High-dose melphalan (Mel) is considered as a current standard preparative regimen in autologous stem cell transplantation (ASCT) for multiple myeloma (MM). Irradiation in total body (TBI) combined with Mel is not superior to Mel alone, and the adverse reactions are increased at the same time. The efficacy of 200 mg/m2 Mel is much better than that of 100-140 mg/m2 Mel in young patients. Several regimens including MelBU, TBC, BCV, MET, MTC, MelBCNU, VMel, MTC as well as bendamustine have similar treatment outcomes compared with 200 mg/m2 Mel. Other strategies need to be evaluated in different trials.

Objective To observe the effect of levocamitine on cardiac function of patients with dilated cardiomyopathy (DCM).Methods 40 patients with DCM were randomly divided into control group (n =20) and the experimental group(20 cases).Control group was given conventional drug such as digitalis,furosemide,benazepril hydrochloride,antisterone for treatment,the experimental group was given levocarnitine on the basis of control group.The treatment efficacy and the situation of cardiac function were compared between the two groups.Results The total effective rate was 95.0％ and 80.0％ in the experimental group and the control group,respectively,the difference was statistically significant(x2 =10.286,P ＜ 0.01).Compared with the control group,the parameters of stroke volume,cardiac output,ejection fraction,and left ventricular fractional shortening rate were significantly increased in the experimental group after treatment(all P ＜ 0.05).Conclusion Levocarnitine can improve cardiac function based on the conventional treatment.

Metabolic markers were released in the process of bone resorption and formation during bone remodelling. These markers have been extensively studied in trials of osteoporosis and other metabolic bone disorders during the past de?cades. Bone metabolic markers can replenish bone mineral density in the management of osteoporosis, but their use in clini?cal practice is challenged by their variability. Recently, there are many great progress in research of bone metabolic markers application in non metabolic bone disorders.

A harmonious physician-patient relationship is closely correlated with hospital culture construction.This paper explores the correlation from the perspectives of roles in building up decent fame of hospitals,promoting the construction of medical ethics,cultivating a fine humanistic medical atmosphere,strengthening the social responsibility of hospitals,and further clarifies the important function of hospital culture construction in constructing a harmonious physician-patient relationship.

Objective:To probe into the influences of psychosocial risk factors and family psyche environment on smoking behavior of adolescents.Methods:Psychosocial risk factors and family psyche environment of 806 adolescents with smoking behavior and that of 3603 controls were investigated with Family Environment Scale, Symptom Checklist 90 and Behavior Questionnaire.Results:Rebelliousness, Risk Taking, Early Maturity, Problem Helplessness of adolescents were related to smoking. The scores of cohesion, expressiveness, achievement orientation and intellectual-culture orientation in Family Environment Scale of the smoking group were lower than those of controls (P

Objective To observe the effects of different doses of Yinxingdamo injection on changes of nerve-specific enolase (NSE) of patients with medium-sized brain injury and discusse the mechanism of Yinxingdamo injection in the treatment of brain injury. Methods The contents of serum NSE in 33 cases of craniocerebral injury were dectected by ELISA test and the results were analyzed. Results NSE levels in patients with brain injury were significantly higher than normal people (p ＜0.05). Yinxingdamo injection can reduce the content of NSE for brain injury patients. This reduction related with the dosage of the medicine, showing the higher the dosage is used, the greater reduction may be.Conclusion Yinxingdamo injection can reduce NSE in serum of patients with brain injury, and this may be the mechanism of Yinxingdamo injection in treating craniocerebral injury.

Non-small cell lung cancer has a poor prognosis. Many patients who were proved to have none lymph node metastasis still relapse after operation. It may be caused by micrometastases which can′t be detected by conventional pathologic technique. Recently immunocytochemistry and moleculer methods are used to detect micrometastases in the peripheral blood, bone marrow or lymph node near the tumor. But the standard and reliable methods need to be developed and the clinical significance of micrometastases need to be discussed.

Objective To investigate the operative outcomes of anatomic and functional reconstruction of the spinal posterior column after resection of intraspinal neoplasms.Methods From January 2010 through October 2014,we treated 32 patients with intraspinal neoplasm in the spine.They were 18 men and 14 women,13 to 62 years of age (average,38 years).The neoplasm was detected in the cervical spine in 10 cases,in the thoracic spine in 14 and in the lumbar spine in 8.All cases received expansive open door laminoplasty via the posterior approach for resection of the intraspinal neoplasm,followed by replantation and titanium plate fixation for anatomic and functional reconstruction of the spinal posterior column.The neural functional recovery,spinal motion and sagittal diameter of the spinal canal before and after operation,spinal stability and graft fusion were observed.Results The patients were followed up for 3 to 23 months (average,13 months).All the intraspinal neoplasms were completely resected.The Frankel grading of neural functional recovery was improved differently in all the cases.By the final follow-ups,the spinal motion was normal in all the cases,without any significant limitation.Graft fusion and rigid internal fixation were achieved in all the cases.Short-term follow-ups revealed no signs of spondylolisthesis or spinal instability.At the final follow-ups,the 3-D CT reconstruction showed no significant shortening in the sagittal diameter of the same spinal canal before and after operation (P ＞0.05).Conclusions For intraspinal neoplasm in the spine,the whole vertebral lamina is opened or removed via the posterior approach to resect the neoplasm,followed by reduction of the vertebral lamina and mini titanium plate fixation to reconstruct the anatomy and function of the original spine.This is an ideal way to treat intraspinal neoplasms in the spine.

Purification of HBGFs from bovine brain through three steps: 40 to 80% saturated ammonium sulfate fractionatton of bovine brain extract, CM-Sephadex C-50 ionexchange chromatographe, and heparin affinity chromatography. SDS-PAGE revealed the presence of a single band a with molecular weights about 16 kilodalton. The ability of HBGFs to stimulate cell proliferation in vitro was studied using human umbilical vein EC as target cells. The result showed that when HBGFs was added to the cultures, EC could be made to long-term serial cultivation, and resuscitated successfully after freezing and the serum requirement for EC growth could be reduced.

As a sort of human capital, health is a concrete manifestation of human productivity.At home and abroad, there are many empirical studies focusing on the economic effects of health that have been conducted, but the research methods have not paid enough attention to the endogeneity of health in those studies.This paper evaluates the effects of health on the income of rural residents in China with the micro panel data from China Health and Nutrition Survey.To get reliable results, the paper controls the endogenity of health by using simultaneous equation model and solves the parameters by using the three-stage least squares method.The study found that health has significantly positive effects on the income of rural residents in China, a conclusion which is in conformity with the economic effects of health.To improve the health of rural residents and fully implement the economic effects of health, the study recommends the government to put more efforts on promoting healthcare services, health-related education, and improving the living standards of rural residents in China.