No abstract available.
Obesity* ; Primary Health Care*

No abstract available.
Obesity* ; Primary Health Care*

No abstract available.
Drug Therapy* ; Obesity*

Renal dysplasia results from aberrant metanephric histogenesis caused fundamentally by a defect in inducer tissue or responding tissue. Dysplastic kidneys vary tremendously in gross and microscopic appearance but are characterized by abnormal organization and a mixed population of primitive structures, such as fetal or immature cartilage, dysplastic ducts, immature tubules, and undifferentiated mesenchyme. We report a case of unilateral multicystic renal dysplasia associated with an ipsilateral ectopic ureteral orifice entering a seminal vesicle cyst in a 33-year-old man. He was admitted due to primary infertility which had developed three years ago. The his semen analysis revealed oligospermia. No evidence of a family history of renal dysplasia was reported. Microscopic examination showed that the entire kidney was composed of cysts lined by flattened cells, dysplastic ducts and immature tubules surrounded by collars of spindle cells, primitive mesenchyme, and a few aberrantly formed glomeruli.
Adult ; Cartilage ; Humans ; Infertility ; Kidney ; Male ; Mesoderm ; Multicystic Dysplastic Kidney* ; Oligospermia ; Semen Analysis ; Seminal Vesicles* ; Ureter*

Adenoid basal cell tumor of the prostate is a rare tumorous lesion that can be misdiagnosed as adenocarcinoma of the prostate. The malignant potential of adenoid basal cell tumor remains uncertain due to small number of reported cases. This 66-year-old man presented with symptoms of urinary tract obstruction. Under the impression of benign prostatic hyperplasia, a transurethral resection of the prostate (TURP) was performed. The patient was alive with no evidence of recurrence or metastasis 15 months after TURP. Microscopically, most of the lesions were composed of nodular collections of small nests of basaloid cells with peripheral palisading, and clusters of tumor cells forming cribriform pattern. Multiple areas of basal cell hyperplasia and atypical basal cell hyperpalsia were also observed. The coexistence of basal cell hyperplasia, atypical basal cell hyperpalsia, and adenoid basal cell tumor with cribriform pattern in this case supports a morphologic continuum from the benign hyperplastic lesion to malignant neoplasia.
Adenocarcinoma ; Adenoids* ; Aged ; Humans ; Hyperplasia ; Neoplasm Metastasis ; Prostate* ; Prostatic Hyperplasia ; Recurrence ; Transurethral Resection of Prostate ; Urinary Tract

No abstract available.
Chronic Disease ; Glycemic Index

Recent investigations have revealed that autocrine growth factors and their receptors are closely related and play an important role in controlling cancer cell growth. We performed an immunohistochemical study on the expression of epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), epidermal growth factor receptor (EGF-R), c-erbB-2, and PCNA labelling index in 60 cases of human gastric carcinomas. TGF-alpha was detected in 38 cases (63.3%), EGF in 26 cases (43.3%), EGF-R in 44 cases (73.3%), and c-erbB-2 in 18 cases (30%). These growth factors, EGF-R and c-erbB-2, were found more often in advanced gastric cancers. The PCNA labeling index was significantly higher in tumors with the expression of EGF-R or c-erbB-2. Tumors with simultaneous expression of EGF, TGF-alpha, EGF-R and c-erbB-2 was associated with a high PCNA labeling index. A correlation was observed between the synchronous expression of growth factors and its receptors and histological differentiation. The results suggest that the expression of EGF, TGF-alpha, EGF-R and c-erbB-2 are closely related and plays an important role in the growth and progression of human gastric carcinoma.
Epidermal Growth Factor* ; Humans ; Intercellular Signaling Peptides and Proteins ; Peptides* ; Proliferating Cell Nuclear Antigen ; Receptor, Epidermal Growth Factor ; Stomach Neoplasms ; Transforming Growth Factor alpha

No abstract available.
Giant Cells* ; Granuloma, Giant Cell*

Exercise prescription for obese patients should be individualized since they are not accustomed to exercise. When we prescribe exercise for obese patients, low impact exercises such as walking, cycling, swimming are recommended. We should pay special attention to obese patients with co-morbidities such as hypertension, diabetes, ischemic heart disease or osteoarthritis when we prescribe exercise. For effective weight loss, it is necessary to improve exercise compliance and increase physical activity level.
Compliance ; Exercise ; Exercise Therapy* ; Humans ; Hypertension ; Motor Activity ; Myocardial Ischemia ; Obesity* ; Osteoarthritis ; Prescriptions ; Swimming ; Walking ; Weight Loss

There is increasing evidence that genes encoding for signal transduction pathway, including ras and epidermal growth factor receptor( EGFR), are involved not only in normal cellular growth and differentiation but also in development and progression of malignant tumors. N-butyl-N- (4-hydroxybutyl) nitrosamine (BBN)-induced rat bladder tumor is an ideal model to study the time related gene expression in stepwise bladder epithelial carcinogenesis. We herein investigated the roles of ras and EGFR by immunohistochemical study in bladder tissues of Sprague-Dawley rats after administration of BBN. Sequential epithelial changes consisting of normal, simple hyperplasia, nodular or papillary hyperplasia, papilloma and superficial transitional cell carcinoma(TCC) were observed in rat bladders in parallel with the duration of BBN administration. The expressions of both ras and EGFR were weak in bladder epithelia of non-BBN-administered rats, whereas, immunoreactivity and number of reactive cell layer were increased in bladder epithelia of BBN-administered rats in parallel with the duration of BBN administration and progression of bladder epithelial changes. These results further support the hypothesis that ras and EGFR may have important roles in development of bladder TCC.
Animals ; Carcinogenesis ; Epidermal Growth Factor* ; Gene Expression ; Hyperplasia ; Immunohistochemistry ; Papilloma ; Rats* ; Rats, Sprague-Dawley ; Receptor, Epidermal Growth Factor* ; Signal Transduction ; Urinary Bladder Neoplasms* ; Urinary Bladder*