No abstract available.
Primary Health Care*

No abstract available.

No abstract available.
Cytomegalovirus* ; DNA* ; Glomerulonephritis* ; Polymerase Chain Reaction*

To investigate the imbalance of the cytokine production profile of T cells from atopic asthmatics, we measured concentrations of IL-4, IL-5 and IFN-y by ELISA method in the culture supernatants of peripheral blood mononuclear cells(PBMCs) and Derrnato-phagoides pteronyssinus(Der p) J-stimulated PBMCs from Der p-sensitized atopic asthmatics, Der p-sensitized healthy atopits, non-atopic asthmatics and healthy non-atopics. The suppressive effect of IFN-y on cytokine production of Der p J-stimulated PBMCs was also examined. The PBMCs from atopics showed higher IL-4 and IL-5 production in response to PHA +TPA and higher IFN-gamma production in response to Der p Jq compared with non-atopits. The Der p J-stimulated PBMCs from atopics showed a tendency of increased IL-5 production in response to Der p J and higher IL-4 and IL-5 production in response to PHA+TPA compared with non-atopics. IL-5 production of Der p J-stimulated PBMCs from atopics was suppressed by IFN It is suggested that an imbalance in IL-4, IL-5 and IFN-y production is a feature of the atopic state. The TH2 characteristics of allergen-stimulated PBMCs could be regulated by IFN-y.
Enzyme-Linked Immunosorbent Assay ; Interleukin-4 ; Interleukin-5 ; T-Lymphocytes

No abstract available.
Adult* ; Humans ; Still's Disease, Adult-Onset*

Acoustic neurinoma are the most frequent tumors in the region of the cerebellopontine angle. They usually present with a gradual onset of symptoms and slow progression. Development of spontaneous hemorrhage with sudden aggravation of symptoms is rare. The authors present a case of acoustic neurinoma associated with a spontaneous intratumoral hemorrhage. Sudden aggravation of symptoms was noticed. The cranial computed tomography revealed multiple blood-fluid levels within the cysts of the tumor which was located in the region of the right cerebellopontine angle. Operation was performed, which confirmed recent hemorrhage within the tumor. Pathological study revealed a typical neurilemmoma associated with hemorrhage, vascular proliferation and macrophages which phagocytosed hemosiderin pigments. The rare sudden aggravation of symptoms in cases of acoustic neurinoma may suggest hemorrhage.
Acoustics* ; Cerebellopontine Angle ; Hemorrhage* ; Hemosiderin ; Macrophages ; Neurilemmoma ; Neuroma, Acoustic*

No Abstract available.
Cross Infection* ; Korea*

OBJECTIVE: To investigate whether the serum levels of IL-10 in patients with rheumatoid arthritis are different from those of normal controls and SLE patients and to find out any correlation with disease activity parameters of rheumatoid arthritis. METHODS: Sera from 20 healthy normal persons, 16 rheumatoid arthritis patients and 16 patients with systemic lupus erythematosus were collected and measured for IL-10 and IL-6. Various disease activity parameters were measured in RA patients. RESULTS: The serum level of IL-10 in RA patients was significantly elevated compared to normal controls but lower than those of SLE patients. In RA patients there was no definite correlation between the disease activity parameters and serum IL-10 levels. Despite significant improvements in terms of various disease activity parameters, there was no significant change of serum IL-10 levels after treatment in RA patients. In seropositive RA patients, positive correlation was found between serun IL-10 and rheumatoid factor levels. CONCLUSION: Our findings show that the serum IL-10 levels in patietns with RA are elevated compared to normal controls but lower than those of SLE patients. There was no correlation between serum IL-10 levels and disease acivity parameters of RA.
Arthritis, Rheumatoid* ; Humans ; Interleukin-10* ; Interleukin-6 ; Lupus Erythematosus, Systemic ; Rheumatoid Factor

OBJECTIVE: To investigate the distribution of serum uric acid levels among 20000 Korean people who visited health screening center and relationships between serum uric acid and a number of biological variables. METHODS: By descriptive analysis on obesity index, blood pressures and various chemical measurements. Serum uric acid levels were measured by uricase method. Stepwise regression analysis of serum uric acid levels on various host variables selected on the basis of univariate analysis was perfomed. Logistic regression analysis was performed for the odds ratios for hyperuricemia. RESULTS: The mean serum uric acid level and prevalence of hyperuricemia were 5.9+/-1.3 mg/dl, 16.6% respectively in men and 4.2+/-l.0mg/dl, 1.69% in women. Serum creatinine concentration was by far the most important correlate with serum uric acid level. Obesity index, serum calcium, triglycerid were also significantly associated with serum uric acid in both sexes. Contributing factors for hyperuricema were calcium, serum GPT and obesity index in both sexes, and serum trig]yceride level, age, hypertension in men only. CONCLUSIONS: The mean serum uric acid level in men is higher than in women throughout all ages and the uric acid level arised after 5th decade in women. There are differences in contributing factors for serum uric acid level between sexes as well as in risk factor for hyperuricemia.
Adult* ; Calcium ; Creatinine ; Epidemiology ; Female ; Humans ; Hypertension ; Hyperuricemia ; Logistic Models ; Male ; Mass Screening ; Multiple Endocrine Neoplasia Type 1 ; Obesity ; Odds Ratio ; Prevalence ; Risk Factors ; Urate Oxidase ; Uric Acid*

Intracranial meningioma is one of the most easily detectable tumor in the preoperative period with the brain computerized tomographic(CT) scan. Although most of them are of benign nature, they present tendency to invade surrounding brain tissue and to recur in spite of complete surgical removal. Authors analysed the clinical features of 27 cases of histologically verified meningiomas and attempted to study the correlation between CT findings and histological types to predict their clinical invasiveness and aggressiveness. Female was predominated in occurance than male in the ratio of 17:10. Mean age of occurance was 40.5-year-old. The most frequent symptoms and signs were headache, papilledema and visual disturbance in order. The most frequent histological type was meningotheliomatous type(55.6%) which was followed by transitional(18.5%), fibroblastic(18.5%) and angioblastic(7.4%) types. In the finding of the brain CT scan, perifocal brain edema was noticed in nearly almost cases and high density of the tumor mass in the precontrast CT scan was predominated in transitional and fibroblastic types. But, marked perifocal brain edema, irregular tumor margin, loss of homogeneity of the tumor density and marked contrast enhancement, which were considered to be more aggressive and invasive findings, were predominated in the meningotheliomatous and angioblastic types. So, these types seemed to be more aggressive and invasive than other types. Large cystic meningiomas were 14.8% in author's cases.
Brain ; Brain Edema ; Female ; Fibroblasts ; Headache ; Humans ; Male ; Meningioma ; Papilledema ; Preoperative Period ; Tomography, X-Ray Computed