A hospital based pilot study, conducted in a Tropical diseases hospital in Ho Chi Minh City of Viet Nam, compared the efficacy of three day regimens of dihydroartemisinin-trimethoprim-piperaquine (DTP total dose 4.7/13/47 mg/kg) with the standard antimalarial regimen in Vietnam, artersunate-mefloquine (A3M total dose 12/25 mg/kg) in non immune patients with uncomplicated falciparum malaria. 114 patients were enrolled (78 to the DTP arm and 36 to the A3M arm). The subsequent open randomised trial conducted at a Provincial Health Station compared DTP, dihydroartemisinin-piperaquine (DP) and A3M in 400 patients. In both studies all patients received derectly observed therapy and were followed for 56 days. The results: In the pilot study, the 56 day cure rate, adjusted for reinfections by PCR genotyping was 97.4% in the DTP group and 100% in the A3M group. In the second study, the cure rate were similar in each group. The DTP regimens were well tolerated, less than 3% of patients experienced possible drug related side effects compared with 16% of A3M patients
Malaria ; Antimalarials ; Malaria, Falciparum ; artemisisnins ; drugs ; therapeutics

To evaluate the effectiveness in malaria vector control of residual spraying with Solfac WP10 at dose of 50mg ai/m2 and bednet impregnated with Solfac EW050 at a dose of 50mg ai/m2, based on bioassays, side effects. The results showed that: in pilot doses, the residual effect with Solfac 10WP produced the residual effect for 6 months on the walls made of wood with the bioassay mortality of 70.60%; for 2 months on the wall made of brick with the bioassay mortality of 61.63%. The residual effect of Solfact EW 050 on polyester bednet is 4 months after 2 washes, with the bioassay mortality of 73.6%. House spraying with Solfac WP10 and bednet impregnation with Solfac EW 050 at a dose of 50mg/ ai/m2 to prevent malaria due to mosquito were found to cause light side effects
malaria ; Antimalarials ; disease ; Culicidae

Research on vetorial role on forest malaria at 4 different ecological arears such as in the villages, forest fringe, deep forest and plot huts in Khanh Phu from Janruary to December, 2002. The results: The Anopheles dirus species component in the plot hut areas and deep forest are not more difference than in the villages. An.dirus account for 83.1% in plot huts and 96.9% in deep forest. The malaria transmission of An.dirus is very high in the plot huts areas and deep forests. The malaria infection risk is gradually increased from villages to forest fringe, then the plot huts in deep forests. Especially, the malaria infection risk in the plot hut areas and deep forests is over 20 fold higher than that in the villages
Malaria ; Parasites ; Disease

442 stool samples in 2 groups of population of Lien Vi commune, Yen Hung district, Quang Ninh provine were examined by Kato method. The infection rate of Ascaris, Trichuris, hookworm were 83.7%, 70.3%, 16.7%, respectively. The infection rate of Opisthorchis viverrini was 5.6%. 607 stool samples from primary and basical schools in the commune were examined. The results showed that the infection rate of Ascaris, Trichuris, Hookworm were 99%, 89%, 7.3%, respectively. The mix infection rate was 70%. It was found that most of the local people were using not standardized latrines. They have a habit of using untreated stool as fertilizer or habit of eating raw fish and their low awareness about disease prevention
Helminthiasis ; Helminths ; Disease ; epidemiology

Parasitological and knowledge – attitude – practice (KAP) surveys were carried out in 200 schoolchildren of Tran Phu primary school, Tam Diep town, Ninh Binh province and 200 their parents in 1999-2000. Information, education and communication (IEC) campaign for control program of helminth diseases and regular deworming every 6 months with albendazole 400mg single dose for all primary school children were implemented. After 1 year, prevalence of infection of Ascaris and Trichuris were reduced by more 50%, intensity of infection of Ascaris, Trichuris and hookworm were reduced by 86.9%, 84%, 100%, respectively. KAP of school children and their parents was changed significantly. Model of soil-transmitted helminthiasis control based on school has effectiveness, practice and extended application
Helminthiasis ; Child ; Disease ; Soil

Study on the status of worm infections and the effectiveness of deworming campains and health education based on community in 570 children from 2 to 5 years and 570 women of reproductive age in Quang Xuong district, Thanh Hoa province from July 2000 to December 2002. The results showed that: among children: the rate of ascariasis and trichuriasis infection were highly prevalent. Worm infection intensity of these species was light – moderate. The relationship between worm infection and malnutrition among children was not found at the baseline survey. The prevalence of hookworm among women reproductive age decreased clearly after the first round of treatment with albendazole 400mg, but no other parasites decreased significantly in both mother and children. There were no influences of interventions to improve anaemia status in both chidren and women reproductive age
Anemia ; Parasites ; child ; education ; growth & development

In recent years, although 2 technical measures (detection, treatment and vector control) were taken regularly and periodically for malaria control in Huong Hoa district, Quang Tri province, their effectiveness still weren’t satisfied, the positive slide rate was 6.9% during early 9 months of 2002 and 12.6% in 2003. The diversification of malaria endemicity: migration of population (exchanges, business, travel), habits of working and overnight in the forest, new settled dwellers, multiple species of vector… were affected interventional measures, so it was difficult to control effectively by primary health systems
malaria ; disease ; epidemiology ; Weights and Measures

Results of demographic survey determined regions, villages in Dak Lak from 2001 to 2003 showed that 24,445 illegal migrants settled down in 66 residential areas in 13 districts of the province. Illegal settlements of migrant villages often were in remote areas where the malaria transmission is high. Understanding of migrant population about malaria disease and control methods was still limited. Indicators of malaria became greater in the number in the early 8 months in 2003 than these in the same period in 2002, mainly in illegal migrant groups. Incidence of malaria in these groups were from 21.2% to 50.9%. 6 out of 9 deaths were illegal migrants
Malaria ; Disease ; Emigration and Immigration ; epidemiology

Most of malaria hot spots occurred in Lao Cai province from 1998 to 1999 were P.falciparum infections. The rate of parasite infections were high (7.06%-33.75%), because of unorganized migration of population from and to the malaria endemic areas. Illegal migrants often went to Dak Lak and all of them were Mong ethnic, accounted for 70% of unorganized migration in the province. Outbreak control activities were taken in high risk spots. During surveillance, there wasn’t any patient and results of slide were negative or low counts and those were nonresident parasites
malaria ; Disease ; Disease Management ; therapeutics

In comparison to the same period in 2002, Bac Giang province have reached 3 goals of malaria control program during early 5 months in 2003: the incidence of malaria increased 10%, only 3 cases of exotic parasite, no death of malaria, no malaria outbreak. Some activities of malaria control program have been taken already : epidemiological surveillance, vector control, communication, training, supplying forms of reports for all villages and districts, appropriate use of expenditures and materials. Results of examination at June 2003 showed that epidemiological situation was still stable and there were good activities in malaria control program
malaria ; Disease ; Disease Management ; epidemiology