1.Preventive effect of sodium hyaluronate gel on postoperative adhesion of hysteroscopic intrauterine adhesions
Jun SU ; Zhiqin CHEN ; Jianhui JIANG
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):142-144
Objective To investigate the Preventive effect of sodium hyaluronate gel on postoperative adhesion of hysteroscopic intrauterine adhesions. Methods 84 cases of IUA patients undergoing hysteroscopy were retrospectively selected,and divided into two groups according to the different ways of prevention and control of IUA,42 cases in each group.The control group was treated with Foley balloon catheter after operation,the study group was treated with sodium hyaluronate gel prevention on the based of control group.The clinical signs of the patients before and after treatment one,two and three months were observed,the therapeutic effects and complication were compared between two groups. Results After treatment one,two and three months,the adhesion type score and the score scale of study group, were significantly decreased,and lower than the control group,the difference was statistically significant (P<0.05).The total effective rate of the study group was 90.48%,which was significantly higher than that of the control group (83.33%),the difference was statistically significant (P<0.05).In the course of treatment,the complication rate of the two groups was 11.90% (5/42),there was no significant difference between the two groups in the incidence of complications. Conclusion Hyaluronic acid sodium gel on hysteroscopic intrauterine adhesions in patients with postoperative adhesions have a significant preventive effect,can improve the treatment efficiency and clinical signs,and with high security.
2.Clinical effect of Kang Shuling gel on the inflammatory factors in Ⅱ degree burns
Qiang HU ; Shuang SUI ; Guodong WANG ; Limin YAO
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):139-141
Objective To investigate the effect of Kang Shueling gel on the degree of inflammation in the patients with Ⅱ degree burns. Methods 86 patients with Ⅱ degree burns from July 2014 to July 2016 in our hospital were divided into the control group and the experimental group by lottery method with 43 cases in each group. The control group was treated with silver sulfadiazine, the experimental group was treated with Kang Shuling gel, the two groups of clinical curative efficacy, inflammatory factors, visual analogue scale (VAS), wound healing rate and wound healing time, wound infection rate and adverse drug reactions were compared. Results After treatment, the total effective rate of the experimental group was 95.34% higher than that of the control group 72.09%, the difference was statistically significant (P<0.05). The tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6) levels of the experimental group was lower than the control group, the difference was statistically significant (P<0.05). The VAS of the experimental group was lower than the control group, the difference was statistically significant (P<0.05).The wound healing rate of the experimental group was higher than that of the control group on the seventh day and the fourteenth day, and the wound healing time was better than that of the control group, the difference was statistically significant (P<0.05). The wound infection rate of the experimental group was lower than that of the control group (P<0.05). There was no significant difference in adverse drug reactions between the two groups. Conclusion The curative effect of Kang Shuling gel on the treatment of Ⅱ degree burns patients worthy of affirmation, could reduce serum inflammatory factors level.
3.Effect of fibroblast growth factor on extraction of tooth in type 2 diabetic patients
Ligang ZHANG ; Lizhen YING ; Bin ZHANG ; Yunyan KE
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):126-128
Objective To investigate the preventive effect of fibroblast growth factor on infection after tooth extraction among type 2 diabetes mellitus patients. Methods 76 patients with infection prevention were treated with basic fibroblast growth factor, and 90 patients in the control group(n= 324). The intervention group was treated with basic fibroblast growth factor and treated with recombinant bovine basic fibroblast growth factor gel. The routine treatment group was treated with routine rinsing liquid for disinfection to prevent infection. Follow-up observation of infection after 1 week. Results In the group of basic fibroblast growth factor, the infectious rate was 2.63%, which was not significantly lower than that of the control group. The level of white blood cells in the group treated with basic fibroblast factor was (6.67±1.08)×109/L, which was significantly lower than that of the control group. The CRP level was (90.33±12.95) mg/L, which was significantly lower than that of the control group Group level (P<0.05). The incidence of fibroblast infection was 2.7% in men and 6.38% in control group. Although there was no significant difference between the two groups, the difference in the total WBC count and CRP level between the two groups was significant different (P<0.05). The group which use of basic fibroblast growth factor, the total white blood cell count and CRP level of the infection prevention intervention group were significantly lower than the control group (P<0.05). Similar results were found in women. Conclusion Fibroblast growth factor can be used to prevent postoperative infection, and achieve satisfactory results.
4.Chaihu Shugan decoction combined with Group cognitive behavioral therapy on effect of HAMD and NIHSS in patients with depression after stroke
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):123-125
Objective To investigate the Chaihu Shugan decoction combined with Group cognitive behavioral therapy on curative effect and neurologic impairment in patients with depression after stroke. Methods 80 PSD patients were randomly divided into our hospital encephalopathy rehabilitation were selected as control group and observation group, 40 cases in each group. The routine drug treatment and rehabilitation training for all patients with Deanxit tablet. The observation group added ChaiHuShuGan Decoction and group cognitive behavioral therapy in the control group based on the treatment. Two groups of patients with 24h before treatment and after 8 weeks of treatment, the Hamilton Depression Scale, the degree of neural function defect scale and evaluation index of Basel. Results After 8 weeks treatment, the total effective rate of the observation group was 95% (38 / 40), and the control group was 75% (40/30), the difference was statistically significant (P<0.05). The improvement of HAMD, NIHSS and BI scores in the observation group were significantly better than those in the control group, the difference was statistically significant (P<0.05). Conclusion ChaiHuShuGan Decoction has synergistic effect with Group cognitive behavioral therapy in the treatment of PSD can significantly improve the symptoms of depression and neurologic impairment, and can improve the quality of life of patients.
5.Influence of Bushenjiangu capsules on the RF, hs-CRP, ESR with rheumatoid arthritis patients
Yong XIAO ; Jianyu SUN ; Zhenmin LUO
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):119-122
Objective To analyze the influence of Bushenjiangu Capsules on rheumatoid factor (RF), hypersensitive c-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR) with rheumatoid arthritis patients. Methods 94 patients with rheumatoid arthritis in the draw method was divided into control group and experimental group the 47 cases, control group treatmented by conventional western medicine, the experimental group based on the control group treatmented by Bushenjiangu Capsules, two groups' of RF, hs-CRP, ESR, Immunoglobulin A, M, G (IgA, IgM and IgG immune globulin), density lipoprotein (HDL-C), low density lipoprotein (LDL- C), triglyceride (TG), total cholesterol (TC), blood lipid, joint swelling, joint tenderness, morning stiffness time, curative effect and adverse reactions were compared. Results After treatmented, the RF, hs-CRP, ESR of experimental group was lower than the control group (57.53±8.13) U/L, (6.30±0.78) mg/L, (21.48±3.03) mm/h vs (74.29±10.56) U/L, (13.14±1.86 )mg/L, (35.60±4.36) mm/h, the difference was statistically significant (P<0.05). The IgA, IgM and IgG, HDL, LDL - C - C, TG, TC, joint swelling count, joint tenderness, morning stiffness time of experimental group was better than control group (2.17±0.29) g/L, (1.53±0.21) g/L, (12.14±1.50) g/L, (1.25±0.15)mmol/L (2.11 ±0.26) mmol/L, (1.34±0.17) mmol/L, (4.03±0.50) mmol/L, (4.35±0.53), (6.30±0.77), (29.71±3.70) min than g/L (2.30±0.28), (2.11±0.26) g/L, (13.76±1.70) g/L, (1.16±0.14) mmol/L (2.29±0.28) mmol/L, (1.53±0.19) mmol/L, (4.50±0.55) mmol/L, (7.63±0.96), (8.51±1.21), (76.38±9.50) min (P<0.05). The total effective rate of experimental group was higher than the control group (93.61%vs 76.59%) (P<0.05).The adverse reaction of two groups was no difference. Conclusion The effect is sure of Bushenjiangu capsule treatment of rheumatoid arthritis, can reduce the levels of RF, hs-CRP, ESR.
6.Effect of astragalus membranaceus on serum free amino acids and chemokines in patients with rheumatoid arthritis
Hewei ZHUO ; Lei ZHANG ; Hao LU
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):107-109
Objective To study and observe the effect of astragalus membranaceus on serum free amino acids and chemokines in patients with rheumatoid arthritis. Methods 60 patients with rheumatoid arthritis in Lishui Hospital of traditional Chinese medicine from October 2014 to May 2016 were selected as the research object,and 60 patients were divided into control group and observation group with 30 cases in each group,according to the method of random number table,the control group were treated with conventional treatment of rheumatoid arthritis,the observation group were treated with astragalus mongholicus on the basic of control group,then the serum free amino acids and chemokines of two groups before the treatment and at 10th,20th,40th and 60th day after the treatment were respectively detected and compared. Results The serum free amino acids and chemokines of two groups before the treatment were compared, while the serum chemokines of observation group at 10th,20th,40th and 60th day after the treatment were all lower than those of control group,the serum free amino acids glutamic acid,asparagic acid and phenylalanine were all lower than those of control group,leucine,γ-aminobutyric acid, glycine and taurine were all higher than those of control group,the difference was statistically significant (P<0.05). Conclusion The influence of astragalus mongholicus for the serum free amino acids and chemokines of patients with rheumatoid arthritis is better,so its application in the patients with rheumatoid arthritis is higher.
7.Influence of asarone injection for the pulmonary surfactant proteins and oxygen supply state of newborns with pneumonia
Jiaolei CHEN ; Jianwei JI ; Junfang GONG
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):104-106
Objective To observe the influence state of asarone injection for the pulmonary surfactant proteins and oxygen supply state of newborns with pneumonia. Methods 72 newborns with pneumonia were selected as the study object, and they were randomly divided into control group (36 cases) and observation group (36 cases), the control group were treated with conventional treatment of pneumonia, the observation group were treated with asarone injection on the treatment method of control group, then the pulmonary surfactant protein indexes, oxygenation function indexes and blood gas analysis of two groups before and after the treatment were respectively detected and compared. Results The pulmonary surfactant protein indexes, oxygenation function indexes and blood gas analysis of two groups before the treatment all had no significant differences, while the pulmonary surfactant protein indexes, oxygenation function indexes and blood gas analysis of observation group at first, second and fifth day after the treatment were all significantly better than those of control group, all P<0.05, there were all significant differences. Conclusion The asarone injection can significantly improve the pulmonary surfactant proteins and oxygen supply of newborns with pneumonia, so its application value in the treatment of newborns with pneumonia is higher.
8.Effects of salvia tetramethylpyrazine on hemorheology in vertebrobasilar transient ischemia attack
Huifei ZHOU ; Bo XIE ; Li QIN ; Jinhe ZHAO ; Changguo ZHANG
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):101-103
Objective To analyze the effect of salvia tetramethylpyrazine on hemorheology in patients with vertebrobasilar transient ischemia attack (VB-TIA). Methods 84 patients with VB-TIA were divided into observation group and control group, 42 cases in each group. They both received the treatment of Ginkgo-diyidamolum injection. The observation group were treated by salvia tetramethylpyrazine, and the control group were treated by compound Danshen injection. The therapeutic effect of the two groups and the changes of blood rheology were compared. Results The clinical remission rate of the observation group was significantly higher than that of the control group, and the time of onset and symptoms of the drug were shorter than those of the control group (P < 0.05). The blood flow velocity of vertebral basilar artery in the two groups were significantly higher than those in the observation group (P < 0.05). After treatment, the hemorheology of the two groups were significantly improved, the high shear viscosity and low shear viscosity, platelet aggregation rate, erythrocyte deformation index, erythrocyte aggregation index and blood haematocrit of observation group improved more obviously (P < 0.05). The incidence of adverse reactions in the two groups was not statistically significant. Conclusion Salvia tetramethylpyrazine could effectively shorten the drug onset time, improve the blood velocity of vertebrobasilar artery, recover blood rheology and stability on the condition of not increasing the adverse reactions, which has a positive effect on the clinical remission rate.
9.Shenmai injection for inhibition of hepatic and renal toxicity and leukocyte disorder during chemoradiotherapy in advanced breast cancer
Mi CHEN ; Shujian YU ; Xinxin LIN
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):74-77
Objective To investigate the Shenmai injection for the inhibition of hepatic and renal toxicity and leukocyte disorder during chemoradiotherapy in the women with advanced breast cancer. Methods 58 cases of female breast cancer patients with stage Ⅳ were selected and randomly divided into 2 groups, 29 cases of each group, and patients were treated with 5-hydroxytryptamine (5-HT3) receptor antagonists and white blood cell growth hormone and other conventional therapy, the control group received gemcitabine plus cisplatin chemotherapy, 28d for 1 cycles, the treatment group received more with Shenmai injection, interval was 15d, 2 groups were treated for 3 cycles. Levels of peripheral blood T lymphocyte subsets, cytokine levels and liver and kidney function, quality of life and clinical efficacy were compared. Results Compared with before treatment, levels of CD3+, CD4+ and CD4+/CD8+ in control group decreased (P<0.05), levels of CD3+, CD4+ and CD4+/CD8+ in treatment group increased (P<0.05), levels of CD8+ decreased(P<0.05), levels of IFN-γ, IL-2 and TNF-α increased(P<0.05), levels of IL-6 decreased(P<0.05), scores of KPS increased(P<0.05), scores of FACT-B decreased(P<0.05), levels of ALT, AST, BUN increased(P<0.05), and levels of CCr, WBC counts decreased(P<0.05), and compared with the control group, levels of CD3+ , CD4+ and CD4+/CD8+ in the treatment group were higher(P<0.05), levels of CD8+ were lower(P<0.05), levels of IFN-γ, IL-2 and TNF-α were higher(P<0.05), levels of IL-6 were lower(P<0.05), and the total efficiency was higher(P<0.05), levels of ALT, AST, BUN were lower (P<0.05), and levels of CCr, WBC counts were higher (P<0.05). After treatment, the efficacy of treatment group was higher than that of control group(Z=-2.142,P=0.032<0.05). Conclusion Shenmai injection can improve the efficacy of radiotherapy and chemotherapy in patients with advanced breast cancer, and it can effectively inhibit the liver and kidney damage and leukocyte disorder.
10.Effect of Liuwei anxiao capsules combined with omeprazole for the gastric electrical parameters and gastrointestinal motility related indexes of patients with functional dyspepsia
Qiumin CHEN ; Dena WU ; Yongliang WU ; Peng CHEN
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):71-73
Objective To study the Effect of Liuwei anxiao capsules combined with omeprazole for the gastric electrical parameters and gastrointestinal motility related indexes of patients with functional dyspepsia. Methods 86 patients with functional dyspepsia in our hospital from December 2014 to July 2016 were selected,and all the patients were randomly divided into control group and observation group,43 cases in each group,the control group were treated with omeprazole,the observation group were treated with Liuwei anxiao capsules on the basis of the control group,then the total effective rates of different symptoms,signs,gastric electrical parameters and gastrointestinal motility related indexes before and after the treatment of two groups were compared. Results The total effective rates of observation group with abdominal pain,abdominal distension,early satiety and belching were all higher than those of control group (P<0.05).3,7 and 14 days after treatment,compared with the pre-treatment, the difference of gastric electrical parameters between the two groups was statistically significant (P<0.05),the ratio of normal slow rhythm rhythm, main electrogastric power and electrogastric frequency in observation group were higher than those in control group (P<0.05),the percentage of bradycardia was lower than that in control group (P<0.05);there were significant differences in the indexes of gastrointestinal motility between the two groups before treatment (P<0.05),the level of MTL before and after meals was higher in the observation group than that in the control group (P<0.05), and the levels of SS before and after meals were lower than those in the control group (P<0.05). Conclusion Liuwei anxiao capsules combined with omeprazole in the treatment of functional dyspepsia in patients with significant effect,can significantly improve the patient's gastric electrical parameters and gastrointestinal motility related indicators,and improve the clinical symptoms.

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