Research progress on malignant tumor after lung transplantation
10.3969/j.issn.1674-7445.2021.05.019
- VernacularTitle:肺移植术后发生恶性肿瘤的研究进展
- Author:
Caihan LI
1
;
Hongtao TANG
;
Lin XU
;
Junjie WANG
;
Kaiyuan JIANG
;
Haoji YAN
;
Haoxuan LI
;
Xiangyun ZHENG
;
Tingting CHEN
;
Siyi FU
;
Dong TIAN
Author Information
1. Medical Imaging Key Laboratory of Sichuan Province, North Sichuan Medical College, Nanchong 637000, China
- Publication Type:Research Article
- Keywords:
Lung transplantation;
Malignant tumor;
Nonmelanoma skin cancer;
Posttransplant lymphoproliferative disease;
Lung cancer;
Immunosuppression;
Risk factor;
Programmed cell death protein 1;
Cemiplimab
- From:
Organ Transplantation
2021;12(5):624-
- CountryChina
- Language:Chinese
-
Abstract:
Lung transplantation has become the most effective treatment of end-stage lung diseases. Along with persistent optimization of lung transplantation technique and perioperative management, the short-term clinical efficacy after lung transplantation has been significantly improved, whereas the long-term clinical prognosis remains unoptimistic. Besides chronic lung allograft dysfunction, postoperative malignant tumors also threaten the long-term survival of the recipients. Common malignant tumors following lung transplantation include nonmelanoma skin cancer, posttransplant lymphoproliferative disease and lung cancer. After solid organ transplantation, a large majority of the recipients require lifelong immunosuppressive therapy. The intensity of immunosuppressive therapy for the lung transplant recipients is generally higher than other organ transplant recipients. Immunosuppression is the main factor which leads to the impairment of anti-tumor immune monitoring function and promotes the incidence and development of malignant tumors. In this article, the risk factors, prevention and treatment of the most common malignant tumors after lung transplantation were reviewed, aiming to provide reference for comprehensive diagnosis and treatment of malignant tumors following lung transplantation.
