Objective: To study the correation between carotid artery atherosclerosis and coronary heart disease (CHD). Methods: Color Doppler flow imaging was employed to evaluate carotid artery atherosclerosis in 90 patients with CHD, carotid artery ultrasonography and coronary angiography were performed simultaneously in 20 cases. Results: The thickness of internus-middle membrane and the index number of atheroma both increased remarkably in all cases, and the group with MI had obvious abnomal parameter of blood stream in internal carotid artery. The conformed rate of coronary angiography with ultrasonography in carotid is 75 % in 20 cases,and the moreserious the pathological change of coronary is, the higher the happening rate of carotid artery atherosclerosis is. Conclusion: The degrees of carotid artery atherosclerosis can reflect the degree of pathological changes of coronary indirectly.

Objective: The aim of our study was to analyse the death cause and related factors of death in hospital of patients after cardiac valve replacement (CVR). Methods: Regression analysis of 34 patients' data was executed. Results: Death rate was 9.9 %, death cause: (1) L.ow cardiac output syndrome is the first complication and death cause (2.6 % ), which was closely related to cardiac function (grade Ⅳ ) before operation, LVEDD＞8.0 cm, LVEF＜0. 40, GR ＞80%, emergency operation, long time of arterial block, etc; (2) Ventricular tachycardia、 ventricular fibrillation is the second cause of death (2. 1%); (3) Respiratory failure (4) Post-operation hemorrhage inducing pericardial tamponade and shock; (5) Postoperation infection of replaced valve and brain complications. Conclusion: The success rate of operation can be increased by selecting patients strictly, improving operation methods, enhancing periopertive monitor.

Objective: To investigate the alteration of red cell deformability (RCD) and adenosine triphosphatase (ATPase) activity of cell membrane in essential hypertensive (EH) patients and essential hypertension patients complicated with cerebral infarction (HCI). Methods: Twenty healthy individuals, 30 EH patients and 30 HCI patients were selected as subjects. The erythrocyte deformability indexes (DI)、 Na+, K+-ATPase and Ca2+ATPase activities were examined. Results: (1) EH patients had significantly higher DI, lower ATPase activity as compared to healthy individuals. There were significantly negative correlation between DI and ATPase activity, and a significantly positive correalation between DI and diastolic blood pressure in EH patients; (2) There was significantly higher DI, lower ATPase activity in HCI patients than those in EH patients. There was significantly negative correlation between DIand ATPase activity in HCI patients. Conclusion: (1) RCD decreases in EH patients, and RCD is correlated to the decreased ATPase of cell membrane and elevated blood pressure; (2) The decreased RCD level may be related to the occurrence of HCI.

Objective: To explore the significance of examination of spectrum ECG in patients with coronary heart disease (CHD). Methods: Spectrum ECG and ECG、 vectorcardiogram examination were meanwhile executed in 254 patients with coronary heart disease. Results: Diagnose coincidence rate of CHD was 66.9% by spectrum ECG and ECG、 vectorcardiogram examination. Conclusion: Spectrum ECG is a new detect method for electrocardiogram information.

Objective: To observe the effects of type 2 diabetes mellitus patients with hypertension on lipid metabolism and insulin sensitivity. Methods: A case-matched study of fasting plasma glucose (FBG), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HIDL), low density lipoprotein cholesterol (LDL), insulin (FIN), C-peptide (FCP) and insulin sensitivity index (ISI) were detected in type 2 diabetes mellitus patients with and without hypertensiorn. Results: Twenty patients with type 2 diabetes mellitus complicated hypertension had higher TG、 FINS and FCP, lower HDL and ISI levels than 20 patients with type 2 diabetes mellitus without hypertension. Conclusion: Type 2 diabetes mellitus with hypertension had more remarkable lipid metabolic disorder and insulin resistance than type 2 diabetes mellitus without hypertension.

Objective: To research the effects of cardiovascular endocrine hormone and insulin-resistance in aged patients with hypertension. Methods: The t-PA of serum (plasma), activity of PAI、 ANP、 ET、 A Ⅰ 、 A Ⅱ and IR were determined in 40 patients with Ⅰ and Ⅱ stage of hypertension and in 30 healthy subjects (control group). Results: The PAI、 ANP 、 ET、 A Ⅱ and total cholesterol and triglyceride levels were apparently higher in patients with hypertension than in healthy control group. The t-PA and IS were obviously lower in hypertensive patients than in healthy control group. Conclusion:The cardiovascular endocrine hormone and insulin-resistance play an important role in genesis and development of hypertension in aged.

Objective: To study clinical significance of endogenous vitamin C 、 E in patients With hypertension and stroke. Methods: The serum vitamin C、 E, Malondialdehyde (MDA), superoxide dismutase (SOD) were determined by ultraviolet spectrophotometry in patients with hypertension (23 cases)、 hypertensive cerebral hemorrhage (CH, 30 cases)、 ischemic cerebrovascular disorders (IC, 25 cases) and control groups (20 cases). Results: Compared with control group, at acute stage of stroke, the Vit C、 E and SOD levels significantly reduced (P＜0. 01), the MDA level significantly increased (P＜0.01); at convalescent stage, the Vit C、 E gradually recover to normal, the SOD still reduced (P＜0.05), the MDA still incresed (P＜0.05). Conclusion: The endogenous Vit C、 E have significant change in patients with acute stage of stroke, it gradually recovers to normal in convalescent stage. Meanwhile the SOD and MDA change accordingly.

Objective: To evaluate the prognostic value of serum troponin Ⅰ (cTnI) in unstable angina pectoris (UA). Methods: Serum cTnI, creatine kinase isoenzyme MB (CK－MB) were simultaneously measured in 25 healthy subjects, 96 UA patients, routine treatment was administered and cardiac events were observed closely within two weeks. Results: Thirteen of 28 UA patients whose cTnI was≥0.3μg/L developed cardiac events, only 3 of 68 UA patients whose cTnI was ＜0. 3 μg/L developed cardiac events within two weeks, there was a significant difference (P＜0. 05). Conclusion: There is a clinical value of serum cTnI measurement in identifying the high risk patients of UA. The patients whose cTnI was≥0. 3μg/L indicate a poor prognosis.

Objective:To explore the clinical application value ofChinese evaluation method of 10-year morbid risk of ischemic cardiovascular diseasesself developed from China.Methods:Chinese evaluation method of 10-year motbid risk ofischemic cardiovascular diseasesdeveloped bv cardiovascular diseaseinstitute of Chinese academy of medical science,was used to evaluate motbid risk of cardiovascular diseases of 2465 community residents in Chaoyang district of Beijing.Relative analysis was done then.Results:(1)Compared with female group,mean values of systolic blood pressure[(122.84±16.42)mmHg vs.(126.83±16.36)mmHg],diastolic blood pressure[(80.67±9.51) mmHg vs.(84.54±9.89)mmHg]and total cholesterol[(4.86±1.06)mmol/L vs.(5.01±0.97)mmol/L]significantly increased in male group,P＜0.001 all;(2)For the ratio of subjects whose 10-year morbid risk of ischemic cardiovascular diseases≥10%(high risk subjects),was of 3.28% in men and significantly more than that of women(1.59%)P ＜0.05.It was consistent withthe data of absolute risk ofischemic cardiovascular diseasesfrom Chinese 9903 cases survey and follow up 15.1 years by the collaborative research group of the Chinese national 10th five years plan project.Conclusion:Chinese evaluation method of 10-year morbid risk of ischemic cardiovascular diseasescan accurately detect distribution condition of morbid risk among population andit makeforto simple screening of high risk population.

Objective:To observe the therapeutic effect of recombinant human brain natriuretic peptide (rhBNP)on patients with cardiorenal syndrome.Methods:The data of 75 patients,who were diagnosed as cardiorenal syndrome and hospitalized in our hospital,were retrospectively analyzed.They were randomly divided into routine treatment group (n=40,received routine treatment)and rhBNP group (n=35,received rhBNP based on routine treatment) according to number table method.The rhBNP was pumped with 0.0075μg·kg-1 ·min-1 using micropump intrave-nously,once/day,about 10h/time and 7d was regarded as a course of treatment.Changes of 24h urine volume,N terminal pro brain natriuretic peptide (NT-proBNP),glomerular filtration rate (GFR)and echocardiograph were recorded in all patients before and 7d after treatment.Results:Compared with routine treatment group after treat-ment,there were significant increase in total effective rate (62.5% vs.94.3%),24h urine volume [(785.2 ± 143.4)ml vs.(965.34±171.8)ml],GFR [(34.1±2.6)ml/min vs.(45.2±5.6)ml/min]and left ventricular e-jection fraction [(35.6±5.5)% vs.(45.9±6.8)%],and significant reduction in NT-proBNP level [(3451.1± 1314.2)pg/ml vs.(1516.43 ± 431.52)pg/ml]in rhBNP group,P<0.01 all.Conclusion:Recombinant human brain natriuretic peptide is safe,effective and can improve renal function in treating patients with cardiorenal syn-drome.