Objective To study the effect of operation after neoadjuvant chemotherapy on gastric cancer patients with Ⅲ,Ⅳ grade.Methods 120 gastric cancer patients with Ⅲ,Ⅳ grade were selected.52 cases in the control group were given routine operation,68 cases in the observation group received neoadjuvant chemotherapy plus operation treatment.The operation resection rate,solid tumor progress assessment and postoperative recurrence rate in three months,six months and one year were observed.Results The radical resection of the observation group was 62.24％ (43/68),which was significantly higher than that of the control group 46.15％ (24/52) (x2 =5.81,P ＜0.05).The palliative resection and laparotomy of observation group were 20.59％ (14/68) and 16.18％ (11/68),which were significantly lower than those of the control group (x2 =4.04,4.92,all P ＜ 0.05).Tumor remission of the observation group was 61.76％ (43/68),which was significantly higher than that of the control group 50％ (26/52)(P ＜ 0.05).The tumor progress of the observation group was 17.65％ (12/68),which was significantly lower than that of the control group 28.85％ (15/52) (x2 =4.17,P ＜ 0.05).The tumor recurrence rates in 3 months and 6 months of the observation group were 10.29％ (7/68) and 17.65％ (12/68),which were significantly lower than those of the control group (x2 =4.61,P ＜ 0.05).Conclusion Neoadjuvant chemotherapy before operation can improve the operation resection rate,reduce the relapse rate,delay the recurrence and metastasis of gastric cancer,improve the prognosis of the patients.

Objectives:To elucidate the changes on contents and molecular structures of chondroitin sulfate in aneurysmal wall of aortic dissection and disscuss its likely roles in the pathogenesis and progression of aortic dissection.Methods:After glycosaminoglycans in aortae being abstracted,chondroitin sulfate were separated and purified respectively through DEAE Sephacel by ion exchange chromatography and then identified by cellulose acetate electrophoresis.Chondroitin sulfate were hydrolyzed with chondroitinase ABC,and then its disaccharide compositions were analyzed by high performance capillary electrophoresis.Results:Compared with the control group, chondroitin sulfate increased significantly(P

Atropine, as an anticholinergic agent, can inhibit the synthesis of acetylcholine in the arcuate nucleus in hypothala-mus and then reduce the secretion of GH. The present study showed that GH secretion was increased during exercise and the elevated GH level could be inhibited by atropine in normal subjects, while in patients with active acromegaly the high basal GH levels could be inhibited neither by 100g of glucose loading nor by 0.6 mg atropine. The blood sugar concentrations remained unchanged during atropine test. It was suggested that atropine test could be used as a GH release inhibitory test in acromegalic patients with overt diabetes mellitus.

ObjectiveTo investigate the effect of early balance training on ambulation after stroke. Methods120 stroke patients were randomly divided into control group and treating group with 60 cases in each group. Patients in control group received neuromedical and traditional rehabilitation treatment, while cases in treating group received early balance training additionally. All patients were assessed respectively with the Fugl-Meyer Assessment and Modified Barthel Index 8 weeks later. ResultsThe ambulation of two groups were improved (P<0.05). But the recovery of treating group was superior to the control group. ConclusionEarly balance training can promote the ambulation of stroke patients.

Allostery, or allosteric regulation, is the phenomenon in which protein functional activity is altered by the binding of an effector at an allosteric site that is topographically distinct from the orthosteric, active site. As one of the most direct and efficient ways to regulate protein function, allostery has played a fundamental role in innumerable biological processes of all living organisms, including enzyme catalysis, signal transduction, cell metabolism, and gene transcription. It is thus considered as "the second secret of life". The abnormality of allosteric communication networks between allosteric and orthosteric sites is associated with the pathogenesis of human diseases. Allosteric modulators, by attaching to structurally diverse allosteric sites, offer the potential for differential selectivity and improved safety compared with orthosteric drugs that bind to conserved orthosteric sites. Harnessing allostery has thus been regarded as a novel strategy for drug discovery. Despite much progress having been made in the repertoire of allostery since the turn of the millennium, the identification of allosteric drugs for therapeutic targets and the elucidation of allosteric mechanisms still present substantial challenges. These challenges are derived from the difficulties in the identification of allosteric sites and mutations, the assessment of allosteric protein-modulator interactions, the screening of allosteric modulators, and the elucidation of allosteric mechanisms in biological systems. To address these issues, we have developed a panel of allosteric services for specific allosteric applications over the past decade, including (i) the creation of the Allosteric Database, with the aim of providing comprehensive allosteric information such as allosteric proteins, modulators, sites, pathways, etc., (ii) the construction of the ASBench benchmark of high-quality allosteric sites for the development of computational methods for predicting allosteric sites, (iii) the development of Allosite and AllositePro for the prediction of the location of allosteric sites in proteins, (iv) the development of the Alloscore scoring function for the evaluation of allosteric protein-modulator interactions, (v) the development of Allosterome for evolutionary analysis of query allosteric sites/modulators within the human proteome, (vi) the development of AlloDriver for the prediction of allosteric mutagenesis, and (vii) the development of AlloFinder for the virtual screening of allosteric modulators and the investigation of allosteric mechanisms. Importantly, we have validated computationally predicted allosteric sites, mutations, and modulators in the real cases of sirtuin 6, casein kinase 2α, phosphodiesterase 10A, and signal transduction and activation of transcription 3. Furthermore, our developed allosteric methods have been widely exploited by other users around the world for allosteric research. Therefore, these allosteric services are expected to expedite the discovery of allosteric drugs and the investigation of allosteric mechanisms.

This article summarizes doctor LI Fu-ren’s academic thoughts on gerocony, such as coexistance with disease is an ordinary state for the old, protecting zhengqi is the essence of gerocomy, dealing correctly with the dialectical relationship between fuzheng and quxie is critical to clinical work, preventing possible disease is the key to anti-aging, etc., and gives an in- depth analysis from aspects of basic theory and concrete medication.

Objective:To compare the clinical effect of lateral and posterior approaches during the total hip replacement(THA) with Minimal-Incision Surgery(MIS).Methods:Twenty-three cases were performed with lateral approach,All were performed by the same surgeon.23 cases who had undergone a MIS THA with lateral approach were compared with 36 cases who had undergone MIS THA with the posterior approaches.The average follow-up period was 12 weeks.The patients were compared with respect to the length of the incision,surgical time,intra-operative blood loss,Harris hip score,component malpositioning,complications.Results:There were no differences between the two approaches with regard to the length of the skin incision,operating time,Harris hip score,component malpositioning and major complications.Statistically significant differences were found in two groups in terms of blood sedimentation and C-reaction protein.Conclusion:Both approaches can be effectively performed without increased risk of complications.Significant benefits of posterior approaches include less soft tissue damage.

As the college students are facing severe employment challenge,all colleges and universities extensively collect information,open up employment base,invite employers and organize campus recruitment to provide services for the graduates,but the result is not satisfactory.The main reasons for this are the old employment concepts of graduates,improper employment orientation,unclear employment policy,lack of job search experience,which needs students and schools to take measures to speed up improvement to help students better understand the situation,refresh employment concepts,timely adjust employment expectations and seize employment opportunity.

Difficult employment situation for college graduates is the root of ideological and political problems.Universities should set up a sound mechanism and carry out the ideological and political education,mental health counseling education,teaching,poor funding and employment guidance from the school reality to enhance the"vulnerable"job-hunting core competitiveness and raise their efficiency.

Objective:To compare the clinical effect of high tibial osteotomy (HTO) with Giebel blade plate or straddle nail internal fixation for the treatment of osteoarthritis of knee with varum.Methods:Twenty-three cases of knee OA with genu varum were performed with HTO,in which 8 case by using Giebel blade plate and 15 cases by using straddle nail.Results:All patients were followed up.The genu varum defection were corrected obviously.Six months after operation,comparison between the two groups showed no significant differences in scoring on HSS standard.One case of nail rupture and two cases of loss of anticipant angle occurred in the group of straddle nail.Conclusion:HTO with either Giebel blade plate or straddle nail both apparently shows many advantages in the treatment of osteoarthritis of knee.HTO with Giebel blade plate can exercise more early and have much less complications than HTO with straddle nail internal fixation.