Advances in butyrates and intestinal immune tolerance in children with cow′s milk protein allergy
10.3760/cma.j.issn.1673-4408.2023.07.004
- VernacularTitle:丁酸与牛奶蛋白过敏患儿肠道免疫耐受研究进展
- Author:
Xiongfeng XIE
1
;
Hong YE
Author Information
1. 福建省儿童医院 福建医科大学妇儿临床医学院，福州 350011
- Keywords:
Children;
Cow′s milk protein allergy;
Butyrates;
Immune tolerance
- From:
International Journal of Pediatrics
2023;50(7):443-446
- CountryChina
- Language:Chinese
-
Abstract:
Cow′s milk protein allergy is common in infants, which is an abnormal immune reaction caused by the imbalance of intestinal immune tolerance system.Butyrates, the fermentation product of intestinal anaerobic bacteria, can be used as a histone deacetylase inhibitors and a ligand of G protein-coupled receptors to regulate intestinal innate immunity and adaptive immune function, thereby inducing intestinal immune tolerance in children with cow′s milk protein allergy, which has potential clinical therapeutic value for cow′s milk protein allergy.However, this theory is still only based on the exploration of mechanisms at the cellular and animal levels and has not been applied in the clinic.This article reviews the intestinal immune mechanism of cow′s milk protein allergy, the anabolism of butyrates and the important role of butyrates in intestinal immune tolerance of cow′s milk protein allergy, aiming to lay a theoretical foundation for further clinical application of butyrate-induced intestinal immune tolerance of cow′s milk protein allergy.
