4.Analysis on incidence of occupational diseases in Guangzhou from 2010 to 2020.
Jing Yi GUO ; Hui Ting LIU ; Yang LIAO ; Han Cheng LUO ; Hai Lin ZHOU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2022;40(4):292-295
Objective: To analyze the incidence characteristics of occupational diseases in Guangzhou from 2010 to 2020, provide scientific basis for formulating occupational disease prevention and control policies. Methods: In January 2021, based on the data of occupational diseases in Guangzhou reported in the Information Monitoring System of Occupational Diseases and Occupational Health, descriptive epidemiological method was used to analyze the types and characteristics of occupational diseases in Guangzhou from 2010 to 2020. Results: A total of 1341 cases of 38 kinds of occupational diseases in 9 categories were reported in the past 11 years. The incidence of occupational pneumoconiosis, occupational otolaryngology and oral diseases and occupational chemical poisoning ranked the top three, accounting for 38.1% (511/1341) , 30.5% (409/1341) and 16.2% (217/1341) of the total cases respectively. The cases of pneumoconiosis in welders and silicosis accounted for 47.7% (244/511) and 34.4% (176/511) of the cases of occupational pneumoconiosis respectively. The cases of noise deafness accounted for 99.8% (408/409) of occupational otorhinolaryngology oral diseases. Acute occupational chemical poisoning cases accounted for 26.7% (58/217) of the occupational chemical poisoning cases, in which dichloroethane poisoning cases ranked the first, accounting for 79.3% (46/58) . Chronic occupational chemical poisoning cases accounted for 73.3% (159/217) of the occupational poisoning cases, in which benzene and lead poisoning cases ranked the top two, accounting for 79.2% (126/159) and 17.6% (28/159) respectively. Conclusion: Pneumoconiosis, silicosis, noise deafness, benzene poisoning, lead poisoning, dichloroethane poisoning should be supervised and managed as key occupational diseases in Guangzhou.
Benzene
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China/epidemiology*
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Deafness
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Ethylene Dichlorides
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Humans
;
Incidence
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Lead Poisoning
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Occupational Diseases/epidemiology*
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Pneumoconiosis/epidemiology*
;
Silicosis
7.Study on biological monitoring indicators of exposure to 1,2-dichloroethane and its determination method in blood.
Liping ZHOU ; Yanjun DENG ; Yimin LIU
Chinese Journal of Preventive Medicine 2016;50(2):179-183
OBJECTIVETo investigate the feasibility of using the concentration of 1,2-DCE in blood as a biological monitoring indicators and build the determination method of 1,2-DCE in blood.
METHODSDose-response relationship of the exposure of 1,2-DCE and the level of 1,2-DCE in rat blood were investigated using the Pearson's correlation analysis. The concentration of 1,2-DCE in blood was determined using Headspace Sampler-Gas Chromatography-Mass Spectrometer (HS-GC-MS). 3.0 ml blood sample diluting with 2.0 ml 1,2-DCE standard serial solution was placed in 15 headspace bottles respectively and heated at 80 ℃ for 20 min.The vapor upon the headspace bottle was separated by capillary column and the concentration of 1,2-DCE was determined by massspectrum in SIM mode to draw a standard work curve. The within-run precision and the between-run precision were calculated by the relative standard deviation (RSD) of the concentration of 1,2-DCE in blood which was determined 6 times in a day and 6 times within 3 days respectively. The recovery rate was calculated by P=(C2 -C0)/C1 × 100%.
RESULTSWhen the treatment groups were exposed at dosage of 1,472, 2,550, 3,093, 3,976, and 4 418 mg/m(3), the average concentration of 1,2-DCE in rat blood was 24.1,231.6,344.3,395.1,538.5 μg/L. There was a positive correlation between the concentration of 1,2-DCE in rat blood and the exposed level of 1,2-DCE.The equation of dose-response relationship was y=0.162x -195.8,r=0.982 2,P=0.003 and the precision of exposure experiments was 7.04% -13.15%. 1,2-DCE contents within 0.259 -2 587 μg/L showed a good linear relationship and the regression equation was y=47 901x -357 446, r= 0.999 8. When the blood containing 0.259 μg/L 1,2-DCE was determined for six times, the average peak/peak signal-to-noise ratio was 56.55. The limit of detection (LOD) was 0.014 μg/L and the limit of quantification (LOQ) was 0.046 μg/L. The within-run precision was 1.23% -2.76% and the between-run precision was 2.21% -4.64%. The average recovery rate was 93.3% - 98.6%.
CONCLUSIONThe concentration of 1,2-DCE in blood could be used as a biological monitoring indicator. The method of the concentration of 1,2-DCE in blood determining by HS-GC-MS was characterized by high sensitivity, wide linear range, small interference, high precision and easy operation.
Animals ; Environmental Exposure ; analysis ; Environmental Monitoring ; Ethylene Dichlorides ; blood ; Gas Chromatography-Mass Spectrometry ; Limit of Detection ; Rats
9.Experience of treatment of subacute encephalopathy induced by 1, 2-dichloroethane poisoning.
Yuan-lin ZHOU ; Wei-jun HONG ; Shao-fa KE
Chinese Journal of Industrial Hygiene and Occupational Diseases 2009;27(4):253-254
Acute Disease
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Adult
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Ethylene Dichlorides
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poisoning
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Female
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Humans
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Male
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Neurotoxicity Syndromes
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therapy
10.Therapy of encephalopathy induced by severe dichloroethane poisoning.
Yi-wen JIANG ; Shu-li LIU ; Li LI ; Chun-yan CAO ; Ying SHI
Chinese Journal of Industrial Hygiene and Occupational Diseases 2006;24(8):506-507
Adolescent
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Adult
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Brain Diseases
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chemically induced
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therapy
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Ethylene Dichlorides
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poisoning
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Female
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Humans
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Male