1.Crosstalk between macrophage-delivered cytokines and cyclooxygenase-2 in breast cancer microenvironment
Weixian CHEN ; Jianhua ZHAO ; Jinhai TANG
Chinese Journal of Clinical Oncology 2013;(13):811-814
A new target in cancer treatment involves tumor-associated macrophages (TAMs) which are infiltrated in microenvi-ronment. By secreting a wide range of cancer-promoting cytokines, such as vascular endothelial growth factor, interleukins, and matrix metalloproteinase, TAMs can promote the proliferation, invasion, and metastasis of cancer cells. Cyclooxygenase-2 (COX-2), an inflam-matory factor that is significant for angiogenesis and immunoregulation within the local microenvironment, may also contribute to can-cer progression and act as a novel target for breast cancer therapy. Several COX-2 inhibitors, such as celecoxib, have shown potential as suppressors of TAMs and the microenvironment. Hence, the current study discusses the crosstalk between TAMs-delivered important cytokines and COX-2 in the breast cancer microenvironment, and then analyzes the value of homologous antagonists alone or in combi-nation with COX-2 inhibitors. This paper aims to provide the theoretical principle of multi-target selection in TAMs blockage, and offer a new direction for biological targeted therapy in breast cancer treatment.
2.Research progress of bladder cancer-related factors
Juanjuan ZHU ; Yun ZENG ; Baoxue YANG
Chinese Journal of Clinical Oncology 2013;(12):741-744
10.3969/j.issn.1000-8179.2013.12.015
3.Clinical observation and follow-up study on oxaliplatin-related neurotoxicity in patients with resectable colorectal cancer
Huilong LIU ; Li WANG ; Jia JIA ; Yanfang LIU ; Fei WANG ; Hongying LI
Chinese Journal of Clinical Oncology 2013;(12):725-729
10.3969/j.issn.1000-8179.2013.12.011
4.Treatment outcomes of different radiotherapies for postoperative gliomas：three-dimensional conformal radiotherapy versus conven-tional radiotherapy
Junbao WEI ; Xiaodong ZHU ; Long CHEN ; Yunli YANG ; Jiangqiong HUANG ; Yingxin LIU
Chinese Journal of Clinical Oncology 2013;(12):721-724
10.3969/j.issn.1000-8179.2013.12.010
5.SAHA inhibition of the human ovarian cancer cell line SKOV3 in vitro
Zheng WANG ; Weiguang WU ; Hongliang YAN ; Zhaoling SUN ; Yajuan TANG
Chinese Journal of Clinical Oncology 2013;(12):698-701
10.3969/j.issn.1000-8179.2013.12.004
6.Pseudomonas aeruginosa injection inhibits proliferation of human carcinoma cell lines
Yibing LIU ; Dali HU ; Yumeng ZHOU ; Qiling HUANG ; Shiyun PAN
Chinese Journal of Clinical Oncology 2013;(12):694-697
10.3969/j.issn.1000-8179.2013.12.003
7.Cytokines secreted by cytokine-induced killer cells modulate resis-tance to cisplatin in the A549/DDP cell line
Yanjuan XIONG ; Chunjuan DU ; Jinpu YU ; Shui CAO
Chinese Journal of Clinical Oncology 2013;(12):685-689
10.3969/j.issn.1000-8179.2013.12.001
8.Research progress of chemokines and chemokine receptors in colorectal cancer
Cui WANG ; Dongzhi HU ; Jianzhong LIU
Chinese Journal of Clinical Oncology 2013;(12):745-748
10.3969/j.issn.1000-8179.2013.12.016
9.Advances in the relationship between thymidine phosphorylase ex-pression and colorectal carcinoma
Chinese Journal of Clinical Oncology 2013;(12):736-740
10.3969/j.issn.1000-8179.2013.12.014
10.Prognostic factors and clinicopathological characteristics of small gastrointestinal stromal tumor of the stomach：A retrospective study of 31 cases
Zhen HUANG ; Yuan LI ; Hong ZHAO ; Jianjun ZHAO ; Jianqiang CAI
Chinese Journal of Clinical Oncology 2013;(12):730-732
10.3969/j.issn.1000-8179.2013.12.012
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