China ; Health Promotion ; methods ; trends ; Humans ; Integrative Medicine ; methods ; trends ; Medicine, Chinese Traditional ; methods ; trends

Biomedical Research ; Carcinoma, Hepatocellular ; virology ; Hepatitis B virus ; genetics ; physiology ; Humans ; Liver Neoplasms ; virology

The peptidyl prolyl cis/trans isomerase Pin1 specifically binds phosphorylated Ser/Thr-Pro protein motifs and catalyzes the cis/trans isomerization of the peptide bond,changes the conformation and influences the stability and activity of the substrates.To date,a subset of proteins has been identified as substrates for Pin1.Pin1 interacts with its substrates and plays crucial roles in cell cycle,neural pathology and immune response.Accumulating studies have revealed that Pin1 isomerase activity is regulated by its post-translational modifications,including phosphorylation and oxidation.Over-expression or regulative imbalance of Pin1 plays an important role in the pathogenesis and therapeutics of human diseases such as cancer and AD.

Objective:To understand the influence factors of suicidal ideation among college students of military medical university and to provide reasonable suggestion for preventing suicide among college students.Methods:701 college students were investigated and multiple logistic regression was used to analyse the major influence factors for suicidal ideation Results:Multiple logistic regression analysis shows the major influence factors for suicidal ideation are score,depression,life events and social support.Conclusions:According to the influence factors of suicidal ideation,taking appropriate measures to prevent suicide among college students is an urgent task.

OBJECTIVETo investigate the efficacy and action mechanisms of Compound Xuanju Capsule (CXC) in the treatment of type III and type IV prostatitis.

METHODSThis study included 88 cases of type III and 18 cases of type IV prostatitis, 14 with male infertility, 27 with ED, and 8 with increased PSA levels. In addition to prostate massage and psychotherapy, the patients were treated with CXC, 3 capsules once, tid, for 3 months. Then changes in relevant indexes were evaluated by the self-control method.

RESULTSThe NIH-CPSI scores of the patients with type III prostatitis were decreased by 47.59% (22.17 +/- 3.48 vs 1.62 +/- 2.53) after 1 month and by 74.61% (22.17 +/- 3.48 vs 5.63 +/- 3.14) after 3 months of CXC medication, with statistically significant differences from the baseline in both the total score and the scores on specific items (P < 0.05). The patients with infertility showed significantly improved sperm quality after treatment as compared with premedication (sperm cone: [12.52 +/- 3.16] x 10(6)/ml vs [28.32 +/- 8.36] x 10(6)/ml, grade a sperm: [10.12 +/- 4.56]% vs [26.06 +/- 10.18]%, grade a + b sperm: [29.89 +/- 8.86]% vs [53.26 +/- 11.29]%) (P < 0.05), and 8 of the patients' spouses got pregnant. Nineteen of the patients with ED were cured, with significant differences in the IIEF-5 score from pretreatment (10.41 +/- 3.65 vs 19.78 +/- 3.00) (P < 0.05). The PSA level was reduced to normal in all the 8 abnormal cases. The WBC count was remarkably decreased and even returned to normal in 19 cases with WBC count > 100/HP ative culture results.

CONCLUSIONCompound Xuanju Capsule is efficacious for type III and type IV prostatitis and those complicated by infertility, ED, PSA elevation, WBC increase, and negative culture results, with no obvious adverse events.

Capsules ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Infertility, Male ; drug therapy ; Male ; Phytotherapy ; Prostatitis ; drug therapy ; pathology ; Sperm Count ; Spermatozoa ; drug effects ; Treatment Outcome

Anniversaries and Special Events ; Integrative Medicine ; Societies, Medical

Anniversaries and Special Events ; Humans ; Integrative Medicine ; methods ; Learning ; Medicine, Chinese Traditional ; methods ; Physicians

Objective To evaluate the capability of SSH/RAD MRH based on SENSE to show gastrointestinal tract anatomic structure,to provide normal anatomic base for gastrointestinal tract disease diagnosis with SSH/RAD MRH and to explore the new examination method for imaging diagnosis in gastrointestinal tract disease.Methods There were 30 healthy volunteers in total including 19 male cases,11 female cases,the age ranging from 20 to 50 with the mean age as 35 year old.All volunteers were asked to drink tap water about 1000-1500mL continuously at 60 minute before examination,to drink tap water 500mL at 20 minute before examination and receive injection of 654-2 10mg in muscle at 10min before examination.MRH were performed by Philips Gyroscan Intera 1.5T superconduct MRI scanner,using SENSE technique,phased-array coil and breath hold.SSH/RAD MRH was performed after the routine abdominal MR scan was done.Results SSH/RAD MRH was successfully performed on all volunteers at one time,and the examination achievement ratio was 100%.All images were evaluated by two senior doctors using blindness method.The ratio of the good-optimal quality images was 93% and the poor-quality images was 7%.Of all images,the stomach manifestation ratio was 65%,the stomach mucous clear manifestation ratio was 80%,the duodenum manifestation ratio was 80%,the jejunum manifestation ratio was 59%,the jejunum diameter was 2-2.5cm,the ileum manifestation ratio was 21%,the ileum diameter was 1.5-2.5cm and the small intestinal mucous clear manifestation ratio was 67%;the colon manifestation ratio was 10% and the colon mucous clear manifestation was 6%.Conclusion SSH/RAD MRH based on SENSE can clearly show the outline and mucous of the stomach,duodenum and jejunum,but can not clearly show the outline and mucous of ileum and colon.The imaging examination that the colon SSH/RAD MRH combined with the routine abdominal MR scan could clearly and conveniently show the anatomical characteristics of gastrointestinal tract.It is a new imaging examination method for gastrointestinal tract examination.

China ; Congresses as Topic ; Humans ; Integrative Medicine ; education ; methods ; trends ; Internationality ; Medicine, Chinese Traditional ; methods ; trends ; Societies, Medical ; organization & administration

Mild cognitive impairment(MCI)is a new concept put forward in recent years.It is a transtrional state between normal aging and dementia.Prospective studies have shown that the orbebility of the patients with MCI converted to dementia is significantly higher than the normal aged.population.The correct diagnosis of MCI contributes to screen the high-risk population of dementia.It will provide the possibility for preventing dementia and decreasing the morbidity of dementia.