Objective To compare and analyze the clinical effect and adverse reaction of oral azithromycin,oral and intravenous erythromycin on the treatment of mycoplasma infection in respiratory tract.Methods In our hospital in January 2015～March 2016 year,clinical datas of 110 cases with mycoplasma infection in respiratory tract in children were analyzed retrospectively.The total cases were randomly divided into the oral azithromycin treatment group(38 cases),oral erythromycin treatment group(36 cases)and erythromycin intravenous group(36 cases).The therapeutic effects and the adverse reactions were evaluated in the three groups.ResultsThe effective rate in the oral azithromycin group was significantly higher than that of the two other groups.The time of fever fading,rales and cough disappearance and the hospitalized day in the the oral azithromycin group were significantly shorter than that in the other two groups.Serum IL-8,TNF-alpha and hs-CRP level and the adverse reaction rate in the the oral azithromycin was significantly lower than that in the other two groups.The differences of all above the indexes were statistically significant(all P<0.05),the above index in the oral erythromycin group and erythromycin intravenous group was no statistical significance.Conclusion Compared with different medication route of erythromycin,it can get better results which oral azithromycin was used on the treatment of children with respiratory tract mycoplasma infection,the adverse reactions rate is lower,is a safe and effective treatment.

Objective To analyze clopidogrel combined with aspirin therapy of acute cerebral infarction the safety and efficacy of micro brain hemorrhage patients.Methods Select from May 2015 and May 2015 months in the hospital for diagnosis and treatment of 76 cases of acute cerebral infarction combined micro cerebral hemorrhage patient study,observation group in the conventional treatment at the same time giving oral aspirin and clopidogrel,the control group in the conventional treatment at the same time,only to give oral aspirin.To observe the nerve function defect National institutes of Health stroke scale score(National Institute of Health stroke scale,NIHSS)and daily life activities ability pap index,determination of patients' blood plasma viscosity,whole blood low shear viscosity,AA induction and the platelet maximum aggregation rate induced by ADP(MARAA,MARADP),observation records during the treatment patients with adverse reactions,were analyzed.Results Compared with before treatment,the observation group and control group after treatment for 2 weeks,NIHSS score,score and blood related indexes were significantly improved,statistically significant difference(P< 0.05).Compared with control group,the observation group after treatment the NIHSS score,pap score and blood related indexes were significantly improved,total effective rate increased significantly,the differences were statistically significant(P< 0.05).Two groups of adverse drug reactions occurred situation is no statistical difference.Conclusion Clopidogrel in combination with aspirin can effective treatment in patients with acute cerebral infarction combined micro brain hemorrhage,and security.

Objective To evaluate the efficacy and safety of levonorgestrel combined with danazol capsules in the treatment of endometriosis patients.Methods Ninety patients with endometriosis were randomLy divided into experimental group and control group(45 cases).The control group was treated with danazol capsules.The experimental group was treated with levonorgestrel on the basis of the control group.The clinical efficacy and serum CA125,CA199,ovarian function,and ovarian function were observed before and one month and three months after treatment.Adverse reaction rate.Results After three months of treatment,the clinical symptoms of the experimental group were lower than the control group(P<0.05); serum CA125,CA199 levels decreased,compared with the control group,the test group decreased significantly(P<0.05); ovarian function recovery Compared with the control group,the difference was statistically significant(P<0.05).two group compared with the incidence of adverse reactions,the difference was not statistically significant.Conclusion Levonorgestrel danazol capsules treatment of endometriosis Bitter patients than the use of danazol capsules better treatment,higher safety,worthy of clinical application to promote.

Objective To analyzethe expression level of peripheral blood mononuclear cell Toll like receptor 4(TLR4)in patients with acute coronary syndrome(ACS)undergoing elective percutaneous coronary intervention(PCI),and intensive atorvastatin on Toll like receptor 4 in clinical treatment.Methods 100 cases of patients with ACS were selected in our hospital from May 2014 to May 2016 were randomly divided into control group and experimental group,control group were given atorvastatin treatment after admission,20mg/d PCI postoperative continuous,after one month still maintain dose of 20mg/d.The experimental group were given atorvastatin treatment after admission,40mg/d,PCI postoperative continuous,after one month reduced to 20mg/d.After admission and a course of treatment,the expression level of peripheral blood mononuclear cells TLR4 was detected by flow cytometry and the Gensini scoring system on coronary lesion degree.At the same time,50 healthy subjects were selected as normal group.Results Compared with healthy subjects,the peripheral blood mononuclear cells TLR4 level in ACS patients has been significantly increased,and the level in patients with unstable angina pectoris is far lower than the level increased in patients with acute myocardial infarction,triple branch lesions groups were significantly higher than them in single and double branch lesion groups,the difference between the three obviously,with statistical significance(P<0.01); According to stepwise multiple linear regression and othercorrelation analysis showed that ACS category and the severity of coronary artery stenosis,coronary artery stenosis score were positively associated with the levels of TLR4(P<0.05); After treatment for one month,the levels of TLR4,the expression of low density lipoprotein cholesterol and total cholesterol levels were significantly lower,high density lipoprotein Cholesterol levels were significantly increased,the differences were statistically significant(P<0.01); compared with the normal group,the experimental group peripheral blood mononuclear cells of patients with Toll like receptor 4 expression level,total cholesterol,low density lipoprotein cholesterol level in the experimental group is higher than the normal group,high density lipoprotein cholesterol increased significantly,comparison between groups the differences were statistically significant(P<0.01).Conclusion The degree of lesions and the occurrence of acute coronary syndrome in patients with peripheral blood mononuclear cells of Toll like receptor 4 expression level increase has certain effect,increase the dosage of atorvastatin can significantly reduce the ACS after PCI in patients with peripheral blood mononuclear cells of patients with Toll4 like receptor expression.

Objective To investigate the preventive effect of octreotide combined with netilmicin sulfate on postoperative infection in suppurative appendicitis and its effect on helper T cell 17(Th17)/regulatory T cells(Treg)imbalance.Methods 148 patients with acute suppurative appendicitis in Xiangshan Hospital of Traditional Chinese Medicine from August 2014 to May 2016 were randomly divided into observation group(n=74)and control group(n=74).All were underwent laparoscopic appendectomy surgery,the control group took netilmicin sulfate combined with ornidazole for anti-infection after operative,while the observation group added octreotide acetate subcutaneously.The levels of serum interleukin(IL)-4,IL-6,IL-10,IL-17,IL-23,transforming growth factor β(TGF-β),interferon γ(IFN-γ)and Th17,Treg cell ratio and expression levels of related transcription factorbefore and after treatment were detected,Th17/Treg change were analyzed.Results The levels of IL-4,IL-6,IL-10,IL-17,TGF-β were decreased,IFN-γ were increased after treatment(P<0.01),the improvement of those indicators in the observation group were supior than control group(P<0.05).Th17,Treg cell ratio and expression levels of related transcription factor orphan nuclear receptorγt(RORγt),Forkhead box protein P3(Foxp3)were decrease,Th17/Treg was reduced after treatment(P<0.01),those indexes in observation group were lower than those in control group(P<0.05).The wound infection,intra-abdominal infections and other adverse events had no significant difference in two groups.Conclusions Octreotide combined with netilmicin sulfate can prevent postoperative infection in suppurative appendicitis,regulate Th17/Treg imbalance,restore immune function,and no significant adverse reactions.

Objective To explore the the effect of Omeprazole combined with operation on treatment of rupture of small intestine in closed abdominal injury.Methods From June 2014 to December 2014,64 cases in Xinchang county people's hospitalwith rupture of small intestine in closed abdominal were divided into the treatment group and the control group,32 cases in each group.The control group were treat with surgery,the treatment group were given surgery combined with Omeprazole.The total effective rate,quality of life,the recovery time of bowel sound and the echaust time in the two groups were compared.Results The total effective rate(90.6％,29/32)in the treatment group was significantly higher than that in thecontrol group(75.0％,24/32),the difference is significant(P< 0.05).The life index in the treatment group is significantly better than that in the control group(P<0.05).The recovery time of bowel sound in the treatment group(15.3±2.6)h,is shorter than that in the control group(23.8±6.8)h; the exhaust time(23.6±2.2)h in the treatment group is lower than that in the control group(32.3±4.6)h,the differencesis statistically significant(P< 0.05).Conclusion It can significantly improve the effect and postoperative indexes which omeprazole combined with surgical treatment on the treatment of rupture of small intestine in closed abdominal injury,Itshould be widely promoted.

Objective To study the effect of dexmedetomidine on stress response and inflammatory reaction of patients with hysterectomy.Methods 96 patients with hysterectomy who received therapy from October 2014 to October 2016 in Jinhua traditional Chinese medicine hospital were selected.According to random number table,those patients were divided into the observation group(n=48)and the control group(n=48).Two groups were treated with total intravenous anesthesia,the observation group was treated with intravenous infusion of dexmedetomidine1μg·kg-1 before anesthesia,pump is completed within 15 minutes,then continuous injection of 0.5μg·kg-1·h-1 speed to the 30min before the end of the operation; the control group was given the same way of infusion of normal saline.The operation time,blood loss,recovery time,extubation time and length of stay were recorded,and the hanges of mean arterial pressure(MAP),heart rate(HR),hydrogen peroxide(H2O2),malondialdehyde(MDA),total antioxidant status(TAS),tumor necrosis factor(TNF)-α,interferon(IFN)-γ,interleukin(IL)-10 at T0(before anesthesia),T1(at the end of pneumoperitoneum),T2(after the end of pneumoperitoneum 30min),T3(postoperative 24h)were recorded.Results There was no significant difference between the two groups in operation time,blood loss,recovery time,extubation time and length of stay; in the control group,the MAP was significantly reduce at T1,T2 was significantly higher,the HR was significantly reduce at T1(P<0.05); there was no significant change of MAP and HR levels in the observation group at each time point; the H2O2 and MDA in the observation group were lower than that of the control group at T1,T2 and T3,and the TAS was higher than that of the control group(P<0.05); the TNF-α,IFN-γ and IL-10 in the observation group were lower than that of the control group at T1,T2 and T3(P<0.05).Conclusion Intravenous infusion of dexmedetomidine before anesthesia is well for patients with hysterectomy,it'is helpful to maintain the hemodynamic stability,and effectively alleviate the stress response,inflammation reaction,it's worth promoting.

Objective To investigate the clinical effect of coagulation therapy in patients with gastric ulcer bleeding.Methods From January 2013 to January 2016 in Xiaoshan First People's hospital 150 cases of gastric ulcer patients with bleeding,using SPSS16.0 software to generate randomly divided into hemocoagulase group(basic treatment + hemocoagulase injection therapy)and control group(basic treatment)of the 75 cases,compared two groups of hemostatic time,hemostatic effect.Results After 72h treatment,the average hemostasis time of hemocoagulase group were significantly lower than the control group(P<0.05),the blood coagulation enzyme in patients with serum VEGF,EGF levels higher than the control group(P<0.05),gastrin and somatostatin levels lower than the control group(P<0.05),hemocoagulase group cure rate is 64％,effective in 22.67％,effective 9.33％,invalid 4％,the control group were 46.67％,25.33％,18.67％,9.33％,two groups compare difference was statistically significant(P<0.05).Conclusion Treatment of gastric ulcer bleeding patients with coagulation enzyme can shorten the hemostatic time,improve the clinical effect of hemostasis.

Objective To investigate the clinical effect of the application of the clinical effect of the use of lamivudine and the safety in the treatment of infantile enteritis.Methods From August 2013 to May 2016 in our hospital for diagnosis and treatment of 112 cases of enteritis were retrospectively analyzed,according to the application in the treatment of antibiotics into ceftazidime group in 60 cases,cefotiam group 52 cases,two groups of children with rehydration,correct electrolyte disorders such as basic treatment,the difference of clinical effect comparison.Results After 3d treatment,ceftazidime group stool frequency was significantly lower than that of cefotiam group(P<0.05); ceftazidime group the duration of diarrhea,stool leukocyte recovery time were significantly lower than cefotiam group(P<0.05); three day,five day after treatment of serum CRP,PCT levels were ceftazidime group significantly lower than cefotiam group(P<0.05); the two groups of serum CRP and PCT levels before treatment were significantly decreased(P<0.05); After five days treatment,5D after treatment,ceftazidime group the effective rate of 58.33％,effective 41.67％,invalid rate 0％,cefotiam group the effective rate was 42.31％,effective 53.85％,invalid rate 3.85％,ceftazidime treatment group is better than that of cefotiam group(P<0.05).Conclusion In the treatment of infantile enteritis,the effect is reliable and the safety is high.

Objective To investigate the effect of simvastatin and aspirin on atherosclerosis and its effect on non endothelium dependent diastolic function(NMD)and blood lipid in patients.Methods Retrospective analyzed a total of 95 the clinical data of patients with atherosclerosis treated in Tianjin Baodi Hospital from August 2014 to May 2016.The patients were divided into simvastatin group and combined treatment group according to their treatment methods,simvastatin group was given simvastatin,combined treatment group was given aspirin on the basis of simvastatin.After four weeks treatment,the difference of plaque quantity,NMD and blood lipid between the two groups were observed.Results After treatment,the size and number of plaques in the combined treatment group were smaller than those in the simvastatin group,the difference was statistically significant(P<0.05),the NMD level in the combined treatment group was significantly higher than that in the simvastatin group,the difference was statistically significant(P<0.05),the levels of IL-18,IL-6 and hs-CRP in the combined treatment group were lower than those in the simvastatin group,the difference was statistically significant(P<0.05),the levels of LDL-C,TG and TC in the combined treatment group were lower than those in the simvastatin group,HDL-C levels were higher than simvastatin group,the difference was statistically significant(P<0.05).Conclusion Simvastatin combined with aspirin can significantly improve the endothelium dependent diastolic function and lipid level in patients with atherosclerosis,and has good therapeutic effect.