Automatic synthesis and myocardial imaging of 11C-meta-hydroxyephedrine
10.3760/cma.j.cn321828-20210512-00161
- VernacularTitle:11C-间羟基麻黄碱的自动化合成及心肌显像研究
- Author:
Yulin HE
1
;
Guojian ZHANG
;
Xia BAI
;
Weina ZHOU
;
Wenrui WANG
;
Xiangcheng WANG
Author Information
1. 内蒙古医科大学附属医院核医学科、内蒙古自治区分子影像学重点实验室，呼和浩特 010050
- Keywords:
Ephedrine;
Isotope labeling;
Carbon radioisotopes;
Positron-emission tomography;
Tomography, X-ray computed;
Myocardium;
Rats
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2022;42(11):672-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To realize a fully automated synthesis of 11C-meta-hydroxyephedrine (mHED) and to perform imaging studies with it. Methods:11C-mHED was prepared by the 11CH 3-triflate method. The crude product was purified by semi-preparative high performance liquid chromatograph (HPLC) to obtain the final product. The radiochemical purity and specific activity were determined by radio-HPLC. The myocardial uptake and excretion process of the agent were monitored by microPET/CT imaging on 5 normal SD rats. The clinical imaging value was evaluated using PET/CT imaging in a patient (male, 42 years old) with myocardial infarction. Results:The automated synthesis of 11C-mHED was realized by a commercial synthesizer. The total synthesis time was about 30 min. The radiochemical yield was (15±2)% (non-decay corrected, n=10) and the radiochemical purity was greater than 98%. The specific activity was about 65 GBq/mmol. MicroPET/CT imaging in normal SD rats showed the myocardial uptake was highest at 10 min after the injection of imaging agent, and then the imaging agent was gradually excreted from the myocardium through the liver and gallbladder. PET/CT imaging of a patient with myocardial infarction showed an imaging agent defect near the apex in the inferior wall of the left ventricle, which was matched with results of ultrasound and electrocardiogram examination. Conclusions:11C-mHED can be successfully prepared automatically, with high radiochemical yield and specific activity. It can also highly concentrate in the myocardium, and the imaging effect with this agent is good in a patient with myocardial infarction.
