Objective:To improve the safety, rationality and efficacy of medication for cancer patients accompanied with malignant neuropathic pain by the participation of clinical pharmacists in the therapy. Methods:Clinical pharmacists participated in the therapy for one neurilemmoma cancer patient with malignant neuropathic pain, and provided a rational and individualized therapeutic regimen according to the drug experience of clinical pharmacists as well as the relevant medical guides and literatures. Results: According to the nature and degree of pain, clinical pharmacists adjusted the type and dosage of opioids and non opioid drugs. The pain was well controlled with pain score at 1-2 points. Besides, the adverse effects were alleviated to ensure the sustained drug treatment. Conclu-sion:The participation of clinical pharmacists in therapeutic practice can improve the normalization of pharmacotherapy for neurilem-moma cancer patients with malignant neuropathic pain, which also can provide ideas and methods for treating the similar patients.

Objective:To investigate the efficacy and safety of dexmedetomidine ( DEX) at different loading doses during atrial fi-brillation ( AF) ablation. Methods:A total of 63 patients with AF undergoing radiofrequency catheter ablation were randomized into three groups:high loading dose group (HDex group, 1. 0 μg·kg-1), low loading dose group (LDex group, 0. 5 μg·kg-1) and NS group (the same volume of saline), and all were with 10 min intravenous infusion. After the loading dose, HDex group and LDex group were maintained continuously at an identical dose of 0. 4 μg·kg-1 ·h-1 DEX till the end of operation. The three groups were given 1% lidocaine local anesthesia at the beginning of surgery, and all the patients were intravenously given fentanyl (1μg·kg-1 · h-1 ) during the operation. The systolic blood pressure ( SBP) , diastolic blood pressure ( DBP) , heart rate ( HR) and Ramsay score were recorded before the iv pump infusion (T0), after the loading dose (T1), at the beginning of operation (T2), 10 minutes after the beginning of radiofrequency ablation (T3) and 10 minutes after the end of radiofrequency ablation (T4) were recorded. The num-ber of assisted ventilation, procedure interruption to adjust the dosage of fentanyl because of intorlerant pain and the total operation time were recorded as well. Results:The Ramsay scores were higher and SBP, DBP and HR decreased more notably in HDex and LDex group at T1, T2, T3 and T4 when compared with those in NS group(P<0. 05). At T1, SBP, DBP and HR decreased more evidently in HDex group than in LDex group. Two cases of bradycardia and two cases of assisted ventilation occurred in HDex group, and two ca-ses of pain caused procedure interruption occurred in NS group. Conclusion: When combined with fentanyl, the loading dose of 0. 5μg/kg/10 min DEX can provide satisfactory sedation and analgesic effects during AF ablation with fewer adverse reactions.

Objective:To analyze the efficacy and safety of targeted drug apatinib combined with tegafur, gimeracil and oteracil capsules (TS-1) in the second-line treatment of advanced gastric mucinous adenocarcinoma. Methods: Totally 48 patients with ad-vanced gastric mucinous adenocarcinoma treated with the second-line regimen were randomly divided into the control group and the treatment group with 24 ones in each. The control group received the chemotherapy of TS-1, and the treatment group received apatinib additionally. The adverse reactions and objective effects were observed. Results:The objective response rate (ORR) was 54. 1% and 33. 3% in the treatment and the control group, respectively. The disease control rate (DCR) was 83. 3% and 54. 2% in the treatment and the control group, respectively. There were significant differences on ORR and DCR in both groups(P<0. 05), while no statisti-cal difference was shown in the adverse reactions (P>0. 05) between the two groups. Conclusion:Apatinib combined with TS-1 ex-hibits evident short-term therapeutic effect on advanced gastric mucinous adenocarcinoma, and the adverse reactions can be tolerated.

Objective:To analyze the situation of therapeutic drug monitoring ( TDM) for 3 new antiepileptic drugs including leve-tiracetam, lamotrigine and oxcarbazepine in our hospital to provide reference for the individualized drug treatment for the children with epilepsy. Methods:The basic information, dose and TDM data of levetiracetam, lamotrigine and oxcarbazepine of the children with ep-ilepsy during 2015 and 2016 were collected and statistically analyzed in our hospital. Results: Without obvious difference in mean dose, the average plasma concentrations of oxcarbazepine in 3-6-year-old,6-10-year-old and 10-18-year-old children were significantly higher than those in less than 3-year-old children(P<0. 05). The mean dose and the average plasma concentrations of lamotrigine in children at different ages had no statistical significance(P>0. 05). The average plasma concentration of levetiracetam in less than 3-year-old children was significantly higher than that in the other children (P<0. 05). The effective rate of clinical treatment within dif-ferent plasma concentration ranges had statistical significance(P<0. 05). Conclusion: There are inter-individual differences in the plasma concentrations of antiepileptic drugs among the children with epilepsy at different ages. So the plasma concentration of antiepi-leptic drugs should be monitored regularly in order to ensure the safety and effectiveness of medication for children.

Depression is a common psychiatric disorder characterized by emotional and depressive symptoms. At present, western medicine treatment time is longer, having certain side effects, the treatment is incomplete and easy to recur, and not suitable for preg-nant women and the elderly and other special populations. The Chinese ancient"hysteria" Gan Mai Datzao decoction was used for the modern treatment of depression and achieved better effect. This article attempts from the clinical application and pharmacological stud-ies, for the past ten years of Gan Mai Dazao decoction decoction to prevent depression in the systematic review and analysis, the rea-sonable use of clinical thought to provide reference.

Shengmai powder, as the most famous decoration of invigorating qi and Yin in Chinese Medicine, has the function of cardiac effects and restoring pulse. It is mainly used to prevent and treat cardiovascular disease in the clinic, and has obvious curative effect. Shengmai powder, could applied in diseases of the neuropsychiatric system as the same, according to the TCM basic theory which is"heart has the function of controlling spirit, consciousness and thinking", while few researches can be found sporadically. The related literature during late 20 years were collected, selected, combed and commented from two aspects of clinical application and ex-perimental pharmacology in order to offer a reference for expanding application of Shengmai powder in neuropsychiatric disease as while. The clinical reports indicated that Shengmai powder, its modified formulas or combination with western-medicine may have effects on many neuropsychic diseases, such as major depressive disorder( MDD) , cerebral apoplexy, Alzheimer disease( AD) , hyperkinetic syndrome of childhood , sudden deafness( SD) , peripheral nerve disease( PN) , neurological dysfunction and so on. It may also reduce toxic and side effects of antipsychotics. Pharmacology experiments results showed that Shengmai powder has lots of functions, for in-stance, Anti-psychology stress, lipid-decreasing, and improving blood rheology and cerebral functions. It provides pharmacological ref-erence on the prevention and treatment in neuropsychic disease applied by Shengmai powder.

Objective:To establish an HPLC method for the determination of flibanserin and its related substances. Methods: A Phenomenex Luna C18 column(150 mm × 4. 60 mm, 5 μm) was used, the mobile phase consisted of 0. 02 mol·L-1 potassium di-hydrogen phosphate solution (pH was adjusted to 6. 0 by sodium hydroxide)-methanol and acetonitrile (4 :1), the flow rate was 1. 0 ml·min-1 , the column temperature was 30℃, the detection wavelength was 260 nm, and the injection volume was 10 μl. Results:Flibanserin and all the related compounds could be well separated. The linear range was 20-500 μg·ml-1(r=0. 9998), the average recovery was 100. 0%(RSD=0. 90%,n=9). The content of the main component in 4 batches of samples was 99. 6%, 99. 8%, 100. 4% and 99. 4%, respectively. The single impurity limit was set at 0. 1% and the limit of total impurities was set at 0. 5%. Con-clusion:The method is specific and accurate, which can be applied in the determination of content and related substances of fliban-serin.

Objective:To investigate the effect of total saponins from Clematis florida Thunb. on rat model of adjuvant arthritis ( AA) . Methods:Wistar rats were randomly divided into six groups:the normal control group, the model control group, the positive control group ( indomethacin, 10 mg?kg-1 ) , high, medium and low dose groups of total saponins from Clematis florida Thunb. with ten rats in each group. The rat model of AA was established with Freund's complete adjuvant and the effects of drugs on body weight and foot swelling of AA rats were observed. After the animals were sacrificed, the serum levels of superoxide dismutase ( SOD) , mal-onaldehyde ( MDA) , nitric oxide ( NO) and glutathion peroxidase ( GSH-PX) were determined. The serum levels of interleukin-8 ( IL-8), IL-10 and tumor necrosis factor-α(TNF-α) were detected by ELISA. Results:On the 8th day of drug administration, total sapo-nins from Clematis florida Thunb. could effectively alleviate the changes in the body weight and foot swelling of the rats to a certain ex-tent when compared with the model control group (P <0. 05 or P <0. 01). There were no significant differences between the high dose group and the positive control group (P>0. 05), and there were significant differences between the low dose group and the high/medium dose groups (P<0. 05). The levels of SOD, MDA, NO and GSH-PX in serum of AA rats were significantly affected by the total saponins from Clematis florida Thunb. . Except for NO indicator of low dose group, the differences between the other groups and the model control group were statistically significant (P<0. 05 or P<0. 01), and there were significant differences in MDA, NO and GSH-PX levels between high dose group and low dose group (P<0. 05). Compared with those in the model control group, the serum levels of IL-8 and TNF-αin each total saponins from Clematis florida Thunb. group significantly decreased and the content of IL-10 sig-nificantly increased (P<0. 05 or P<0. 01). There was no significant differences in the levels of IL-10 and TNF-α between the high dose group and the positive control group (P>0. 05), and the differences in IL-8 and IL-10 between high dose group and low dose group were statistically significant (P<0. 05). Conclusion: The total saponins from Clematis florida Thunb. have good therapeutic effect on AA, and the underlying mechanism may be related to the reduction of lipid peroxidation and the inhibition of pro-inflammatory cytokines.

Objective: To develop an ultra-performance liquid chromatography-tandem mass spectrometry ( UPLC - MS/MS ) method for the determination of nine fat-soluble vitamins in health foods. Methods:The samples were extracted by ultrasonic in organic solvents followed by the separation on a Waters ACQUITY UPLC BEH C18 column(100 mm × 2. 1 mm, 1. 7 μm) with gradient elution of 0. 1% formic acid in methanol and 0. 1% formic acid solution as the mobile phase and in a mode of atmosphere pressure chemical i-onization multiple reaction monitoring (MRM). Results:The method exhibited a good linear relationship (r≥0. 99) with the detection limit between 0. 9 and 38. 3μg/100 g for the nine fat-soluble vitamins. The recoveries were 78. 5%-114. 9% and the RSDs were 1. 57%-11. 1%(n=6). Conclusion:The analytical method is simple, rapid, accurate and sensitive, and suitable for the determina-tion of fat-soluble vitamins in nutritional supplements.

Objective:To develop a method of quantitative analysis of multi-components by single marker ( QAMS) for five index components in Yinzhihuang oral liquid. Methods:Using baicalin as the reference,an HPLC method with a Venusil MP C18 (2) column (250 mm × 4. 6 mm,5 μm) was applied,the mobile phase was acetonitrile-0. 1% phosphoric acid with gradient elution,the flow rate was 1. 0 ml·min-1 ,the detection wavelength was 327 nm, the column temperature was 35℃ and the injection volume was 10μl. The relative correction factors among the five index components were detected by QAMS. The five index contents were determined respec-tively by an external standard method and QAMS, and the results obtained from the two different methods were compared to verify the practicability and stability of QAMS. Results: The established QAMS method was used to determine the five index components in 6 batches of Yinzhihuang oral liquid. There were no significant differences in the calculated values and the determined ones (P>0. 05). Conclusion:The QAMS method is simple,effective and accurate in determining the contents of five index components in Yinzhihuang oral liquid,which can be used for the quality control of Yinzhihuang oral liquid and provide reference for the further studies.