1.Lymphocyte Subsets and Mood States in Panic Disorder Patients.
Joo Eon PARK ; Sang Wook KIM ; Quehn PARK ; Do Un JEONG ; Bum Hee YU
Journal of Korean Medical Science 2005;20(2):215-219
This study was conducted to examine lymphocyte subset counts and mood states in panic disorder patients. Twenty patients with panic disorder and 20 age- and gendermatched normal healthy subjects were recruited for the study. We used the Spielberger State (STAIS) & Trait (STAIT) Anxiety Inventory, Hamilton Depression Rating scale (HAMD) and Hamilton Anxiety Rating scale (HAMA) to measure mood states in all subjects. Lymphocyte subsets counts were made by flow cytometry. Panic patients showed significantly higher scores for anxiety and depression than normal subjects. Panic patients showed no differences in terms of the numbers of immune cells, as compared with normal healthy subjects, other than a lower proportion of T suppressor cells and a higher T helper cell/T suppressor cell ratio. HAMA and STAIS scores were common factors that could predict T cell numbers and proportions, T helper cell numbers, and natural killer cell proportions in panic disorder patients. We suggest that anxiety levels are related to the T-cell population in panic disorder patients and that quantitative immune differences may reflect altered immunity in this disorder.
Adult
;
*Affect
;
Female
;
Humans
;
Lymphocyte Subsets/*immunology
;
Male
;
Panic Disorder/*immunology/psychology
;
Regression Analysis
;
Research Support, Non-U.S. Gov't
2.A Case of Salmonella-triggered Reactive Arthritis in a Child, Initially Presented as Juvenile Rheumatoid Arthritis.
Eon Woo SHIN ; Do Suk CHUNG ; Sang Jin PARK ; Seung YANG ; Yong Joo KIM ; Ha Baik LEE
Pediatric Allergy and Respiratory Disease 1999;9(3):320-326
Salmonella-triggered reactive arthritis appears one to three weeks after the onset of salmonella infection and presents with asymmetric, usually migratory, oligo- or polyarthritis. The course is usually self-limiting and symptoms last two to six months. We experienced a 10-year-old male patient who presented to a local pediatric center with long-lasting fever and right ankle joint pain. The pain migrated to the left ankle joint, both wrists, and both knees and he was diagnosed as juvenile rheumatoid arthritis and was medicated with NSAIDs and corticosteroid. In the meantime, 20 days prior to the transfer to our hospital he was febrile with nausea and abdominal pain and the antibody titer of S. typhi O Ag by Widal test was 1 : 320, and an antibiotic therapy was followed. Soon after, the fever subsided but the migrating joint symptoms continued and he was transferred to our hospital. Widal tests were weekly checked and the antibody titers of S. typhi O Ag were 1 : 160, 1 : 320, 1 : 320, 1 : 160, 1 : 160, respectively. ESR was 55 mm/hr, CRP 9.18 mg/dl, HLA-B27 positive and his endoscopic findings of the colon showed mild lymphoid hyperplasia and mucosal nodularities in the cecum and ileocecal area. Stool cultures and duodenal juice culture for Salmonella and Shigella were all negative. He was treated with ibuprofen and bactrim and the joint symptoms were gradually mitigated. After discharge, he maintained mildly elevated CRP levels and antibody levels by Widal tests, but was free from symptoms except for several episodes of finger pains for 11 months.
Abdominal Pain
;
Ankle Joint
;
Anti-Inflammatory Agents, Non-Steroidal
;
Arthritis
;
Arthritis, Juvenile*
;
Arthritis, Reactive*
;
Cecum
;
Child*
;
Colon
;
Fever
;
Fingers
;
HLA-B27 Antigen
;
Humans
;
Hyperplasia
;
Ibuprofen
;
Joints
;
Knee
;
Male
;
Nausea
;
Salmonella
;
Salmonella Infections
;
Shigella
;
Trimethoprim, Sulfamethoxazole Drug Combination
;
Wrist
3.Parasternal Recurrence after Curative Resection of Breast Cancer.
Eun Ji CHUNG ; Chang Ok SUH ; Won PARK ; Hy Do LEE ; Kyung Shik LEE ; Gwi Eon KIM
Journal of the Korean Cancer Association 1998;30(2):253-261
PURPOSE: We tried to find the patients characteristics of parasternal recunence, to classify the parasternal recunence according to the radiological and clinical features, and to evaluate the efficacy of local radiotherapy. MATERIALS AND METHODS: Between August 1987 and April 1997, twenty one patients with parastemal recurrence of breast cancer after surgery with or without adjuvant chemotherapy were treated with radiotherapy. Age distribution at initial operation was ranged from 31 to 79 years(median 48 years). Sixteen(76.2%) cancers were in the right breast and five(23.8%) were in the left. The pathologic types were infiltrative ductal carcinoma in 18 patients and medullary carcinoma in 3 patients. Eight patients had stage I, three had stage IIa, six had stage IIb, one had stage IIIa diseases and we had no information about the initial stage of the other 3 patients. Parasternal recurrence were diagnosed by biopsy in 7 patients, and the other 14 recurrences were diagnosed by clinical and radiologic findings such as chest CT, whole body bone scan. All the patients were treated with radiation for the parasternal recurrent tumors. In addition, five patients also received chemotherapy(FAC or Taxol based protocol) and one patient also received partial resection before radiotherapy. Radiotherapy was delivered with Co-60 gamma-ray or 4~6 MV X-ray or electron beam to both supraclavicular lymph nodes and parasternal areas with total doses of 3000~6480 cGy(median 6100 cGy). RESULTS: The range of interval between curative resection and parasternal recurrence were 4~110 months(median 34 months). The main symptoms of the parasternal recurrence were a painless mass(n=10). The duration of symptom before diagnosis ranged from one to 36 months(median 7 months). Among 21, five patients(23.8%) presented distant metastses at the diagnosis of parasternal recurrences. The parasternal recurrences were classified into three groups according to radiologic and clinical findings; the recurrent tumors originated from sternum and invaded into adjacent tissues(Group 1, n=5), tumors originated from intemal mammary lymph nodes and invaded into sternum or parasternal tissues(Group 2, n=6), tumors originated from medial chest wall and invaded into sternum or parasternal tissues(Group 3, n=10). In nineteen patients(19/21; 90.5%) there was complete response of parasternal recurrence following radiotherapy. Although the follow up period was relatively short(3~78 montbs, median 14 months), there were no local recurrence in radiation field in 19 patients with complete response. Among the 16 patients without distant metastases at diagnosis of parasternal recurrence, nine patients were alive without any evidence of disease. CONCLUSION: Chest CT scan is necessary and effective in patients with parastemal discomfort, pain, swelling or palpable mass after mastectomy. And we found that radiotherapy was very effective for the local treatment of parasternal recunence in terms of symptom palliation and local control of tumor. Although we classified the parasternal recurrence into three groups, we could not reach any conclusive results because of short follow up duration and insufficient patients number.
Age Distribution
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Biopsy
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Breast Neoplasms*
;
Breast*
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Carcinoma, Ductal
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Carcinoma, Medullary
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Chemotherapy, Adjuvant
;
Diagnosis
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Follow-Up Studies
;
Humans
;
Lymph Nodes
;
Mastectomy
;
Neoplasm Metastasis
;
Paclitaxel
;
Radiotherapy
;
Recurrence*
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Sternum
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Thoracic Wall
;
Tomography, X-Ray Computed
4.Clinical Application and Evaluation of Preoperative Bleeding Tendency using Platelet Function Analyzer (PFA(R))-100.
Jihu HAN ; Eon Rok DO ; Tae Seob KIM ; Chen ZHANG ; Dae Hwan PARK
Archives of Aesthetic Plastic Surgery 2013;19(1):56-63
Routine preoperative tests such as BT/CT, PT/PTT and CBC, could not test abnormal hemostasis that take drugs and health functional food. We used platelet function analyzer (PFA(R))-100, to evaluate preoperative bleeding tendencies. From November 2008 to February 2010, 306 surgical patients were tested preoperative PFA in our hospital. There are 2 tests in PFA(R)-100. The Pre Operative EPI (collagen/epinephrine) assay tests extrinsic platelet function, whereas the Pre Operative ADP (collagen/adenosine diphosphate) assay tests intrinsic platelet function. We divided normal and abnormal groups by the PFA(R)-100 assay tests. If either of results were abnormal in the two tests, the patient was divided to the abnormal group. 306 surgical patients were observed with hemorrhagic complications. All of the patients were divided normal and abnormal groups by the PFA(R)-100 test result. The normal group was made up of 286 (93.5%) patients, the abnormal group was made up of 20 (6.5%) patients. We observed each group hemorrhage complication including sever echymosis and hematoma, and analyzed each group complication rate. There were 9 (3.1%) cases of complication in the normal group. There were 3 (15.0%) cases of complication in the abnormal group. To evaluate preoperative bleeding tendency, PFA(R)-100 can be complementary examination with previous routine blood coagulation tests.
Adenosine Diphosphate
;
Blood Coagulation Tests
;
Blood Platelets
;
Functional Food
;
Hematoma
;
Hemorrhage
;
Hemostasis
;
Herbal Medicine
;
Humans
;
Platelet Function Tests
;
von Willebrand Diseases
5.The Change of Eyebrow Height after Blepharoptosis Correction.
Tae Seob KIM ; Dong Gil HAN ; Eon Rok DO ; Dae Hwan PARK
Archives of Aesthetic Plastic Surgery 2013;19(1):46-50
Blepharoptosis patients use frontalis muscle unconsciously to widen eye, and it results in several aesthetic problems-such as forehead wrinkling and elevated eyebrow. So forehead wrinkling and elevated eyebrow can be resolved with correction of blepharoptosis. We evaluated the change of eyebrow height in 30 patients who were corrected blepharoptosis through photogrammetry. The mean age of the patients was 36.8 years old and the mean follow up periods were 6 months. Horizontal line passing medial and lateral canthal corner in both eyes was drawn in Photopshop. From the horizontal line, 3 vertical lines perpendicular to this line were drawn passing medial and lateral canthal corner and the vertically oriented center of the pupil. Eyebrow height was measured through these 3 vertical lines. The average length of decreased value of the eyebrow height were 3.64 mm in H1, 3.31 mm in H2, 2.79 mm in H3. In unilateral cases, 2.42 mm in H1, 2.86 mm in H2, 2.78 mm in H3, and in bilateral cases, the decreased values were 4.25 mm in H1, 3.53 mm in H2, 2.79 mm in H3. From this study, the author would like to introduce the method to calculate the changes of eyebrow height after blepharoptosis correction and the values objectively.
Blepharoptosis
;
Eye
;
Eyebrows
;
Follow-Up Studies
;
Forehead
;
Humans
;
Muscles
;
Photogrammetry
;
Pupil
6.Acquired Simulated Brown Syndrome Combined with Blepharoptosis after Upper Blepharoplasty.
Eon Rok DO ; Won Ho HA ; Dae Hwan PARK
Archives of Craniofacial Surgery 2012;13(2):130-134
PURPOSE: Brown syndrome is motility disorder of the eyeball which shows limited elevation in adduction and occurs very rarely after eye surgery. The authors have experienced a case of strabismus-like Brown syndrome combined with blepharoptosis and report this case with the review of literatures. METHODS: A 28-year-old female suffered from hypotropia in the primary gaze and severe blepharoptosis with diplopia of the right eye after upper blepharoplasty. Rotation showed an inability to elevate the adducted right eye. She underwent extraocular muscle surgery about the 7 mm tucking of the right superior rectus muscle and 6 mm recession of right inferior rectus muscle. Intraoperatively, injury of the superior rectus muscle and foreign body were observed. Seven months after the extraocular surgery, the patient underwent frontalis muscle transfer on the right upper eyelid for the correction of blepharoptosis. RESULTS: Postoperatively, the patient was orthophoric in the primary gaze, and she had improvements in the correction of blepharoptosis and eyeball movement. CONCLUSION: Repeated eyelid surgeries increase the risk of ocular motility disorder. Careful approach is essential for the proper treatment and successful outcome in secondary surgeries.
Adult
;
Blepharoplasty
;
Blepharoptosis
;
Diplopia
;
Eye
;
Eyelids
;
Female
;
Foreign Bodies
;
Humans
;
Muscles
;
Ocular Motility Disorders
7.Ultrasonographic Assessment of Nonsurgical Treatment of Postburn Hypertrophic Scar.
Tae Do KANG ; Ki Eon JANG ; Dong Sik PARK ; Sun Bok KIM ; Eun Ha JUNG
Journal of the Korean Academy of Rehabilitation Medicine 1999;23(2):397-404
OBJECTIVE: To evaluate the effectiveness of nonsurgical treatment and to evaluate the usefulness of ultrasonographic assessment in postburn hypertrophic scar. METHODS: The subjects were twenty-seven burn patients with hypertrophic scar. Hypertrophic scars were treated by four different methods: triamcinolone acetonide injection (Group I), pressure garment application (Group II), combination treatment of triamcinolone acetonide and garment (Group III) and no treatment (Group IV). To assess the effectiveness of each treatment method, ultrasonographic measurement of scar thickness and punch biopsy of scar were done before and after treatment. RESULTS: After 4 weeks treatment, the scar thickness decreased by 14.9 9.4% in Group I, 4.7 8.4% in Group II and 20.5 13.2% in Group III. However the scar thickness increased by 10.0 13.5% in Group IV (no treatment). The pathologic findings didn't show significant change. CONCLUSION: The TA solution injection therapy and pressure garment therapy were effective methods for the treatment of the postburn hypertrophic scar, but the combinations of both therapies was more effective than each single therapy. The ultrasonography can be used as objective measure to assess effectiveness of therapy.
Biopsy
;
Burns
;
Cicatrix
;
Cicatrix, Hypertrophic*
;
Humans
;
Triamcinolone Acetonide
;
Ultrasonography
8.Ultrasonography in Adhesive Capsulitis of Shoulder.
Tae Do KANG ; Dae Hyun HWANG ; Kwang Ik JUNG ; Dong Sik PARK ; Ki Eon JANG
Journal of the Korean Academy of Rehabilitation Medicine 1998;22(4):944-949
OBJECT: To find out the anatomical changes of adhesive capsulitis of the shoulder by the ultrasonography. METHOD: We examined 20 patients with a adhesive capsulitis of the shoulder. Ultrasonographic findings were analysed by a radiologist who measured the synovium thickness of anterior, posterior and axillary plane and coracohumeral ligament length of the shoulder. RESULTS: Synovium thickness of the shoulder was measured with a mean value of 1.4+/-0.3 mm in the anterior plane, 1.4+/-0.4 mm in posterior plane and 1.8+/-0.5 mm in axillary plane of the unaffected sides and a mean value of 1.7+/-0.5 mm in the anterior, 1.8+/-0.4 mm in posterior and 3.2+/-1.0 mm in axillary planes of the affected sides. Coracohumeral ligament length was measured with a mean value of 27.8+/-7.9 mm in the unaffected side and 26.3+/-8.1 mm in the affected side. CONCLUSION: The characteristic appearance of the adhesive capsulitis of the shoulder by ultrasonography was an increased synovium thickness in the axillary plane compared to the unaffected side. This study demonstrates that the ultrasonography is a valuable tool for the evaluation and follow up for the adhesive capsulitis of shoulder.
Adhesives*
;
Bursitis*
;
Humans
;
Ligaments
;
Shoulder*
;
Synovial Membrane
;
Ultrasonography*
9.Immediate Distal Digit Reconstruction with Short Vascular Pedicled Partial Toe Transfer.
Sun Hee PARK ; Hak Soo KIM ; Seong Eon KIM
Journal of the Korean Microsurgical Society 2012;21(1):27-33
We studied the results of the immediate microsurgical reconstruction of the distal digit injury with short vascular pedicled partial toe transfer. Thirteen patients with amputation or crush injury of the distal digit who underwent partial toe transfer at the authors' institute over 8-year period were reviewed. Delay between initial injury and reconstruction ranged from 1 to 9 days. All flaps were harvested on a short vascular pedicle, with anastomoses performed at a proximal interphalangeal joint level on the fingers and metacarpophalangeal joint level on the thumbs. Good to excellent cosmetic and functional results were obtained in all cases, with nearly normal-looking fingertip. The mean static two point discrimination was 10 mm. Immediate reconstruction with short vascular pedicled partial toe transfer is an excellent option for the reconstruction of the compostie defect of the distal digit.
Amputation
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Cosmetics
;
Discrimination (Psychology)
;
Fingers
;
Humans
;
Joints
;
Metacarpophalangeal Joint
;
Toes
10.A Case of Idiopathic Congenital Neonatal Cholestasis in a Patient with Down Syndrome.
Tae Eon HUH ; Hyun Jeong DO ; Ji Sook PARK ; Jung Sook YEOM ; Eun Sil PARK ; Ji Hyun SEO ; Jae Young LIM ; Chan Hoo PARK ; Hyang Ok WOO ; Hee Shang YOUN
Pediatric Gastroenterology, Hepatology & Nutrition 2012;15(2):117-121
Down syndrome is a rare cause of neonatal cholestasis. Neonatal cholestasis in a patient with Down syndrome is usually associated with severe liver diseases, such as neonatal hemochromatosis, myeloproliferative disorder and intrahepatic bile duct paucity. We experienced a case of idiopathic neonatal cholestasis in a patient with Down syndrome, which resolved spontaneously.
Bile Ducts, Intrahepatic
;
Cholestasis
;
Down Syndrome
;
Hemochromatosis
;
Humans
;
Infant, Newborn
;
Liver Diseases
;
Myeloproliferative Disorders