OBJECTIVE: To observe the effect of the polyglycol (PEG) modification of trimeric ? peptide(?3) on it’s anti-metastasis ability. METHODS: Using adhesion test to study the effects of ?3 and ?3-PEG on the adhesion of tumor cells to FN. Using artificial basal membrane to study the effects of ?3 and ?3-PEG on the invasion and recombination of basal membrane of tumor cells. RESULTS: Comparing to negative control,?3 and ?3-PEG could both inhibit the adhesion of SMMC-7721 and HCCLM6 tumor cells to FN with time-dependently(P

Chronic Disease ; therapy ; Drugs, Chinese Herbal ; therapeutic use ; Heart Failure ; drug therapy ; Humans ; Medicine, Chinese Traditional

Anticoagulants ; therapeutic use ; Atrial Fibrillation ; complications ; Humans ; Thromboembolism ; etiology ; prevention & control

China ; Dyslipidemias ; prevention & control ; Guidelines as Topic ; Humans

Female ; Humans ; Maternal Health Services ; Maternal Mortality ; Pregnancy

Objective To analyze and compare in vitro deposition results of budesonide inhalation suspension made by 3 jet nebulizers. Methods Self-made budesonide inhalation suspension was selected as a model drug, and the in vitro deposition properties was determined by breathing simulator and the next generation pharmaceutical impactor (NGI) with Pari Turob BOY N?BOY SX and Omron NE-C28 nebulizers. Results The mass median aerodynamic diameter (MMAD) of aerosol measured with the three kinds of nebulizers ranged between 4.95 and 6.54 µm, geometric standard deviation(GSD)ranged between 1.66 and 2.10,fine particle dose (FPD) ranged between 87.64 and 101.47 µg and fine particle fraction (FPF) ranged between 37.75% and 53.88%. Delivery rates of Pari Turob BOY N and BOY SX were similar, while the delivery rate of Omron NE-C28 was low. The total delivery of each nebulizer was about 0.11 µg. Statistical analysis showed that different nebulizer had no significant difference on delivered dose, but had significant difference on delivered rate(P<0.01)and aerodynamic measurement results(P<0.05). Conclusion Different jet nebulizers for budesonide inhalation suspension have certain influence on its in vitro deposition. The suitability of the Omron NE-C28 is the best among the three kinds of nebulizers.

Objective To discuss the pe rc utaneous laser disc decompression (PLDD) therapy by adopting the Nd: YAG Laser C L-50 Device under X-ray monitor supervision. Methods A total of 378 cases were included in this study. There was 198 males and 180 fe males, the age ranged from 19 to 76 years, with the average of 43.9 years, and the course of diseases from 1 month to 16 years. 17 cases of lumbar interverteb ral disc prolapse were diagnosed between L2 and L3, 35 cases between L3 and L4, 140 cases between L4 and L5, and 116 cases between L5 and S1. 60 cases with two intervertebral disc prolapses at the same time, and 10 cases with three interve rtebral disc prolapses at the same time. A total of 458 intervertebral-dis c operations were conducted with PLDD. All the cases selected had been examined by CT or MRI, and their clinical symptoms and physical signs were in compliance with the diagnosis standards for prolapse of lumbar intervertebral disc. Results After PLDD operation, 268 cases were cured within 1 month with a cure rate of 70.90%; 259 cases were cured in 3 months with a cu re rate of 68.52%, 260 cases were cured in 6 months with a cure rate of 68 .25%. Stable results were found with curing satisfaction rate, effective rate and failure rate. Conclusion X-ray guided PLDD therapy is an ideal non-operative therapy for curing lumbar intervertebral disc prolap se with micro-trauma, little pain, quick recovery and good effect. PLDD has ac hieved encouraging effects both in its recent clinical outcome and long term eff ect as well.

In the 58th American Society of Hematology Annual Meeting, some clinical results on B-cell lymphoma were reported. This review will focus on the recent progress of diffuse large B-cell lymphoma and mantle cell lymphoma in this annual meeting.

By the way of searching engines and finding website linkages, the author retrieved the domestic and foreign medical ethics information resources on internet,enumerated some main websites related to medical ethics, analyzed the present condition,and suggested that we should hasten the construction of medical ethics information resources on internet.