Autoradiographic study was performed in order to know the distribution of exogenous C(14)-glucose by lung fluke, Paragonimus westermani, incubated in Tyrode medium containing 10 uCi/ml of labeled substance. After 1 hour incubation at 37C, microautoradiographs of this fluke showed that black grains derived from radioactive carbon were accumulated mainly in the parenchyme and subcuticular musculature. The muscular tissues such as oral sucker, pharynx and ventral sucker revaled considerable density of fine grains. Slight radioactivity was also observed in the regions of ovary, testes, vitelline follicles, eggs in uterus, intestinal ceca, and even in excretory bladder. Structures showing the least activity included the cuticle and uterine tubules of this fluke.
parasitology-helminth-trematoda- Paragonimus wertermani ; autoradiography ; biochemistry-glucose ; Tyrode ; glucose

No abstract available.

Dysplastic nodule (DN), which is nodular hepatocellular proliferation of at least 1mm in diameter, is detected most often through radiological and pathological observations in chronic advanced liver diseases. DNs characteristically contain portal tracts and they can be classified into low grade for mild atypia and high grade for at least moderate atypia that is insufficient for the diagnosis of malignancy. DNs are supplied portal venous blood and arterial blood supply. In unpaired arteries, new angiogenesis, shows stepwise increases in the following order of DN low grade, DN high grade, early hepatocellular carcinoma and hepatocellular carcinoma. There are convincing clinicopathological data to support the premise that DNs are considered to be precancerous lesions and early stages of multistep processes of hepatocellular carcinogenesis. Extensive clinicopathological and molecular study can provide a better understanding of the characteristics of DNs and new therapeutic approaches to DNs.
Arteries ; Carcinogenesis ; Carcinoma, Hepatocellular ; Diagnosis ; Liver Diseases ; Liver*

No abstract available.
Humans ; Myocardial Infarction* ; Young Adult*

No abstract available.
Joints*

No abstract available.
Hyperlipidemias*

BACKGROUND: Elevated plasma homocysteine level (tHcy) is one of the risk factors for coronary artery disease (CAD). It has been demonstrated that doses of folate as low as 0.25 mg/d significantly decreased tHcy in healthy, young women. Homozygosity for C-677T polymorphism in the Methylenetetrahydrofolate reductase (MTHFR) gene seems to be correlated with an elevated tHcy in the situation of low blood folate concentrations. In this study, we evaluated the response of the low dose folate treatment on the tHcy and whether genetic variation of MTHFR gene might influence the response of the folate treatment in korean CAD patients. METHODS: CAD patients (n=3), confirmed by coronary angiography, and controls were analyzed for CAD risk factors including tHcy and MTHFR gene C-677T polymorphism. Patients were treated with daily 0.25mg folate for 4weeks and the level of folate and tHcy was reevaluated. RESULTS: Low dose folate treatment for 4weeks significantly increased folate level (38%, p<0.05), but did not influence tHcy. Patients whose tHcy was decreased with folate replacement (n=1) were characterized by low basal folate level (7.0+/-2.6 vs 9.1+/-2.7 nmol/L, p<0.05) and high basal tHcy (12.6+/-4.4 vs 8.6+/-2.4 micromol/L, p<0.05) compared to the patients whose tHcy was unaffected or increased with folate. tHcy was decreased 11.2% and 12.6% each in patients with high basal tHcy (>10 micromol/L) and low folate level (<7 nmol/L), but increased 7.3% and 4.5% in patients with low tHcy and high folate level (p<0.05, each). MTHFR C-677T polymorphism was not a significant contributing factor for tHcy and for the response to folate treatment. CONCLUSION: Low dose folate treatment can decrease tHcy in CAD patients with low basal folate level and high basal tHcy. C-677T MTHFR gene mutation does not influence the effects of low dose folate treatment on tHcy in Korean CAD patients.
Coronary Angiography ; Coronary Artery Disease* ; Coronary Vessels* ; Female ; Folic Acid* ; Genetic Variation ; Homocysteine* ; Humans ; Methylenetetrahydrofolate Reductase (NADPH2) ; Plasma ; Risk Factors

Extracapsular cataract extraction with posterior chamber intraocular lens in 24 eyes of 24 diabetics. With and without diabetic retinopathy, were followed up postoperatively for an average of 14 months to determine the incidence of diabetic retinopathy, the final visual acuity and factors predictive of progression of retinopathy and final visual acuity. Overall, retinopathy progressed in 52% of operated-on eyes. Cataract extraction was highly associated with progression of diabetic retinopathy. Women had a significantly increased risk of progression of retinopathy in the operated-on eye compared to men. Visual acuity improved in 22 of 24 orerated-on eyes : however, only 11 eyes achieved a visual acuity of 0.5 or better and only 7 eyes achieved a visual acuity of 0.7 or better. Patients treated with oral hypoglycemic agents had a worse visual prognosis than those treated with insulin. The prognosis of patients with diabetic retinopathy about to undergo cataract surgery, even extracapsular cataract extraction with placement of a posterior chamber lens, is guarded.
Cataract Extraction ; Cataract* ; Clinical Study* ; Diabetic Retinopathy* ; Female ; Humans ; Hypoglycemic Agents ; Incidence ; Insulin ; Lenses, Intraocular ; Male ; Prognosis ; Visual Acuity

1. We have reported here a case of left marked hydronephrosis due to left aberrant renal vessel, which was treated by ablative procedure. 2. Aberrant renal vessel is a rare disease, but is a relatively common cause of uretero-pelvic obstruction with intrinsic ureteropelvic stenosis. Clinically it is important that this disease may he easily complicated with the conditions such as obstruction, hydronephrosis and infection, and also, the surgeon may inadvertently lacerate the structure with resultant profuse hemorrhage during the operation.
Constriction, Pathologic ; Hemorrhage ; Hydronephrosis* ; Rare Diseases

A clinical study was made on 85 cases' of urinary lithiasis among the number of 3795 out-patients, during 5 years and 8 months from January 1964 to August 1969, and 80 cases were analyzed by a chemical method. (70 cases were safely reserved stone, 10 cases were by litholapaxy.) The results were as following: 1. The incidence of urinary calculi was 2.2%, male to female ratio being approximately 3.7: l. 2 83 cases of urinary calculi were found in the Chonnam district and 2 cases were found in the Chonbuk district 3. The age of the patients ranged from 20~40 years in approximately 65.6%. 4 The location of the urinary calculi was in ureter in 47%, kidney (29.4%), bladder(14.2%) and urethra (9.4%). 5. The most favored predilection of ureteral stone was lower third of ureter in approximately 47% of all cases 6. In a number of urinary calculi in each location 83.5% (71 cases) was single. The most common sire, was below 0.5cm in its diameter, and weight, below 0.5Gm on 41 cases (51.25%). 7. The clinical symptoms of upper urinary tract lithiasis showed flank pain in 81.5%, hematuria in 35. 4%, and suprapubic discomfort in 30. 8%, ,but in lower urinary tract, painful urination was in 85%, urgency in 60%, stoppage of urinary stream in 65% and hematuria in 40%. 8. The microscopic hematuria showed 87.1%, which incidence was higher in lower urinary tract calculi, and pyuria was revealed in 39. 9%. 9. The most frequent surgical intervention was ureterolithotomy in 38.5% (35 cases). 10. The results of chemical analysis of 80 urinary calculi showed the mixed type of calcium-phosphate and calcium oxalate in 40% (32 cases), calcium oxalate in 12. 5% (10 cases), calcium phosphate in 12.5% (10 cases), the mixed type of calcium-phosphate and ammonium-phosphate in 10% (8 cases), calcium-carbonate in 10% (8 cases) and urate in 3.75% (3 cases). 11. Cases of bilateral urinary calculi were revealed in 13.8%.
Calcium ; Calcium Oxalate ; Calculi ; Female ; Flank Pain ; Hematuria ; Humans ; Incidence ; Jeollabuk-do ; Jeollanam-do ; Kidney ; Lithiasis ; Male ; Outpatients ; Pyuria ; Rivers ; Ureter ; Urethra ; Uric Acid ; Urinary Calculi ; Urinary Tract ; Urination ; Urolithiasis*