1.Clinical anesthesia drugs and patient safety
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):447-448
With the development of modern medicine, anesthesia has become a separate subject, anesthesia is safe or not is directly related to the safety of patients with surgery and anesthesia in the whole process, there are security risks every kind of. Therefore, how to in the hospital in strict control of anesthesia safety hazards, ensure the patients with surgical treatment safety, has become an important subject, establish relevant measures according to various risk factors is very important.
2.Comparative analysis of radiotherapy and 89Sr radionuclide therapy in the treatment of cervical metastatic cancer pain
Qi YANG ; Jianqiang WANG ; Fan ZHOU ; Xueyuan FAN ; Liqiang ZHONG ; Yuming JIA
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):436-437
Objective To compare the effect of 89Sr radionuclide therapy and radiotherapy in the treatment of metastatic cancer pain of vertebral column. Methods 80 patients with cancer pain of vertebral metastasis in the second People's hospital of Yibin from April 2015 to April 2017, were randomly divided into the control group treated by radiotherapy treatment (n=40) and the the observation group treated by 89Sr radionuclide therapy(n=40), and the effect of treatment were compared between two groups. Results In the observation group, the total effective rate of pain response in patients with metastatic cancer pain of vertebral column was 85.0%, and the control group was 82.5%. There was no significant difference between two groups. The onset time of treatment in the observation group was (6.5±1.7)d, significantly shorter than that of the control group (12.9±2.6)d, and the difference was statistically significance (P<0.05). Conclusion The application of 89Sr radionuclide therapy in the treatment of vertebral metastatic pain is equivalent to the radiotherapy in improving the pain response, but the efficacy could be achieved in a short period of time, so it is worth popularizing widely in clinical practice.
3.Clinical analysis of non-obstructive ureteral calculi with drug- enhanced ultrasonography
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):434-435
Objective To investigate the clinical effect of drug enhanced ultrasonography in the diagnosis of non obstructive lower ureteral segments. Methods 60 cases of non obstructive lower ureteral calculi were treated in our hospital from January 2015 to January 2017. They were divided into 2 groups according to different diagnostic methods. The patients in the control group were diagnosed by X ray digital tomography, and the observation group were treated with drugs to enhance the diagnostic value of ultrasonography. The clinical diagnosis of two groups of patients were recorded in detail, and the data obtained were compared and analyzed.Results The diagnostic effect of the observation group was better than that of the control group, the diagnostic accuracy of the separation of the ipsilateral pelvis and ureter diameter was higher than that of the control group, and the diagnostic accuracy rate of the stones was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion The drug enhanced ultrasound imaging in diagnosis of patients with non obstructive ureteral stones of high value, the accurate diagnosis of patients with renal pelvis and ureter diameter light separation, the diagnostic rate, it is widely used in clinical.
4.Comparative study of laparoscopic surgery combined with chemotherapy drugs in patients with cervical cancer
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):423-424
Objective To investigate the clinical efficacy of laparoscopic surgery combined with chemotherapy drugs in patients with cervical cancer. Methods 60 patients with cervical cancer treated in our hospital from January 2015 to July 2016 were randomly divided into two groups:control group (n=30) and observation group (n=30). The two groups were treated with chemotherapy, the control group was treated with open surgery, the observation group was treated with laparoscopic surgery, the clinical efficacy of the two groups were compared. Results The operation time of the observation group was longer than that of the control group (P<0.05). The amount of bleeding, the exhaust time and the length of stay in the observation group were shorter than those in the control group (P<0.05). Conclusion Laparoscopic surgery for cervical cancer patients is effective, less trauma, and is conducive to postoperative recovery. It is worthy of popularization and application.
5.Diagnostic value and clinical analysis of combined detection of serum H-FABP, hs-CRP and cTnT in patients with myocardial infarction
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):409-411
Objective To evaluate the diagnostic value of serum cardiac fatty acid binding protein (H-FABP), high sensitivity C-reactive protein (hs-CRP) and cardiac troponin T (cTnT) in the diagnosis of myocardial infarction. Methods From August 2015 to July 2016, 50 patients with myocardial infarction were treated as group A, and 48 patients with chest pain caused by other factors were treated as group B, and 53 patients were selected in our hospital physical examination of patients without chest pain as C group. The levels of H-FABP, hs-CRP and cTnT were compared between the three groups. The levels of H-FABP, hs-CRP and cTnT in patients with myocardial infarction at 5 h, 10 h, 24 h and 3 d after admission were compared . Results The positive rate of serum H-FABP, hs-CRP and cTnT in group A was significantly higher than that in group B, group C[(82.00%, 41.00), 68.00% (34/50), 76.00% (38/50) VS 8.33%(4/48), 14.58%(7/48),10.42%(5/48) VS 0.00%(0/53),0.00%(0/53),0.00%(0/53)], and the difference was statistically significant (P<0.05). The positive rate of H-FABP and hs-CRP was higher than that of admission at 10 h, 24 h and 3 d at 5 h after admission. The positive rate of cTnT was higher than that at 5 h, 24 h and 3 d at admission (P<0.05). The positive rate of H-FABP was significantly higher than that of the control group (P<0.05). Conclusion Combined detection of serum H-FABP, hs-CRP and cTnT can improve the diagnostic value of myocardial infarction and reduce the misdiagnosis rate.
6.Research Progress on Bioactivity of Hydroxytyrosol
Jixu WU ; Xinyan GUO ; Xiangjing MENG ; Fei LIU ; Peixue LING
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):443-446
Olive oil is one of the important byproducts in agriculture. It is rich in oleuropein, which can be hydrolyzed into several bioactive phenolic compounds, including hydroxytyrosol (HT).There are many literatures have been confirmed that HT has significant pharmacological effects in the anti-inflammatory, anti-virus, regulation of metabolic disorders and treatment of degenerative diseases. However, HT has severe instability in vivo and in vitro. It is a challenge how to improve its stability through structural transformation or utilization of pharmaceutical means to processing. This paper will focus on biological activity of HT and its stability improvement, and provid some new ideas for expanding the research and promoting the development of HT in the field of Medicine.
7.Effect analysis of continuous epidural anesthesia and psychological intervention in painless labor
Wei JIANG ; Jingjun YING ; Hua LI
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):441-442
Objective To analyze the clinical effects of continuous epidural anesthesia and psychological intervention in painless labor. Methods From June 2016 to December 2016110 cases of maternal treatment in Ningbo city town of dragon longsai hospital as the research object, randomly divided into control group and observation group, control group of women to provide continuous epidural anesthesia, the observation group in continuous epidural anesthesia combined with psychological intervention measures. Results The two groups of pregnant women at different time scales VAS score, duration and other indicators, the data into the SPSS software, given the corresponding analysis and draw conclusions. Results The two groups of pain VAS score had no significant difference, the observation group each time after analgesia VAS score decreased than the control group(P<0.05); the first stage of the observation group was shorter than the control group (P<0.05), there was no significant difference between the 2 groups of second, third labor time. Conclusion Conclusion Epidural anesthesia and psychological intervention combined with painless labor have good analgesic effect and shorten the first stage of labor. .
8.Effect of rapid rehabilitation surgery on the curative effect and pulmonary function of elderly patients with lung cancer
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):438-440
Objective To study effect of rapid rehabilitation surgery on the curative effect and pulmonary function of elderly patients with lung cancer. Methods 240 patients of lung cancer who received therapy from March 2014 to March 2016 in Ningbo Yinzhou People's Hospital were selected as research objects. According to the draw method divided into control group and experimental group, 120 cases ineach group. The control group was treated with routine nursing intervention, while the experimental group was treated with concept intervention of rapid rehabilitation surgery. Then extubation time, exhaust time, antibiotic use time, ambulation time, hospitalization time, lung function index, the MOS item short from health survey (SF-36) and Visual Analogue Scale/Score(VAS ) , adverse reactions rate of two groups were compared. Results The extubation time, exhaust time, antibiotic use time, ambulation time and hospital stay in the experimental group were significantly lower than those in the control group, the difference was statistical y significant (P<0.05); The levels of forced expiratory volume in one second (FEV1), forced vital capacity(FVC), forced expiratory volume in one second(FEV1/ FVC)were significantly higher than those of the control group, the difference was statistical y significant (P<0.05),Psychological quality, role quality, physiological quality and social quality score were significantly higher than those of the control group, the difference was statistical y significant (P<0.05), VAS scores were significantly lower than those in the control group, the difference was statistical y significant (P<0.05). The total incidence of adverse reactions was significantly lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion The concept of rapid rehabilitation surgery has significant curative effect on elderly patients with lung cancer surgery, can improve the pulmonary function, reduce the incidence of complications, reduce the length of stay and benefit the prognosis of patients.
9.Application analysis of MSCT multiphase enhancement scanning in the atypical hemangiomas
Zhe GONG ; Shenrong ZHANG ; Zhiqin TONG
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):431-433
Objective To analyze multislice CT (MSCT) multiphase multiphase enhancement scanning in the atypical hemangiomas. Methods During February 2013 from January 2014, chosing125 cases of patients with atypical hemangiomas in our hospital were retrospectively analyzed. Results There was a total of 240 lesions in 125 patients, multiple (2 or higher) in a total of 70 cases, 55 cases of single. A total of 170 were located in the right lobe, 70 were located in the left lobe, lesions was 0.8 to 4.5 cm in diameter, the average was (2.53±0.21) cm. A total of 205 lesions were circular, a total of 35 as lobulated or irregular. CT scan, a total of 155 were low density, 85 in equal density. A total of 120 state clearly, realm for part of the fuzzy and parts out of a total of 35, 85 was fuzzy. A total of 45 lesions density uneven, a total of 195 was lesions density uniformity. In 240 intrahepatic lesions, a total of 145 lesions present performance1, 80 lesions belong to 2 kinds of forms, 15 lesions characterized by 3 kinds of forms. Conclusion Although a few hemangiomas reinforcement is not typical, by the mutiperiodic enhanced MSCT scanning remain their respective characteristics, in identification of its pathological changes has important diagnostic value.
10.Four changes of plasma D- dimer and coagulation in pregnant women at different stages of pregnancy and their value of test
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):429-430
Objective To observe and analyze the four changes of plasma D- dimer and coagulation in pregnant women at different stages of pregnancy, and to explore the value of the test. Methods The subjects of this study were 120 pregnant women who underwent routine physical examination in our hospital, according to different stages of pregnancy (early pregnancy, middle pregnancy, late pregnancy, and before delivery) Four D- dimer and four blood coagulation tests were performed in pregnant women, and the results were observed and compared. Results During the pregnancy, D- dimer has increase trend (P<0.05); early in pregnancy, pregnancy and late pregnancy, PT has shortened(P<0.05); pregnancy, APTT has shortened (P<0.05), at the end of pregnancy and parturient period, showing a significant shortening (P<0.05); phenomenon in early pregnancy to mid pregnancy stage, FIB increased significantly (P<0.05), and at the end of pregnancy to perinatal period, with a sharp increase (P<0.05). Conclusion It is of great significance to perform dynamic monitoring of of plasma D- dimer and coagulation four indices in pregnant women during pregnancy.

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