Advances in study of regulation of tumor immune inflammatory microenvironment by cancer-associated fibroblasts
10.3969/j.issn.1674-8115.2020.09.020
- VernacularTitle: 肿瘤相关成纤维细胞调控肿瘤免疫炎症微环境的研究进展
- Author:
Wei-Guang ZHAO
1
Author Information
1. Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Cancer-associated fibroblasts (CAFs);
Tumor immunity;
Tumor microenvironment
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2020;40(9):1288-1293
- CountryChina
- Language:Chinese
-
Abstract:
Cancer-associated fibroblasts (CAFs) are a major population that resides in the tumor microenvironment. Multiple soluble molecules secreted by CAFs remodel the extracellular matrix, thus promoting tumor growth, invasion and metastasis. It is now considered that CAFs play an important role in the regulation of tumor immunity, in which an increasing number of molecular mechanisms of tumor microenvironment remodeling are being discovered. This article reviews the molecular markers of CAFs, the crosstalk between CAFs and tumor cells or immune cells, as well as the progress on therapeutic targeting of CAFs.
