Long-Term Outcomes of Hemispheric Disconnection in Pediatric Patients with Intractable Epilepsy.
10.3988/jcn.2014.10.2.101
- Author:
Yun Jeong LEE
1
;
Eun Hee KIM
;
Mi Sun YUM
;
Jung Kyo LEE
;
Seokho HONG
;
Tae Sung KO
Author Information
1. Division of Pediatric Neurology, Department of Pediatrics, Asan Medical Center Children's Hospital, Seoul, Korea. tsko@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
seizure;
hemispherectomy;
hemispherotomy;
psychomotor outcomes
- MeSH:
Child;
Chungcheongnam-do;
Cohort Studies;
Electroencephalography;
Encephalitis;
Encephalomalacia;
Epilepsy*;
Follow-Up Studies;
Hemispherectomy;
Humans;
Infant;
Infant, Newborn;
Infarction;
Paresis;
Patient Selection;
Quality of Life;
Retrospective Studies;
Seizures;
Spasms, Infantile;
Sturge-Weber Syndrome;
Walking
- From:Journal of Clinical Neurology
2014;10(2):101-107
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND PURPOSE: Hemispherectomy reportedly produces remarkable results in terms of seizure outcome and quality of life for medically intractable hemispheric epilepsy in children. We reviewed the neuroradiologic findings, pathologic findings, epilepsy characteristics, and clinical long-term outcomes in pediatric patients following a hemispheric disconnection. METHODS: We retrospectively studied 12 children (8 males) who underwent a hemispherectomy at Asan Medical Center between 1997 and 2005. Clinical, EEG, neuroradiological, and surgical data were collected. Long-term outcomes for seizure, motor functions, and cognitive functions were evaluated at a mean follow-up of 12.7 years (range, 7.6-16.2 years) after surgery. RESULTS: The mean age at epilepsy onset was 3.0 years (range, 0-7.6 years). The following epilepsy syndromes were identified in our cohort: focal symptomatic epilepsy (n=8), West syndrome (n=3), and Rasmussen's syndrome (n=1). Postoperative histopathology of our study patients revealed malformation of cortical development (n=7), encephalomalacia as a sequela of infarction or trauma (n=3), Sturge-Weber syndrome (n=1), and Rasmussen's encephalitis (n=1). The mean age at surgery was 6.5 years (range, 0.8-12.3 years). Anatomical or functional hemispherectomy was performed in 8 patients, and hemispherotomy was performed in 4 patients. Eight of our 12 children (66.7%) were seizure-free, but 3 patients with perioperative complications showed persistent seizure. Although all patients had preoperative hemiparesis and developmental delay, none had additional motor or cognitive deficits after surgery, and most achieved independent walking and improvement in daily activities. CONCLUSIONS: The long-term clinical outcomes of hemispherectomy in children with intractable hemispheric epilepsy are good when careful patient selection and skilled surgical approaches are applied.
