[Objective] Sorting and summing up Professor ZHANG 's clinical experience in the diagnosis and treatment of atlanto-axial joint subluxation, to develop the thought of clinical diagnosis and treatment of the disease. [Methods]Via studying with professor ZHANG, and collectting some cases,consulting the related literature and data.Finally, discuss and summarize it. [Results] Diagnosis found and appliedFour tenderness(Below the foramen magnum, trapezius muscle and at the junction of the skull,fengchi point,wangu point).Method combined with primary symptom and signs, X-ray. Treatment, application of error correction manipulation, light effect;And with local acupuncture point injection, menstruation invigorates the circulation of reinforcement. [Conclusion] Professor ZHANG's method of diagnosis and treatment of atlanto-axial joint subluxation is unique,clear, simple, has obvious curative effect, worth clinical application and promotion.

Hypoxia- inducible factor-1 ( HIF-1) promotes tumor deterioration, invasion and metasta-sis. Treatment targeting the HIF-1 signal pathway is becoming a hot research. In addition to uniquely selective inhibition of topoisomerase Ⅰ(Topo Ⅰ) ,the recent studies show that camptothecin compounds can regulate the activity of HIF-1 through decreasing HIF-1 protein translation and have been classified as a non-selective chemical inhibitor of HIF-1.

Sphingosine analogue FTY720 exerts good immune suppressive effect by inducing lymphocytes apoptosis and homing, which can be used for organ transplant rejection as well as anti-autoimmune disease treatment. Recent studies have found that FTY720 plays anti-tumor potential by inducing growth arrest and apoptosis as well as inhibiting tumor metastasis.

AIM:To establish a method for determining notoginsenoside R_1,ginsenoside Rg_1 and ginsenoside Rb_1 in Jingkang Capsules(Radix Rehmanniae praeparata,Radix Polygoni multiflori,Radix et Rhizoma Notoginseng,etc.). METHODS: A Diamonsil C_(18) column(250 mm?4.6 mm,5 ?m) with acetonitrile-water as the mobile phase was used for gradient elution,the flow rate was 1.0 mL/min and the UV detection wavelength was at 203 mn. RESULTS: There was a good linear relationship at a range of 0.327-2.180 ?g for notoginsenoside R_1(r=(0.999 4))(the average recovery was 98.23% with RSD of 1.53%(n=6)),0.909-6.060 ?g for ginsenoside Rg_1(r=1.0)(the average recovery was 99.04% with RSD of 1.00%(n=6)),0.672-4.480 ?g for ginsenoside Rb_1(r=0.999 8)(the average recovery was 98.17% with RSD of 1.31%(n=6)).CONCLUSION: The method is simple,quick and accurate.It can be used for the quality control of Jingkang Capsules.

Objective To explore the effect of Azithromycin on the immune mechanisms through the IL - 23 /IL - 17 axis way by observing the changes in serum levels of IL - 23,IL - 17 in rats with Adriamycin - induced nephro-sis. Methods A total of 135 rats were randomly divided into control group,model group,Azithromycin intervention group,Prednisone intervention group and united intervention group. The model was induced through a tail intravenous injection of Adriamycin for 2 times. Nine rats were randomly selected from every group to detect blood and urinary bio-chemistry,and to observe the changes of the serum levels of IL - 23,IL - 17 by enzyme - linked immunosorbent assay in 4,6,and 8 weeks. Results Compared with the model group in the 8th week,the levels of 24 - hour urinary protein [model group(354. 83 ± 70. 87)mg/ d,Azithromycin intervention group(94. 59 ± 22. 67)mg/ d,Prenisone intervention group(65. 64 ± 8. 71)mg/ d,united intervention group(47. 44 ± 9. 56)mg/ d],cholesterol[ model group(8. 71 ± 1. 60)mmol/ L,Azithromycin intervention group(3. 54 ± 0. 30)mmol/ L,Prenisone intervention group(3. 10 ± 0. 18) mmol/ L,united intervention group(2. 56 ± 0. 40)mmol/ L]were reduced significantly,while the levels of albumin [model group(16. 77 ± 3. 15)g/ L,Azithromycin intervention group(33. 82 ± 1. 16)g/ L,Prenisone intervention group (37. 80 ± 2. 73)g/ L,united intervention group(40. 78 ± 2. 63)g/ L]were increased obviously in the intervention groups,and the differences were statistically significant(F = 152. 243,99. 838,155. 836,all P ﹤ 0. 05). The serum levels of IL - 23[model group(29. 60 ± 3. 97)ng/ L,Azithromycin intervention group(29. 61 ± 2. 62)ng/ L,Prenisone intervention group(29. 74 ± 2. 23)ng/ L,united intervention group(30. 31 ± 2. 20)ng/ L],IL - 17[ model group (22. 38 ± 2. 51)ng/ L,Azithromycin intervention group(21. 97 ± 1. 89)ng/ L,Prenisone intervention group(21. 43 ± 2. 42)ng/ L,united intervention group(21. 51 ± 2. 07)ng/ L]in the model group and 3 intervention groups were higher than the control group[(17. 35 ± 3. 01)ng/ L,(14. 03 ± 2. 42)ng/ L]in the 4th week,and there were significant differences(F = 33. 819,21. 373,all P ﹤ 0. 05);and the levels of IL - 23[in the 6th week,Azithromycin intervention group(27. 20 ± 1. 71)ng/ L,Prenisone intervention group(24. 39 ± 2. 06)ng/ L,united intervention group(21. 41 ± 1. 71)ng/ L,model group(35. 78 ± 3. 21)ng/ L;in the 8th week,Azithromycin intervention group(24. 60 ± 2. 91) ng/ L,Prenisone intervention group(21. 01 ± 1. 02)ng/ L,united intervention group(18. 93 ± 1. 35)ng/ L,model group (44. 47 ± 7. 84)ng/ L],IL - 17[in the 6th week,Azithromycin intervention group(19. 12 ± 0. 37)ng/ L,Prenidone in-tervention group(18. 54 ± 0. 36)ng/ L,united intervention group(17. 57 ± 0. 42)ng/ L,model group(26. 69 ± 3. 70) ng/ L;in the 8th week,Azithromycin intervention group(17. 44 ± 0. 46)ng/ L,Prenidone intervention group(16. 37 ± 0. 49)ng/ L,united intervention group(14. 71 ± 0. 99)ng/ L,model group(34. 03 ± 3. 45)ng/ L]in the 3 intervention groups were significantly lower than those of the model group in the 6th ,8th week(F = 82. 963,44. 659 in the 6th week, F = 75. 085,200. 383 in the 8th week,all P ﹤ 0. 05). The levels of IL - 23,IL - 17 in united intervention group were lower than those in respective intervention groups(P ﹤ 0. 05),and the levels in Prednisone intervention group were lower than those in Azithromycin intervention group(P ﹤ 0. 05). Conclusions IL - 23 / IL - 17 axis' high activity may be one of the immunologic mechanisms of Adriamycin - induced nephrosis. Azithromycin may inhibit the high activity of IL - 23 / IL - 17 axis to relieve the Adriamycin - induced nephrosis. The inhibition on IL - 23 / IL - 17 axis of Azithro-mycin was similar to Prednisone,and Azithromycin may enhance the effectiveness of Prednisone.

The physical change of astigmatism in human eye is analyzed in this article.Different methods for astigmatism applied in clinic are expound and compared with advantages and disadvantages.It is important that analyzing carefully and designing customized normgram for astigmatism eye to approach the perfect visual function after reasonable treatment.

To illustrate the kinds of applicator, indication, side effects, long term follow?up results, clinical experience and the latest developments of intracavitary/interstitial brachytherapy (IC/IS?BT),more than 50 research articles concerning IC/IS?BT about cervical cancer were reviewed.

Hereditary hearing impairment is caused by genetic defects and is a common clinical disease. Since the lack of efficient treatment method, genetic counseling is more important in this field. It provides information about inherited disorders and focuses on assessment and interpretation of the risk for occurrence of genetic conditions in the family. Presented in this paper are classification of hereditary hearing impairment and methods to perform probability analysis using features of pathogenic genes and information of pedigree.

Objective: To investigate the relationship between attributional style and personality. Methods: We measured undergraduates with Attributional Style Questionnaire(ASQ)and Sixteen Personality Factor Questionnaire(16-PF).Results: Students with high-sensitivity, high-insecurity, high-tension, anxiety, not tough poise and low marks in Mental Health are apt to have negative attributional style. These personalities are the nuclear personalities of negative attributional style. Students with high-suspiciousness, high-insecurity,anxiety and low marks in Academic Achievement and Adjustment are apt to attribute fatefully. Conclusion: The nuclear personalities for negative attributional style are high-sensitivity, high-insecurity, high-tension, anxiety, not tough poise and low marks in Mental Health.

Objective:To investigate the characteristics of occupational burnout of psychiatrists,and explore its organi-zational factors.Methods:106 psychiatrists were assessed by CMBI,Job Demands and Decision Latitude scale,Distributive and Procedural Justice scale,Cross-Culture Role Conflict,Ambiguity,and Overload scale,Work Interference with Family and Family Interference with Work scale,Social Support scale.Results:Hierarchical multiple regression indicated that work interference with family,role conflict,workload and role ambiguity could significantly predict emotional exhaustion;family interference with work could significantly predict depersonalization;colleague support and role ambiguity could significantly predict reduced personal accomplishment.Conclusion:Status of reduced personal accomplishment of psychiatrists is serious.Occupational burnout has particular related factors.