Gout is the most common inflammatory arthritis among Filipinos, characterized by hyperuricemia leading to mono- sodium urate crystal deposition and an ensuing inflammatory response. Though typically a disorder of middle- aged and older adults, tophaceous gout presenting before the age of 30 is rare and suggests aggressive disease progression. Allopurinol, a first-line urate-lowering therapy, is generally effective but may cause rare, potentially life-threatening adverse reactions such as allopurinol hypersensitivity syndrome (AHS). Febuxostat, a non-purine xanthine oxidase inhibitor, is an alternative for patients intolerant to allopurinol. Although hypersensitivity reactions to febuxostat are extremely rare, isolated case reports document their occurrence in both patients with prior AHS and in allopurinol-naïve individuals. Hypersensitivity to both agents is exceedingly uncommon and presents a major therapeutic challenge. In such cases, febuxostat desensitization, conducted in collaboration with allergy specialists, may permit a viable solution to safely reintroduce urate-lowering therapy and prevent further disease progression. This case report describes a patient with young-onset, tophaceous gout who developed severe hypersensitivity reactions to both allopurinol and febuxostat — an unusual and challenging therapeutic dilemma. The case highlights the need for individualized management strategies, including the consideration of drug desensitization, in patients with limited urate-lowering options.

BACKGROUND AND OBJECTIVE

The burden of treatment delay in breast cancer is high, especially among developing countries. Despite adversely affecting morbidity and mortality, treatment delay remains unexplored in the Philippines. This study aimed to determine treatment delays among breast cancer patients in a tertiary hospital during surgery, neoadjuvant chemotherapy, and adjuvant chemotherapy, and to identify predictors of delay.

A cross-sectional study was conducted among breast cancer patients seen between January 1, 2012 to December 31, 2018. The following outcomes were investigated: ≥90 days from initial diagnosis to surgery, ≥8 weeks from diagnosis to initiation of neoadjuvant chemotherapy, and >120 days from diagnosis to initiation of adjuvant chemotherapy. Summary statistics were reported as percent for categorical data and as mean for continuous data. The individual correlations were performed using Chi-square for qualitative data and t-test for quantitative data while predictors were determined through logistic regression.

A total of 324 patients were included in this study. The majority of the patients were less than 65 years old living in urban areas. More than half of the patients were overweight or obese, hypertensive, and diabetic. The following delays were observed: 61.1% (n = 198) with any type of delay, 23.8% (n = 53) with delay in surgery, 53.8% (n = 120) with delay in adjuvant chemotherapy, and 74.3% (n = 75) with delay in neoadjuvant chemotherapy. The patients noted to have any type of delay were more likely to be hypertensive (p = 0.046) and residing in urban areas (p = 0.041). There were no differences in the distribution of age, body mass index, and presence of co-morbid conditions such as hypertension, diabetes mellitus, coronary artery disease, and heart failure among those with any form of delay compared with no delay.

The present study shows the presence of treatment delay among breast cancer patients and may be used to enact policy changes to optimize breast cancer care delivery. Further studies may be done to identify other factors affecting these delays and policy changes are recommended to address these gaps in surgery and chemotherapy administration among breast cancer patients.

BACKGROUND AND OBJECTIVES

The demographic background, level of knowledge, and attitude of caregivers are pillars of care in dementia. Family and non-family members take on this role. Studies have been done on their knowledge and attitude, but none have focused on them during hospitalization, wherein greater stress is imposed on both the caregiver and the patient. This study aims to determine the profiles, and its association with knowledge, and attitudes of caregivers of hospitalized patients with dementia in a tertiary hospital in Metro Manila.

A single-center descriptive cross-sectional design using Demographic profile Questionnaire, Alzheimer’s Disease Knowledge Scale (ADKS), and Dementia Attitude Scale (DAS) were used on Filipino caregivers of inpatients with dementia in Metro Manila. Simple and multivariable linear regression were used to assess demographic factors in relation to the attitude and knowledge of the caregivers.

Eighteen females with a mean age of 49 (SD=8) years old participated. Ten participants completed college. Six (33.3%) of the respondents were family members, five (27.8%) were occupational caregivers, four (22.2%) were house-helps, and two (11.1%) were nurses. Majority (66%) had 3-10-year duration of caregiving. Mean score of knowledge scale is 21.17 out of 30. Age, education, caregiver role, and attitude were positively associated with knowledge. The mean score for attitude level is 119.83 out of 140. Age, education, duration, caregiving role, patient’s age, and knowledge were positively associated with attitude; with education being statistically significant (p=0.046).

Caregivers exhibited reasonable knowledge for such caregivers to carry out their duties on inpatients with dementia at an adequate level, with several factors correlating positively, indicating areas for improvement. Their attitude scores revealed positive disposition; with education emerging as statistically significant. Continuing education and targeted interventions can further enhance quality of caregiving.

BACKGROUND AND OBJECTIVE

Given the rigors of medical training with its high documented prevalence of mental issues as well as the global need to safeguard the well-being of medical students, there is an urgency to assess the well-being of medical students and their perception of support from their respective medical schools during their education. This also applies in the context of public medical school students in the Philippines, where there is still a relative lack of literature. This cross-sectional study investigates the well-being and such perceptions of medical students at the University of the Philippines College of Medicine (UPCM).

The study uses a quantitative approach using a subset of secondary data from a college-wide survey online that was disseminated, through convenience sampling, to medical students from October 3, 2018 to December 3, 2018. A total of 432 responses were included in the analysis, out of the total student population of the included learning unit levels of 809. Participants were grouped based on their entry into medical school, either through the Integrated Liberal Arts and Medicine (INTARMED) program or lateral entry. Exclusion criteria comprised responses from Learning Unit I-II (pre-medical proper) students and incomplete survey sets. Responses were interpreted using established scales such as the World Health Organization Well-Being Index (WHO-5), Perceived Stress Scale-4 (PSS-4), and Oldenburg Burnout Inventory-Medical Student (OLBI-MS). Data analysis involved statistical techniques including one-way ANOVA and independent samples t-test using Statistical Package for the Social Sciences (SPSS).

The findings suggest that medical students at UPCM generally find the administrative and academic systems satisfactory, but express concerns about inadequate educational resources and infrastructure, especially as they progress through their studies and engage more with clinical settings like the Philippine General Hospital (PGH). As students advance through the program, there are different patterns for wellbeing outcomes, including decreasing perceived stress and increasing burnout. In particular, LU IV and LU VII students reported lower well-being and higher burnout levels, respectively. This is potentially due to heavier workloads and clinical responsibilities. Lateral entrants, who are older and typically enter with prior degrees, tend to have higher well-being and lower burnout compared to INTARMED students, suggesting age and previous educational experience may play a role in adjustment and coping mechanisms.

Overall, the study highlights the medical students’ generally satisfactory perception of medical educational aspects, as well as the patterns of wellbeing throughout their medical college experience. Furthermore, it identifies different areas for improvement to ensure effective education and student mental health. By analyzing trends across different year levels, the study provides insights for interventions and program refinements, while also suggesting avenues for further research to assess student experiences over time.

OBJECTIVE

This study aimed to investigate the determinants linked to stunting among infants and young children aged 0-23 months in the Fourth District of Camarines Sur.

An analytical cross-sectional study was conducted among 628 primary caregivers with infants and young children aged 0-23 months in four municipalities of the Fourth District of Camarines Sur, Philippines, using a two stage stratified random sampling design. Data on sociodemographic and economic factors were collected through face-to-face interviews. Infant and young child feeding (IYCF) indicators were assessed using a list-based approach, while weight and length were evaluated using the World Health Organization Anthro Plus software. Descriptive statistics and multiple logistic regression were done using R statistical software version 4.3.1.

The study revealed that the prevalence of stunting was of significant public health concern, reaching 42.8%. Holding other variables constant, age of the child (OR=0.77; 95% CI: 0.63-0.94), having college undergraduate mothers (OR=0.26; 95% CI: 0.05-1.28), and belonging to a poor income household (OR=0.40; 95% CI: 0.14-0.88) were associated with stunting among infants aged 0.01-6.00 months. Moreover, after controlling for the confounding effects of other variables, age (OR=1.09; 95% CI: 1.05-1.14) and sex of the child (OR=1.55; 95% CI: 1.05-2.28) were associated with stunting among older children aged 6.00-23.99 months.

This study emphasizes the challenge of stunting in the Fourth District of Camarines Sur. None of the IYCF indicators were associated with stunting; however, maternal education, the child’s age, sex, and socioeconomic status were identified as significant factors influencing stunting. Addressing these determinants through targeted interventions focusing on improving maternal education and enhancing socio-economic conditions were crucial to reducing stunting in the study areas.

OBJECTIVE

This study assessed the level of health system responsiveness of Rural Health Units (RHUs) in Cagayan Valley Region along seven domains of responsiveness namely dignity, autonomy, confidentiality, choice of provider, prompt attention, communication, and quality of basic amenities, and five core components of the health system namely health governance, health human resource, health information system, access to medicines and technology, and service delivery.

A cross-sectional research design was adopted using survey as the primary means of data collection using a researcher-developed questionnaire. The study was conducted in RHUs of 15 identified municipalities in the region. The municipalities were chosen based on their low performance in the LGU health score cards for 2019. A total of 618 clients and 235 health workers were included in the study. Frequency, percentage, and mean were used to analyze the profile and level of health system responsiveness. T test and one-way ANOVA were used to test significant differences.

The results showed that the RHUs included in the study have very good level of health system responsiveness, with overall percentage scores ranging from 73.55 to 88.08, in all domains assessed. However, choice of providers within the facilities (62.71%) and access to medicine and technology (77.45%) were the least responsive among all the identified domains. Significant differences in the clients’ assessment of the responsiveness of the RHUs were seen when grouped according to their sex, age, educational attainment, income level, overall level of health, frequency of visits, and distance of home to facility. The RHUs’ location, whether in an urban or rural area, number of staff, and number of barangays catered also were found to determine the level of health system responsiveness. Moreover, not all RHUs were able to comply with basic requirements of the Department of Health specifically along the services offered.

It can be concluded therefore that the RHUs, despite the limitations in certain aspects are still able to meet the expectations of the clients and health workers in the delivery of health services. However, in order to maximize responsiveness of these facilities, DOH requirements for these facilities should be met.

Objectives: The purpose of this study was to examine the influence of the local Vietnamese government initiative, the ‘invisible healthcare system’, on the activities of Organization A, which focuses on oral health projects. Methods: Since 2000, Organization A has conducted preventive care and oral health-focused activities in central Vietnam, with formal and informal interventions from local Vietnamese governments. This study conducts an in-depth analysis of the relationship between local Vietnamese governments and oversea non-government organizations (NGOs) from the perspective of the recipient country. Results: First, the initial step involves aligning intentions with the local Vietnamese government through negotiations, such as reaching agreements on the operation of oral health programs. Second, efforts should be made to understand the implicit aspects of Vietnamese policies regarding oversea NGO activities. For instance, it can be the People’s Aid Coordination Committee (PACCOM), which has a policy to manage oversea NGOs. The policies of PACCOM inherently reflect an ‘invisible healthcare system’ and a ‘nationalist-oriented character’. Conclusions Finally, oversea NGO activities in Vietnam increasingly require a focus on ‘localization’and ‘Vietnamization’ to effectively achieve the desired outcomes.

Objective: : Although Republic of Korea is an advanced country in medical technology with a successful treatment rate for serious diseases, such as cancer, and has improved technology for highly difficult surgery, many excellent medical doctors and physicians are struggling due to the recent unreasonable medical environment. Specialization in brain tumor surgery also faces challenges in Republic of Korea, including low financial incentives, legal threats, and limited career prospects. In response, the Korean Brain Tumor Society (KBTS) formed the Future Strategy Committee to assess these obstacles and propose solutions. Methods: : A survey was conducted among the KBTS members to understand their perceptions and concerns across different career stages. Results: : The findings revealed a decline in interest among chief residents in brain tumor surgery, owing to limited job opportunities and income prospects. Neurosurgical fellows expressed neutral satisfaction but highlighted challenges, such as low patient numbers and income. Faculty members with varying levels of experience echoed similar concerns, emphasizing the need for improved financial incentives and job stability. Despite these challenges, the respondents expressed dedication to the field and suggested strategies for improvement. Conclusion : The KBTS outlines a vision that focuses on practical excellence, comprehensive research, professional education, responsibilities, and member satisfaction. Addressing these challenges requires collaborative efforts among healthcare institutions, professional societies, and policymakers to support brain tumor specialists and enhance patient care.

Background/Aims: This study aims to investigate the association between Binge Eating Disorder and functional dyspepsia in a Mexican population, focusing on symptomatology and demographic characteristics. Methods: We conducted a cross-sectional study on 1016 subjects, evaluating binge eating disorder (BED) and functional dyspepsia based on the Rome IV criteria. Data collection included sociodemographic information, gastrointestinal symptom severity, and anxiety/depression screening using validated tools. A multivariate logistic regression analysis with the 2 test was conducted for comparison analysis. Results: The prevalence of dyspepsia in BED was 53.6% (95% CI, 46-56). Postprandial fullness (OR, 1.52; 95% CI, 1.06-2.17; P = 0.021) and overlap syndrome (OR, 1.80; 95% CI, 1.25-2.60; P = 0.002) were significantly associated with BED. Patients with BED also presented more severe postprandial distress syndrome (P = 0.027). Anxiety was prevalent in BED patients, while depression was more prominent in patients with BED and dyspepsia overlap. Conclusions BED patients have a high prevalence of dyspepsia with an association between postprandial fullness and this eating disorder. BED appears to be more prevalent in younger individuals and males. These findings underscore the importance of considering dyspepsia in the management of BED and highlight the need for further research on this association.

BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by extreme immune activation, resulting in pathologic inflammation that may be life-threatening. Early recognition is crucial since survival largely depends on early initiation of treatment which utilizes a combination of chemotherapy, immunotherapy and in some cases even bone marrow transplantation.

OBJECTIVES: This study aims to describe the clinical characteristics, treatment received and outcome of patients diagnosed with HLH at the Philippine Children’s Medical Center from 2004 to 2017.

METHODS: A retrospective analysis of records of children 0 -18 years of age diagnosed with HLH from January 2004 to December 2017 was done.

RESULTS: A total of 39 patients were included in the study which gave an incidence of 1.22 per 3000 patients admitted under 18 years of age. There were 29 males (74.4%) and 10 females (25.6%) with a male to female ratio of 2.9:1 Mean age was 6.12 ± 3.89 years. The average time from initial presentation to diagnosis was 6 weeks and 2 days. The most commonly seen clinical and laboratory features observed in these patients were fever (100%), splenomegaly (71.8%), anemia (87.17%), thrombocytopenia (79.48%) and hypertriglyceridemia (69.23%). Only 5 patients were confirmed to be familial HLH with 3 having XLP gene mutation, and one each having syntaxin and perforin gene mutations. Majority of patients received a combination of treatment based on the HLH 2004 regimen while almost one third only received antibiotics. Only 23% of patients survived during the study period and all but one of these patients received drug combinations based on the HLH 2004 protocol.

CONCLUSION: HLH is a rare but important condition that must be recognized early and treated appropriately to optimize survival. The mortality rate of 39 patients seen in this institution is high. There is a need to better utilize the diagnostic criteria of the disease and to employ a more uniform treatment strategy. Increasing awareness among health care personnel can also improve case finding, characterization and treatment.