Advances of chromatogram retention time alignment algorithms in proteomics.

Author: Yi LIU ¹ ; Cheng CHANG ² ; Yunping ZHU ²
Author Information

1. The Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
2. Proteome Research Center, Beijing 102206, China.
Publication Type:Review
Keywords: algorithm; chromatography; proteomics; retention time alignment; software
MeSH: Algorithms; Proteomics/methods*
From:Chinese Journal of Biotechnology 2022;38(3):961-975
CountryChina
Language:Chinese
Abstract: Chromatography is a basic process in the current proteomics workflow, and the retention time alignment of the chromatogram is one of the important steps to effectively improve the identification and quantification accuracy. After years of development, a series of algorithms for retention time alignment have been developed. This review summarizes the advances of chromatographic retention time alignment algorithms and tools for proteomics analysis from the perspective of proteomics users, and discusses the development and future application directions.