1.A Case of Botulinum Toxin Injection for Treatment of Functional Dyspepsia
Soonchunhyang Medical Science 2024;30(1):43-45
Functional dyspepsia is a condition with chronic indigestion symptoms such as epigastric pain or discomfort, early satiety, and bloating without an alternative organic disease. The symptoms are similar to those of functional dyspepsia, but abnormal retention of food in the stomach should be identified in gastroparesis. In this case, botulinum toxin injection was performed for treatment in a patient who complained of symptoms such as nausea, early satiety, abdominal distension, and poor appetite without no abnormal findings in gastric emptying scan. Through this case, a possibility was found that antral and pyloric dysfunction may cause symptoms of functional dyspepsia, without gastric emptying abnormalities.
2.A Case of Skin Burns Occurring during Laparoscopic Surgery
Yujun PARK ; Jeong Soo CHOI ; Hae Rim CHUN ; Jinhun CHUNG
Soonchunhyang Medical Science 2024;30(1):46-48
Skin burn injury from light cables is a rare complication of laparoscopic surgery. We report the case of a 57-year-old female who underwent laparoscopic-assisted right hemicolectomy under general anesthesia. During surgery, the anesthesiologist discovered that the tip of the light cable, with the light source powered on, penetrated the surgical drape and was positioned on the right forearm of the patient, where a bulla measuring 2.0× 2.5 cm in size and a second-degree burn were identified. All medical personnel participating in laparoscopic and arthroscopic procedures should always be aware that the light cable can cause burns to the patient. Additionally, after connecting the light cable to the scope, the light source should be activated. The light cable should not be placed around the patient or on the surgical drape while the light source is active. Immediately after completing the surgery, the power to the light source should be turned off, and the light cable should be placed in a safe place.
3.A 12-Year-Old Boy with Sleep-Related Epilepsy and Laryngeal Lymphoid Hyperplasia: A Case Report
Ara KIM ; Han Na JANG ; Seung Soo KIM
Soonchunhyang Medical Science 2024;30(1):39-42
Differentiating between nocturnal seizures and sleep-related behaviors is challenging; a detailed history and careful examination are imperative. There have been some case reports of patients who were comorbid with nocturnal seizures and obstructive sleep apnea (OSA). Here, we report a case of an overweight 12-year-old boy diagnosed with sleep-related epilepsy and comorbid OSA. We were able to make these two diagnoses by performing polysomnography with full extended electroencephalography on our patient, who complained of recurrent nocturnal choking episodes during sleep. What differentiates our case is that after further evaluation, the cause of our patient’s OSA was ultimately determined to be laryngeal lymphoid hyperplasia.
4.Low-Dose Baclofen-Induced Encephalopathy in a Patient with End-Stage Renal Disease: A Case Report
Chang-Woo KIM ; Jong-Myun LEE ; Jae-Sang LEE ; Tae-Hoon DO ; Hye-Jin MOON ; Jee-Eun YOON
Soonchunhyang Medical Science 2024;30(1):32-35
Baclofen, a gamma-aminobutyric acid-B receptor agonist, is commonly used for central-origin muscle spasticity and spasm and neuropathic pain. Baclofen toxicity has been reported to cause a range of symptoms including drowsiness, confusion, respiratory depression, seizures, and even coma, particularly with dosage significantly exceeding therapeutic levels. Given that the baclofen is predominantly eliminated through the kidneys, patients with renal failure are at substantial risk for neurotoxic effects. We report a case of baclofen-induced encephalopathy in a patient with end-stage renal disease, characterized by an altered mental state with myoclonus following the consumption of a low dose of baclofen.
5.A Case of Thrombocytopenia with MYH9 Gene Mutation Found in Siblings
Ju Young KIM ; Kyeong Bae PARK
Soonchunhyang Medical Science 2024;30(1):36-38
Myosin heavy chain 9 (MYH9) related diseases are autosomal dominant diseases characterized by macrothrombocytopenia and inclusion bodies in leukocyte, which can be accompanied by extra-hematologic symptoms such as sensorineural hearing loss, renal dysfunction, and cataract. They are often diagnosed incidentally in adulthood or misdiagnosed as idiopathic thrombocytopenic purpura (ITP), leading to unnecessary treatment with intravenous high-dose gamma-globulin, steroids, or splenectomy. Here, we report the case of a brother and sister confirmed to have a MYH9 gene mutation during follow-up. An 8-year-old boy was confirmed to have thrombocytopenia at birth and treated with intravenous gamma-globulin under suspicion of ITP or sepsis. He was discharged after showing an increase in platelet count. Subsequently, during outpatient workup, he exhibited thrombocytopenia, large platelets, and neutrophilic inclusion bodies. His 10-year-old sister also presented with the same findings. In 2021, DNA analysis revealed that they share a mutation (c.4270G> A, p. Asp1424Asn), a pathogenic variant associated with MYH9-related disorder.
6.A Nationwide Study on Emergency Department Utilization among Pediatric Patients in Korea: A Special Focus on Pediatric Emergency Medical Centers
Soonchunhyang Medical Science 2024;30(1):13-22
Objective:
Despite Korea’s low birth rate, pediatric emergency medical centers (PEMCs) are grappling with overcrowding. This study evaluates the use of PEMCs in Korea amid a declining birth rate and increased overcrowding.
Methods:
Data from 176 emergency medical centers (EMCs, 2018–2021) was analyzed using the National Emergency Department Information System, focusing on demographics, Korean Triage and Acuity Scale (KTAS) scores, and pediatric patient outcomes. The most common complaints and diagnoses were identified by the EMC level. This study also examined the characteristics of patients visiting PEMCs.
Results:
There was a 48% drop in pediatric visits to EMCs during the coronavirus disease 2019 (COVID-19) pandemic. The majority of patients were boys aged 1–4, primarily visiting in the evenings and weekends. The breakdown of cases included 66% disease-related and 34% injury-related. Notably, 8.5% of these visits were via ambulance, 36% were high-acuity according to KTAS, 88% resulted in discharge, and 11% in hospitalization. The median stay was 85 minutes, with 83% utilizing local emergency services. Fever, abdominal pain, and vomiting were the most common complaints, comprising 40% of all visits.
Conclusion
Despite a decrease in birth rates, PEMC usage in Korea saw an initial rise followed by a significant decrease during the COVID-19 pandemic. Children aged 1–4 were the most frequent users. The majority of cases were medical rather than trauma-related, and resulted in patient discharge. Strategic redirection of non-urgent cases may help alleviate overcrowding in emergency departments.
7.Histological Findings of Osteomyelitis in Patients with Diabetic Foot and Their Correlation with Radiologic Findings
Kyeongmin KIM ; Eunjung LEE ; Sung Hun WON ; Soo Bin PARK ; In Ho CHOI
Soonchunhyang Medical Science 2024;30(1):7-12
Objective:
Osteomyelitis in patients with diabetic foot has been diagnosed clinically, radiologically, and histologically. However, the accuracy of these diagnostic modalities is not well established. In this study, we histologically reviewed patients who underwent surgical procedures for diabetic foot osteomyelitis and correlated these histological features with radiological findings.
Methods:
Eighty patients who were clinically diagnosed with diabetic foot osteomyelitis, who underwent surgical treatment between November 2017 and February 2022, were enrolled. Hematoxylin and eosin-stained slides and radiological findings were reviewed.
Results:
Eighty patients were radiologically examined by magnetic resonance imaging (MRI) (49 cases) and/or 99mTc-hexamethyl-propylene amine oxime-labeled white blood cells single-photon emission computed tomography (SPECT)/computed tomography (CT) (65 cases). MRI findings were suggestive of osteomyelitis in 35 cases (71.4%) and soft tissue inflammation in 46 cases (93.8%). In SPECE/CT, 60 cases (92.3%) and 64 cases (98.4%) showed signs of osteomyelitis and soft tissue inflammation, respectively. Histologically, both bone and soft tissue lesions were found in 32 cases (40%), only bone tissue lesions in seven cases (8.8%), and only soft tissue lesions in 40 cases (50%). The sensitivity and specificity of MRI for osteomyelitis were 83.3% (10/12) and 28.6% (4/14), and that of SPECT/CT was 100.0% (12/12) and 12.5% (2/16), respectively. Moreover, those of by MRI findings for soft tissue inflammation were 90.6% (29/32) and 0% (0/12), while that of SPECT/CT was 97.4% (38/39) and 0% (0/18), respectively.
Conclusion
For accurate histological diagnosis of diabetic foot osteomyelitis, sufficient specimens should be obtained. White blood cell SPECT/CT seems to be a more sensitive modality than MRI for the detection of osteomyelitis.
8.High-Resolution Time-of-Flight Magnetic Resonance Angiography with a Volume Rendering Algorithm for Detection of Unruptured Aneurysms: Correlations with Digital Subtraction Angiography
Soonchunhyang Medical Science 2024;30(1):23-31
Objective:
We investigated the diagnostic accuracy of high-resolution magnetic resonance angiography (HR-MRA) with volume rendering (VR) post-processing techniques for the detection of cerebral aneurysms compared with conventional MRA (C-MRA) using digital subtraction angiography (DSA) as the gold standard.
Methods:
HR-MRA was performed for 51 possible aneurysms of 38 patients on C-MRA. For each possible aneurysm, readers recorded their level of confidence on a 5-point scale. All patients underwent DSA, which was used as the standard of reference. Receiver-operating characteristic (ROC) analysis and the area under the ROC curves (AUC) were used to determine the effectiveness of C-MRA and HR-MRA in detecting cerebral aneurysm with and without VR algorithm. The increased discriminative value was examined by calculation of Net Reclassification Index (NRI) and Integrated Discrimination Improvement (IDI) index.
Results:
DSA revealed 37 aneurysms in 26 patients. In aneurysm-based analysis, HR-MRA showed higher diagnostic accuracy than C-MRA, and increased diagnostic accuracy on adding VR (C-MRA vs. HR-MRA, P< 0.01; C-MRA with VR vs. HR-MRA with VR, P< 0.01, respectively). The differences in AUC, IDI (19.38%, Z= 3.18, P< 0.01) and NRI (46.3%, Z= 6.32, P< 0.01), on adding VR to the HR-MRA, were also statistically significant. The application of HR-MRA with VR increased the detection rate of aneurysms less than 3 mm.
Conclusion
The application of HR-MRA with VR algorithm improves diagnostic performance for the detection of intracranial aneurysms, especially when the aneurysm is less than 3 mm. Clinically, HR-MRA with VR algorithm could facilitate the accurate differentiation of aneurysms from infundibula and prevent unnecessary, invasive procedure before aneurysmal rupture.
9.Comparison between Total Hip Arthroplasty for Avascular Osteonecrosis of Femoral Head and That for Fixation Failure of Femoral Neck Fracture
Soonchunhyang Medical Science 2024;30(1):1-6
Objective:
To compare the clinical and radiologic results between primary total hip replacement arthroplasty (THRA) in patients with avascular necrosis of femoral head (AVN) and secondary THRA in patients with fixation failure of femoral neck fracture.
Methods:
From March 2014 to February 2021, we retrospectively evaluated a total of 53 patients who underwent either THRA for AVN (33 cases) or THRA for fixation failure of femoral neck fracture (20 cases). Clinical performances and Hemodynamic scales were evaluated. Radiologic analyses were conducted to assess stem alignment, stem stability, the appearance of heterotrophic ossification, stress shielding, and any signs of osteolysis or loosening.
Results:
THRA for AVN showed a mean blood loss of 881 mL and a 2.1 g/dL preoperative–postoperative (preop–postop) hemoglobin (Hb) difference. Meanwhile, THRA for fixation failure of femoral neck fracture showed a mean blood loss of 1,072 mL and a 3.2 g/dL preop–postop Hb difference (P= 0.017 and P= 0.034, respectively). The mean operation time was 70 minutes in THRA for AVN and 91 minutes in THRA for fixation failure of femoral neck fracture (P= 0.035). Stem alignment was varus 1.50° in AVN and varus 3.50° in fixation failure of femoral neck fracture. There was one case of a varus femoral stem in AVN and six such cases in the fixation failure of femoral neck fractures. This was a statistically significant difference (P= 0.010 and P= 0.020, respectively).
Conclusion
Secondary THRA in patients with fixation failure of femoral neck fracture showed longer operation time, larger bleeding, and more varus stem alignment than primary THRA in patients with AVN.
10.Perforation of a Meckel’s Diverticulum Following Ingestion of a Chicken Bone: A Case Report and Literature Review
Soonchunhyang Medical Science 2024;30(2):49-51
Perforation of a Meckel’s diverticulum with a foreign body is a rare complication. Whether in children or adults, fish bones have been reported to cause perforation in a Meckel’s diverticulum, but few cases have been reported in which swallowing relatively large bones such as chicken bones results in perforation. We report a case of perforation of a Meckel’s diverticulum caused by swallowing a chicken bone.

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