1.Observation on the effect of psychological intervention of iron combined with erythropoietin in the treatment of anemia in hemodialysis patients
Xi'er HE ; Yan-qin DING ;
Chinese Journal of Biochemical Pharmaceutics 2017;37(8):262-263,266
Objective And effect of psychological intervention observation and analysis of iron combined with erythropoietin in the treatment of anemia in hemodialysis patients and the effect of. Methods 110 cases of Shaoxing Hospital of Traditional Chinese Medicine in anemic hemodialysis patients with January 2015 to February 2016 underwent diagnosis and treatment as the research object of the study, all the patients were randomly divided into 2 groups, respectively for the test group and control group, 2 groups of 55 cases. The control group was treated with erythropoietin receptor activator and psychological intervention treatment, experimental group was treated with ferrous succinate combined with erythropoietin receptor activator for treatment, but also psychological nursing intervention, observation and comparison of the symptoms of anemia, 2 groups of patients after treatment of adverse reaction etc. Results The experimental group patients with red blood cells, serum ferritin, hemoglobin and hematocrit were significantly higher than control group, the difference was statistically significant (P<0.05); side effects in test group than in the control group, the difference was statistically significant (P<0.05). Conclusion Iron combined with erythropoietin treatment in anemic hemodialysis was more effective at the same time, then the implementation of the corresponding psychological intervention, can reduce the adverse reactions in patients with symptoms, improve the safety of the treatment, and has high applicationvalue.
2.Efficacy and safety of low molecular weight heparin combined with aspirin and urokinase in the treatment of acute myocardial infarction
Zabeer tan Gulistan ; immortals A-yi
Chinese Journal of Biochemical Pharmaceutics 2017;37(5):382-384
Objective To investigate the efficacy and safety of low molecular weight heparin combined with aspirin and urokinase in the treatment of acute myocardial infarction.MethodsEighty patients with acute myocardial infarction were randomly divided into control group and observation group.Forty patients in the first affiliated hospital of Xinjiang Medical University from January 2013 to January 2016 were randomly divided into control group and observation group.Forty patients were treated with low molecular weight heparin combined with enteric-coated aspirin;Observation group in the control group based on intravenous thrombolytic therapy.The changes of blood vessel recanalization rate, serum factor level, treatment effect and complication were observed and compared.ResultsThe levels of serum IL-6, IL-8, IL-10 and HSP70 in the two groups were significantly lower than those in the control group (P<0.05).The postoperative complications and acute mortality were significantly lower in the observation group than in the control group (P<0.05).ConclusionLow molecular weight heparin combined with aspirin and urokinase in the treatment of acute myocardial infarction can effectively improve the rate of coronary artery opening, reduce the incidence of complications, safe and reliable, worthy of clinical promotion.
3.Clinical analysis of serotretine combined with metformin in the treatment of senile diabetic patients with sulfonylurea failure
Chinese Journal of Biochemical Pharmaceutics 2017;37(7):296-298
Objective To investigate the clinical effect of sitagliptin combined with metformin in the treatment of sulfonylurea-deficient elderly patients with diabetes mellitus.Methods Sixty patients with diabetes mellitus were enrolled in our hospital from January 2013 to December 2016.The patients were divided into observation group(30 cases) and control group(30 cases) according to the random number method.The patients in the observation group were treated with sitagliptin and metformin.The patients in the control group were treated with gemcitabine, and the clinical treatment effect, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, fasting C peptide and postprandial 2hC peptide Level of statistical comparison.Results The clinical effect of the observation group was significantly higher than that of the control group.Before and after treatment, the fasting blood glucose, 2h postprandial blood glucose, glycosylated hemoglobin, fasting C peptide and postprandial 2hC peptide level were not significantly different After fasting blood glucose, 2h postprandial blood glucose and glycosylated hemoglobin levels were significantly lower than before treatment, after treatment of fasting C peptide and postprandial 2hC peptide levels were significantly higher than before treatment.Conclusion The clinical efficacy of serotretine combined with metformin in the treatment of elderly patients with diabetes mellitus is similar to that of Yuxing, and the combination is more convenient and more suitable for clinical treatment.It is worthy to be popularized and applied in clinical practice.
4.Effect of Xingnaojing injection on cognitive function recovery in acute cerebral infarction
Qiaopei YANG ; Menghui QI ; Zuiyi GUAN
Chinese Journal of Biochemical Pharmaceutics 2017;37(3):156-158
Objective To explore the effect of Xingnaojing injection on cognitive function recovery in patients with acute cerebral infarction. Methods 100 patients with cerebral infarction who were hospitalized from November 2015 to October 2016 were selected and randomly divided into experimental group and control group, with 50 cases in each group.The patients in the control group were treated with routine treatment of cerebral infarction, including treatment of blood circulation, intravenous drip of mannitol to reduce intracranial pressure, subcutaneous injection of low molecular weight heparin sodium anticoagulant, control of blood pressure and blood glucose to appropriate level, and prevention of venous thrombosis.On the basis of the control group, the experimental group received Xingnaojing injection treatment , according to moderate moderation dose and drip rate.We adjusted the dosage and the drop rate according to the illness.The cognitive function was assessed by using Montreal Cognitive Assessment Scale ( MoCA) and minimum mental state examination (MMSE) at admission and after one month of treatment.Results At one month after treatment, the MoCA score of the experimental group and the control group was (27.44 ±2.97), (25.08 ±0.54) respectively, which was higher than that before treatment, but the experimental group was significantly higher than the control group, the difference was statistically significant ( P<0.05 ) .The MMSE scores of the experimental group and the control group were (21.06 ±1.43), (20.29 ±1.16) respectively, the score did not changed compared with before treatment, and the difference was not statistically significant.Conclusion Xingnaojing injection can improve cognitive impairment in patients with acute cerebral infarction, MoCA is better than MMSE in assessmenting the cerebral infarction patients cognitive situation.
5.Influence of Shenmai injection for the postoperative infection and related serum indexes of patients with breast cancer
Pengfei LI ; Xiaochun WANG ; Linbo ZHU ; Pengbin ZHANG ; Ji LI
Chinese Journal of Biochemical Pharmaceutics 2017;37(3):153-155
Objective To observe the influence of Shenmai injection for the postoperative infection and related serum indexes of patients with breast cancer,in order to provide evidence for the prevention of patients'postoperative infection.Methods 90 patients with breast cancerwere selected as the study object,and all the patients were randomly divided into control group(conventional postoperative treatment group)45 cases and observation group (conventional treatment and Shenmai injection group)45 cases,then the postoperative infection rates,inflammatory indexes and immune indexes before the treatment and after the treatment at different time were compared .Results The total postoperative infection rate of observation group was one case (2.22%),and it had no obviously difference compared with four cases (8.89%) of control group,the inflammatory indexes including PCT, TNF-α, IL-6 and hs-CRP at first,third and seventh day after the treatment were all lower than those of control group ,the immune indexes including CD3 +、CD4 +、CD8 +及 CD3 +CD4 +were all better than those of control group ( all P<0.05 ) .Conclusion The Shenmai injection can effectively control the postoperative infection rate of patients with breast cancer,and it also plays active improvement role for the infection related indexes.
6.Curative efficacy of Xianlinggubao capsules combined with Lugua polypeptide injection in vertebral osteoporosis
Yongxin JIN ; Xiaoqiang LV ; Zhiying LIU
Chinese Journal of Biochemical Pharmaceutics 2017;37(3):147-149
Objective To explore curative efficacy of Xianlinggubao capsules combined with Lugua polypeptide injection in treatment of vertebral osteoporosis.Methods 90 patients of vertebral osteoporosis from March 2014 to March 2015 in our haspital were selected as research objects and randomly divided into the observation group and control group,with 45 cases in each group.The control group were treated with Lugua polypeptide injection, while the observation group were treated with Xianlinggubao capsules combined with Lugua polypeptide injection.Then bone mineral density, osteocalcin, visual analogue scale (VAS), Oswestry disability index (ODI) score, curative effect in two groups after treatment were compared.Results Ater treatment, bone mineral density, osteocalcin in observation group was than that in control group [(0.99 ±0.13)g/cm2 vs(0.89 ±0.14)g/cm2, (41.05 ±5.30)μg/L vs(35.80 ±5.23)μg/L],the difference was statistically significant(P<0.05); VAS、ODI score in observation group were lower than those in control group[(1.21 ±0.30)分vs(4.65 ±1.08)分、(18.24 ±4.97)% vs(31.26 ±5.73)%],the difference was statistically significant (P<0.05).The total effective rate of observation group was statistically higher than that in the control group 95.55%(43/45),the difference was statistically significant vs77.77%( 35/45 ) ( P<0.05 ) .Conclusion Xianlinggubao capsules combined with Lugua polypeptide injection is well for vertebral osteoporosis,which can improve the bone metabolism of patients, promote bone growth and improve treatment efficacy.
7.Effects of moxifloxacin,tinidazole and psychological intervention on pelvic in terrention
Chinese Journal of Biochemical Pharmaceutics 2017;37(10):282-283
Objective To investigate the clinical effect of moxifloxacin combined with tinidazole and psychological intervention in the treatment of pelvic inflammatory disease. Methods The control group treated with moxifloxacin combined with tinidazole,pelvic inflammatory disease,the study group patients were given pelvic inflammatory tinidazole, moxifloxacin, combined with psychological intervention treatment (tinidazole and moxifloxacin administration methods and drug sources are the same as the control group). The clinical efficacy of two groups of pelvic inflammatory disease patients treated with 12 days was recorded. Results The group of patients with pelvic inflammatory disease were successfully completed corresponding treatment, the total effective rate of the study group was 95.65%, the control group was 68.18%, study group patients with pelvic inflammatory disease clinical curative effect was significantly better than the control group (P<0.05). Conclusion The application of moxifloxacin,tinidazole and psychological intervention in the treatment of pelvic inflammatory disease can significantly improve the clinical efficacy of patients, and is conducive to the protection of their quality of life, physical and mental health.
8.Vancomycin and meropenem combined with lumbar cistern drainage and curative effect of psychological intervention on the basis of the analysis of intracranial infection in treatment of brain injury after operation
ling Xiao FANG ; jing Xiao SHEN
Chinese Journal of Biochemical Pharmaceutics 2017;37(10):272-273,275
Objective To explore the basis of intracranial infection after craniocerebral operation with drainage combined with treatment in the application of vancomycin, meropenem and lumbar cistern on the use of psychological intervention clinical value. Methods 55 cases with intracranial infection craniocerebral injury patients were admitted to the Department of neurosurgery in Third Hospital of Jiaxing City in July 2012 to July 2017, the basic treatment in the application of drainage combined with vancomycin, meropenem and lumbar abroad, pay attention to the implementation of psychological nursing. Results The total effective rate of the group was 94.6%. Compared with before treatment, the number of WBC and protein in CSF decreased significantly, and the level of glucose increased significantly, with statistical difference (P<0.05). Compared with the intervention, the psychological status score improved obviously after intervention, with statistical difference (P<0.05). Conclusion The patients with craniocerebral injury complicated with intracranial infection after operation, basic drainage combined with treatment in application of meropenem and vancomycin, lumbar cistern on the use of psychological nursing, can improve the total clinical efficiency, improve psychological status.
9.Effect of psychological intervention and insulin treatment on anxiety in elderly patients with diabetes mellitus
Chinese Journal of Biochemical Pharmaceutics 2017;37(10):270-271
Objective To investigate and analyze the effect of psychological intervention and insulin treatment on anxiety in elderly patients with diabetes mellitus. Methods 92 elderly patients with diabetes mellitus from January 2016 to January 2017 in the first affiliated hospital of Wenzhou medical university chengdu campus were randomly divided into the control group and the experimental group, 46 patients for each group. The control group was treated with conventional insulin therapy, the experimental group was given psychological intervention on the basis of the control group, strengthened communication and exchanges, increased confidence. The anxiety levels of two groups were compared and analyzed. Results After treatment, 46cases were satisfied in the experimental group, and 40 cases were satisfied in the control group. The satisfaction degree of nursing in the control group was 86.96%, significantly lower than 100.00% in the experimental group, which was statistically significance (P<0.05). After the intervention, the HAMA score of the experimental group was (10.54±5.40), significantly lower than (14.63±5.23) of the control group with statistical significance (P<0.05). Conclusion The application of psychological intervention combined with insulin treatment in elderly patients with diabetes could significantly improve the anxiety and the satisfaction of nursing, and has the significance of clinical promotion.
10.Observation on the effect of psychological intervention combined with clopidogrel and Aspirin Enteric-coated Tablets in treatment of non ST segment elevation acute myocardial infarction
Chinese Journal of Biochemical Pharmaceutics 2017;37(10):268-269
Objective To investigate the effect of psychological intervention, Plavix, Aspirin Enteric-coated Tablets combined in the treatment of non ST segment elevation acute myocardial infarction. Methods 102 patients with non ST elevation acute myocardial infarction were selected in Taizhou Central Hospital from January 2015 to January 2017 and divided into study group (n=51) and control group (n=51) by single and double number (hospital admission order) method. The control group were treated with clopidogrel, Aspirin Enteric-coated Tablets, the study group on the basis of routine treatment, were given plavix, Aspirin Enteric-coated Tablets, comprehensive psychological intervention program. Results The total effective rate of the study group was 90.20%, and the total effective rate of the control group was only 70.59%, the difference was statistically significant (P<0.05). Conclusion The application of psychological intervention combined with plavix, Aspirin Enteric-coated Tablets treatment of non ST elevation acute myocardial infarction can significantly improve the clinical efficacy, to ensure the quality of life, life is of positive significance to safety.

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