4%, vomiting in 71.4%, diarrhea in 64.3%, GI bleeding in 50%, convulsion in 42.9%, and edema in 35.7%. Altered mental state was found in 100%, hepatomegaly in 64.3%, and splenomegaly in 21.4%. Laboratory findings revealed D-dimer positive in 92.9%, the mean hemoglobin level 8.2+/-2.1g/dL, BUN 35.7+/-24.0mg/dL, creatinine 1.9+/-1.5mg/dL, AST 561.0+/-1,412.1IU/L, ALT 858.9+/-1,649.8IU/L, blood glucose 229.5+/-197.4mg/dL, ammonia 195.4+/-129.7pg/dL, and total bilirubin 4.9+/-8.2mg/dL. On serologic tests, rotavirus and Epstein-Barr virus was found in 1 patient(7.1%), respectively. The mortality rate was 78.6%. CONCLUSION: We found that shock and disseminated intravascular coagulation(DIC) played important roles in the pathogensis of HSE syndrome, and encephalopathy, hepatic and renal insufficiency, and respiratory failure were secondary complications resulting from shock and DIC. Despite vigorous treatment, the prognosis was very poor. We feel more efforts should be focused on investigating the etiology and pathophysiology of HSE to prevent as well as develop a specific therapy. (J Korean Pediatr Soc 2000;43:814-819)
Age of Onset
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Ammonia
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Bilirubin
;
Blood Glucose
;
Creatinine
;
Dacarbazine
;
Death, Sudden*
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Dehydration
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Diarrhea
;
Edema
;
Female
;
Fever
;
Hemorrhage
;
Hepatic Encephalopathy
;
Hepatomegaly
;
Herpesvirus 4, Human
;
Humans
;
Infant*
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Male
;
Mortality
;
Pediatrics
;
Prognosis
;
Renal Insufficiency
;
Respiratory Insufficiency
;
Rotavirus
;
Seizures
;
Serologic Tests
;
Shock
;
Shock, Hemorrhagic*
;
Splenomegaly
;
Vomiting
4.Multiple primary lung cancer: A case report.
Young Han YOON ; Doo Yeon LEE ; Ki Beom LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(9):722-725
No abstract available.
Lung Neoplasms*
;
Lung*
5.The study of immune function in the repeaters of college enterance examination.
Ki Joo LEE ; Young Cho CHUNG ; Gi Seok HAN
Journal of Korean Neuropsychiatric Association 1992;31(1):60-67
No abstract available.
6.Red Blood Cell Indices, Serum Iron and Total Iron Binding Capacity in Children with Helicobacter pylori Infection.
Soo Joon PARK ; Chang Han LEE ; Ki Sup CHUNG
Journal of the Korean Pediatric Society 2000;43(6):755-762
PURPOSE: H. pylori infection was recently reported to be associated with unexplained iron-deficiency anemia(IDA) in children and adolescents. H. pylori-related IDA was thought to occur due to GI blood loss, scavenging of iron by H. pylori and iron malabsorption. The aim of this study was to examine how the status of H. pylori infection and age of children affected RBC indices, serum iron level and TIBC. METHODS: We performed esophagogastroduodenoscopy, and examined RBC indices, serum iron and TIBC on 178 pediatric patients with recurrent abdominal pain. H. pylori infection was assessed by CLO test and silver stain of gastric biopsy specimen. RESULTS: H. pylori infection was found in 42 of 178 patients(23.6%). In children with H. pylori infection, the prevalence of iron deficiency(ID) and IDA(39.0% and 10.3%, respectively) was higher than in children without H. pylori infection(29.6% and 4.1%, respectively), but there was no statistically significant difference. Serum iron level was lower(69.5+/-32.7 vs 77.3+/-34.1g/dL; P= 0.08) and TIBC was higher(380.8+/-50.4 vs 366.9+/-47.0g/dL; P=0.09) in children with H. pylori infection than in children without H. pylori infection. All RBC indices and iron saturation were lower in children with H. pylori infection than in children without H. pylori infection, but there was no significant difference between the two groups. In correlation analysis, serum iron, Hgb, Hct, MCV and MCH were significantly increased by age in children without H. pylori infection (P<0.05), but MCH and MCHC were decreased significantly(P<0.05) by age in children with H. pylori infection. In multiple regression analysis, the change of serum iron, MCH and MCHC by age was significantly influenced by the status of H. pylori infection(P<0.05). CONCLUSION: H. pylori infection decreases RBC indices and serum iron and increases TIBC in children. These changes become prominent as age increases. This age effect rnay be related to the duration of H. pylori infection. (J Korean Pediatr Soc 2000;43:755-762)
Abdominal Pain
;
Adolescent
;
Anemia, Iron-Deficiency
;
Biopsy
;
Child*
;
Endoscopy, Digestive System
;
Erythrocytes*
;
Helicobacter pylori*
;
Helicobacter*
;
Humans
;
Iron*
;
Prevalence
;
Silver
7.Median sternotomy for simultaneous bilateral bullectomy.
Young Tae KWAK ; Dong Ki HAN ; Shin Yeong LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(7):763-768
No abstract available.
Sternotomy*
8.A Study on the Blood Pressure Measurements in Newborn.
Ran NAMGUNG ; Ki Soo PAI ; Chul LEE ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1988;31(5):541-546
No abstract available.
Blood Pressure*
;
Humans
;
Infant, Newborn*
9.Acetabular Revision with Hemispherical Porous Coated Prosthesis.
Chang Dong HAN ; Ki Won KANG ; Woo Suk LEE
The Journal of the Korean Orthopaedic Association 1999;34(1):23-30
PURPOSE: To report the results of acetabular revisions performed with the cementless, hemi-spherical porous coated component supported by viable host bone and minimal allobone graft for acetabular deficiencies. MATERIALS AND METHODS: A retrospective study was completed for 22-revision acetabular components, using the cementless hemispherical porous coated prosthesis and minimal femoral head allograft. There was an average follow up of 48 months, with a range of 24 to 84 months. Radiographic measurements were performed in several aspects; cup-allograft contact, inclination, vertical and horizontal migration of acetabular cup, and acetabular zone by modified zone of DeLee and Charnley, in which location, size and progression or non-progression of radiolucent zone were recorded. The acetabular deficiencies were classified by the American Academy of Orthopaedic Surgeons Committee and were type I in 2 hips (9%), type II in 12 hips (55%), and type III in 8 hips (36%). Twenty acetabular cup cases of Harris-Galante II were used in this study, 1 case of Harris- Galante I, and 1 case of Duraloc. The average size of the cup was 57(44-66) mm. RESULTS: The average cup-allograft contact was 72.5% in 19 cases and we could not differentiate the margin between the host bone and the allograft in 3 cases. There was no significant vertical or horizontal migration of acetabular cup. Radiolucent zones in follow-up radiographs were 8 cases in zone IA, 4 cases in zone IB, 4 cases in zone IIB, 9 cases in zone IIC, 8 cases in zone IIIA, and 7 cases in zone IIIB. One case showed 2 mm radiolucent area in zone IIC and another case showed 3 mm radiolucent area in zone IIB, but the radiolucencies were not progressive. The remaining cases showed less than 0.5 mm radiolucent area or no radiolucent zone. The average period of bony incorporation was 13.1 months. CONCLUSIONS: We suppose that acetabular revision with the cementless hemispherical porous coated cup supported by viable host bone and minimal bone graft produces good results.
Acetabulum*
;
Allografts
;
Follow-Up Studies
;
Head
;
Hip
;
Prostheses and Implants*
;
Retrospective Studies
;
Transplants
10.Osteoblastoma: A Case Report
Han Koo LEE ; Chung Yong HONG ; Sung Ki KIM
The Journal of the Korean Orthopaedic Association 1979;14(1):129-132
Osteoblastoma is a benign lesion somewhat similar to ostoid osteoma histologically but different from it clinically, roentgenologically and grossly. The autors have experienced a case of benign osteoblastoma of the neural arch of the Iumbar spine, and treated the case by total laminectomy and conflrmed with biopsy.
Biopsy
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Laminectomy
;
Osteoblastoma
;
Osteoma
;
Spine