Objective:By analyzing the construction of the university-enterprise joint R&D platform of Peking University Health Science Center, this study aimed to provide effective support for universities, especially medical universities, and to enhance their scientific and technological innovation capacity and adapt to the requirements of high-quality development of the innovation integration of national universities.Methods:This study to analyzed and summarized the construction and work experience of the university-enterprise joint R&D platform of Peking University Health Science Center from 2020 to 2023.Results:The university-enterprise joint R&D platforms of Peking University Health Science Center have achieved initial results in project collaboration, paper production, patent applications, and research reports by standardizing its management mechanism and leveraging its disciplinary advantages.Conclusions:It is suggested to strengthen management mechanisms, long-term operation, rights protection, transformation orientation, new model exploration, and other aspects, thereby continuously encouraging the co-construction of universities and enterprises and promoting innovation and integration.

Objective:This study aimed to introduce the technology transfer mechanism of Mayo Clinic and explore its implications for public hospitals in China.Methods:This study summarized Mayo′s technology transfer concept, management mechanism, and operation model through typical case analysis.Results:Mayo adhered to the core value of patient needs first and took it as the foundation for business operations. It practiced the operation management model of joint development of medicine, education, and research, and built a sound organizational structure, high-quality talent reserves, and a complete resource support system, which assisted in the birth of high-quality and transferable achievements.Conclusions:Public hospitals should optimize technology transfer from awareness, clinical orientation of basic research, translational medical system throughout the entire industry chain, specialized achievement transformation management team, and talent incentive mechanism.

Objective:This study aimed to explore the management system and procedures for broad consent in healthcare institutions for the effective and efficient implementation of broad consent, to protect the rights and interests of research participants, and to improve research efficiency.Methods:Using the 6W2H analysis method, key decision points such as background, goal orientation, operating mode, time node, applicable scope, key roles, procedure operation, and operating costs were explored and analyzed.Results:Broad consent should be implemented to protect the rights and interests of research participants as the primary core goal, and collaborate with multiple departments to establish a matching management system.Conclusions:The implementation of broad consent still faces many challenges. It is necessary to improve the scientific ethics governance system, increase the popularization of science to win public support, and strengthen the supervision of personal information protection.

Objective:Referring to the Code of Medical Research Integrity and Related Conduct, to investigate the current status of scientific research integrity management of tertiary medical institutions, and to understand the current status and possible problems of scientific research integrity construction in working mechanism, institutional specifications, education guidance, supervision and punishment of various institutions.Methods:An electronic questionnaire was distributed to 72 researchers covering 46 tertiary medical institutions. The research content included basic information about the institution, the construction of the management mechanism, and the current status of research integrity management.Results:All of the surveyed medical institutions established scientific research integrity systems, publicized the policy of scientific research integrity regularly, carried out self-inspection, and conveyed the cases of notifications and alerts.84.29% of units had ″related courses for academic norms/scientific research integrity″, training were set up in ″student enrollment″ for 82.86% of the units, in ″employee recruitment″ for 94.29% of the units, in "project application" for 84.29% of the units, etc. The incidence of research misconduct in medical institutions, in descending order, is improper authorship, duplicate application, split publication, failure to obtain ethical approval, and multiple submissions. The contributing factors came from the pressure of title promotion(72.86%), the lack of scientific research integrity knowledge (71.43%), and interest motivation(70%). The analysis showed that there was a correlation between the ″convenient and open channels for research misconduct complaints and reports″ and the occurrence of ″scientific research misconduct″.Conclusions:The tertiary medical institutions have well-established scientific research integrity management systems, have taken scientific research integrity as a regular management feature, and have used diversified publicity, education, and training methods to promote academic norms and knowledge of research integrity.

Objective:This study aimed to explore the challenges faced by colleges and universities in performing their institutional responsibilities set forth by the Ethical Review Measures of Life Science and Medical Research Involving Human Participants (hereinafter referred to as the Measures), demonstrate the key points and main challenges in standardizing the ethical review and ethical management of colleges and universities, to provide a possible reference for daily working practices.Methods:Based on the interpretation of the policy document, combined with practical experiences in ethical review and ethical management, this paper summarized identified problems faced and proposed feasible practical suggestions.Results:The Measures strengthen the ethical review norms for life science and medical research involving human participants by reaffirming the responsibility of institutions. Colleges and universities might face some challenges and more systematic design is needed.Conclusions:The ethical review and ethical management work at colleges and universities need further consideration, top-down design model should be developed, to set work priorities, and at the same time, more innovative ways should be adopted to facilitate ethical review reliance and coordinate more streamlined review of cooperative research, and improve the quality and efficiency of ethical review promptly.

Objective:This paper analyzed the current situation of clinical research continuing review in China, and puts forward countermeasures to strengthen continuing review in combination with the requirements of the Measures for the Ethical Review of Life Science and Medical Research Involving Humans, so as to provide a certain reference for standardizing the ethical continuing review of research institutions.Methods:Through literature research, this paper systematically sorted out the current situation of continuing review, and analyzed many problems and related reasons in the process of continuing review of clinical research in China based on the practical experience of ethical review.Results:The requirements for continuing review in the Measures for Ethical Review of Life Science and Medical Research Involving Humans included demphasizing the implementation of continuing review, the entrusted ethics committee should be responsible for continuing review, clarifying the responsibility for continuing review of cooperative research, clarifying the responsibility of participating research institutions for continuing review, and increasing the responsibility of the ethics committee to supervise the submission of continuing review. Countermeasures to strengthen continuing review included the health authorities urging research institutions to strengthen continuing review, research institutions to increase efforts to implement continuing review, establishing a standardized continuing review process, strengthening the ethics training of researchers and other relevant personnel, establishing a multi-channel communication and consultation method between the ethics committee and researchers, strengthening the review capacity of ethics committee members, allocating a corresponding number of ethics committee staff, and using information technology to improve quality and efficiency.Conclusions:Continuing review is indispensable in the whole process of research development, and all parties should take measures to ensure the quality and efficiency of continuing review, standardize continuing review, and promote the healthy development of life science and medical research.

Objective:This study aimed to explore the implementation plan of the grid management joint scientific research clinic and to evaluate its impact on enhancing the scientific research capabilities of nursing staff.Methods:Nursing research team developed an implementation strategy for the grid management joint scientific research clinic in 2023 and then promoted it across the hospital. The scores of nursing staff were compared on the self-evaluation scale, general self-efficacy scale, and research innovation achievements before (April-December 2022) and after (January-September 2023) the implementation.Results:The research capabilities of nurses increased significantly from 103.13±2.56 to 141.32±18.09 ( P<0.001), and their self-efficacy increased significantly from 1.95±0.26 to 2.15±0.53 ( P<0.001). The number of college-level and above scientific research projects, the number of journal publications, the number of authorized patterns, the number of participation in academic exchanges at the municipal level and above in nursing societies, and the number of scientific research awards at the municipal level and above all increased compared with the previous ones with statistical significance. Conclusions:Implementing the grid management joint scientific research clinic is beneficial for improving overall nursing research capabilities, nurses' self-efficacy, and the effectiveness of scientific research training. This provides a reference for other hospitals to enhance the training of nursing staff's scientific research capabilities.

Objective:To test the practical effect of the research projects outpatient strategy for application of the National Natural Science Foundation (NSFC) in a hospital of Chinese medicine.Methods:We compared the number and success rate of the National Natural Science Foundation of China grant awards before and after the implementation of the research projects outpatient strategy, and further analyzed the promotional effect of the research projects outpatient strategy on general programs and youth scientists funds through univariate analysis and multivariate Logistic regression.Results:Since the implementation of the research projects outpatient strategy, both the number of NSFC grant awards and the success rate continuously increased, indicating that the strategy played a positive role in improving the overall success rate of the hospital. However, this effect was primarily reflected in the assistance provided to applications for youth scientists funds. The main favorable factor for winning general programs was the applicant′s preliminary foundation. Applicants who have previously received NSFC funding had a higher success rate.Conclusions:The strategy of research projects outpatient can promote the winning of NSFC youth scientists funds.

Objective:This study aimed to analyze the specific measures and practical effects of standardizing the management of patent conversion work in a certain district tertiary hospital, aiming to provide valuable references and guidance for improving patent conversion management for other hospitals of the same level.Methods:This study selected a series of standardized management measures taken by the hospital from July 2022 to December 2023 as the research object, including but not limited to the approval process before patent application, the combing and optimization of the approval process of patent conversion application, and the formulation and implementation of the tax reduction system and other policies.Results:The smooth implementation of various standardized management patent transformation measures in the hospital effectively improved the efficiency of patent quality control and patent conversion. Specifically, it was reflected in the shortening of the ″application conversion contract signing″ period, as well as a significant increase in the total number of patent implementation conversions and the total amount of conversion contracts signed.Conclusions:By standardizing the management of hospital patent conversion, not only can the efficiency and success rate of patent conversion be effectively improved, but also can effectively promote the development of hospital innovation and conversion work.

Objective:This study aimed to analyze the focuses and shortcomings of the current medical achievements transformation policy, and to put forward references and suggestions for the subsequent formulation of medical science and technology innovation achievement transformation policy.Methods:46 policy texts were retrieved from Peking University Magic Treasure, Law Star, and other related websites of the State Council, the National Health Commission, the State Administration of Traditional Chinese Medicine, and other relevant ministries and commissions, and the policy clauses were systematically quantitatively analyzed from three dimensions of supply, demand, and environment using policy tool theory.Results:The number of policy documents issued from 2015 to 2022 showed a fluctuating increase. There were 25 normative policies, accounting for 54.3%, and 21 guiding and operational policies, accounting for 45.7%. Environmental policies accounted for 74.9%, while demand-oriented policies accounted for 3.1% among the 587 codes.Conclusions:It is suggested to reduce the dependence on environment-based policy tools, optimize the distribution structure of sub-categories such as tax incentives and financial support, strengthen the support of supply-based policy tools to promote the high-quality development of the transformation of medical scientific and technological achievements, increase the driving role of demand-based policies to enhance the appropriate allocation of clinical demand, further optimize the policy system for the transformation of medical scientific and technological achievements, and strengthen the supporting measures of relevant special policies.