1.Action Mechanisms of Hormone Binding to Cell Surface Receptors: 3) TGF-beta; Binding to Serine-threonine Kinase Receptors and Action Mechanisms.
Journal of Korean Society of Endocrinology 2000;15(3):353-366
No Abstract Available.
Protein-Serine-Threonine Kinases*
;
Receptors, Cell Surface*
;
Transforming Growth Factor beta*
2.Crossroad between inflammation and carcinogenesis in colon.
Marie YEO ; Young Joon SURH ; Ki Baik HAHM
Korean Journal of Medicine 2006;70(2):130-137
Current evidences have expended the concept that chronic inflammation might play a crucial role in the development and progression of colorectal cancer. For instance, chronic ulcerative colitis (UC) is associated with a 10- to 40-fold increased risk of developing colorectal cancer (CRC) compared to the general population. However, the specific mechanistic link between chronic inflammation and carcinogenesis in colon has not been integrated into molecular understanding. In this current review, we will provide an update on the molecular pathogenesis of colitis-associated colorectal cancer, focused on 1) the differences of molecular mechanism between the colitis-associated colorectal cancer (CAC) and the sporadic colorectal cancer (SCC), 2) the plausible and contributive role of chronic inflammation in colon carcinogenesis, and 3) lessons learned from colitis-associated animal model. Understanding of molecular pathogenic mechanism underlying the colitis-associated colorectal cancer will facilitate the development of novel treatment strategies for prevention of colitis-associated colorectal cancer.
Carcinogenesis*
;
Colitis, Ulcerative
;
Colon*
;
Colorectal Neoplasms
;
Inflammation*
;
Inflammatory Bowel Diseases
;
Models, Animal
3.Perfecting Video Capsule Endoscopy: Is There Need for Training?.
Clinical Endoscopy 2013;46(6):599-600
No abstract available.
Capsule Endoscopy*
4.Helicobacter pylori infection and COX-2.
Korean Journal of Medicine 2002;62(2):125-127
No abstract available.
Helicobacter pylori*
;
Helicobacter*
5.Helicobacter pylori infection and COX-2.
Korean Journal of Medicine 2002;62(2):125-127
No abstract available.
Helicobacter pylori*
;
Helicobacter*
6.Establishment of Cell Line for in Vitro Study of Helicobacter pylori Infecfion.
The Korean Journal of Gastroenterology 2006;47(5):402-403
No abstract availble.
Animals
;
*Cell Line
;
*Helicobacter Infections
;
*Helicobacter pylori
;
Humans
7.A Case of Colonic Cavernous Hemangioma Misdiagnosed as a Pedunculated Polyp.
Journal of the Korean Society of Coloproctology 2009;25(2):125-128
Gastrointestinal hemangioma is a relatively uncommon benign vascular tumor that can occur anywhere in the gastrointestinal tract. It is the second most common vascular lesion of the colon and a clinically important entity because of the possibility of massive hemorrhage when complicated. In gross appearance, hemangioma presents variously as a pedunculated, subpedunculated, or flat elevated lesion similar to a submucosal tumor. A typical case of hemangioma is relatively easy to diagnose because the lesion presents as translucent blue-purple vessels under the mucosa. However, it can be difficult to diagnose in some cases, especially if it does not have its usual characteristic color or is covered with normal mucosa. We incidentally found a colonic hemangioma that had the unusual appearance of a pedunculated polypoid lesion with normal mucosa. It was misdiagnosed as a pedunculated polyp with a long, thick neck and treated by using an endoscopic mucosal resection.
Caves
;
Colon
;
Gastrointestinal Tract
;
Hemangioma
;
Hemangioma, Cavernous
;
Hemorrhage
;
Mucous Membrane
;
Neck
;
Polyps
9.A Case of Hypertrophic Cardiomyopathy with Myocardial Infarction and Normal Coronary Arteriogram.
Ki Baik HAHM ; Woong Ku LEE ; Seung Yun CHO ; Keum Soo PARK ; Yang Soo JANG ; Nam Sik CHUNG
Korean Circulation Journal 1986;16(2):291-298
Patients with hypertrophic cardiography often complain of chest pain and have electrocardioagrams suggesting myocardial damage or ischemia. Some of three patients have associated coronary arterial atherosclerosis. Transmural myocardial infarction may occur in patients with hypertrophic cardiomyopathy in the absence of significant atherosclerosis of the extramural coronary arteries, about which several pathophysiologic exlpanations were discussed. Presented here, a case of 49-year-old man with hypertrophic cardiomyopathy accompanied with myocardial infarction and angiographically normal coronary arteries is reported. Asymmetric septal hypertrophy, characteristic morphologic abnormality of hypertrophic cardiomyopathy, was progressed to dilated cardiomyopathy after the occurrence myocardial infarction.
Atherosclerosis
;
Cardiomyopathy, Dilated
;
Cardiomyopathy, Hypertrophic*
;
Chest Pain
;
Coronary Vessels
;
Humans
;
Ischemia
;
Middle Aged
;
Myocardial Infarction*
10.Relationship of Serum Anti-p53 Antibody with p53 Expression in Liver Tissue of Chronic Diseases.
Young Soo KIM ; Young Jun SHIN ; Ki Baik HAHM ; Hee Jung WANG ; Yun Mi JIN ; Sung Won CHO
The Korean Journal of Hepatology 1998;4(2):131-142
BACKGROUND/AIMS: The p53 mutations have been described as the most common genetic alteration during development and progression of malignancy in a wide range of human cancers. Mutant p53 proteins have a prolonged half-life accounting for increased levels of p53 protein frequently detected in tumors. This can induce the production of anti-p53 in the senzn of patients with HCC. We determined the relationship of serum anti-p53 with p53 expression in the liver tissue of chronic liver disease and the correlation of serum anti-p53 with serum alpha- fetoprotein(AFP) in patients with HCC. METHODS: In sera of same patients, we analysed the anti- p53 using ELISA system As controls we tested 50 healthy individuals and 20 patients with chronic hepatitis. Immaiohistochemical study for the presence of mutant p53 was performed on liver tissue from 50 patients with cirrhosis and 30 patients with HCC using monoclonal antibody clone DO-7 and LSAB kit by ABC method. RESULTS: Anti-p53 was positive in 9(30%) of 30 patients with HCC. Among nine patients with positive anti-p53, only two patients had detectable p53 expression in their tumor tissues. Anti-p53 was positive in 5(10%) of 50 patients with liver cirrhosis. The AFP was elevated in 21(70%) of 30 patients with HCC. Among the 9 AFP- negative HCC patients, 4(44.4%) were found to be positive for anti-p53. P53 expression was detectable in 9(30%) of 30 HCCs and 1(3.3%) of RO surrounding non-tumorous cirrhotic tissues. CONCLUSION: Mese findings suggest that anti-p53 was not correlated with the status of p53 expression in liver tissue and serological testing for anti-p53 antibody may be complementary to serum AFP for diagnosing of HCC with normal serum AFP.
Carcinoma, Hepatocellular
;
Chronic Disease*
;
Clone Cells
;
Enzyme-Linked Immunosorbent Assay
;
Fibrosis
;
Half-Life
;
Hepatitis, Chronic
;
Humans
;
Liver Cirrhosis
;
Liver Diseases
;
Liver*
;
Serologic Tests