Objective To investigate the clinical efficiency and immune adjustment of oxymatrine capsule and acitretin in the treatment of psoriasis.Methods Eighty patients with psoriasis were randomly divided into treatment (T) and control (C) groups.The T group took orally oxymatrine one capsule (0.2g) three times a day and one acitretin (10 g) two times a day.The C group only took orally one acitretin (10 g) two times a day.The T and C groups were applied the same drug for external use.Moreover,another 40 normal volunteers were set as normal control group.The peripheral blood T cell subset CD3 +,CD4 +,CD8 +,CD4 +/CD8 + were detected in all the three groups (T,C,and normal) before and after treatment.Results The effective rate was 92.5％ in the T group,and 72.5％ in the C group with statistical significance (x2 =8.66,P ＜ 0.05).The symptom integral decline index of two groups before and after treatment has statistical significance (t =10.02,P ＜ 0.05).For the peripheral T cell subset CD3 +,CD4+,CD8 +,CD4 +/CD8 + in the T group,a significant difference was found between pretreatment and posttreatment [(57.13 ±8.14)％,(37.62 ±7.97)％,(33.01 ±2.97)％,(1.24 ±0.51)％ vs (60.09 ±11.53)％,(43.02±7.67)％,(25.63 ±4.24)％,(1.73 ±0.69)％,t =3.08 ～9.02,P ＜0.01].However,there was not any statistical significance between pretreatment and posttreatment in the C group (P ＞ 0.05).Conclusions The treatment of common psoriasis combined with oxymatrine capsule and acitretin had a good curative effect and it improved the imbalance of peripheral blood T cell subsets.

Objective:To investigate the distribution and regulation of uterine NK cells in mouse uterus during early pregnancy. Methods:Using a unique uNK cell marker,Dolichos biflorus agglutinin (DBA) lectin,to localize NK cells in uterus of normal pregnancy,delayed implantation and artificially induced decidualization. Results:DBA staining is mainly distributed in some vascular endothelial cells during embryo pre-implantation. In D5 of pregnancy after embryo implantation,NK cells were distributed in the stroma of uterine mesometrial pole,with round,immature and small lymphocyte-like cells. During D7 and D8 of pregnancy,the immunostaining results showed that uNK cells were increasingly accumulated in the mesometrial pole of implantation sites,with their morphology changing from small round cells with scattered cytoplasm to large and mature cells with heavy cytoplasmic granules. In the artificially induced decidualization model,the distribution and maturity of NK cells are similar to those of the normal pregnancy in the mouse uteri. Conclusion:The distribution and maturation of uterine NK cells are dependent of uterine decidualization in mouse early pregnancy.

OBJECTIVE:To study the protecting and therapeutic effect of compound Zigui capsule on climacteric syndrome and the mechanism of the action in rats,so that it may provide a theoretical basis for clinical treatment METHODS:The climacteric syndrome model was made by ovariectomy in rats and the effects of compound Zigui capsule on hemorheological parameters were observed RESULTS:Compound Zigui capsule could lower blood viscosity,plasma viscosity,blood reduced viscosity and red cell rigidity index It could also inhibit platelet adhesion CONCLUSION:Compound Zigui capsule has obvious preventive and therapeutic effects on rat's climacteric syndrome

OBJECTIVE:To prepare compound Zigui capsules METHODS:The capsules were prepared by taking placenta,Angelicae Sinensis and Peony as main components encapsulated with ?-cyclodextrin The content of paeoniflorin was determined by UV-spectrophotometry The linear range was 2～12?g/ml The average recovery was 99 95%(r=0 9 989)with a RSD of 1 43%(n=5) RESULTS & CONCLUSION:The formulation of compound Zigui capsules are rational,preparation technic being stable and the therapeutic effect on climacteric syndrome is satisfactory The quality control is simple,accurate and repeatable

目的了解残疾人生活满意度现状,分析社会支持、应对方式与残疾人生活满意度的关系。方法采用生活满意度指数A问卷(LSIA)、应对方式问卷、社会支持评定量表对某省级康复医院残疾病人进行调查。结果与结论不同性别的残疾人在生活满意度、社会支持和应对方式方面都存在差异。残疾人生活满意度与社会支持呈显著正相关;与应对方式中解决问题和求助因子正相关,与自责、幻想、退避和合理化因子负相关。

目的探讨目标健康教育对精神分裂症患者临床疗效。方法将100例精神分裂症患者随机分为研究组与对照组，配合药物治疗的同时，对照组采用传统的健康教育。研究组给予阶段式目标健康教育。患者入、出院时采用护士用住院患者观察量表、健康教育知识测评、满意度调查问卷评定健康教育效果。结果研究组患者出院时护士用住院患者观察量表总分较对照组明显升高（P<0.01），健康教育知识知晓测评表及满意度调查问卷评分均较对照组明显提高（P<0.01）。结论实施目标健康教育能提高精神分裂症患者的疗效。

Objective To explore the effects of conductive education on children with cerebral palsy. Methods 116 children were dividedinto observation group (n=60) and control group (n=56). The observation group received conductive education and the control group receivedcomprehensive rehabilitation therapy. The effects were compared. Results The motor function, performance state and social adaptationin the observation group were better than in the control group after treatment (P<0.05). Conclusion Conductive education can facilitatethe recovery of children with cerebral palsy.

Abstract: Objective　To understand the epidemic characteristics of plague and the phenotypic characteristics of Yersinia pestis strains strains in Dulan County, Qinghai Province, so as to provide theoretical reference for timely adjustment of the local plague surveillance program and prevention of plague recurrence, as well as effective experimental basis for clinical treatment and prevention. Methods　The biochemical characteristics, virulence factor identification and plasmid analysis of 23 Yersinia pestis strains isolated from Dulan County, Qinghai Province from 1964 to 1994 were studied by conventional methods and molecular biology techniques. At the same time, the different region (DFR) method was applied to study the genetic typing of 23 Yersinia pestis strains isolated from Dulan County, Qinghai Province according to 23 different regions of plague genome and the designed primers based on PMT1. Results　Among the 23 Y. pestis strains isolated from Dulan County, 22 strains of Y. pestis were palaeotypic biotypes, and biochemical types were Qinghai-Tibet Plateau type, and 1 strain was incompatible with both biotypes and biochemical types in this area. And 86.96% (20/23) of Y. pestis strains had four virulence factors (F1+, Pst I+, VW+, Pgm+). All of the tested strains produced F1 and Pst I, while 95.65% (22/23) of tested strains were positive for VW, and 86.96% were Pgm positive. All the 23 strains carried three plasmids, with a relative molecular weight (Mr) of 6×106, 45×106, 52×106, and these plasmids formed a stable plasmid spectrum: 6×106, 45×106, 52 ×106. The DFR typing results showed that Yersinia pestis could be divided into two genotypes, namely G05 and G08. Nineteen Yersinia pestis strains were G08 and four strains were G05. Conclusions　The 23 strains of Yersinia pestis isolated from Dulan County were mostly of Qinghai-Tibet Plateau type, and had stable biochemical characteristics. The virulence of Yersinia pestis was strong. The results of plasmid analysis and genotyping showed that the Yersinia pestis had the etiological characteristics of Qinghai-Tibet Plateau, which was consistent with the characteristics of Marmota himalayana plague foci in Qinghai-Tibet Plateau.

Objective:To explore the relationship between pulse wave velocity(PWV)and blood pressure classification in patients with hypertension in pretherapy and posttherapy.Methods:Totally,183 patients with essential hypertension were recruited in the study and their brachial-ankle PWVs were recorded by an automatic arterial stiffness measurement device.PWVs were compared between patients with varied blood pressures in pretherapy and posttherapy.Results:There was significant diference in PWV between patients with pretherapy and posttherapy[(2 080?26)cm/s vs(1 604?32)cm/s,P