1.A rare case of disseminated Histoplasmosis mimicking Varicella in a 28-year-old immunocompetent female.
Sheehan Mae A. Tolentino ; Jacqueline Michelle D. Melendres ; Francisco Rivera IV ; Maicka Kiersten O. Agon ; Miyahra Haniko Lopez
Journal of the Philippine Medical Association 2023;101(2):33-38
Histoplasmosis is well-characterized as a fungal
disease that more commonly occurs in North America,
mostly endemic in Ohio and Mississippi river valleys.
The clinical spectrum of histoplasmosis ranges from
asymptomatic infection to a fatal disease. Progressive
disseminated histoplasmosis is typically seen in
immunocompromised individuals and presents with
non-specific systemic symptoms associated with
cutaneous manifestations of papules and nodules.? We
report a case of a 28-year old Filipino female with a
history of exposure to soil activities months before
consult. The patient presented with a 3-week history of
erythematous macules, vesicles, and pustules over the
face, arms, and trunk, which evolve into papules and
plaques with hemorrhagic crusting. Patient was initially
diagnosed and treated as a case of varicella but had no
improvement with initial management. Histopathologic
findings were consistent with histoplasmosis. The
patient was started with oral itraconazole, but
unexpectedly expired before any improvement in
cutaneous symptoms were noted.
Disseminated histoplasmosis
;
Itraconazole
2.Mistaken identity: Eumycetoma masquerading as Squamous cell carcinoma
Catherina Jessica Sutantoyo ; Johannes F. Dayrit ; Ma. Teresita G. Gabriel ; Glen Purnomo ; Reynaldo L. Ugalde
Journal of the Philippine Dermatological Society 2018;27(1):81-83
We report a case of eumycetoma in a Filipino patient who presented with a solitary reddish brown, moist, multinodular tumor on the
dorsum of the left foot of 2 years duration. Biopsy with Periodic acid Schiff (PAS) & Gomori methenamine silver (GMS) staining, fungal
culture, ultrasound and X-ray of the foot were done in our institution which confirmed the diagnosis of eumycetoma. The patient was
successfully treated with itraconazole 400/day for 3 months, followed by 200mg/day for the succeeding 9 months, leading to complete
resolution of the lesion leaving an atrophic hypopigmented scar. A high index of suspicion supported by diagnostic tests aided in the
early detection of the disease which also resulted to complete resolution of the disease.
Mycetoma
;
Mycoses
;
Itraconazole
3.A Simple Detection Method of the Resistance to the Treatment of Onychomycosis: A Case Report of Aspergillus sydowii Onychomycosis.
Jin Chun SUH ; Jung Sub YEUM ; Gun Yoen NA ; Seon Kyo SEO ; Moo Kyu SUH
Annals of Dermatology 2001;13(1):62-65
A 35-year-old housewife was diagnosed with onychomycosis and treated by oral terbinafine, 250mg/day, for 4 months. Clinically all infected nails improved gradually. However, her left great toe-nail was not improved thereafter. At that time the proximal end of the onychomycotic lesion was marked with surgical blade, and terbinafine therapy was continued for four weeks. However, the onychomycotic nail was not improved, and the scratch mark passed by the proximal end of the infected nail. Therefore, we detected the resistance to the therapy and switched the medication to itraconazole 100 mg/day and then another scratch mark was done at the proximal end of the onychomycotic lesion. After another 2 weeks the infected nail went along with the scratch mark distally, and showed clinical improvement. After 8 weeks therapy of itraconazole, she was cured clinically and mycologically. The fungal culture was identified as Aspergillus sydowii.
Adult
;
Aspergillus*
;
Humans
;
Itraconazole
;
Onychomycosis*
4.Comenting on the treatment results of the laryngitis due to aspergillus by itraconazol in the national ent institute
Journal of Medical Research 2003;26(6):100-107
In the Endoscopy Department of ENT National Institute from July 1999 to April 2003, 76 cases of fungal laryngititis were treated. Two isolated types of fungi were Aspergillus (73.63%) and Candida (22.36%) and the mixe of both two type (2.63). In 59 cases of Aspergillus infection, the treatment with itraconazole gave good results in 100%. Patients’ voice had totally recovered and fugal test showed negative results first before stopping treatment. The average duration of treatment lasts 6.27 weeks with no relapse after 6 months.
Therapeutics
;
Laryngitis
;
Aspergillus
;
Itraconazole
;
drugs
5.Close contact investigation of TB in high-burden, low- and middle-income countries
Malaysian Family Physician 2014;9(2):11-17
Tuberculosis (TB) remains a very common disease in most of the low- and middle-income countries. As a result of high disease burden, TB control measures in these countries are usually concentrated on intensifying active disease case-finding and early treatment of infectious TB. On the contrary, in countries with low disease burden, the focus is on contact investigation to identify latently infected individuals and prophylactically treating them to prevent disease reactivation and transmission. These two strategies are deemed important for the effective TB
control. Nonetheless, WHO cautions that targeted contact investigation and latent TB infection (LTBI) treatment should only be undertaken by countries that have the operational capacity/resources and have achieved ≥ 85% treatment success rate of active TB. The screening of LTBI
is further challenged by the lack of a “gold standard” test to identify and validate individuals with this condition. Tuberculin skin test (TST) is still the preferred investigation as it is cheap, widely available and validated in many trials. The sensitivity and specificity of the newer test—interferon gamma release assay (IGRA) for LTBI screening has been encouraging in low
prevalence countries. However, the evidence supporting such usage remains uncertain in high burden settings. Diagnosis of LTBI should adhere to the strict criteria outlined in the guidelines to avoid misdiagnosing active TB as LTBI. The treatment of the latter involved only one or two anti-TB drugs. It has been demonstrated that in the properly conducted contact screening and LTBI treatment, chances of the emergence of multi-drug-resistant TB is very low.
Tuberculosis
;
Poverty
;
Antifungal Agents
;
Itraconazole
6.Chromoblastomycosis, overlooked and undiagnosed: The disease as a mimic of other neglected tropical diseases
Charmaine Vanessa S. Chamberlin ; Maria Christina Filomena R. Batac ; Eileen Liesl A. Cubillan
Acta Medica Philippina 2019;53(4):383-387
Chromoblastomycosis is an endemic mycoses which has been misdiagnosed or underdiagnosed in the past. This may be due to the clinicopathologic characteristics that it shares with other neglected tropical diseases such as leprosy and cutaneous tuberculosis. Correlating clinical findings with histopathologic cues will lead clinicians to correct diagnosis and subsequent treatment success.
Chromoblastomycosis
;
Invasive Fungal Infections
;
Itraconazole
7.A Case of Chromoblastomycosis Showing a Good Response to Itraconazole.
Han Uk KIM ; Ge Yeong SON ; Chull Wan IHM
Annals of Dermatology 1997;9(1):51-54
Chromoblastomycosis, a chronic fungal infection of the skin and subcutaneous tissue, is known to be difficult to treat. Recently itraconazole has proved effective for treatment of this infection, but requires a prolonged treatment course. We experienced a case of chromoblastomycosis caused by Fonsecaea pedrosoi in a 68-year-old Korean man showing a complete resolution with a short course of oral itraconazole, 200 mg daily, for six weeks.
Aged
;
Chromoblastomycosis*
;
Humans
;
Itraconazole*
;
Skin
;
Subcutaneous Tissue
8.Nasofacial Zygomycosis by Conidiobulus Coronatus Responsive to Itraconazole.
Aru HANDA ; K K HANDA ; AK KARAK ; Abhay SINHA
Journal of Rhinology 2000;7(2):157-159
Conidiobolomycosis/Nasofacial zygomycosis is a relatively rare disease entity. It is almost always caused by Conidiobolus coronatus and is also known as conidiobolomycosis. It has been more commonly reported in tropical countries than in other regions. Diagnosis is made mainly on a clinical and pathological basis as fungal cultures may be difficult to grow. Different antimycotic drugs have been tried for its treatment. This report probably is the first case in English literature that has shown a very good response to treatment with itraconazole.
Conidiobolus
;
Diagnosis
;
Itraconazole*
;
Rare Diseases
;
Zygomycosis*
9.Change of the Growth Rate of the Great Toenail in Patients with Onychomycosis According to Systemic Antifungal Medication.
Kwang Yeoll YEO ; Jeong Soo KIM ; Jae Hong KIM ; Hee Joon YU
Korean Journal of Medical Mycology 2003;8(4):177-188
BACKGROUND: Onychomycosis is one of the most common diseases of nails, accounting for 50% of all nail problems and a recent rise in the prevalence of onychomycosis has been noted. It has been known that the growth rate of nails is influenced by age, sex, seasonal factor, individual health and familial tendency. Several drugs, also, have been known to influence the growth rate of nails. OBJECTIVE: We want to know the influence of antifungal drug, itraconazole and terbinafine that used widespread recently, to the growth rate of nail. METHODS: This study was performed the 41 patients with distal subungal onychomycosis affecting only one sided great toenail and affected area more than 50%. The growth rate of the affected and the unaffected toenails in the same patients according to the medication of itraconazole or terbinafine was measured. Also, the growth rate of nails in 36 people with normal toenail was measured. RESULTS: No growth rate differences were seen in comparing the great toenails affected to onychomycosis in itraconazole and terbinafine group (p> 0.05). Also no growth rate differences were seen in great toenails not affected to onychomycosis in itraconazole and terbinafine group and no growth rate differences with the toenails of normal control (p> 0.05). CONCLUSION: There was no difference of itraconazole or terbinafine to the growth rate of nail. Even though there was no statistical significance, the possibility of the drug effect as normal nail growth became faster with the antifungal medication can not be excluded. So study with comparison of nail growth rate before and after antifungal medication will be needed in the future.
Humans
;
Itraconazole
;
Nails*
;
Onychomycosis*
;
Prevalence
;
Seasons
10.The Long Term Efficacy and Relapse Rate of Itraconazole Pulse Therapy Versus Terbinafine Continuous Therapy for Toenail Onychomycosis: a 96-week follow-up study.
Chong Hyun WON ; Juneyoung LEE ; Kapsok LI ; Mi Ra CHOI ; Beom Joon KIM ; Jee Soo AN ; Kyu Han KIM ; So Yun CHO ; Sang Eun MOON ; Jeong Aee KIM ; Hee Chul EUN
Korean Journal of Medical Mycology 2007;12(3):139-147
No abstract available.
Follow-Up Studies*
;
Itraconazole*
;
Nails*
;
Onychomycosis*
;
Recurrence*