Postoperative nausea and vomiting (PONV) is a long-standing issue, not a new concept in anesthesiology. Despite many studies over the last several decades, PONV remains a significant problem due to its complex mechanism. This review presents a summary of the mechanism underlying the pathogenesis of PONV, focusing on preventive treatment, particularly the use of new drugs. In addition, we discuss the latest meta-analysis results regarding correct clinical use of classic drugs. I also summarize the latest trends of postdischarge nausea and vomiting and the pharmacogenetics, which is attracting a great deal of attention from other medical fields in PONV-related studies. Finally, we discuss the drawbacks of existing studies on PONV and suggest a focus for future investigations.
Anesthesiology ; Nausea ; Pharmacogenetics ; Postoperative Nausea and Vomiting* ; Vomiting

No abstract available.
Postoperative Nausea and Vomiting*

No abstract available.
Postoperative Nausea and Vomiting*

No abstract available.
Postoperative Nausea and Vomiting*

No abstract available.
Postoperative Nausea and Vomiting*

No abstract available.
Ondansetron* ; Postoperative Nausea and Vomiting*

Nausea and vomiting during early pregnancy is a common phenomenon, but very little data is available about the mechanism of this condition, and the etiology of hypereme sis is still unknown. One of the most popular hypothesis is that abnormal hormone levels, especi-ally thyroid hormone, may be possible etiologic factor of nausea and vomiting. The object of this study is to investigate the relationship between the presence or ab- sence of nausea and vomiting in early pregnancy and thyroid function. Twenty patients suffering from hyperemesis gravidarum of first trimester of pregnancy and twenty from morning sickness were selected. 20 non-pregnant and 20 pregnant women without nausea and vomiting were selected to age-matched control groups. Thyroid function was evaluated by using T3, T4, and TSH radioimmunoassay. Comparison between groups were analyzed with the paired t-test. In this study, we found that a significant increase in serum total T4(p<0.001) and T3 (p<0.05), and a significant decrease in serum TSH(p<0.001) were observed in pregnancy with hyperemesis gravidarum relative to the level in normal pregnancy. These results were correlated with the severity of nausea and vomiting. In conclusion, highly elevated T3 and T4 were closely linked to the cause of the vomi- ting in pregnancy with hyperemesis gravidarum. Further study is needed to evaluate more clearly the thyroid status of patients with hyperemesis gravidarum and to seek a therapy.
Female ; Humans ; Hyperemesis Gravidarum* ; Morning Sickness ; Nausea ; Pregnancy ; Pregnancy Trimester, First ; Pregnant Women ; Radioimmunoassay ; Thyroid Gland* ; Tolnaftate ; Vomiting

No Abstract available.
Anesthetics* ; Delirium* ; Postoperative Nausea and Vomiting*

Background: Compared to adult patients undergoing upper limb surgery who receive general endotracheal anesthesia (GETA), those who receive peripheral nerve block (PNB) have better postoperative outcomes. Objective: To compare postoperative outcomes of PNB and GETA for orthopedic upper limb surgery among pediatric patients. Design: Cohort study. Setting: Southern Philippines Medical Center, Davao City, from December 2015 to May 2016. Participants: 94 boys and girls, 3 to 18 years old, who received either PNB or GETA for orthopedic upper limb surgery. Main outcome measures: Postoperative pain by visual analogue scale (VAS), need for postoperative rescue opioid doses. Main results: Of the 94 patients in this study, 47 (50%) received PNB, and the rest received GETA prior to surgery. Patients in the two anesthesia groups were comparable at baseline. The PNB group had lower mean VAS scores compared to the GETA group both at the post-anesthesia care unit (0.70 ± 1.52 versus 4.15 ± 1.78; p<0.001) and at the Orthopedics Ward (0.45 ± 1.49 versus 4.13 ± 1.68; p<0.001). The proportion of patients given postoperative rescue opioid doses was significantly lower in the PNB group (6/47; 12.77%) than in the GETA group (21/47; 44.62%; p=0.0006). Conclusion Pediatric patients for orthopedic upper limb surgery who received PNB had less pain postoperatively and needed postoperative rescue opioid doses less frequently compared to those who received GETA.
Anesthesia, Conduction ; Postoperative Nausea and Vomiting

Humans ; Postoperative Nausea and Vomiting ; Research Design