During routine dissection, additional muscular head of extensor digitorum brevis muscle attaching to the third toe and accessory muscle perforated by the branch of the deep peroneal nerve were observed in the right foot of a 71-year-old male cadaver. The additional muscular head originated from the dorsal surface of cuboid bone, and ran parallel with the third tendon of the extensor digitorum brevis muscle. It was conjoined with the third tendon of extensor digitorum brevis at the middle of its course. The accessory muscle was a small muscle which was covered with the muscle belly of the extensor hallucis brevis muscle. It originated from the dorsal surface of the calcaneus, and inserted to the lateral one-third of transverse retinacular band. These two variants were innervated by the branches of deep peroneal nerve. The branches of deep peroneal nerve were compressed under the tendon of extensor hallucis brevis and around the site where the nerve branch perforated the small muscle. The clinical significances of these variations and tendon of extensor hallucis brevis muscle were discussed.
Aged ; Cadaver ; Calcaneus ; Foot ; Head ; Humans ; Male ; Peroneal Nerve ; Tarsal Bones ; Tarsal Tunnel Syndrome* ; Tendons ; Toes

Reconstructing the impact of infectious disease on past populations is one of the main fields in paleopathological studies. The initial phase of paleopathology was descriptive, focusing on the identification and presence of disease in the past. However, currently paleopathological studies are moving toward probing questions about the larger picture of origin and transmission of disease agents. In this study, paleopathological studies of major infectious disease (i.e., tubuerculosis, treponemal disease and leprosy) were reviewed through osteoarcheological work published in American Journal of Physical Anthropology, International Journal of Osteoarchaeology, Journal of Archaeological Science and International Journal of Paleopathology from 1981 to 2017. A basic objective of this research was to examine many types of research in paleopathology and to characterize research trend in this field. As paleopathological studies becomes more abundant, the approaches to infectious disease have been increasingly specialized and interdisciplinary from 1980. Also, methodology used in paleopathology continues to evolve through the holistic approaches of molecular analysis, radiology and histopathology. Ultimately, this study reinforces the importance for retention of large-scale skeletal collections for paleopathological study in population perspective. In the near future, Korean paleopathology can contribute in the reconstructions of the history of disease and its effect on past human populations.
Anthropology, Physical ; Communicable Diseases* ; Humans ; Leprosy ; Paleopathology ; Syphilis ; Tuberculosis

Although commercialization of mobile phones has raised much concerns about the effects of radiofrequency radiation on the human body, few experimental studies have been conducted on the effects of radiofrequency radiation on physiological homeostasis, immune and inflammatory responses. Therefore, we presently investigated the effect of 835 MHz radiofrequency radiation on spontaneous wheel exercise, hormone and cytokines levels in the plasm of mice. Mice were divided into 4 groups as control, exercise, radiofrequency radiation, radiofrequency radiation & exercise group. The body weight, corticosterone and blood cytokine levels were checked for 10 weeks. Followed by the exposure to radiofrequency radiation for 6 hours a day, the more increase in body weight was observed in the radiofrequency radiation & exercise group than in the spontaneous exercise group. When the amount of spontaneous exercise was measured for 10 weeks, the amount of exercise was increased in the both control and spontaneous exercise group, while the amount of exercise was decreased in the radiofrequency radiation group. To determine whether the homeostasis, immune and inflammatory responses are indirectly affected by radiofrequency radiation exposure, IL-1β, IL-6, IL-12 (p70), TNF-α, IFNγ, and GM-CSF were measured by ELISA kit, respectively. As a result, the blood levels of IL-6, IL-12 (p70) and TNF-α in the spontaneous exercise group were higher than that of control group, and each cytokine levels in the radiofrequency radiation & exercise group were lower than that of control group. However, the corticosterone, IL-1β, IFNγ and GM-CSF didn't show statistically significant differences in all groups. It has been confirmed that exposure to high frequency electromagnetic waves for a long time can affect the amount of exercise, body weight, and some inflammatory cytokines such as IL-6, IL-12 (p70) and TNF-α.
Animals ; Body Weight ; Cell Phones ; Corticosterone* ; Cytokines* ; Electromagnetic Radiation ; Enzyme-Linked Immunosorbent Assay ; Granulocyte-Macrophage Colony-Stimulating Factor ; Homeostasis ; Human Body ; Interleukin-12 ; Interleukin-6 ; Mice* ; Radiation Exposure

This study aims to determine the effects of formaldehyde exposure on self-reported symptoms of respiratory-eye mucosa and integumentary system during anatomy practices among Korean medical students. Data were collected using the web-based survey. Study subjects in 1st and 2nd grade medical student, and having anatomy dissection in medical college and medical graduate school. A total of 463 students from the 14 medical college and medical graduate school participated in this study. The results show that 261 (56.4%) of the participants responded feeling discomfort above moderate at anatomy dissection. After anatomy dissection, 104 (43.2%) students responded aggravating the symptom allergic rhinitis, xerophthalmia and so on. 209 (95.0%) of them responded the new symptom's appearance. In the result of multiple logistic regression, women (OR: 2.000, 95% CI: 1.169~3.421) and the students with feeling discomfort (OR: 3.190, 95% CI: 1.807~5.632) were more likely to increase the risk of pre-existing respiratory · eye mucosal system symptom's aggravation than the counter parts. For pre-existing integumentary system symptom's aggravation, risk is significantly higher in elder age group (OR: 2.612, 95% CI: 1.187~5.750) and with disapproval protective equipments (OR: 2.217, 1.006~4.885). In case of new symptom's appearance, people with feeling discomfort above moderate (OR: 5.097, 95% CI: 1.075~24.160) in respiratory · eye mucosal system were more likely to increase the risk of new symptom's appearance. And for integumentary system, risk was higher in people with feeling discomfort (OR: 1.921, 95% CI: 1.218~3.031), in woman (OR: 1.711, 1.090~2.686) and without enough protective equipments preparation (OR: 1.953, 1.189~3.210). This study confirms the protective equipments for minimizing exposure from chemicals for cytological fixation (e,g formaldehyde) is not worn enough and students in anatomy dissection experience discomfort and disease after anatomy dissection. Therefore, this study indicates that the safe guideline in anatomy dissection should be enhanced and institutional strategy to protect student's right of health should be provided.
Female ; Formaldehyde* ; Humans ; Integumentary System* ; Logistic Models ; Mucous Membrane* ; Rhinitis, Allergic ; Students, Medical* ; Xerophthalmia

Gross anatomy, with cadaver laboratory dissection, is in a unique position to preside over a rich number of activities such as the team work, integrity, active learning, communication in the small group-all aspects of professional conduct. The purposes of this study are to investigate the correlation of professionalism with academic performance and the characteristics of groups of students in the performance variables. First-year Pusan National University School of Medicine students (n=108) from the Class of 2015 taking the gross anatomy course were required to do the self- and peer assessment about the professional behaviors of each of the six members of their dissecting group. The students were classified into one of four subgroups based on their deviation from the self- and peer assessment medians, such as high peer/high self (HP/HS), high peer/low self (HP/LS), low peer/high self (LP/HS), low peer/low self (LP/LS). There were significant higher scores in the high peer groups (HP/HS, HP/LS) in comparison with low peer groups (LP/HS, LP/LS) in the academic performance of end-of-term (F=3.24), credit (F=3.54), pre-Lab (F=3.94), practical examination (F=3.60) scores. Significant correlations among academic performance variables were observed generally. There were some differences in the correlation in the practical examination and other variables. The relatively high correlation between practical examination and other variables is HP/HS, followed by LP/LS, LP/HS and then HP/LS. In conclusion, peer- and self assessment subgroups showed a significant differences in the academic performance. This assignment would be available to evaluate work habits of professionalism in the gross anatomy laboratory. It is suggested that HP/HS group was more adaptable in the contextual leaning the gross anatomy course.
Busan ; Cadaver ; Humans ; Peer Group ; Problem-Based Learning ; Professionalism ; Self-Assessment*

Diabetic calcaneal insufficiency avulsion (CIA) fracture are unusual injury. The treatment may be challenging due to the low healing potential from diabetes or Charcot neuroarthropathy, so far. The poor surgical outcomes and surgical failures from treatment of the traumatic calcaneal avulsion fractures were associated with poor bone stock, lack of proper fixation, and the wound problem. Thus, the proper treatment for diabetic CIA fracture was still controversy. This report described two cases of diabetic CIA fracture treated with fixation of fracture fragment and calcaneal tenodesis. In both cases, fracture fragments were re-avulsed despite of fixation. Through investigation for the fate of fracture fragment from these cases, we discussed the proper treatment strategy in diabetic CIA fracture.
Tenodesis ; Wounds and Injuries

The paper describes a minimally invasive tracheostomy technique that uses an intercartilaginous incision without resection of the tracheal cartilage and discusses its feasibility. A total of 20 adult cadavers (13 males and 7 females) were included in this study. The distance from the arch of the cricoid cartilage to the thyroid isthmus, maximal displacement of the thyroid isthmus, number of tracheal rings underneath the thyroid isthmus, and maximally opened distance resulting from an intercartilaginous incision were measured. The mean distance from the arch of the cricoid cartilage to the thyroid isthmus was 21.4±5.0 mm. The thyroid isthmus mainly overlaid the 3rd and 4th tracheal rings. The mean maximal displacement of the thyroid isthmus was 9.0±2.8 mm. Minimally invasive tracheostomy via an intercartilaginous incision is a feasible technique. A skin incision 2 cm below the cricoid cartilage enables exposure of the thyroid isthmus and anular ligament between the 2nd and 3rd tracheal rings. The intercartilaginous incision allows sufficient space for the tracheostomy tube. An intercartilaginous incision without resection of a tracheal ring can be a good alternative tracheostomy technique, especially for patients who require transient tracheostomy.
Adult ; Cadaver* ; Cartilage ; Cricoid Cartilage ; Humans ; Ligaments ; Male ; Skin ; Thyroid Gland ; Tracheostomy* ; Tracheotomy

There are various methods for anatomy learning. Recently, there is infographics as a way to effectively transmit large amounts of data and complex information. In this way, medical students made anatomical data as ‘anatographic’. A total of 205 participants including 60 pre-medical students, 111 medical students, and 34 doctors participated in the study. We have shown an example of anatographic, and we surveyed its applicability and the satisfaction of each method. They use textbooks, Google, other searching sites, and applications for anatomy learning. The usefulness according to the 5-point scale was 3.75 for textbooks and 3.60 for Google, 2.53 for applications and 2.08 for searching sites, respectively. The utility of anatographic was 3.59, which was significantly higher than that of the application or other searching sites (p < 0.05). Anatographic is useful because of easy search for tags and questions, information share and learning from anywhere using your smartphone. On the other hand, there was the hassle of online access and the reliability of the data could be reduced for doctors to use. There was a problem that students used the smartphone outside of learning. Anatographic is the most beneficial system for the head, neck, and nerves, and it is easier to understand complex structures. Anatographic have shown potential as an educational source that can effectively transmit vast amounts of anatomical knowledge, and they will be useful for future anatomy education.
Education* ; Hand ; Head ; Humans ; Learning ; Methods ; Neck ; Smartphone ; Students, Medical

This study investigated whether α-asarone could promote proliferation and differentiation of neural progenitor cells into the neuronal cell types in in vitro and ex vivo studies. For in vitro assay, neural progenitor cells were isolated from fetal cerebral cortex (E15) and checked cell proliferation rate and neural progenitor cell marker in neurospheres. Treatment of α-asarone, particularly at a concentration of 3 µM, promoted the proliferation of neural progenitor cells and effectively differentiated neural progenitor cells into neurons. For ex vivo assay, a hippocampi slice culture system from 7 day postnatal rat fetuses was used. Although slight tissue damage was observed in the hippocampus after the high concentration (100 µM) of α-asarone, however, α-asarone enhanced the proliferation of neural progenitor cells in dentate gyrus region and also effectively differentiated into neuroblast at concentration of 30 µM. Consequently, α-asarone promotes the proliferation of neural progenitor cells and effectively differentiates neural progenitor cells into neurons. Therefore, our results support the therapeutic benefits of α-asarone for treating neurodegenerative diseases.
Animals ; Cell Proliferation ; Cerebral Cortex ; Dentate Gyrus ; Fetus ; Hippocampus ; In Vitro Techniques ; Neurodegenerative Diseases ; Neurons ; Rats ; Stem Cells*

The flexor digitorum superficialis (FDS) muscle is located in the intermediate layer of the muscles in the anterior compartment of the forearm. Variable but individual variations have been reported in the FDS regarding the number of head and the origin, distribution and interconnections of muscle slip and insertion to finger. In this case, we report a concomitant complex variation in FDS which was observed in a cadaver during a routine dissection classes for the undergraduate medical students. It includes the variation which is the separation of the tendon of FDS into the superficial and deep layers, the structural variations in muscle slips and associated tendon variations, the finding of Gantzer' muscle leading to flexor pollicis longus muscle. These complex variations in FDS are very rare case and this report summarizes the related phylogenetic and embryological significance.
Cadaver ; Fingers ; Forearm ; Head ; Humans ; Muscles ; Students, Medical ; Tendons