Objective To explore the clinical efficacy of combination therapy with promethrin and gliclazide sustained-release tablets in the treatment of obese patients with type 2 diabetes mellitus with poor blood glucose control. Methods Selected from December 2015 to March 2017 in our hospital treated 96 cases of insulin treatment of poor blood glucose control in obese patients with type 2 diabetes, were randomly divided into study group and control group, 48 cases in each group.The study group were treated with Novolin 70/30(Novolin 30R)combined with Gliclazide Sustained-release Tablets,while the patients in control group were treated with Novolin 30R combined with repaglinide. Results The decrease of FBG, 2h PG, HbAlc, HOMA-IR and the increase of HOMA-IS in the study group were better than those in the control group (P<0.05).There was no significant difference in BMI between the two groups after treatment and BMI in the control group was significantly higher than that before treatment (P<0.05),CRP was not statistically significant before treatment.Conclusion The application of Novolin 30R and Gliclazide Sustained-release Tablets after treatment can make the use of insulin alone poor glycemic control in obese patients with type 2 diabetes have more desirable clinical efficacy,is conducive to ensuring the safety and effectiveness of drugs.

Objective To study the clinical value of ultrasonography in the diagnosis of ketamine associated cystitis. Methods 60 cases were confirmed by pathological examination to determine the occurrence of ketamine associated cystitis in clinic, all patients underwent ultrasound examination, recording bladder morphology, wall thickness, cavity size (thickness, diameter, length and diameter), calculation of residual urine volume and bladder capacity according to the relevant data. The pictures were assigned to 2 or more specialists, and the double blind scan was used. The ultrasonographic findings of 60 patients with ketamine associated cystitis were recorded and compared with the pathological diagnosis. Results 60 cases of ketamine related cystitis were successfully examined with no interruption and withdrawal. The success rate of ultrasonography was 100.00％. The analysis showed that the coincidence rate of ultrasonography and pathological diagnosis was 60 (91.67％ and 8.33％) respectively, and there was no significant difference between the two groups. Conclusion the use of ultrasound has a detection rate of ketamine associated cystitis ideal, to provide a reliable basis for the diagnosis and treatment of ketamine associated cystitis doctor, has important value on the quality of life of patients with treatment effect and security.

Objective To investigate the effect of metronidazole powder on the prevention of alveolalgia after extraction of mandibular impacted teeth. Methods two groups of mandibular teeth underwent surgical removal treatment, study group for teeth after Metronidazole Tablets will grind it into powder and dexamethasone sodium phosphate filling extraction wound and sutured; the control group were only given mandibular teeth tight control suture. Two groups of patients with postoperative mandibular impacted teeth were treated with oral amoxicillin for 1 weeks and effective follow-up, record the occurrence of dry socket, the data input SPSS software to give the corresponding analysis and conclusions. Results The incidence of dry socket after tooth extraction was 3.45％ in the study group and 20.69％ in the control group. The difference between the 2 groups was statistically significant(P<0.05). Conclusion Application of metronidazole powder of mandibular impacted tooth extraction, can significantly reduce the incidence of alveolalgia, it is worthy of clinical application.

Objective To investigate the effect of ceftidine in operating room intervention and its effect on the quality of intervention. Methods Select 2016 May to May 2017, hangzhou normal university affiliated hospital operating room of our hospital, 366 cases of patients with skull, 2 groups randomly divided into two groups, control group routine surgery, the team combined use of cephalosporins he totally, compared two groups of two groups patients therapeutic effect. Results The intracranial infection was significantly lower in the two groups than in the control group (P<0.05). In the two groups, the number of live bacteria and the comparison of enzyme value were significantly lower than that in the control group (P <0.05). Intervention quality compared two groups of 2 groups of patients, the team of PCT in patients with calcitonin (former) and CRP (CRP), TNF alpha (tumor necrosis factor alpha) and white blood cell count were significantly lower than control group (P< 0.05). Conclusion Children with oral ulcer treatment, the therapeutic effect of smecta ideal, clinical application shall be the head to prevent the use of cephalosporins in patients with surgical intervention in the operating room he totally, can improve the quality of intervention, reduce the incidence of infection.

Objective To summarize and analyze the effect of mannitol combined with Xueshuantong on the treatment of early swelling and pain in patients with tibial and fibula fracture. Methods In Huzhou central hospital from June 2014 to January 2017, 100 cases with early swelling and pain with tibia and fibula fractur were divided into the observation group (50 cases) and the control group (50 cases). The control group were given routine mannitol combined with Xueshuantong treatment and routine nursingcare, at this basis, the observation group were received nursing intervention. The effect of the treatment and nursing in the two groups were compared. Results The total effective rate, nursing service satisfaction and the VAS score after treatment between the two groups were statistically significant (P<0.05). Conclusion The treatment of mannitol combined with Xueshuantong and strengthening clinical nursing intervention is helpful to improve the therapeutic effect and alleviate the pain of the patients with early swelling and pain with tibia and fibula fracture.

Objective To observe the application of allopurinol in the treatment of gouty nephropathy, and evaluate its clinical effect on the level of serum creatinine and urea nitrogen. Methods Patients with gouty nephropathy from April 2015 to May 2017 in Xining first people's hospital 126 patients as the research object, divided into observation group and control group of 63 cases with double blind random method, given the reference group of patients basic treatment, the observation group treated with allopurinol in the reference group on the basis, effects were compared between the two groups the clinical therapeutic effect and serum creatinine and blood urea nitrogen, blood pressure level. Results After 12 months of therapy, compared two groups of patients before treatment, serum uric acid, creatinine, blood urea nitrogen, blood pressure (systolic blood pressure, diastolic blood pressure) were improved, and the observation group was obviously better than that of control group (P<0.05); the observation group total efficiency of treatment group was 88.89％ (56/63), the reference group was 74.60％ (47/63), with significant difference between two groups (P<0.05). Conclusion Allopurinol can be used in the treatment of gouty nephropathy. It can help to improve the clinical effect and improve the clinical symptoms of the patients. It is of practical value.

Objective To investigate the clinical effect of vitrectomy with single slice vitrectomy (PDR) and preoperative injection of monoclonal antibody (mAb) for treatment of proliferative diabetic retinopathy. Methods According to clinical treatment were randomly 64 cases of PDR patients in our hospital in February 2016-February 2017 were divided into observation group and control group, 32 cases (37 eyes) single vitreous body resection were included in the control group, the remaining 32 cases (41 eyes) from preoperative intravitreal injection 0.5mg Lei Zhu monoclonal antibody drug treatment after resection of vitreous body were included in the observation group. The operation time, the best corrected visual acuity before and after the operation were recorded and compared between the two groups. The incidence of iatrogenic hiatus, frequency use, vitreous volume and hyphema were recorded in the two groups. Results The operation time of the observation group was (96.47±12.67) min, which was significantly shorter than that of the control group (128.56±13.78) min (P<0.05). The best corrected visual acuity of the two groups was basically at the same baseline level, and the corrected visual acuity of the 30d observation group was obviously improved and better than that of the control group (P<0.05). Compared with the control group, the incidence of iatrogenic hiatus, electrocoagulation, vitreous volume and hyphema was lower in the observation group (P<0.05). Conclusion Intravitreal injection of ranibizumab therapy after resection of vitreous body regimen in the treatment of PDR is safe and effective, not only helps to shorten the operation time, and lower incidence of postoperative complications, postoperative recovery of visual acuity is good, it is worthy of clinical popularization and wide application of bed.

Objective To investigate the clinical efficacy of amoxicillin combined with pectin in the treatment of chronic atrophic gastritis. Methods According to the different treatment methods will be January 2015 to March 2017 patients with chronic atrophic gastritis in our hospital 80 cases groups:control group with clarithromycin+amoxicillin+bismuth pectin bismuth pectin treatment,observation group treatment;detailed records of two groups before and after treatment(pathological atrophy,intestinal metaplasia,dysplasia,chronic the inflammatory activity and the integral changes),the levels of inflammatory factors(IL-2/IL-6/CRP)incidence level changes and adverse reaction,the obtained related data for comparative analysis. Results Amoxicillin and bismuth pectin(observation group)in treatment of chronic atrophic gastritis is better than clarithromycin+bismuth pectin(control group)treatment,patients with pathological score decreased than the control group,the levels of inflammatory factors is better than the control group,the incidence rate of adverse reaction was lower than the control group,the difference was statistically significant(P<0.05). Conclusion Chronic atrophic gastritis patients choose amoxicillin and bismuth pectin treatment effect significantly,can greatly reduce the pathological integral,improve clinical symptoms,and can reduce the level of inflammatory factors in patients with a low incidence of adverse reactions,it is worthy of widely used to treat patients with chronic.

Objective To discuss the treatment of psychological intervention combined with different doses of methylprednisolone in treating bronchial asthma with acute onset treatment. Methods Randomly selected from January 2015 to March 2016 in our hospital with acute onset of bronchial asthma in 74 patients, divided into experimental group 37 cases and control group 37 cases, control group was given intravenous injection of methylprednisolone 40 mg/ times, two times a day, given routine nursing; the experimental group patients were treated with intravenous infusion of methylprednisolone 80 mg every time. Psychological intervention on the basis of the control group, the treatment of the two groups of patients with effective rate comparison. Results The effective rate of the treatment group was 94.59％, the effective rate of treatment group was 91.89％, the effective rate of treatment group is two level, the differences between groups was not statistically significant; the experimental group of patients with asthma duration and hospitalization time was significantly lower than the control group, the differences between groups was statistically significant (P<0.05). Conclusion For patients with acute onset of bronchial asthma treated in different doses of methylprednisolone treatment effect, but the duration of asthma patients after psychological intervention and hospitalization time was shortened, the clinical effect is good, worthy of promotion and application.

Objective Analysis of nitroglycerin combined with predictive nursing in the clinical application of coronary heart disease patients. Methods From January 2015 to December 2016, 200 patients with coronary heart disease were treated with angina pectoris. The patients were randomly divided into observation group and control group (100 cases). The control group was treated with routine nursing mode, and the patients in the observation group were treated with predictive nursing mode. The differences of hospitalization time and quality of life scores between the two groups were observed. The anxiety and depression of the two groups were observed before and after treatment, and the satisfaction of the two groups was observed. Results The scores of hospitalization and quality of life in observation group were better than those in control group (P<0.05). There was no statistically significant difference between SAS score and SDS score before treatment, but SAS score and SDS score of observation group were significantly lower than those of control group (P<0.05). The satisfaction degree of the patients in the observation group was better than that in the control group (P<0.05). Conclusion Predictive nursing has a good effect in the clinical nursing of patients with coronary heart disease and angina pectoris. It can effectively improve the patients' anxiety and depression, shorten the hospital stay and improve the quality of life. It is worth to be used in clinical practice.