A case of Toxic Epidermal Necrolysis affecting 24 years old, male Korean, who has been suffering from Pulmonary Tuberculosis, is presented. The skin lesions of the case have been developed about two months after administration of Thioacetazone, 150 mg. per day. The cause of this case may be due to Thioacetazone, one of the antituberculous drugs. Diagnosis of Toxic Epidermal Necrolysis was estsblished by clinical characteristics, histopathological and laboratory studies, and review of literatures were made also.
Diagnosis ; Humans ; Male ; Skin ; Stevens-Johnson Syndrome* ; Thioacetazone ; Tuberculosis, Pulmonary ; Young Adult

Dyschromatosis Symmetrica Hereditaria (Toyama) is one of the pigment anormaly hereditary skin disease which is known to manifest the Japanese. Various authors such as Toyama, Matsumoto, Komaya-Dohi and Ichikawa-Hiraga have reported the disease under different diagnostic name. Clinical characteristics of the disease are shown to have multiple reticular dark brown spotty macular skin lesion mostly over the face, neck, back of hands, feet, fingers and toes, which are affecting symmetrically, without subjective symptom, and occasionally the pigmented and depigmented macular lesions are intermingled. Among these author's reports to the disease, one postulate those which Matsumoto and Komaya-Dohi's cases were essentially similar type in clinical manifestation and were described as showing spotty pigmented macules intermingling with the depigmented over the areas as those of Toyama's. In this article, a case of Dyschromatosis Symemtrica Hereditaria manifesting 21 years old Korean male, which is similar to Matsumoto's type, is presented. Search for the heredity back ground revealed that the grandfather and mother were affected by this disease, and authors assumed the types of heredity of the disease to be irregular non-sexlinked dominant inheritance. Authors presented also distinctions of the histopathological findings of the disease which are hyperkeratosis, increased melanin granules in stratum mucosum layer and imperfect or immatured granular cells, and discussions of differential diagnosis and review of literatures are made.
Asian Continental Ancestry Group ; Diagnosis, Differential ; Fingers ; Foot ; Hand ; Heredity ; Humans ; Male ; Melanins ; Mothers ; Neck ; Skin ; Skin Diseases ; Toes ; Wills ; Young Adult

The distribution of the patterns of pubic hair and axillary hair was observed in 1970 men and 1761 women from 17 to 59 years of age. Among the 4 types usually found, the horizontal type predominated in male pubic hair irrespective of age, and the acuminate type, sagittal type and the disperse type followed in order. In the fernale public hair patterns, two new types were observed: a "linear type" and a "few type". The horizontal type was the predominant form and the acuminate type, the linear type, the few type, the disperse type and the sagittal type came in order. Women with no pubic hair rna,de up 4.4% of the total. But the patterns of pubic hair changed with age toward the types of little hair count such as the few and the linear type. In the axillary hair patterns of men, the whole type predominated and the brachial type, the central type came in order and men with no axillary hair made up 8.0% of the total. This distr!bution also changed with age, the central type being the commonest type in advanced age. In the a,xillary hair patterns of women, the whole type also predominated but with age, the numters of persons with no axillary hair increased. As to the relation of the body weight and the hair pattern, no conspicuous relation was found except for the female pubic hair pattern. In this group, persons below ideal body weight had low hair count, with statistical significance.
Body Weight ; Female ; Hair* ; Humans ; Ideal Body Weight ; Male

No abstract available.
Skin*

As increasing numbers of antibiotics, adrenocorticosteroids, and antitumor agents have come into use, so increasing numbars of mycotic diseases have been identified. Qtomycosis, a mycotic infection of the extcrnal ear which is occasionally accompanied by dermatitis of the surrounding skin, is corsidered to be such a disease. While opinion vari.es as to whether otomycosis is caused by a saprophytic or a pathogenic organism, our clinical obs:rvations revealed pathological inflammation of the external auditory canal with profuse fungal elements. During August 1975, l3 specimens of ear wax were taken from patients whv visited the out-patient ENT clinic of this hospital. All patients had had their ears clea,ned at a barber shop prior to visiting the ENT clinic. Because ar cleaning instrumenta (scoops and brushes) are re-used m Korean Sarber shops, 204 of theae in- strum.ent;s were randomly selected from different barber shops and examined. KGH mounts and Lactophenol cot@ten blue stains were used to examine the specimens. Qf the lR ear wax specimens, I2 samples (92. 3%) reveaIed Aspergillus sp. and 1 sample (7. 7%) revealed Penicillium sp. Of the 204 ear cleaning instrumenta tested, l94 colonies grew in culture. Of these cultures, 146 (75. 3 %) were Aspergillus sp., 9 (4. 6%) were Mycelia sterila, 5 (2. 6%) were Fenicillium sp., 4 (2. 1 %) wr Al- terna,ria, 2 (l. 0%) were Stemphylium sp., 1 (0. 5%) was Geotrichum sp., and 27 (13. 9%) were of an unknown species. Of the 146 Aspergillius sp. cultures, 99 (67. 8%) were Asp. terreus, 17 (11.6%) were Asp. glaucus, 5 (3.4%) were Asp. niger, 17 (11. 6%) were Asp. flavus-oryzRC, R (2. 1 %) Were Asp. versicolor, and 5 (3. 4 %) were athers. Beca.use of the close correlation between the fungi cultivated from ear wax apc imens and those cultured from ea,r cleaning instruments, the authors believe that the ear cleaning instruments used in the barber shops could well have been the primary source of infection. In this study the authors also discuss the probable causative factbrs of otomycosis arrd a review of the literature is presented.
Anti-Bacterial Agents ; Antineoplastic Agents ; Aspergillus ; Cerumen ; Coloring Agents ; Dermatitis ; Ear ; Ear Canal ; Epidemiologic Studies* ; Fungi ; Geotrichum ; Humans ; Inflammation ; Niger ; Otomycosis* ; Outpatients ; Penicillium ; Skin ; Viperidae

We present here a case of phaeornycotic subcutaneous abscess caused by Wangiella dermatitidis in a 34-year-old male, who had multiple asymptomatic subcutaneous masses of 7 months duration over the neck and right axilla. ]n this case, we could observe typical gross colony morphology of W. dermatitidis. which showed creamy greyish, yeast-like colony with aerial mycelia after 3 to 4 weeks. ]n histopathologic study, we found mixed cell granuloma and fungal structure in biopsy specimen. We comfirmed W. dermatitidis by exoantigen test, and treated the subcutaneous lesions by surgical excision and ketoconazole with good result. This case is the first reported in Korea.
Abscess* ; Adult ; Axilla ; Biopsy ; Exophiala* ; Fungal Structures ; Granuloma ; Humans ; Ketoconazole ; Korea ; Male ; Neck

From January 1971 to December 1980 the authors observed 165 cases of chronic ulcers of the extrernities in the Department of Dermatology, Chonnam University Hospital. The results obtained can be summarized as follows. 1) During this period, the mean average percent of ulcer patients seen was 0.41 of the yearly total patients. 2) The ages of onset was quite varied with the highest group in the 5th decade. The ratio of men to women was 2.93: 1. 3) The most common predilection site was right lower extremity. 4) Leprosy, especially T-type, was the most comrnon underlying disease.
Female ; Male ; Humans

The air-borne fungi are usually considered to be as non-pathogenic and saprophytic organisms. However, those can be causative factors of certain allergic disease, and produce mycotoxic diseases such as caused by aflatoxin B1,or opportunistic infections, since various kinds of antitumor agents and adrenocorticosteroids have been introduced to therapeutics, and those who are affected some malignant tumors or metabolic anomalous diseases. As the first step toward. understanding and controlling the diseases, the studies on the population of air-borne fungi seem to be necessary. Authors studied the fluctuations of population of air-borne fungi at monthly intervals from June 1974 through May 1975 and at various times of the day at different places in th hospital, and the results obtained were as follows: 1. The identified fungi species and the percentage of colony counts of each species were Hormodendrum sp. (37. 2% ), Penicillium sp. (18. 8% ), Aspergillus sp, (17. 6 % ), Alternaria sp. (6.3 %), Mycelia sterila (2.6 %), Paecilomyces sp. (1.2 %) RhodO torula sp. (1. 1 % ), Oospora, sp. (0, 7 % ), Rhizopus sp. (0. 6 %. ), Geotrichum sp. (0.4%), Monilia sp. (0.4%), Mucor sp. (0.4%), Trichoderma sp. (0.4%.), Trichosporon sp. (0. 1%), Stemphylium sp. (0. 1 % ), Helminthosporium sp. (0. 1%) Gliocladium sp. (0. 1,: ), Saccharomyces sp. (0. 1 % ), Trichothecium sp. (0. 03 % ), and other unknown species(11. 6%) in decreasing order of frequency. 2. The monthly fluctuations of number of cultured colonies of four major airborne fungi (Hormodendrum, Penicillium. Aspergillus, and Alternaria) were 649 in June, 105 in July, 372 in August, 431 in September, 188 in October, 241 in November and 89 in December 1974, and 92 in January, 115 in February, 77 in March, 178 in April and 116 in May 1975. 3. It was suggested that there might be a relationship among the humidity, the temperature and the population of the air-borne fungi because the abrupt drop in July seemed to be related to high level of tbe,humidity (86.8%) and the temyerature (24. 3'C). And since the total number of colonies decreased markedly in December 1974 and Junuary 1975, it seemed to be closely related to cold weather temperature. 4. The number of cultured colonies at various times of the day did not show much fluctuation, except that Aspergillus sp. showed sudden tremendous increase at. one occasion, at 3: 00 P.M. on 15th of June and that gradual increase of Hormodendrum sp. was noted on another occasion from 12: 00 A.M. on 15th of September. 5. With regard to the locations of sampling, such as the operating room, laboratory, ward and out-patient department in the hospital, the difference in the identified. fungi species, the number of colony counts and the relationship with the humidity A the temperature was not evident. Authors reviewed relevant literatures and made discussions also.
Aflatoxins ; Alternaria ; Antineoplastic Agents ; Aspergillus ; Candida ; Cryptococcus ; Fungi* ; Geotrichum ; Gliocladium ; Helminthosporium ; Humans ; Humidity ; Mucor ; Operating Rooms ; Opportunistic Infections ; Outpatients ; Paecilomyces ; Penicillium ; Rhizopus ; Saccharomyces ; Trichoderma ; Trichosporon ; Weather

The pathogenicity of Demodex folliculorum (DF) is not well established, becausc this cutaneous parasite can be found very often not only from acneic skin lesions but also on healthy human skin, surface, particularly on sebaceous gland-rich and functionaIly active areas of the skin, i.e. on face, and therefore, the mite has been generally considered as normal inhabitant of human skin. However, as is the case with candidiasis, the parasite could also be pathogenic in the state of disturbed host-para-site relationship. To find out the pathogenicity of the mite, the authors studied the incidence of finding DF from different sites of face in several groups of 60 acneic patients (various types of acne vulgaris and rosacea) and 30 normal subjects as control. And the results obtained were as follows: the mite was found in 33 cases out of the acnei patients (55%), in male patients 67% (12 out of l8) were positive and in fernales 50% (21 out of 42). In the control group of 3O (15 each sex), 17 cases (9 males and 8 females) had thc mite, the incidence rate being 57%, The incidence rate of DF in various types of acneic skin lesions were: 85% in rosacea. 80% in pustular acne 71% in cvstic acne and 32% in papular acne. The distribution of the mite in various sites of the face differed markedly in the acneic and normal groups. In the control group 17 (57 %) were positive on nose, 3 (10%) on cheek, 2 (7%) on chin, and none on the forehead. Among 60 acneic patients, however, 18 (30%) were positive on cheek, 17 (28%) on nose, 15 (25%) on chin 12 (20 %) on forehead. In addition, the acuthors observed two cases of demodicidosis in the dogs. These two dogs were siblings and lived together with other dogs of the same lineage, but the other dogs were not affected. In spite of vigorous treatment with 15 % benzyl benzoate aqueous emulsion and 10 % crotamiton ointment applied topically for two to three weeks, the dogs died within one to two months. Slight improvement only was noted in the first week of the treatment, but the dogs were gradually emaciated, leading to death. At the onset of the disease, both dogs were two to three months old. Histopathological studies of the affected skin revealed dense patchy lymphocytic infiltration predominantly in perifollicular area, follicular keratotic plugging and egg-like materials in the Iumen of hair follicle. Histopathology of the affected canine skin appeared similar to that of human demodicidosis except that the mitelike material was observed lodged in the lumen of hair follicle. The morphology of demodex folliculorum canis seemed slightly different from that of the human strain (DF hominis). It is generally smaller in size and has narrower and shorter stunted abdomen than human strain, otherwise it is almost alike. The human demo3icrdosis can be effectively treated with 15% benzyl benzoate aqueous emulsion, 1% gamma benzene hexachlrode cream and 10 % crotamiton ointment, and it seems to be most effective agent being crotamiton ointment among them. It is suggested that demodex folliculorum, which has been hitherto thought to be harmless, can be pathogenic in certain individuals and that some immunologic factors might be implicated in the process of the demodicidosis.
Abdomen ; Acne Vulgaris ; Animals ; Benzene ; Benzoates ; Candidiasis ; Cheek ; Chin ; Dogs ; Dronabinol ; Forehead ; Hair Follicle ; Humans ; Immunologic Factors ; Incidence ; Male ; Mites ; Nose ; Parasites ; Rosacea ; Siblings ; Skin ; Virulence*

Nevus lipomatosus cutaneous superficialis(NLCB) is a rare condition consisting of ectopic fat tissue in the dermis and having the predilection for the pelvic girdle, especially gluteal region. The patient was a 20 year-old female. About 8 years prior to the first visit she had noticed the rice-sized papules on her lower back, which had been gradually increased in size and coalesced to become two, cerebriform, skin colored to yellowish tumor masses of soft consistency, distributed on both sides of the midline of lower back, and measuring respectively 3.5X7.Qcm and 7.0x11.5cm in size. Jihe biopsy specimen taken from the tumor mass revealed the ectopic presence of fat lobules occupying half of the reticular dermis. The fat lobules consisted of almost mature fat cells with the presence of dilated capillaries in their centers.
Adipocytes ; Biopsy ; Buttocks ; Capillaries ; Dermis ; Female ; Humans ; Nevus* ; Skin ; Young Adult