Application of dual hypothermic oxygenated machine perfusion in ex vivo split liver transplantation
10.3969/j.issn.1674-7445.2021.05.008
- VernacularTitle:低温双通道氧合机械灌注在离体劈离式肝移植中的应用
- Author:
Junkai REN
1
;
Tong ZHANG
Author Information
1. Department of Hepatic Surgery, Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
- Publication Type:Research Article
- Keywords:
Split liver transplantation;
Donor liver preservation;
Machine perfusion;
Dual hypothermic oxygenated machine perfusion;
Ischemia-reperfusion injury;
Static cold preservation;
Expanded criteria donor;
Donation after cardiac death
- From:
Organ Transplantation
2021;12(5):550-
- CountryChina
- Language:Chinese
-
Abstract:
The technology of split liver transplantation is becoming increasingly mature with rapid development. During ex vivo splitting, the depletion of intracellular energy sources [such as adenosine triphosphate (ATP)] and other metabolic disorders may lead to cell damage and dysfunction, which will be aggravated by reperfusion injury of liver transplantation, clinically manifested as postoperative complications and transplantation failure. To further improve the quality of donor liver in ex vivo split liver transplantation, research teams at home and abroad apply machine perfusion to enhance the quality of donor liver. In this article, the research progresses worldwide on machine perfusion of donor liver in ex vivo split liver transplantation were reviewed, and the application and prospect of dual hypothermic oxygenated machine perfusion (D-HOPE) in ex vivo split liver transplantation were elucidated, aiming to provide reference for increasing the source of donor liver for ex vivo split liver transplantation and further resolving the current status of donorliver shortage.
