Clinical and pathological analysis of congenital granular cell tumor.

Chen Zheng; Jimei SU; Xin Liang; Juan WU; Weizhong GU; Xiong Zhao

Return

Clinical and pathological analysis of congenital granular cell tumor.

Author: Chen ZHENG ¹ ; Jimei SU ¹ ; Xin LIANG ¹ ; Juan WU ¹ ; Weizhong GU ² ; Xiong ZHAO ³
Author Information

1. Dept. of Stomatology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
2. Dept. of Pathology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
3. Dept. of Burn & Plastic Surgery, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
Publication Type:Journal Article
Keywords: B-ultrasonic; congenital granular cell tumor; pathology; surgical treatment
MeSH: Infant; Child; Pregnancy; Humans; Female; Granular Cell Tumor/surgery*; Retrospective Studies; Neoplasm Recurrence, Local; Anesthesia, General; Diagnosis, Differential
From: West China Journal of Stomatology 2022;40(6):710-715
CountryChina
Language:English
Abstract: OBJECTIVES:This study aims to explore the clinical and pathological characteristics of congenital granular cell tumors and provide some references for clinical diagnosis, differential diagnosis, and treatment.
METHODS:Nine ca-ses of congenital granular cell tumors who visited the Children's Hospital of Zhejiang University School of Medicine from February 2008 to March 2022 were retrospectively analyzed. Herein, its clinical characteristics, pathological characteristics, treatment, and prognosis were summarized and analyzed.
RESULTS:We found that nine patients were all female, aged 1‑38 days when they saw the doctor. Three of them were attached in maxillary and the other six were attached in mandible. Meanwhile, six tumors were found during the mother's pregnancy at 28-39 weeks and three tumors were found at the baby's birth. One case was excised surgically under local anesthesia, and the other cases were excised surgically under general anesthesia. After 1 month to 12 years of follow-up, patients have no recurrence, however, two cases emerged new teeth from the tumor resection site. Histopathology of all excised lesions was congenital granular cell lesion.
CONCLUSIONS:Congenital granular cell tumor is a benign tumor and the prognosis is good. Therefore, surgical resection of the tumor can be done without extensive resection, and it generally does not relapse. Thus, ultrasonography during pregnancy is an important method for the early detection of congenital granular cell epulis.