0.05; emphysema in animals inhaling diphosgene into lower rispiratory tract (LRT) alone was obvious with Pden (0.59?0.05) being different from that of control animals, P

The bactericidal activity of serum and cere brospinal fluid (SBA and CBA)of ceftroiaxone (CTRX), cefotaxime(CTX) cefuroxime(CFR) in the patients undergoing surgery of skull and brain were studied by means of microdi luted method. The results showed antibacterial activity of CTRX against, enterobactericeae in vitro or in serum and cerebrospinal fluid (CSF) was the highest, it is suggested that the schadule of CTRX per 12hr may be used in prevention and treatment of serious infections after surgery of skull and brain.The bacteria The SBA and CBA of CFR were less ,but its antibacterial spectrum was wide and bactezi cidal activity of CTX against gram positive strains and enterobactericeae in sencm and CSF were higher, CTX may be used in treatment of infections of nervous system caused by mixed bacteria, the cost was lower, so CFR may be selected in the moderate infections. The CBA was a synthesized guide reflexing the antibactieral activity and penetration into barrier, so it is impostand reference to select antibiotics of infection after surgery of skull and brain.

The procedure of treating prostate cancer is as the following: After local prostatectomy or radiotherapy or local palliative therapy, androgen-dependent prostate cancer(ADPC) should be given first-line endocrinal therapy. Almost all patients will be developed from ADPC to hormone independent prostate cancer (HIPC) after 14 ～ 30 months, including androgen-independent prostate cancer(AIPC) and hormone-refractory prostate cancer(HRPC). Second-line endocrinal therapy and chemotherapy should be given, respectively. Antibone metastasis therapy is given when bone metastasis occurred. All medical methods should be used rationally and comprehensively to improve the management of prostate cancer.

MIC,according to which,the antibiotics frequently used for treating respiratory infections were divided into three groups:Time-dependent(with minimal or no PAE),Concentration-dependent(with PAE),Time-dependent and Concentration-enhanced(with PAE),In addition,the most appropriate antibiotic administration methods are also explored respectively in the article.Finally,several measures of preventing emergence of resistance are proposed based on the theory of MPC.

Breast Neoplasms ; pathology ; Female ; Humans ; Middle Aged ; Neoplasm Metastasis ; Neoplasms ; pathology ; Nose Neoplasms ; secondary ; Skin Neoplasms ; secondary

Adult ; Aged ; Aged, 80 and over ; China ; epidemiology ; Humans ; Middle Aged ; Pneumoconiosis ; epidemiology

Biomedical Research ; Humans ; Integrative Medicine ; Medicine, Chinese Traditional

Adult ; Aged ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Occupational Exposure ; Pneumoconiosis ; diagnosis ; epidemiology ; Welding

Objective Utilizing the characters of pyrrolidine dithiocarbamate known as a specific inhibitor of NF‐κB and imidapril known as a specific inhibitor of angiotensin converting enzyme ,this study was to initially investigate the relationship between NF‐κBp65 and AngⅡ during the process of myocardial ischemia reperfusion injury .Methods Rat models of myocardial ischemia reper‐fusion injury were successfully established .The observation point is 60 min of reperfusion after 30 min(I30 min R60 min ) ischemia ,the DNA activate of NF‐κBp65 was detected by ELISA ;the content of AngⅡ in blood plasma and cardiac were determined by radioim‐munoassay .We pretreated with pyrrolidine dithiocarbamate ,imidapril ,and both of them to observe changes of the same indexs .Re‐sults Compared with I30 min R60 min ,Pyrrolidine dithiocarbamate ,Imidapril and pyrrolidine dithiocarbamate add imidapril could all ob‐viously inhibit NF‐κBp65 activation and depress the content of Ang Ⅱ in blood plasm and cardiac ,the pyrrolidine dithiocarbamate add imidapril was most obviously .Conclusion During the process of myocardial ischemia‐reperfusion injury ,NF‐κBp65 had been activated ,and the content of Ang Ⅱ in blood plasm and cardiac had increased .NF‐κBp65 and AngⅡ could influence and promote each other during myocardial ischemia reperfusion injury .

Armillaria mellea is a kind of medicinal and edible fungus belonging to Tricholomataceae family. It possesses comprehensive biological activities, such as hypnotic, sedative, improving cardiocerebral blood circulation, hypoglycemic, antioxidant, and immune regulation. Besides, it can inhibit tumor. A. mellea contains characteristic chemical constituents, such as, protoilludane sesquiterpenoid aromatic esters, diterpenoids, triterpenoids, polysaccharides, adenosine, and various types of secondary metabolites. This paper summarizes the chemical composition and biological activity of A. mellea to provide the reference for developing and utilizing it.