No abstract available.
Epidermal Cyst* ; Herpes Zoster*

No abstract available.
Knee* ; Nevus* ; Organoids*

Proliferating trichilemmal tumor (PTT) is an uncommon neoplasm originated from the outer root sheath of a hair follicle. Malignant transformation occurs occasionally in proliferating trichilemmal tumors, which can be manifested by sudden rapid growths. Histologically, the malignant proliferating trichilemmal tumors (MPTTs) have shown severe nuclear atypia, marked cellular pleomorphism with atypical mitoses, dyskeratotic cells and infiltrating margins. Squamous cell carcinoma (SCC) should be differentiated with MPTT which indicates characteristic trichilemmal keratinization. Large tumor is considered as a risk factor of metastasis in SCC, but the relationship between tumor size and metastasis in the MPTT is not yet clarified. In this report, two patients have large erythematous nodules with focal ulceration and necrosis on their scalps and were diagnosed as MPTT. Despite the large sizes of the tumors, there were no evidences of metastases. Herein, we report 2 cases of the large MPTT which are presented without metastasis.
Carcinoma, Squamous Cell ; Hair Follicle ; Humans ; Mitosis ; Necrosis ; Neoplasm Metastasis* ; Risk Factors ; Scalp* ; Ulcer

No abstract available.
Dermatitis, Allergic Contact

No abstract available.
Adult ; Humans

No abstract available.
Angiofibroma ; Carbon ; Carbon Dioxide ; Lasers, Gas

BACKGROUND: Acquired bilateral nevus of Ota-like macules (ABNOM) is a dermal pigmented lesion common in individuals of Oriental origin. The Q-switched Nd:YAG laser (QSNYL) has been used successfully to treat a variety of benign, dermal, pigmented lesions, including nevus of Ota lesions. The similarity between ABNOM and nevus of Ota suggested that QSNYL may also be effective in the former. OBJECTIVE: To determine the efficacy and side-effect profiles of QSNYL treatment of ABNOM in Korean patients. METHODS: Of 42 Korean patients with ABNOM, 29 were treated with QSNYL (1,064 nm, 3 mm spot size, fluence 8~9.5 J/cm2), for up to 10 sessions each. Clinical photographs were taken before and after treatment. Lesion clearance was graded and complications such as hyperpigmentation, scarring, hypopigmentation, and erythema were assessed. RESULTS: Of the 29 treated patients, 19 (66%) showed excellent or good results. Of the patients who were treated more than 3 times, 76% showed good to excellent results. Two patients experienced post-laser hyperpigmentation (PLH), which persisted for more than one month, but no patient experienced persistent erythema or hypertrophic scarring. CONCLUSION: QSNYL is safe and effective in the treatment of ABNOM in Korean patients. Short-interval repetitive treatment is especially useful in improving therapeutic results and reducing PLH.
Cicatrix ; Cicatrix, Hypertrophic ; Erythema ; Humans ; Hyperpigmentation ; Hypopigmentation ; Laser Therapy ; Nevus ; Nevus of Ota

Mucoepidermoid carcinoma is the most common primary salivary gland malignancy. About 60% of mucoepidermoid carcinomas occur in the major salivary glands and 35% in the minor glands, in which the palate and buccal mucosa are the most frequent sites. Histologically, tumor cells, composed of intermediate, mucous, epidermoid, and clear cells in widely varying proportions, form numerous sheets, islands, duct-like structures and cysts. Many foci of mucin production are prominent. Herein, we report a case of a 37-year-old man who presented a nodule on left buccal mucosa. After the diagnosis, he was referred to a dental surgeon, by whom the tumor was radically excised. But, tumor cells were observed at one of the resection margins. As a result, he received radiation therapies (6 weeks, 60 Gy). He is now undergoing regular follow ups without any signs of recurrence.
Adult ; Carcinoma, Mucoepidermoid ; Follow-Up Studies ; Humans ; Islands ; Mouth Mucosa ; Mucins ; Palate ; Recurrence ; Salivary Glands ; Salivary Glands, Minor

Chondrosarcoma is the second most commonly encountered primary malignancy of bone, accounting for as much as 20% of such tumors. It most frequently involves the large limb bones (femur, tibia, and humerus), the scapula, and the ribs. Metastases are relatively rare and tend to occur late in the course of the disease. The lungs are the most common site of metastases. Metastatic chondrosarcoma to the skin is extremely rare, with only 10 cases described in the English literature. We herein report a case of disseminated cutaneous metastases from chondrosarcoma, presented as multiple papules and nodules on the trunk, scalp, and upper extremities.
Accounting ; Chondrosarcoma ; Extremities ; Hip ; Lung ; Neoplasm Metastasis ; Ribs ; Scalp ; Scapula ; Skin ; Tibia

BACKGROUND: Lichen sclerosus et atrophicus (LS et A) is an uncommon chronic lymphocyte-mediated dermatosis that causes substantial discomfort and morbidity, most commonly in adult women. It occurs predominantly in the anogenital area, and extragenital lesions also occur. OBJECTIVE: The aim of this study is to compare clinical and histopathologic features of genital and extragenital LS et A. METHODS: We retrospectively reviewed the medical records and 31 biopsy specimens of 29 patients who had been diagnosed with LS et A between January 2001 to June 2007 in Asan Medical Center. RESULTS AND CONCLUSION: The male to female ratio of genital LS et A and extragenital LS et A was 1:20, 1:3 respectively. Mean age at onset of genital LS et A and extragenital LS et A was 47.8 and 36.9 respectively. The color of the lesions was mostly white, irrespective of the involved area. Genital LS et A lesions were mostly located on labium majora or minora. Extragenital LS et A lesions were mostly located on the trunk, head and neck. The predominant symptom for genital LS et A was pruritus, whereas extragenital LS et A was mostly asymptomatic. The main treatment regime of LS et A was topical corticosteroid. The combination therapy with topical corticosteroid and pimecrolimus/tacrolimus resulted in symptomatic relief as well as improvement of skin lesions, without significant side effect. Histopathologically all LS et A cases showed vacuolar alteration, papillary dermal hyalinization, and dermal lymphohistiocytic infiltration. Hypergranulosis, exocytosis, red blood cell extravasation, lichenoid inflammatory cell infiltration were more frequently observed in genital LS et A (p<0.05). Follicular plugging, epidermal atrophy and loss of rete ridges were more frequently observed in extragenital LS et A (p<0.05).
Adult ; Atrophy ; Biopsy ; Erythrocytes ; Exocytosis ; Female ; Head ; Humans ; Hyalin ; Lichen Sclerosus et Atrophicus ; Lichens ; Male ; Medical Records ; Neck ; Pruritus ; Retrospective Studies ; Skin ; Skin Diseases