Research progress on the role of gut microbiota alterations in the pathogenesis of neuromyelitis optica spectrum disorders

VernacularTitle:肠道菌群改变在视神经脊髓炎谱系疾病发病机制中的作用研究进展
Author: Rui ZHAO ¹ ; Libin JIANG
Author Information

1. 首都医科大学附属北京同仁医院,　北京　100730
Keywords: Demyelinating autoimmune diseases; CNS; Enterobacteriaceae; Allergy and immunology; Review
From: Chinese Journal of Ocular Fundus Diseases 2022;38(5):419-422
CountryChina
Language:Chinese
Abstract: Neuromyelitis optica spectrum disorders (NMOSDs) are a class of immune-mediated inflammatory demyelinating diseases of the central nervous system that mainly involve the optic nerve and spinal cord. As an important environmental factor, the gut microbiota may play an important role in the occurrence and development of NMOSDs. Previous studies have shown that the structure and number of intestinal flora in NMOSDs patients are different from those of normal healthy people. The altered intestinal flora may cross-react with central nervous system autoantigens, induce T cell differentiation, and affect short-chain fatty acids, etc. The metabolite secretion pathway triggers the occurrence of NMOSDs. The summary of the changes of gut microbiota in patients with NMOSDs and the possible underlying mechanisms by summarizing the literature, aim to provide more effective treatments for the prevention and treatment of NMOSDs in the future.