Human ; Pathology

OBJECTIVE

The objective of this study was to determine the validity and reliability of a Filipino translation of the Catquest 9-SF questionnaire for measuring the patient reported visual outcomes of Filipino cataract patients in a tertiary hospital.

The English version of the Catquest-9SF questionnaire was translated into Tagalog or Filipino, back translated into English and finally translated again into Filipino using the WHO forward backward-forward translation technique. The final Filipino version of the questionnaire was administered to 90 patients who were awaiting cataract surgery and fit the inclusion criteria. The response patterns as well as the overall construct of the Filipino questionnaire were evaluated using the Rasch model in terms of specific components for reliability and validity.

The Filipino version of the Catquest-9SF showed high reliability for person and item components based on Person Separation Index (PSI). All questions showed good fit statistics based on Show Mean Square (MNSQ), as well as unidimensionality using Principal Component Analysis (PCA). Differential Item Functioning (DIF) was not seen across all age groups, while only one question showed DIF among different sex groups.

The results of the Rasch analysis show good overall functioning of the Filipino version of the Catquest-9SF. It is a valid and reliable tool that can be used to measure the visual disability outcomes of Filipino cataract patients.

OBJECTIVE

To compare the refractive absolute error when axial length (AL), anterior chamber depth (ACD) and keratometry (K) are sourced from different measuring devices (IOL Master vs a combination of automated keratometer and A-scan) and inputted into the Barrett Universal II or SRK/T formula.

This was a retrospective study. Medical charts of eyes that underwent uncomplicated phacoemulsification with in-the-bag implantation of Envista or multifocal FineVision IOL were reviewed. The results of manifest refraction at 1 month after surgery were collected. The predicted refraction corresponding to the IOL power implanted was collected from 4 IOL sheets: using the SRK/T with AL, ACD, and K from IOL Master (Group A); SRK/T formula with AL and ACD from A-scan and K from the automated keratometer (Group B); Barrett formula with AL, ACD and K from IOL Master (Group C); and Barrett formula using with AL, ACD from A-scan and K from automated keratometer. For each group, the absolute error, prediction error, and variances of prediction error were computed.

A total of 132 eyes were included in the study: 56 in the monofocal group and 76 in the multifocal group. The means of manifest refraction spherical equivalent (MRSE) were 0.06 ± 0.38 D and –0.08 ± 0.31 D in the monofocal and multifocal groups, respectively. When AL and K were obtained from various sources and entered into the Barrett formula, the mean absolute error difference in both the monofocal (p = 0.70) and multifocal (p = 0.10) groups did not reach statistical significance. If the SRK/T formula was used, similar outcomes were observed (monofocal p = 0.97; multifocal p = 0.37). When compared to A-scan groups, the prediction error variances are significantly smaller in the groups that used the IOL Master as their data source. Among the four groups, the Barrett group using IOL Master as the data source showed the lowest overall variation of prediction error (monofocal F = 0.04; multifocal F = 0.03).

Though the refractive outcomes may not be statistically different, using the IOL Master as the source of AL and K makes the refractive outcomes more consistent and predictable. Combining the AL and K from the IOL Master with the Barrett Universal II formula further increases the predictability of refractive outcomes.

OBJECTIVE

This study compared the proportion of dry eye disease (DED) diagnosed using the Philippine criteria with that diagnosed using the Asia Dry Eye Society (ADES) criteria among participants, and characterized DED features using clinical tests and the OCULUS Keratograph® 5M (K5M; OCULUS Optikgeräte GmbH, Wetzlar, Germany).

This multicenter, cross-sectional study included participants with and without DED. Participants completed the Ocular Surface Disease Index (OSDI) questionnaire and underwent fluorescein tear breakup time (FTBUT) measurement, fluorescein staining of the cornea, lissamine green staining of the conjunctiva, Schirmer 1 test without anesthesia, and basal tear secretion test (BST). The OCULUS K5M was used to measure noninvasive tear breakup time (NIKBUT) and tear meniscus height (TMH), and to perform meibography.

The analysis included 344 eyes from 172 patients with DED and 44 eyes from 22 normal participants. Patients with DED were mostly female (66.3%). Compared to normal participants, patients with DED were older (42.7 ± 14.6 years) and had higher OSDI scores (28.6 ± 21.0). Among those diagnosed with DED using the Philippine criteria, 53.2% met the ADES criteria. Evaporative DED was the predominant type (53.2%). DED eyes had lower FTBUT (5.0 ± 3.3 seconds) and NIKBUT (12.3 ± 5.9 seconds) than controls (p CONCLUSION

There were disparities between the Philippine and ADES criteria for DED diagnosis and differences in tear measurements using clinical tests and the OCULUS Keratograph, indicating the need to harmonize diagnostic standards.

OBJECTIVE

Despite being a preventable and treatable condition, central microbial keratitis (CMK) and its complications remain to be a significant cause of vision loss in our country. This study presents the demographic profile, risk factors, etiologies, treatments, and outcomes of CMK in the Philippines.

The study was a two-center, prospective, non-randomized clinical study involving the patients of the External Disease and Cornea Clinics of two tertiary eye referral centers in the Philippines. It was conducted as the Philippine leg of the Asia Cornea Society Infectious Keratitis Study (ASCIKS).1 Patients with a clinical diagnosis of CMK rendered by a cornea specialist, and who signed the consent form, were recruited into the study. They underwent uniform sample collection and culture techniques as described in the ACSIKS. All patients were followed-up for 6 months. Data collected included demographics, risk factors, culture results, management, and treatment outcomes. Descriptive statistics and frequency were used to analyze the data.

A total of 348 patients diagnosed with CMK were included. Trauma (65.5%) among the middle-aged (42.9 ± 17.9 years) male population was the most significant risk factor for development of CMK, followed by contact lens wear (12.9%), prior ocular surgery (6.0%), and ocular surface diseases (3.4%). Bacterial keratitis (53.2%) was still the most common etiology of CMK, followed by fungal keratitis (27.0%), Acanthamoeba keratitis (5.7%), and viral keratitis (2.0%). Aspergillus species (18.3%) were the most common microbial isolates. Pseudomonas species (13.9%) were the most common bacterial isolates. The median time from onset of symptoms to consultation with the study centers was 2 weeks. Medical treatment was enough to treat the infection in 34.8% of cases. Surgical intervention was necessitated in 22.6% with evisceration/enucleation done in 1 out of 3 patients who had surgery.

Bacterial infection remains the most common cause of CMK in the Philippines, followed by fungal infection. Significant risk factors include trauma and contact lens wear. Aspergillus species and Pseudomonas species were the most common fungal and bacterial isolates, respectively. Despite medical treatment, almost a quarter of the cases still required surgical intervention.

OBJECTIVE

To determine the foveal avascular zone (FAZ) thickness and other FAZ measurements in eyes of healthy Filipino adults aged 20-49 years.

This single-center, cross-sectional, observational study evaluated 186 subjects (372 eyes) of Filipino adults 20 to 49 years of age. Using Angioplex®, the automated software of the optical coherence tomography angiography (OCTA) machine, the FAZ area, perimeter, circularity, vascular density, and perfusion in the superficial FAZ were recognized. Statistical analysis was done using SPSS version 23. The mean and standard deviation of the values of superficial capillary free zone measurements were calculated.

The mean FAZ area was 0.297 ± 0.112 mm2, the mean circularity was 0.667 ± 0.080, and the mean perimeter was 2.316 ± 0.80 mm. These parameters were all larger in the female population (p CONCLUSIONS

In eyes of healthy Filipino adults aged 20-49 years, females exhibited larger FAZ area, higher circularity, and lower CMT, compared to males. Additionally, females displayed lower central vessel density and perfusion. While FAZ area and perimeter remained stable with age, circularity decreased, and CMT increased.

OBJECTIVE

This study assessed the correlation of macular pigment optical density (MPOD) and varying levels of exposure to video display terminals (VDT) among young adult Filipinos.

This cross-sectional, analytical, single-center study compared the MPOD, measured using the Zeiss VISUCAM 500, between two groups of individuals aged 20 to 35 years old with differing VDT exposure. The more exposed group consisted of individuals who spent at least 8 hours per day on VDTs for the past 1 year, while the less exposed group spent less than 6 hours per day. Student’s t-test and chi-square test were used to compare the two groups, while Pearson's r coefficient was utilized to determine the relationship between MPOD and VDT exposure.

A total of 80 individuals (40 in each group) were included in the study. Both groups had similar profiles, except for refractive errors, which were significantly higher in the prolonged VDT exposure group (p = 0.02). The prolonged exposure group averaged 10 hours of VDT use per day, compared to 3 hours in the low VDT exposure group. The MPOD level, particularly the maximum optical density (Max OD), was significantly lower in the prolonged VDT exposure group (0.2034 DU) compared to the low VDT exposure group (0.2467 DU) (p = 0.0051). A negative weak correlation was observed between the VDT exposure hours and MPOD levels (Max OD r = –0.387, p = 0.0005).

This study found a weak but significant negative correlation between prolonged VDT exposure and lower MPOD levels, suggesting that extended screen time may contribute to reduced macular pigment density. While the correlation was weak (r = –0.387), these findings underscore the potential risk of diminished macular health with increased VDT use. The results highlight the importance of promoting protective strategies, such as reducing screen time and encouraging dietary or lifestyle changes that support eye health, especially among individuals with high VDT exposure.

OBJECTIVES

This study aims to describe patterns of IPV-associated ophthalmic injuries among women: Specifically, it seeks to identify factors associated with ophthalmic injuries in women secondary to IPV, determine practices and/or protocols in identifying IPV-associated ophthalmic injuries, and to examine practices in referral to ancillary services for IPV survivors with such injuries.

A systematic literature search was conducted for observational studies published from 2009 to 2022 using PubMed, Google Scholar, HERDIN, and the Cochrane Library. Studies were screened and appraised using the Newcastle-Ottawa Quality Assessment Scale (NOS) for risk of bias. Relevant data on injury types, screening protocols, and referral practices were extracted and synthesized. Analysis of risk of bias (ROB) for each study utilizing the NOS scale indicated that four studies exhibited a good ROB.

A total of 567 female patients with IPV-related facial injuries were included in the selected studies. Of these, 98 cases (17.28%) involved ophthalmic injuries, including orbital fractures, subconjunctival hemorrhages, and contusions. Factors associated with these injuries included delayed healthcare-seeking behavior, bilateral and recurrent trauma, and psychological distress. Current practices in IPV identification were found to be inconsistent, with a lack of standardized screening protocols, especially in ophthalmology settings. Referral to ancillary services was often suboptimal due to poor interdepartmental coordination and absence of formal pathways.

There is a significant gap in the recognition and management of IPV-associated ophthalmic injuries among women. Establishing standardized screening protocols and improving referral systems can enhance care outcomes and provide holistic support for survivors, particularly in low-resource settings.

OBJECTIVE

This is a case report of a 60-year-old woman with a juxtapapillary choroidal melanoma who underwent globe-sparing treatment using linear-accelerator (LINAC)-based hypofractionated stereotactic radiotherapy (FSRT).

Clinical data, ophthalmologic findings, and imaging results were obtained through retrospective chart review.

At three months and nine months post-treatment, tumor thickness decreased by 20.5% (from 13.00 mm to 10.34 mm) and 33.2% (to 8.69 mm), respectively. Partial resolution of subretinal fluid and vitreous hemorrhage was confirmed clinically and by B-scan. No metastatic spread was detected on liver ultrasound and chest radiography. Best-corrected visual acuity in the treated eye remained stable at hand motion. Radiation-induced dry eye was managed effectively with preservative-free sodium hyaluronate eye drops.

LINAC-based hypofractionated FSRT achieved marked local control and tumor regression in this case of a medium-large, juxtapapillary choroidal melanoma, while preserving the globe and the baseline vision. In regions without access to plaque brachytherapy, this technique offers a practical, cost-efficient, and multidisciplinary approach to eye-conserving therapy.

OBJECTIVE

This study determined the diagnostic accuracies of Growth and Retinopathy of Prematurity (GROP) criteria and a novel modified G-ROP criteria on identifying retinopathy of prematurity (ROP) in infants referred for screening at a tertiary hospital.

This was a single-center, cross-sectional, retrospective study. Medical records of infants referred for ROP screening from January 2012 to December 2021 were reviewed. Infants were labelled as “requiring ROP examination” if they met the 2020 Philippine Academy of Ophthalmology – ROP Working Group (PAO-ROPWG) screening consensus, G-ROP, or modified G-ROP criteria. We compared the accuracy of each criterion in predicting prethreshold ROP, evaluating sensitivity, specificity, and predictive values, as well as percentage of low-risk infants. Statistical analysis used Chi-square tests and one-way ANOVA with post hoc testing.

Of the 873 infants, 162 infants (18.6%) were noted to have ROP of any stage. Type 1 ROP developed in 15.4%, and type 2 ROP in 16.7%. The 2020 PAO-ROPWG consensus had 100% sensitivity (95% CI: 86.3%- 100%) in detecting type 1 and 2 ROP while 323 infants (37%) were low-risk. G-ROP criteria had 100% (95% CI: 86.3%-100%) sensitivity and 79.2% (95% CI: 76.4%-81.9%) specificity in predicting type 1 ROP, and 88.89% (95% CI: 70.84%-97.65%) sensitivity and 79.1% (95% CI: 76.2%-81.8%) specificity in predicting type 2 ROP, while 672 infants (77%) were classified as low-risk. Modified G-ROP criteria had a 100% (95% CI: 86.3%-100%) sensitivity in predicting type 1 and 2 ROP, 54.9% (95% CI: 51.5%-58.3%) and 55.1% (95% CI: 51.7%-58.5%) specificity in predicting type 1 and type 2 ROP, respectively, while 472 infants (54%) were classified as low-risk.

G-ROP and modified G-ROP criteria showed high sensitivity and better specificity compared to the 2020 PAO-ROPWG consensus. Their stricter criteria for gestational age and birth weight likely enhanced specificity. Further research is needed to confirm these findings in a broader population.