Objective:To study the speech articulation and the consonant /r/acoustic features of articulation disorders caused by velopharyngeal insufficiency.Methods:According to “Uyghur speech articulation test scale”and the classification method used in Uyghur articulation disorders the articulation and characterization of consonant /r/of 31 cases with velopharyngeal insufficiency were examined,scored and classified.Results:The cases of mild(-x =81),moderate(-x =51)and severe(-x =21)voice disorder in the 31 patients were 9,12 and 10 respectively.Among the 3 groups,CD,CA,F1,F3 and F4 were different(P <0.05),F2 was not (P>0.05).Conclusion:“Uyghur speech articulation test scale”and speech articulation classification standard have certain clinical value in of the study of Uyghur articulation disorders.There are differences in pathological consonant acoustic parameters of consonant/r/between and patients with velopharyngeal insufficiency and the subjects with normal speech.

Objective To investigate the effect of community nursing intervention on the dementia caregivers'quality of life at home.Methods General situation questionnaire,simple intelligent state scale and patients daily life ability scale were used to evaluate patients' medical condition.Health questionnaire (SF-36) was used to assess the caregiver's quality of life at baseline and 3,6,9,12,18 and 24 months after the intervention.Results Compared with the control group,three dimension scores of the caregivers,including physical function(PF),restriction of physical heahh(RP) and mental health(MH),were significantly increased at 9,12,18 and 24 months after intervention,and the difference was significant(PF:t values were 2.084,2.118,2.051 and 2.591,respectively; RP:t values were 2.204,2.377,3.032 and 3.785,respectively; MH:t values were 2.112,2.369,3.204 and 2.913,respectively; all P＜0.05).Moreover,there was significantly difference between the two groups in two dimension scores of restricted role caused by emotional problems(RE) and general health(GH) at 12,18 and 24 months after intervention(RE:t values were 2.211,2.471 and 2.779,respectively; GH:t values were 2.158,2.485 and 2.887,respectively; all P＜ 0.05).For the intervention group,RP,RE,PF,MH and GH at 24 months showed statistically significant difference with baseline(t values were 3.131,3.293,2.457,3.618 and 3.433,respectively; all P＜0.05).However,there was no difference between the two groups in body pain(BP),vitality(VT) and social function (SF),and there was no statistically significant difference before and after the intervention(all P＞0.05).There was no statistically significant difference before and after the intervention in each dimension scores of SF-36 of the control group(P＞0.05).Conclusion Community nursing intervention can improve senile dementia caregivers'quality of life.

Objective To evaluate the levels of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP),high sensitive C-reactive protein (hs-CRP) and the correlation in the patients with actue coronary syndrome (ACS).Methods One hundred and eight patients with ACS as ACS group,while 84 healthy controls as control group.ACS group included non-ST-segment elevation myocardial infarction (NSTEMI) group (37 cases),ST-segment elevation myocardial infarction (STEMI) group (35 cases),unstable angina(UA) group(36 cases).Recorded and compared the levels of NT-proBNP and hs-CRP in two groups,and the correlation was analyzed.Results The levels of NT-proBNP and hs-CRP in ACS group were significantly higher than those in control group [(1264.8 ±671.8) ng/L vs.(337.0 ± 10.6) ng/L,(15.42 ± 8.03) mg/L vs.(6.92 ± 0.59) mg/L,P ＜ 0.05].The correlation between hs-CRP and NT-proBNP level was positive in ACS (r =0.46,P ＜ 0.05).The levels of NT-proBNP in NSTEMI group,STEMI group,UA group,control group,differences among groups were statistically significant (P ＜ 0.05).The levels of hs-CRP in NSTEMI group,STEMI group,UA group were significantly higher than those in control group (P ＜ 0.05).There was no statistically significant difference in the levels of NT-proBNP between STEMI group and UA group (P ＞0.05).And the levels of NT-proBNP and hs-CRP increased with the increasing of coronary artery lesion counts,the differences among groups were statistically significant (P ＜0.05).Conclusion ACS can be early diagnosed through combined detection of NT-proBNP and hs-CRP,and NT-proBNP and hs-CRP can be used as important makers to evaluate prognosis and risk stratification.

Objective To investigate the correlation and standard estimate error of anthropometric indicators and abdominal visceral fat by quantitative computed tomography (QCT) .Methods We measured the height ,weight ,waist circumference(WC) , hip circumference(HC) in 568 Chinese adults (including 234 males and 334 females) .Abdominal adipose tissue was quantitatively measured by tissue composition module of Mindways QCT software using QCT scan data .The total fat area(TFA) and the visceral fat area(VFA) were measured in a slice in the inferior of T12 ,L1 ,L2 ,L3 ,L4 ,L5 vertebra and umbilicus level .The subcutaneous fat area(SFA) ,total abdominal fat volume ,total visceral fat volume(TVFV) and total subcutaneous fat volume(TSFV) were calculated from measurements .Correlations among BMI ,WC ,HC ,WHR and VFA was assessed .Standard estimate error(SEE) of BMI ,WC , HC ,WHR in the prediction of the VFA by QCT was calculated .Results Correlation between WC and VFA in different anatomical locations was better than BMI ,HC and WHR ,the correlation coefficients R2 was 0 .48-0 .64 in male and 0 .53-0 .66 in female ,all P<0 .01 .The SEE of WC in the prediction of the VFA measured by QCT were 25 .36-31 .57 cm2 (male) ,23 .64-25 .31 cm2 (fe‐male) ,or 23 .13% -27 .78% (male) ,25 .44% -36 .03% (female) .Conclusion The standard estimate error of anthropometry pa‐rameters in the prediction of VFA was significant .QCT is a more accurate measurement of VFA ,and it has the potential of clinical application .

Objective To study the response of the retinal neuronal adaptive system to changes of background illumination (BG) by measuring the oscillatory potentials (OPs) and the a- and b-waves of the electroretinogram (ERG) in different BG illuminations. Methods The a- and b- wave and the digitally filtered OPs were simultaneously recorded from Wistar Fu rats aged from 25 to 29 days during dark adaptation (DA) and during 6~8 minutes of BG illuminations at four levels increased successively by steps of two log units, i.e., "low scotopic" level of 1.43?10 -6 cd/m 2, "high scotopic" of 1.43?10 -4 cd/m 2, "low mesopic" of 1.43?10 -2 cd/m 2 and "high mesopic" of 1.43?10 2 cd/m 2. Full field stimulus flashes of 75 msec duration and 1.43?10 2 cd/m 2 intensity was delivered at an interval of 1 minute. Results Five OP wavelets were recorded in DA and during scotopic BG illuminations. The number of wavelets was reduced to three as the eyes were exposed to mesopic BG levels. However, the sum of OPs amplitudes (SOPs) increased as the BG was intensified, except at "high mesopic" level, by which a significant decrease of SOPs occurred. The amplitudes of the a- and b-waves remained unchanged at the two scotopic BG and decreased as the BG intensity increased to mesopic levels. Conclusion The response of retinal neural adaptive system of the Albino rat to changes of BG light is more sensitive and robust than the slow components of the ERG. The enhancement of the oscillatory responses at "low mesopic" illumination level suggests that using proper BG light may be conducive to reducing the variation of OPs.

OBJECTIVE: To investigate the pharmaceutical thinking of clinical pharmacists about drug therapy. METHODS: Pharmaceutical thinking of clinical pharmacist was analyzed in respect of choice of drug, dosage and usage, selection of solvent, compatibility, administration route and ADR, combining with medication order for one cases of acute severe biliary pancreatitis. RESULTS&CONCLUSION: There is significance to guarantee the safety of drug use and carry out pharmaceutical care by improving pharmaceutical thinking of clinical pharmacist.

Objective To study the therapeutic and preventive effect of acupuncture therapy on acute ischemic cerebrovascular syndrome (AICS) and result of transcranial Doppler (TCD). Methods The 140 cases were randomized into acupuncture group and control group, 70 cases in each, to observe the clinical therapeutic effect and to use TCD for comparing the result before and after the treatment. Results The total effective rate of the acupuncture group and the control group was 97.14% and 55.71% respectively. The result of acupuncture group was significantly superior to that of the control group (P

Objective To explore the curative effects of treating vaginal bleeding after drug-induced abortion with self-made biochemical mixture. Methods A total of 100 pregnant patients were randomly recruited into a control group and a treatment group. Both groups were treated with mifepristone and misoprostol. On this basis, the control group was administrated with Motherwort herb preparation orally, and the treatment group was treated with self-made biochemical mixture orally. Both groups were treated for 7 days. Therapeutic effects were observed after the treatment. Results The total effective rate was 76% and 94% in the control group and the treatment group respectively, showing statistical difference (χ2=8.663, P＜0.05).Conclusion It is effective to treat vaginal bleeding after drug-induced abortion with self-made biochemical mixture.

Objective To investigate the characteristics of cognitive function impairment in patients with epilepsy. Methods Forty-five epilepsy patients and twenty age-,gender-,and education-matched healthy controls were submitted to a wide neuropsychological battery,including Raven's standard progressive matrices,auditory verbal memory test,logical memory test,visual memory test,Stroop color words test,trail making test,verbal fluency test,Boston naming test,math and complex figure test,etc. Results The epilepsy patients performed significantly worse than the controls in the verbal delayed memory,verbal short memory,cued recall,immediated recall of logical memory test,visual spatial memory,attention,information processing speed test,word finding difficulty and logical reasoning.Conclusion There exists impairment in various cognitive domains in patients with epilepsy,and the main impaired areas are memory,executive functions and logical reasoning.

Objective To explore the influence of perioperative factors on postoperative pulmonary infection in patients with esophageal cancer.Methods According to the inclusion criteria in the present study, clinical data of 150 patients undergoing radical prostatectomy for esophageal cancer in our hospital was retrospectively analyzed.In accordance with whether the occurrence of pulmonary infection or not, 32 patients were regarded as pulmonary infection group and 118 patients were designated as no-pulmonary infection group.The dosage of anesthesia drug, intubation time, single lung ventilation time, operation time, anesthesia time, extubation time, intraoperative blood loss, crystal transshipment, colloid transshipment, intraoperative total amount of rehydration, anesthesia methods and one-lung ventilation way were recorded.The indexes of anesthesia factors were compared between the two groups.Multivariable logistic regression analysis was performed to predict the risks of postoperative pulmonary infection for anesthesia factors.Results Total sufentanil and propofol dose, single lung ventilation time, operation time, anesthesia time, extubation time and the percentage of uninterrupted expansion of lung, nose sputum suction catheter and pethidine postoperative analgesia in pulmonary infection group were respectively significantly higher than that of non-pulmonary infection group (all P<0.05).There were no statistical differences of dosage of midazolam and atracurium, intubation time, intraoperative blood loss, crystalloid volume, colloid volume, the total infusion volume, anesthesia methods and intraoperative one-lung ventilation mode between the two groups.Multivariable logistic regression analysis revealed that each increase of sufentanil total dose of 7.5 μg (OR=1.65, 95%CI 1.24-2.85), each increase of 10 min in single lung ventilation time (OR=2.14, 95%CI 1.32-3.62), each increase of 20 min in anesthesia time (OR=1.87, 95%CI 1.46-3.15), nose sputum suction catheter (OR=2.03, 95%CI 1.27-3.46)as well as pethidine postoperative analgesia (OR=3.44, 95%CI 2.25-5.13) were all risk factors for postoperative pulmonary infection (P<0.05).Conclusion Appropriate amount of sufentanil usage reduces single lung ventilation time and anesthesia time as well as implementing fiber bronchoscope for sputum suction, and postoperative use of self-control vein analgesia can decrease the incidence of postoperative pulmonary infection in esophageal cancer patients.