Objective To observe the clinical efficacy of Xing Nao An Shen Jie Yu needling method (brain-awakening mind-calming and anti-depression needling method) in treating depression after cerebral stroke. Method Totally 120 patients with depression after cerebral stroke were randomized into two groups: the acupuncture group was intervened by An Shen Xing Nao Jie Yu needling method, while the Western medication group was by oral administration of Fluoxetine Hydrochloride capsules. The Hamilton Depression Scale (HAMD), National Institute of Health Stroke Scale (NIHSS), and Barthel Index (BI) were adopted to evaluate the depression degree, neural function deficit, and activities of daily living after 4-week and 8-week treatments. Result The total effective rate was 96.5% in the acupuncture group, versus 83.9% in the Western medication group, and the difference was statistically significant (P<0.05); the acupuncture group was superior to the Western medication group in improving the HAMD, NIHSS, and BI scores (P<0.01), and its therapeutic efficacy present with a feature of time-effect. Conclusion Xing Nao An Shen Jie Yu needling can significantly improve the symptoms of depression after cerebral stroke, promoting the recovery of neural function and enhancing the quality of life.

OBJECTIVE To understand infection status and drug resistance of Ureaplasma urealyticum(Uu) and Mycoplasma hominis(Mh) in female genitourinary tract in the local region.METHODS The results of mycoplasma cultivation and susceptibility tests of female vaginal secretions specimen in 409 cases during from Sep 2007 to Apr 2008 were analyzed retrospectively.RESULTS Among 409 cases,the positive rates were mycoplasma cultivation(57.2%).Uu(72.6%),Mh(3.4%) and combined infection(23.9%).Drug resistance of Uu to ten kinds of common antibiotics showed that minocycline

Objective:To discuss the clinical effect of preoperative interventional chemotherapy and pathological changes in uterine cervical cancer.Methods:preoperative interventional chemotherapy by femoral intubatton were done in 21 patients with uterine cervical cancer.The project of chemotherapy was bleomycin 45mg and cisplatin or oxaliplatin 80mg/m2.Rusults:21 cases of uterine cervical cancer including 7 cases ofⅠstage and 14 cases of Ⅱstage received one or two times of preoperative interventional chemotherapy.All of the patients successfully completed cervical cancer radical therapy.All of the specimens were sent for pathological examination.A lot of lymphocyte cells infiltration and necrosis were found in the cancer tissues.Conclusion:preoperative interventional chemotherapy for uterine cervical cancer proves to reduce the local cancer size as well as decrease the bleeding of cancer.The patients can receive cervical cancer radical therapy after the interventional chemotherapy.

In this work, rare specific binders to botulinum neurotoxin antigen were selected from human phage immunized library through three rounds of panning in vitro. Of them, clone ScFvB17 is of high affinity and specificity to target antigen. B17 is of 750bp encoding 250 amino acid. Analysis results of gene structure showed V-genes of B17 belonging respectively to VH4 or? chainⅡ family are new antibody Fv genes. More important result showed that recombinant ScFvB17 expressed in E.coli could bind specific for neurotoxin competing with antiserum. Successful selection of human phage antibody library and obtaining specific ScFv against botulinum neurotoxin serotype A provide useful materials for further study on detection of neurotoxin and human engineering therapeutic antitoxin.

In this paper, some study methods of pharmacokinetic, the explanation ways of data and experimental methods of transdermal therapeutic system(TTS) were described. The advancement of modern science accelerates the development of pharmacokinetic of TTS and makes more progress in this field.

Objective:To discuss the diagnosis,treatment of uterus cornea pregnancy.Methods:Retrospective analysis was made in 21 cases of uterus cornua pregnancy is recent 10 years.Results:8 cases were diagnosed uterus cornua,9 cases were misdiagnosed ectopic pregnancy,1 case was misdiagnosed rupture of uterus of artifical obortion,1 case was misdiagnosed pregnancy with uterus septus,1 case was misdiagnosed choriocarcinoma.Surgical treatment was done in 19 patients,and the other 2 cases received conservative therapy.Conclusion:Cornual pregnancy is often misdiagnosed as ectopic pregnancy or other diseases.More careful gynecological and transobdominal ultrasound examination will improve the accuracy of diagnosis.

Objective To measure the sizes of the left and right internal jugular veins (IJV) and transverse sinuses (TS) with three dimensional contrast‐enhanced MRA(3D CE‐MRA) ,and discuss the correlation of cerebral venous sinus and IJV .Methods One hundred and ten patients without vasculopathy and blood flow abnormalities were selected for 3D CE‐MRA ,55 cases for each gender .The images were taken three‐dimensional reconstruction on work‐station by different software .The normal IJV and TS was measured and the statistical comparison between the bilateral IJV and TS was analyzed .Results (1)The inside diameter of IJV re‐duced in turn at the measurement point of J1 ,J2 and J3 .The internal diameter of the right side of IJV was broader than left one ,and there was significant difference between the size of left and right side (P<0 .05) in these measurements .The internal diameter of the right side of TS was broader than left one ,there was difference between the sizes of the left and right of TS (P<0 .05) .(2)The proportion of R>L ,R

The soluble antigen was isolated from pig retinal extract by precipitation with ammonium sulfate followed by molecular sieve. 50 ?g S antigen with equal volume complete Freund's adjuvant was injected into double hind foodpads of guinea pigs. Two weeks later, experimental autoimmune uveitis developed. Its pathologic feature is that a great number of lymphocytes infiltrated into chroid which was thickened gradually from anterior to posterior. Inflammatory variation was relative to disease phase. Ultrastructure pathology was characterized by swelling and necrosis in the inner and outer segments of photorecepter cells. This result suggests that S antigen has significant effect on inducing experimental autoimmune uveitis and the outer layer of retina is the sensitive target organ of S antigen.

AIM Protective action of TMP on hearts and brains under the condition of the acute hypoxia was studied. METHODS On the device of mice acute hypoxia ,ability of tolerancing hypoxia of mice was investigated,and superoxide dismutase(SOD) and malondialdehyde(MDA) and nitric oxide(NO) contents in hearts and brains were measured.RESULTS TMP could make the resisting hypoxia action in mice strengthen significantly,and the action had a does dependent increase. TMP made SOD contents in hearts and brains in does dependent increase;MDA contents in hearts and brains were not notable in low does ,but TMP could decreased MDA contents in hearts and brains in middle and high does ( P

[Objective] To evaluate the efficacy and safety of quadruple therapy based on moxifloxacin and bismuth in the treatment of Helicobacter pylori eradication failure.[Methods] A prospective,randomized,comparative study was conducted in which 136 eligible patients were randomly divided into the extended quadruple group (66 patients,and the quadruplex therapies are Pectin bismuth 100 mg tid + lansoprazole 30 mg bid + amoxicillin 1000 mg bid + moxifloxacin 400 mg qd) and the classical quadruple group (70 patients,and the quadruple therapies are colloidal pectin bismuth 100 mg tid+ lansoprazole 30 mg bid +tetracycline tablet 750 mg Bid + metronidazole tablets 400 mg bid combination) and were under treatment for 14 days.One month after the treatment,endoscopy,rapid urease test,and 13-carbon/ 14-carbon urease breath test were used to evaluate the adverse effects and adherence of the drugs in the two groups respectively.[Results] In the extended quadruple group,among 60 patients who had completed the final treatment and follow-up survey,55 were successfully treated,with eradication rates of (83.3％,55/66)and 91.7％ (55/60) according to intention-to-treat (ITT) and Per-protocol (PP) respectively.In the classic quadruple group,64 patients completed the final treatment and follow-up survey.Among them,37 cases were successful,and the eradication rates according to ITT and PP remedy are 52.9％ (37/70) and 57.8％ (37/64) respectively.The difference was statistically significant (P ＜ 0.001).Adverse drug reactions and compliance monitoring showed no significant difference between the two groups (P ＞ 0.05).[Conclusion] The quadruple therapy based on moxifloxacin and bismuth displays a higher eradication rate than that of the classical bismuth quadruple therapy on the first-time elimination failure of Helicobacter pylori while shows no difference in safety consideration,thus can serve as remedial therapy for the primary Hp eradication failure.