No abstract available.
Ophthalmology*

Here, we report 3 cases of mixed tumor of the lacrimal gland. The age of the patients were 43, 26 and 35 respectively. The two of these were male and one female. The most outstanding complaint was exopthalmos. A mass was palpated on the orbit and eye ball deviation in downward position was present in all cases. Pathologic findings were mixed tumor of the lacrimal gland with no evidence of malignancy. These tumors were well encapsulated and any evidence of involving bone and soft tissue was not found. Modified Kroenlein-Berke operation was performed and tumor mass was removed entirely with finger dissection in all cases. The vision was not improved but the cosmetic result was satisfactorr.
Female ; Fingers ; Humans ; Lacrimal Apparatus* ; Male ; Orbit

The tension lowering effects of Diamox and other carbonic anhydrase inhibitors are well known and they are widely used against a various forms of glaucomas. This paper deals with the clinical experiences in normal and glaucomatous human eyes with Diamox-Sequels, kindly supplied by Lederle Laboratories and Yuhan Corp. MATERIALS AND METHODS: Normal healthy persons, 15 females and 20 males, were studied on their 45 eyes. Glaucomatous disease had been ruled out by careful examinations of intraocular pressure, visual fields and fundus. They had been also checked for the diurnal variations of intraocular pressure during the daytime. One capsule (500mg) of Diamox Sequels was given to each individual and the changes in the intraocular pressure were studied at various time intervals up to 53 hours after the administration. Tonometry was carried out by the Goldmann's applanation tonometer. The effects of Diamox Sequels on the glaucomatous eyes were studied in the same way. The glaucomatous eyes included 10 eyes of 7 chronic simple glaucoma patients, 5 eyes of 3 chronic narrow-angle glaucoma patients and 5 eyes of 5 secondary glaucoma subjects. They received one capsule of Diamox Sequels and the intraocular pressure was measured one or two times daily. The results of long-term treatment were also studied by daily administration of one capsule of Diamox Sequels, follow-up periods being from 3 to 19 days. No medication, oral or local, of antiglaucomatous drugs were allowed for at least 3 days prior to this study. The differences due to age, sex and type of glaucoma were not considered here. At the same time, the effects of a single 500mg of ordinary Diamox tablet were studied in normal ~md glaucomatous eyes. RESULTS: (1) Normal eyes. The intraocular pressure began to fall 1 hour after the administration. The tension gradually fell and the maximal reduction of tension occurred after 9.8 hours and the extent of maximal fall was 4.5mm Hg on the average, 29.4 % of the original intraocular pressure. The tension gradually rose and returned to the original level between 23~50 hours (average 43 hours). Side effects were noted in 4 cases, e.g., 11.4 %. (2) Glaucomatous eyes. The effects were noted within the first 1~2 hours and became maximal after 13 hours, the extent of the maximal fall 40.1 % of the original pressure, e.g., 16.2 mmHg. The original tension was restored after 30 hours. By long-term administration of Diamox Sequels, 8 eyes(40 %) showed excellent results, their intraocular pressure maintained below 21 mmHg. Sede-effects were noted in 3 cases(20.0 %). COMMENTS: The effects of Diamox Sequels and Diamox tablet on normal and glaucomatous subjects were summarized in table 1. As shown, Diamox Sequels has the longer duration of hypotensive actions and the time of maximal fall of intraocular pressure delayed considerably, as compared with Diamox tablet. In almost all cases, its action continued for more than 24 hours. In glaucomatous eyes, the time of maximal reduction of ocular tension was slightly later and the maintenance of low tension was slightly shorter than those in normal eyes. The extent of the maximal fall, however, was almost the same after administration of Diamox Sequels and Diamox. Side effects were encountered in 11~20% of cases by Diamox Sequels, and in 40-60% of cases by Diamox. This is one of the most striking advantages of Diamox Sequels over Diamox. Thus it is concluded that Diamox Sequels has the longer hypotensive actions and fewer side effects.
Acetazolamide* ; Carbonic Anhydrase Inhibitors ; Female ; Follow-Up Studies ; Glaucoma ; Glaucoma, Angle-Closure ; Glaucoma, Open-Angle ; Humans ; Intraocular Pressure ; Male ; Manometry ; Strikes, Employee ; Visual Fields

There were many instances in which glaucoma, esp. primary, combined with hearing disturbance. The etiology of these cases has not been known until now. We had 15 primary glaucoma patients for whom pure tone audiometry wa~ performed, and could find the hearing defect in high tone in 5 cases (1/3 among those patients). The audiometric curve was similar to that in the presbycusis, but severer in degree than that occured within the normal physiological aging process. The average age was 62.4 year in the group with the hearing defect, and 45.6 year in the group without the hearing defect. There were no relationship between the hearing defect and intraocular tension, visual field change, glaucomatous cupping, and duration of glaucoma. These results may support the opinion of the authors that the hearing disturbance in glaucomatous patients is related to the arterioscIerotic changes which aggrevate the presbycusis, and not related to glaucoma itself. On the otherhand, however, it is stilI impossible for us to rule out that the pleiotropic and multifactorial genetic factors may play as a common important role in the hearing disturbances and glaucoma. And further studies would be necessary for these problems.
Aging ; Audiometry ; Glaucoma* ; Hearing* ; Humans ; Presbycusis ; Visual Fields

40 patients who were diagnosed as the palsy of the third, fourth and sixth cranial nerve at Seoul national university hospital, were evaluated to reveal the etiology and clinical feature. The palsy of sixth cranial nerve is most common, and those of third and fourth cranial nerve followed it. Trauma was the most common cause of the palsy of the third, fourth, and sixth cranial nerve. Most of the palsy of the third cranial nerve involved both upper and lower branch, and aberrant regeneration was observed at 8 cases and its major cause was also trauma. The palsy of sixth cranial nerve was more frequently accompanied other cranial nerve palsy than those of the other two. Average recovery rate was 44.8% and, that of the sixth cranial nerve was higher than those of the other two.
Abducens Nerve Diseases* ; Abducens Nerve* ; Cranial Nerve Diseases ; Humans ; Oculomotor Nerve ; Paralysis ; Regeneration ; Seoul ; Trochlear Nerve

In order to prevent the formation of postoperative adhesions and delay the time of adjustment, the authors tried 5-fluorouracil and physical barriers of polytetrafluoroethylene, Interceed, Viscoat in rabbits. Fluorouracil delayed the adjustment for up to one week after surgery in three out of four eyes. Combined use of Interceed and 5-fluorouracil of addition of Viscoat could delay the adjustment for up to two weeks after surgery I one out of four eyes. Combined use of pophtetrafluoroethylene and 5-fluorouracil of addition of Viscoat could delay the adjustment for up to four weeks after surgery in four out of five eyes. In conclusion, combined use of polytetrafluoroethylene, 5-fluorouracil and Viscoat could be more helpful for delayine adjustment in rabbits.
Fluorouracil* ; Polytetrafluoroethylene ; Rabbits ; Strabismus*

We examined 646 neonates 1~3 days after birth at Seoul National University Hospital and Chungnam National University Hospital between April 1, 1986 and Dec. 31, 1986. To make neonates attentive, they were examined before feeding and if neonate was not attentive, we used side to side rocking or up and down movement to stimulate attentiveness. Their eye positions were tested with Hirschberg method and extraocular muscle function was tested with oculocephalic maneuver. Of these 646 neonates, 288(44.6%) had orthophoria, 337(52.2%) had exotropia, 6(0.9%) hadesotropia, 12(1.9%) had intermittent exotropia, 2(0.3%) had intermittent esotropia, and 1(0.2%) had exo-esotropia. None had infantile esotropia. Four months after birth, we reexamined 198 infants. Two of 88 infants who were orthophoric on previous examination had intermittent exotropia and 101 of 103 infants who were exotropic after birth had orthophoria. Two infants who were esotropic and 5 infants who were intermittently exotropic after birth had orthophoria. None had infantile esotropia.
Chungcheongnam-do ; Esotropia ; Exotropia ; Humans ; Infant ; Infant, Newborn* ; Parturition ; Seoul

A study on the pathologic findings after recession and resection of extraocular muscles in rabbits was performed. Fibrosis of extraocular muscles increased with time, which showed no difference between recessed and resected muscles. Inflammation and foreign body reaction decreased with time, which showed no difference between recessed and resected muscles. Adhesions of extraocular muscles to the sclera were observed from 1 month after operation. The resected muscles showed milder adhesion to the sclera than recessed one. The operated extraoculr muscles showed atrophies at 1 month, which showed no difference between recessed and resected muscles. According to our results, when reoperation is needed, fibrosis of extraocular muscles after recession and resection should be considered in making decision of recession and resection amount of muscles.
Atrophy ; Fibrosis ; Foreign-Body Reaction ; Inflammation ; Muscles* ; Rabbits* ; Reoperation ; Sclera

The effect of 1% atropine solution and 1% atropine ointment on healing of corneal epithelium in 20 rabbits was studied. Corneal epithelium was removed by #15 blade in central area of 7mm in diameter under topical anesthesia with 0.5% pontocaine. 1% atropine solution was applied three times daily to Rt. eyes, and 1% atropine ointment to Lt. eyes. Progress of epithelial healing was observed by fluorescent staining of the wound. At the end of 24 hours, fluorescent staining area was 46.90% in average for Rt. eyes, and 51.90% in average for Lt. eyes. At the end of 48 hours, it was 7.83% for Rt. eyes, and 11.0% for Lt. eyes. At the end of 72 hours, All of Rt. eyes did not stain, but 2 of 10 Lt. eyes were faintly stained. Difference between ophthalmic solution and ointment on the effect of corneal epithelial healing was not significant.
Anesthesia ; Atropine ; Epithelium, Corneal* ; Rabbits ; Tetracaine ; Wounds and Injuries*

The rabbit's cornea was injured by tile application of concentrated hydrochloric acid, and the effects of beta-ray on this Chemical burn were studied. The epithelization of the corneal ulceration, the extent of opacity and neovascularization of irradiated eyes showed no significant difference from the nonirradiated eyes by fractionated irradiation of betaray, the total doses being 900 rep.
Burns* ; Burns, Chemical ; Cornea* ; Corneal Ulcer ; Hydrochloric Acid