No Abstract Available.
Hyaluronic Acid* ; Phacoemulsification*

Acrysof intraocular lens (IOL) (Alcon,Dallas,USA), the first commercially available foldable acrylic IOL, which was approved for marketing in the United states on December, 1994 and in the Korea on August, 1997.It is made with an acrylic/methacrylic polymer. Characteristics of the Acrysofistiguished from commonly used foldable silicon IOLs include improved elastic properties (not slippery when wet), slow and controlled unfolding, and a high refractory index resulting in a thinner lens. We experienced vacuolesin Acrysof IOLs which has no visual influence in 4 cases and report this unusual cases with a review of available literature.
Korea ; Lenses, Intraocular* ; Marketing ; Polymers ; Silicones ; United States ; Vacuoles*

A 10 month-old female visited our out-patient clinic, whose chief complaint was an enlargement of right eyeball since 5 month ago. Her physical examination disclosed Cafe-au-lait spots on abdomen and back and a tumor-like mass was seen on right vitreous cavity by slit lamp biomicroscopy, indirect ophthalmoscopy, and orbit CT. The working diagnosis was either neurofibromatosis or retinoblastoma, but choroidal hemangioma was also another possibility tomographically. However, MRI suggested the possibility of choroidal malignant melanoma unexpectedly. Subsequently the eye was enucleated and the tumor was confirmed to be a choroidal malignant melanoma. We report this interesting case and the other case of choroidal malignant melanoma diagnosed by MRI in 57 year-old male.
Female ; Humans ; Hemangioma

PURPOSE: TGF-beta is a key regulator of epithelial-mesenchymal transition. Among the TGF-beta responses, cell migration is closely associated with the expression of matrix metalloproteinases (MMPs). Therefore, we determined which MMPs are regulated by TGF-beta and examined the TGF-beta signaling involved in this event, focusing on Src family tyrosine kinases (SFKs) METHODS: First we examined the expression of MMPs in rat lens explant culture treated with TGF-beta and LECs attached to the anterior capsules of patients with nuclear (N), anterior polar (AP) cataracts using RT-PCR and immunofluorescence staining. It was examined whether the expression of MMPs is regulated by SFKs. RESULTS: The study using RT-PCR and immunofluorescence staining showed the expression of MMP-2 and -14 in explants and the expression of MMP-14 LECs of AP cataracts. The expression of MMP-2 and -14 was blocked by PP2 in explants. Furthermore, the activated form of SFKs was observed in LECs of AP cataracts by immunofluorescence staining. CONCLUSIONS: We suggest a novel role of SFKs signaling in the expression of MMP-14 induced by TGF-beta.
Animals ; Capsules ; Cataract ; Cell Movement ; Epithelial Cells* ; Epithelial-Mesenchymal Transition ; Fluorescent Antibody Technique ; Humans ; Matrix Metalloproteinases ; Rats ; src-Family Kinases ; Transforming Growth Factor beta*

The scleritis is developed after taruma, infection or associated with systemic disease in 505 such as connective tissue disease, granulomatous disease & metabolic disease, in which the most common disease is rheumatoid arthritis[RA]. Scleromalacia perforans characterized by progressive thinning of the sclera in the absence of symtoms and with minimal inflammatory signs is a typical type of scleritis in rhematoid arthritis patient. And necrotizing scleritis is associated with long-standing and severe RA in 4-10%. However, there has been no effective method for preventing those diseases. In order to prevent recurrence of pterygium, anti-metabolic agent or radioactive material has been applied to excision site. However, in case of RA, excessive application of above method or aggressive excision of pterygeal mass is rather avoided to prevent postoperative necrotizing scleritis. In this study, we reported a case of enucleation with histology due to severe necrotizing scleritis with extensive exposure of choroid in a 67-year-old man having a past history of RA for 20 years and pterygium excision[OS] 15 years ago.
Aged ; Arthritis ; Arthritis, Rheumatoid* ; Choroid ; Connective Tissue Diseases ; Humans ; Metabolic Diseases ; Pterygium* ; Recurrence ; Sclera ; Scleritis*

To compare clinical results between sulcus insertion of intraocular lens(IOL)(Group I) and transscleral fixation of IOL(Group II), visual acuity, spherical equivalent, astigmatism, corneal thickness and intraocular pressure were evaluated, retrospectively. This study was performed on 37patients(43 eyes), who could have been followed up more than 12 months from September 1994 to August 1997. Six mm scleral incision at 12 o'clock position and sulcus insertion of IOL were used with 2 interrupted sutures in cases of aphakia either with some remained anterior capsule or with continuous curvilinear capsulorhexis(Group I, 12 eyes). The same incision and suture method with transscleral fixation of IOL were used in case of aphakia with little remained anterior capsule(Group II, 31 eyes). In Group II, 10-0 polyprolene sutures were buried beneath the scleral flaps at both three and nine o'clock meridians following transscleral fixation of IOL. Uncorrected visual acuity(UCVA) was improved in both Group I and Group II, except for 4 cases of Group II. Lack of improvement of UCVA did not seem to be related to the operative methods. The changes of UCVA, astigmatism, corneal thickness and intraocular pressure were not statistically significant between the two groups. In conclusion, transscleral fixation of posterior chamber-intraocular lens turned out to be safe and effective in certain cases of insecure zonule or posterior capsule, although its surgical procedure is more complicated than that of posterior chamber-intraocular lens implantation into the sulcus without fixation.
Aphakia ; Astigmatism ; Intraocular Pressure ; Lenses, Intraocular* ; Meridians ; Retrospective Studies ; Sutures ; Visual Acuity

Phaco-drill technuque, is a method of phacoemulsifying cataractous lens with a bevel down position of phacotip, thus concentrating vacuum and ultrasonic power on center of the lens. This enables the phacoemulsification to be completed with a lower setting of energy. In this study, we evaluated the efficacy of the phaco-drill technique by measuring corneal endothelial cell damage. Since August 1997, we examined 170 patients who had under-gone phacoemulsification using phaco-drill technique, for uncorrected visual acuity, number, shape and size of corneal endothelial cell, and corneal thickness before and 2 months after surgery. the mean visual acuity was 0.26+/-0.24 before operation,and the mean visual acuity at 1 day and 2 months postlperatively was 0.59+/-0.32 and 0.82+/-0.26, respectively. The mean time of phacoemulsification was 58+/-41 seconds, and the average power(surgeon mode)was 8.6+/-0.26%. Mean volume of irrigating solution used in the operation was 116.12+/-52.10cc and that of aspirated solution was 63.34+/-30.37cc. The number of endothelial cells decreased from 2450+/-308.6 cell/mm2 before operation to 2234+/-372.2 cell/mm2 2 months after operation(9.2% decrease). The size of endothelial cells increased from 33.78+/-5.53/micrometer(2) before operation to 34.70+/-5.79/micrometer(2) 2 months after the operation(2.7% increase). The regularity of the cells (hexagonality) showed a decrease of 3%, from 57.47+/-10.16 before operation to 55.81+/-10.49% 2 months after the operation. The corneal thickness increased from 528+/- 36micrometer before operation to 590+/-8micrometer 1 dat(11.7% increase) and 531+/-4micrometer(0.5% increase) after the operation. From the results of this study we suggested that phaco-drill technique might be one of effective methods of phacoemulsification for less damage of corneal endothelial cells and less fluid consumption.
Cataract ; Corneal Endothelial Cell Loss ; Endothelial Cells ; Endothelium, Corneal* ; Humans ; Phacoemulsification ; Ultrasonics ; Vacuum ; Visual Acuity

PURPOSE: Suction ring is needed to fix the cornea during LASIK procedure. But if we choose the suction ring inappropriately, we meet the various problems such as conjunctival edema, conjunctival hemorrhage, ocular pain, and prolongation of operation time. To investigates various factors affecting the thickness of suction ring(1-4) in LASIK procedure. METHODS: We performed LASIK procedure by using SCMD microkeratome and VISX STAR laser on 398 eyes from Dec. 1996 to Feb. 1999. We compared difference on pachymetry, keratometry, corneal diameter, spherical equivalent according to the thickness of suction ring and analyzed these factors with One-Way ANOVA test. RESULTS: The results are that keratometry affected size of suction ring significantly. The flap size and hinge size are affected by size of suction ring significantly, but others did not show significant results. CONCLUSIONS: These results suggest that we need to choose the size of suction ring according to keratometry during LASIK procedure for decreasing various complications.
Cornea ; Edema ; Hemorrhage ; Keratomileusis, Laser In Situ* ; Suction*

PURPOSE: Anterior Polar Cataract (APC) develops by a mechanism different from that of other age-related cataracts, and outside of Korea, it is an extremely rare condition. We investigated the prevalence and epidemiological characteristics of APC in Koreans. METHODS: The evaluation on the prevalence of APC in comparison to the other age-related cataracts was performed on the 2,108 cataract patients who were treated at 5 different areas in Korea from August 2003 to December 2003. The demographic characteristics of APC were studied on the, 656 cataract patients who were treated from January 2004 to January 2005 at one hospital. These patients were classified according to the type of lens opacity (nuclear, cortical, posterior subcapsular, mixed and APC). RESULTS: The prevalence of patients with APC among all the cataract patients was 6.02% during the 5 months in this hospital-based study. Eighty-seven per cent of patients with APC were male. In contrast, the proportion of female was greater than 50% in the other cataracts. The mean age of APC patients was 52.7 years. Among the APC patients, 38.9% were under 50 years of age, 42.6% in their 50s, 14.8% in their 60s, and 3.7% were in their 70s. However, 80% of patients were over the age of 60 years in nuclear, cortical, and mixed-type cataracts. CONCLUSIONS: The prevalence of APC among all cataracts was high in comparision with another country. The proportion of APC was high in individuals younger than 60 years of age, and in males.
Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Cataract/classification/*epidemiology ; Female ; Hospitals, General/*statistics & numerical data ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Ophthalmology/statistics & numerical data ; Prevalence ; Sex Distribution

Currently, although LASIK has proved to be effective for correcting the high myopia, it is increasingly being favored for correcting the moderate myopia. We compared the clinical results after excimer laser photorefractive keratectomy(PRK)and laser associated in situ keratomileusis(LASIK)for the correction of moderate myopia from -4.00 diopter to -6.25 diopter. 31patients(40 eyes)who underwent LASIK with microkeratome(SCMD, USA) and STAR laser(VISX, USA)and 29 patients(38 eyes)who underwent PRK with the same laser were examined retrospectively. Mean uncorrective visual acuity(UCVA)was 0.64+/-0.24 7 days after surgery which was 63%of that at postoperation 6 months in the PRK, while that was 0.73+/-0.21 7 days after surgery which was 85%of that at postoperation 6 months in the LASIK(p<0.05). However, at 2 and 6 months postoperatively, the mean UCVA was similar between two procedures(0.93+/-0.15, 0.96+/-0.14 for PRK and 0.85+/-0.22, 0.82+/-0.22 for LASIK, respectively (p>0.05)). At 7 days, the mean spherical equivalent for PRK was +1. 81+/-0.82 D, which was significantly more overcorrected than that for LASIK(+0.47+/-1.07 D(p<0.05)). In addition, the overall refractive regression from 7 days to 6 months was 1. 58D in the PRK compared with regression of 0.96D over the same period in the LASIK, while the mean refractive regression from 2 months to 6months was similar between two procedures(0.27 D for PRK and 0.39 D for LASIK). Cylindrical error within 1D was increased from 0.48 +/-0.36D before operation to 0.69+/-0.31 D of 6 months after operation in LASIK(p>0.05), whereas it was decreased from 0.39+/-0.31 D to 0.07+/-0.31D in PRK (p<0.05). Conclusively, although improvement in UCVA and mean spherical equivalent is more rapid in LASIK than in PRK, the increased propensity of cylindrical error and undercorrection in LASIK requires further investigation.
Keratomileusis, Laser In Situ* ; Lasers, Excimer ; Myopia* ; Retrospective Studies