1.Action Mechanisms of Hormone Binding to Cell Surface Receptors: 3) TGF-beta; Binding to Serine-threonine Kinase Receptors and Action Mechanisms.
Journal of Korean Society of Endocrinology 2000;15(3):353-366
No Abstract Available.
Protein-Serine-Threonine Kinases*
;
Receptors, Cell Surface*
;
Transforming Growth Factor beta*
2.Crossroad between inflammation and carcinogenesis in colon.
Marie YEO ; Young Joon SURH ; Ki Baik HAHM
Korean Journal of Medicine 2006;70(2):130-137
Current evidences have expended the concept that chronic inflammation might play a crucial role in the development and progression of colorectal cancer. For instance, chronic ulcerative colitis (UC) is associated with a 10- to 40-fold increased risk of developing colorectal cancer (CRC) compared to the general population. However, the specific mechanistic link between chronic inflammation and carcinogenesis in colon has not been integrated into molecular understanding. In this current review, we will provide an update on the molecular pathogenesis of colitis-associated colorectal cancer, focused on 1) the differences of molecular mechanism between the colitis-associated colorectal cancer (CAC) and the sporadic colorectal cancer (SCC), 2) the plausible and contributive role of chronic inflammation in colon carcinogenesis, and 3) lessons learned from colitis-associated animal model. Understanding of molecular pathogenic mechanism underlying the colitis-associated colorectal cancer will facilitate the development of novel treatment strategies for prevention of colitis-associated colorectal cancer.
Carcinogenesis*
;
Colitis, Ulcerative
;
Colon*
;
Colorectal Neoplasms
;
Inflammation*
;
Inflammatory Bowel Diseases
;
Models, Animal
3.A Case of Colonic Cavernous Hemangioma Misdiagnosed as a Pedunculated Polyp.
Journal of the Korean Society of Coloproctology 2009;25(2):125-128
Gastrointestinal hemangioma is a relatively uncommon benign vascular tumor that can occur anywhere in the gastrointestinal tract. It is the second most common vascular lesion of the colon and a clinically important entity because of the possibility of massive hemorrhage when complicated. In gross appearance, hemangioma presents variously as a pedunculated, subpedunculated, or flat elevated lesion similar to a submucosal tumor. A typical case of hemangioma is relatively easy to diagnose because the lesion presents as translucent blue-purple vessels under the mucosa. However, it can be difficult to diagnose in some cases, especially if it does not have its usual characteristic color or is covered with normal mucosa. We incidentally found a colonic hemangioma that had the unusual appearance of a pedunculated polypoid lesion with normal mucosa. It was misdiagnosed as a pedunculated polyp with a long, thick neck and treated by using an endoscopic mucosal resection.
Caves
;
Colon
;
Gastrointestinal Tract
;
Hemangioma
;
Hemangioma, Cavernous
;
Hemorrhage
;
Mucous Membrane
;
Neck
;
Polyps
4.Establishment of Cell Line for in Vitro Study of Helicobacter pylori Infecfion.
The Korean Journal of Gastroenterology 2006;47(5):402-403
No abstract availble.
Animals
;
*Cell Line
;
*Helicobacter Infections
;
*Helicobacter pylori
;
Humans
5.Perfecting Video Capsule Endoscopy: Is There Need for Training?.
Clinical Endoscopy 2013;46(6):599-600
No abstract available.
Capsule Endoscopy*
6.Helicobacter pylori infection and COX-2.
Korean Journal of Medicine 2002;62(2):125-127
No abstract available.
Helicobacter pylori*
;
Helicobacter*
7.Helicobacter pylori infection and COX-2.
Korean Journal of Medicine 2002;62(2):125-127
No abstract available.
Helicobacter pylori*
;
Helicobacter*
9.Pathogenesis of Helicobacter pylori-induced Gastric Cell Injury.
Hanyang Medical Reviews 2007;27(3):34-40
H. pylori infection has been revealed to cause chronic gastric inflammation, which may progress to gastric ulcers and duodenal ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma as well as gastric adenocarcinoma. The mechanisms by which bacterial infection leads to gastric mucosal damage include the direct effects of virulence factors produced by H. pylori, such as cagA, vacA or urease, the propagation and perpetuation of inflammation, oxidative stress, and the induction of apoptosis in infected gastric epithelial cells. In the current review, the pathogenic mechanisms with their clinical relevance will be described.
Adenocarcinoma
;
Apoptosis
;
Bacterial Infections
;
Duodenal Ulcer
;
Epithelial Cells
;
Helicobacter pylori
;
Helicobacter*
;
Inflammation
;
Lymphoid Tissue
;
Lymphoma
;
Oxidative Stress
;
Stomach Ulcer
;
Urease
;
Virulence Factors
10.Endoscopically Diagnosed Gastric Cancers: Looking Alike, but Behave Differently.
Clinical Endoscopy 2013;46(2):111-112
No abstract available.