Objective To explore the clinical significance of cytokines expression including CD11b,CD18,IL-8 and IFN-? in patients with psoriasis.Methods 55 patients with psoriases,including vulgaris,pustulosa,arthropathica and erthrodermic ones,were enrolled into the case group and 40 healthy persons as control.The expressions of CD11b,CD18 were detected by flow cytometry,while IL-8 and IFN-? with ELISA.Results The expression of CD11b,CD18,IL-8 and IFN-? in patients with psoriasis was significantly higher than those in control.Conclusions The ultra expression of CD11b,CD18,IL-8 and IFN-? might relate with the immunopathology of lymphocyte cell activation in psoriasis.This might provide the dependable basis for its treatment.

Objective To study the effects of Grape Procyanidins(GPC)on hemorheology in long distance runner.Method In vitro study: 22 long distance runners were divided into two groups randomly,the experimental group and control group.With ten days period,the experimental group was given GPC 200 mg per day;while the control group were given the capsule of starch 200 mg per day.In vivo study: the vein blood samples were taken from 5 long distance runners and every example was divided into five parts,and then treated with different concentrations of GPC or H2O2.Items of the hemorheology such as Er,HCT,Eb,Ep,PFC and VAI were tested both in vivo and vitro before and after the study.Results in vitro study: all items of the experimental group showed significant decline at then end of the study than those before the study.The contents of Er,Eb and Ep before the study(6.830?0.164,4.145?0.177,1.647?0.020,respectively) were significantly higher than those after the study(6.759?0.158,4.088?0.173,1.621?0.013,respectively)(P

Objective To investigate the clinical characteristics and classification of diabetic patients with unprovoked ketoacidosis.Methods According to body mass index(BMI),56 patients were divided into 3 groups: low body weight group(LBW,BMI25 kg/m2,n=20).Clinical characteristics,including age,gender,the course of the disease,positive rate of glutamic acid decarboxylase antibody(GAD-Ab) and the function of islet beta-cell,were compared between these three group.Results There were no significant differences in some clinical features(glycemia,and ketosis status) at beginning of disease between 3 groups.The level of serum TG and Insulin was higher in OBW group than that in other groups.Only 3 patients were found GAD-Ab positive in LBW group.Conclusion The clinical and immunological characteristics of OBW and LBW patients were quite different,some of the obese patients should be classified into type2 diabetes,and some into idiopathic type1 diabetes.

Objective To investigate whether the combination of glipizide-XL with glucophage was more rational in insulin resistance and insulin secretion in patients with type 2 diabetes mellitus(T2DM).Methods The changes of insulin resistance and insulin secretion were evaluated from variations of IAI(insulin sensitivity index),IR(insulin resistance index.),IS(insulin secretion index)and HBCI(B-ce1l function index)in cases treated with glipigide-XL and glucophage or either for 18 weeks.Results IAI\IR standing for insulin resistance were higher significantly,and IS & HBCI standing for insulin secretion were lower significantly in patients with T2DM than in normal group(P

Objective To find out the main influence factors for smoking cessation.Method The follow-up survey was carried out in the 300 persons among participants from international Quit &Win in 2004 in TianJin,and they were interviewed by phone or face to face.Result The smoking cessation rate of one year was 51.00%.The effect of smoke quitting was the same among age,marriage and educated history,but different in occupation Smoking relapse was affected by the surrounding people.Conclusion The effect of smoking cessation were satisfactory,some measures should be adopted according to the influence factors for the quitting.

Objective To explore the controlling level of fasting blood glucose(FBG) and glucosylated hemoglobin(GH) in order to stop occurrence of nephropathy in diabetic mellitus.Methods Data was collected by retrospective study,analyzed by non-conditional Logistic regression.Then the controlling levels of blood glucose and glucosylated hemoglobin were studied by regression equation.Results It was regarded that under 6.8 mmol/L of FBG and 5.9% of GH,diabetic nephropathy can be prevented;while under 6.0 mmol/L of FBG and 5.3% of GH,the onset of diabetic nephropathy was strictly controlled.Conclusion it is more important to control strictly on the threshold of fasting blood glucose and glucosylated hemoglobin for prevention of diabetic nephropathy.

Objective To investigate the relationship between smoking and the occurrence of pulmonary tuberculosis among type 2 diabetics(DM-PTB).Methods A hospital-based case-control study was carried out at three hospitals in Tianjin from 2001 to 2002.87 cases of newly-diagnosed pulmonary tuberculosis with type 2 diabetes mellitus and 129 controls by frequency-matched by gander and age were recruited and interviewed.Univariate and multivariate unconditional logistic regression analysis was conducted.The adjusted odds ratio(OR) and 95% confidence interval(CI) were estimated.Results Higher smoking index(OR=1.399,95%CI=1.098～1.782)?beginning smoking at younger(OR=2.028,95%CI=1.076～3.821)?large consumption of cigarets per day(OR=1.349,95%CI=1.087～1.674)?no smoking cessation after diabetes diagnosis(OR=5.327,95%CI=1.703～16.661) were significantly associated with DM-PTB after adjusted for other risk factors.Among female diabetics large consumption of cigarets per day? beginning smoking at younger higher smoking index were generally associated with increased risk of pulmonary tuberculosis;while without smoking cessation after diabetes diagnosis might be risk factor among the male;higher smoking index might increase the risk of pulmonary tuberculosis among younger(youger than 60y) diabetics.Conclusion Smoking control or cessation among type 2 diabetics might decrease the risk of pulmonary tuberculosis.

Objective To evaluate the compliance effect of secondary prevention on high risk patients of gastric cancer and to investigate their knowledge,attitudes,and practice about gastric cancer.Methods 206 high risk patients of gastric carcinoma cancer were investigated with questionnaires.Results of all cases,54 patients were compliant,69 patients semi-compliant,and 83 patients were not compliant in monitoring cohort.The results showed distribution of the compliant patients was significantly different with their gender,occupation and family income per person,and not significant with their education background.Conclusion The compliance and KAP of the patients on high risk for gastric cancer aren't satisfied,which needed to be enhanced in the future.

Objective To investigate the levels of serum high sensitive C-reactive protein(hs-CRP) in different stages of diabetic nephropathy and the relationship between hs-CRP and relative metabolic indexes.Methods According to their urinary albumin excretion rate(UAER),164 patients with type2 diabetes mellitus were divided into three groups: 51 patients with normal UAER,59 patients with microalbuminuria and 54 patients with clinical proteinuria.The concentration of hs-CRP,relative clinical biochemical profiles and the body height,weigh,systolic & diastolic blood pressure were measured and analyzed.Correlation analysis was also done between hs-CRP and other relative indexes.Result The levels of hs-CRP were increased with increment of UAER.Pearson correlation analysis and stepwise linear regression indicated that hs-CRP was positive correlated with duration,triglyceride(TG),BMI,MAP,HOMA-IR,fibrinogen(FIB),UAER,serum creatinine(Cr),HbA1C,but negative correlated with high-density lipoprotein(HDL-C) and HOMA-B.The levels of hs-CRP in female were higher than those in male.Conclusion High level of serum hs-CRP concentration maybe a risk factor for the onset of type2 diabetes mellitus and diabetic nephropathy.

Objective To investigate the effect of insulin resistance(IR) on the persons with abnormal blood glucose who underwent dietary interventions.Methods 194 individuals with abnormal blood glucose were selected from hyperlipidemia population taking the community intervention program in districts of Beijing.The insulin resistance and insulin action index(IAI) were calculated with fasting blood glucose(FBG) and fasting blood insulin(FINS),and analyzed the relationship of variety on their blood glucose,serum lipids and body weight,body mass index(BMI),waist circumference,waist hip ratio(WHR).Results 1) Blood glucose(FBG),triglyceride(TG),waist circumference and WHR had significant positive relationship with IR but negative with IAI;2) In the intervention group,FBG and TG were reduced significantly in the subgroup with highest IAI.Conclusions IR was related with blood glucose,serum lipids,waist circumference and WHR,but no significant relation with body weight and BMI;It was possible that IR had some effect on dietary intervention.