In the past 10 years, 118 cases with primary congestive cardiomyopathy of first admittance to this institution were treated.12 cases died in the course of hospitalization. Out of the 106 cases discharged after clinical recovery, 91 cases were followed up. In the follow-up period, 1 year survival rate was 85.25%, 2 year survival rate 67%, 5 year survival rate 43.7%, and 10 yaar survival rate 25.5%, as calculated with the life-span table method. The results suggest that the remote prognosis of this disease is poor. The factors influencing the prognosis of this disease were the age of the patient, the heart size, and the status of heart functions. Severe and complicated cardiac arrhythmias could worssen the outlook of the patient even though no heart failure occurred. Early and long term administration of vessel-dilatating agent such isoscorbide dinitrate can improve the prognosis but steroid therapy has no effect.

Objective:To explore a method for pericardiocentesis and drainage,the duration,posture of drainage and the fluid volume by drainage.Methods:Forty patients half lying on the bed,the puncture was performed via the subxiphoid route after the site,depth and direction of needle entry were confirmed by echocardiography.Using seldinger method,we put the central venous indwelling catheter into pericardial sac and connect it with an aseptic bag for drainage.Results:Catheter pericardiocentesis in 40 patients was successful without complications.Duration of use of the indwelling pericardial catheter ranged from one day to seven days,the average is 1.5?2 days.The fluid volume removed was one hundred and eighty to two thousands milliliters,mean volume is 750?600ml.After drainage,chest discomfort and short breath were alleviated obviously.Prominent jugular veins disappeared.Reductions of heart rate were significant.Cardiac function improved.Conclusion:Seldinger technique is a safe method for pericardiocentesis and drainage with the assistance of echocardiographic diagnosis and guidance.It can avoid myocardial trauma and drain the pericardial effusions effectively.

Objective:To compare the effects of simvastatin,xuezhikang and pravastatin in patients with primary hyperlipidemia.Methods:Sixty patients were randomly divided into three groups,simvastatin 20mg were taken once a day at night;provastatin 10mg were taken once a day at night;xuezhikang 0.6g were taken twice a day in the morning and at night.Blood samples were taken before and 4 weeks,8 weeks,12 weeks after the treatment.Results:In simvastatin group:the serum levels of total cholesterol(TC),low-density lipoprotein cholesterol(LDL C) decreased markedly at the end of 4 weeks compared with those of the baseline ( P 0.05).In xuezhikang group:after 4 weeks of treatment,TC,TG,LDL C reduced markedly( P 0.05).From the change rates,we can see after 8 weeks,12 weeks of treatment the level of LDL C drcreased more significantly in simvastatin group (40%,45%) than in xuezhikang (31%,36%) and provastatin (31%,35%) ( P 0.05).Conclusion:The clinical effects of simvastatin,xunzhikang,provastatin on primary hyperlipidemia were equal among the three groups,but the time is different about when they take great effects respectively.Next,LDL C lowering effect of simvastatin was significant.Finally,xuezhikang was the best in reducing TG among the three groups and it has a relatively good economic effectiveness.

Objective:To study the optimal intensity of warfarin therapy for prevention of thromboembolism in elderly patients with nonvalvular atrial fibrillation and to determine the safe range of INR.Methods:Warfarin was used for anticoagulant therapy for thirty-seven patients with nonvalvular atrial fibrillation.The patients were followed up and INRs were measured regularly.Results:When the dosage of warfarin changed from 2.11 milligram to 2.41 milligram,the range of INR was between two and two point five (2.0～2.5).When the dosage changed from 2.41 milligram to 2.70 milligram,the INR was between two point five and three (2.5～3.0).No atrial fibrillation related thromboembolism and major hemorrhage occurred in all patients.It required different number of days to reach the safe INR limits by raising or lowering the dosage of warfarin in the patients.Conclusion:Warfarin is effective in preventing stroke in elderly patients with nonvalvular atrial fibrillation.The optimal intensity of warfarin ranges from 2.11 milligram to 2.41 milligram and the safe range of INR is between two and two point five (2.0～2.5).

0.05).But the incidence of the coronary artery pressure decreasing and ventricular fibrillation,the time to stop bleeding,the bedrest time and vessel complication in 5F group were less than those in 6F group(P

Objective:To investigate the risk of heparin leading to upper gastrointestinal bleeding in elderly patients undergoing percutaneous coronary intervention(PCI).Methods:To compare characteristics of unfractionated heparin and low molecular weight heparin,the dosage and lab indexes.Results:The upper gastrointestinal bleeding is easy to happen in elderly patients with disease of digestive tract when using heparin in PCI.Conclusion:The patients before undergoing PCI,especially the elderly,need to have a general examination,make an overall assessment with care to digestive disease.Doctors should pay more attention to the heparin dosage and lab indexes in order to avoid serious complications.

Objective:To identify the influence of personality characteristics on adult patients' satisfaction after initial orthodontic treatment and offer references to rise quality of orthodontic treatment.Methods:85 patients(34 males and 51 females;average age 23.3years?4.4years who treated their teeth by fixed orthodontics were included in the study.Satisfaction questionnaire was used to assess the satisfaction with the dentition in the study sample.The NEO Five Factor inventory was used to assess personality profiles and traits in the study samples.Comparisons between groups were made by using Logarithm of likelihood ratio test.Results:This test provides a comprehensive assessment of personality according to the five major domains namely Neuroticism,Extroversion,Openness,Agreeableness and Conscientiousness.Satisfaction of higher neuroticism scores is relative low(P0.05).Conclusion:Different personality traits were found to be correlated with adult patients' satisfaction with their dentition during initial orthodontic treatment.The orthodontists should pay more attention to higher neuroticism scores adult patients during treatment.In according to strengthen the communication between the orthodontists and outpatients,the therapeutic effect of adult orthodontic treatment could be increased.

Objective:To explore the participation mode of clinical pharmacists in anti-infective therapy. Methods:Clinical phar-macists provided rational medication suggestions for anti-bacterial and antifungal therapy, and carried out pharmaceutical care for one patient with lung and intracranial infection after decompressive craniotomy for severe brain injury. Results: According to the sugges-tions of clinical pharmacists, fluconazole therapeutic regimen and amphotericin B therapeutic regimen was applied in turn respectively with the treatment course of 32d and 28d. During the treatment, the pharmacists also provided therapy advice on the infection induced by Staphylococcus epidermidis and Pseudomonas stutzeri, ADR warning and monitoring of fluconazole and amphotericin B, and adjust-ment of anti-infective therapy according to the results of antimicrobial susceptibility testing. The therapeutic effect was significant. Conclusion:The participation of clinical pharmacists in drug treatment can optimize medical therapy, which contributes to the coopera-tion between doctors and pharmacists.

There are various forms of rehabilitation after total knee arthroplasty.In this paper,we reviewed the relevant literature at home and abroad,summary and analysis of the current form of postoperative rehabilitation,respectively from the beginning and end of exercise time,the frequency,the indicators of measurement,etc..

Objective To explore the effect of the different doses of oxytocin(OXT) on stress model aggressive behaviour in Wistar rats.Methods According to random number table,40 pregnant rats were divided into experimental stress groups (A, B, C) and control group(D) with 10 samples in each group.Before forced swimming test, rats in experimental groups (A, B, C)were given OXT via intraperitoneal injection with 0.3 mg/kg, 1.0 mg/kg,2.0 mg/kg;rats in group D were given equal volume of normal saline in the same way.At the 3rd day all rats were tested with maternal aggression,including mothers' following indices as total aggression times,biting times,pinning times,attack latency and duration of attack.Elevated plus maze (EPM) test was applied to analyze the behavioral changes.Results In terms of the duration of attack and attack latency,the indexes of group A and group D were significantly different from relevant data ((147.60±23.92) s and(79.70±9.88) s, P＜0.05), while other indexes had no difference(P＞0.05).The duration of attack and attack latency had a significant difference ((3.10±0.87) times, (13.60±5.14)times, (91.30±9.74)s and(167.20±30.02) s, P＜0.01) between group B and group D except total aggression times(P＞0.05).Group C and group D in given indexes had significant differences showing (6.40± 1.34) times, (15.10±4.35) times, (23.70±3.46) times, (49.80± 5.53) s and (215.60± 39.55) s (P＜0.01).Group A and group B in given indexes had significant differences (P＜ 0.05);and group B and group C had a significant difference (P＜0.01)except pinning times(P＞0.05).In EPM ,the open arm entry ratio and the open arm time ratio of both group A and group D were significantly different from respective percentage (0.47±0.13) and (0.13±0.05) (P＜0.01).The significant difference was found in group B and group D(P＜0.01);group A and group B had a statistical difference(P＜0.05);there was no difference in both groups in open arm time ratio(P＞0.05).Conclusion Oxytocin potentially mediates maternal aggression by attenuating stress, and improves the intimate bonding between mother and pups,which means dose dependency of OXT in this process.