Acute myeloid leukemia (AML) is a highly heterogenous disease with multiple signaling pathways contributing to its pathogenesis.A key driver of AML is the mutation of FMS-like tyrosine kinase receptor-3 (FLT3) gene.Mutations in FLT3,primarily the FLT3-internal tandem duplication (FLT3-ITD),are associated with decreased progression-free and overall survival.Due to the importance of FLT3-ITD and its pathway in the prognosis of patients with AML,it has stimulated efforts to develop therapeutic inhibitors of FLT3.Although the FLT3 inhibitors show a certain degree of antileukemia activity,their clinical effect has some limitations as a single drug.Now,Quizartinib (AC220) is the potent second generation FLT3 selective inhibitors.Based on the resistance mechanism for FLT3 inhibitom,more and more scholars has been studying the inhibition of FLT3-ITD+ cell lines and primary leukemia cells by AC220 alone and in combination with cytotoxic chemotherapies/protein kinase inhibitors as well.However,the clinical effects of a variety of combination plan remain to be further investigated.

OBJECTIVE: To evaluate the value as well as correlation between blood drug level and blood routine results in patients using cyclospone A (CsA) following renal transplantation via analyzing varies of immunosuppressive agents used in renal transplantation. METHODS: Retrieval-related contents were collected by computer from Chinese Journal Full-Text Database with of "renal transplantation, CsA, and therapeutic drug monitoring". Simultaneously, data of patients who received CsA treatment after renal transplantation in the Department of Laboratory, Liaoning Provincial Electrical Hospital were selected. All the literature was retried and analyzed. RESULTS: A total of 717 patients were included in the final analysis. It demonstrated that 6 sorts of immunosuppressive agents, such as mizoribine, sirolimus, zenapax, mycophenolate, and basiliximab play an important role in immune suppression after organ transplantation. However, there still exist problems need to be further explored. CsA was more suitable for clinical application with lower price and good curative effect, which worked better combined with other immunosuppressive agents. CONCLUSION: A best curative effect of CsA can be achieved by timely adjusting therapeutic regimen under the patient's condition. Meantime, a high efficiency and low toxicity drug with specific tolerance is the ultimate goal of immunosuppressive agents.

In order to adapt to the changes of medicine mode and market needs, the Nursing Department of Fujian TCM gave an elective course of nursing etiquette, and made teaching designs for the course, including the designs of teachers training, teaching objects, teaching contents and teaching methods. At the end of the course, the authors conducted questionaire, interview and examination among the students, and analyzed the data by statistical methods, and believed that the result was good. Besides, the article discussed the meaning of setting the Nursing etiquette course, and gave some suggestions on the course building.

Objective To confirm the advantages resources of well-adapted Korean left-behind children,in order to provide reference for implementation of mental health for community left-behind children.Methods The research instruments included 4 questionnaires:The Left-Behind Children Resiliency Scale,Perceived Social Support Scale,Adolescent Self-Rating Life Events Check List and SocioDemographic Characteristics of Respondents.470 Korean left-behind children were selected by convenience sampling method and the data underwent analysis by SPSS 16.0.Results Well-adapted Korean left behind children were significantly higher than the mal-adjusted children in resilience,social support,education level of guardians and contact frequency of parents with children.The frequency of life events and stress was Rower than the mal-adjusted children.Conclusions Advantages resources of well-adapted Korean left-behind children include:good social support and infrequent occurrence of adverse life events and stress.

Oncogenesis is a sophisticated process which is polygenic , multi-stage,and multi-step.Livin as an apoptosis inhibi-ting factor , is one of the members of apoptosis inhibiting factor family , it expresses highly in many tumor tissues , and is closely related to the occurrence and development of urological tumor .Tumor growth can be inhibited by interfering the expression of Livin in tumor tis-sue,which will reduce the resistance to apoptosis and increase the rate of cell apoptosis .In recent years , more and more attention was paid to the studies of Livin on gene targeting therapy .Further research of Livin might provide new ideas for the early diagnosis , clinical treatment and evaluation of prognosis of tumor .

Embryonic stem(ES) cells are derived from totipotent cells of the early mammalian embryo and are capable of unlimited, undifferentiated proliferation in vitro. The establishment of mouse ES cell lines demonstrated the unmatchable convenience for the study of mouse embryonic development and the particular gene regulation and function. It has been long expected to construct such cell line for human. Here we summarized the development in the construction of human ES cell line, its potential utilization in various fields and the possible ethical dilemmas it brought with were also discussed.

Objective: To compare the safety and efifcacy of rivaroxaban and warfarin for treating the patients with left ventricular thrombus. Methods: A total of 31 patients with left ventricular thrombus were studied, the patients were randomly divided into 2 groups:Warfarin group, n=16, the patients initially received oral warfarin and low molecular weight heparin at (2.5-3) mg/day, when the INR value reached 2.0-3.0, heparin was stopped and warfarin was continued, the INR value was monitored every 3 days for 3 times, when INR value was stably kept at 2.0-3.0, it was then monitored for every 2 weeks. Rivaroxaban group,n=15, the patients received oral rivaroxaban at 10 mg twice a day. All patients were followed-up for 3 months, the thrombus remission time, new onset of thrombosis, embolism and bleeding events during treatment period were compared between 2 groups. Results: The patients’ age, gender, complication, size of thrombus and medication were similar between 2 groups. Compared with Warfarin group, Rivaroxaban group had the shorter thrombus remission time, (60.00±5.50)d vs (71.00±8.50) d,P<0.01, while the new onset of thrombosis and embolism events as cerebral embolism and systemic embolism were similar between 2 groups, Warfarin group had slightly higher bleeding events, allP>0.05. Conclusion: Rivaroxaban had better effect than warfarin for treating the patients with left ventricular thrombus without increasing the risk of bleeding.

Acquired aplastic anemia(AA) is a disease of bone marrow failure mediated by autoimmune T cells. CD4+CD25+ regulatory T cells, which have immunosuppressive and anergic, belong to a subpopulation of T cells specialized for immune regulation and play important roles in the development of autoimmune T cells. Foxp3 plays a significant role in the development and function of regulatory T cells which have been confirmed by many investigations. In recent years, the relationship between CD4 +CD25 +Foxp3 + regulatory T cells and AA has become a hot spot of research. What’s more, its clinical significance is becoming more and more obvious in AA.

Child ; Dental Occlusion ; Humans ; Tooth Eruption

Taking the basic theory of Chinese medicine as the instruction, through the bidirectional features of clinical manifestations, the relative etiology and pathology, acupoints and treatments, the bifunctional law in acupuncture theory is discussed. And it is held that after the confirmation of bidirectional symptoms of some diseases or syndromes, acupoints which have special functions in the bifunctional theory of acupuncture with a narrow meaning can be taken as major acupoints. And at the same time, other proper acupoints and flexible treating methods can be selected under the instruction of the bifunctional law of the broad meaning, so as to get the best therapeutic effect.
Acupuncture Points ; Acupuncture Therapy ; Humans ; Medicine in Literature ; Meridians