Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy.
10.15430/JCP.2016.21.4.216
- Author:
Bokyung SUNG
1
;
Hae Young CHUNG
;
Nam Deuk KIM
Author Information
1. Department of Pharmacy, College of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan, Korea. nadkim@pusan.ac.kr
- Publication Type:Review
- Keywords:
Apigenin;
Chemoprevention;
Apoptosis;
Autophagy
- MeSH:
Apigenin*;
Apium graveolens;
Apoptosis*;
Autophagy*;
Cell Cycle Checkpoints;
Cell Line;
Cell Proliferation;
Chamomile;
Chemoprevention;
DNA Damage;
Fruit;
Humans;
In Vitro Techniques;
Inflammation;
Oxidative Stress;
Petroselinum;
Rutaceae;
Vegetables
- From:Journal of Cancer Prevention
2016;21(4):216-226
- CountryRepublic of Korea
- Language:English
-
Abstract:
Apigenin (4′,5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer chemopreventive agent has increased. Significant progress has been made in studying the chemopreventive aspects of apigenin both in vitro and in vivo. Several studies have demonstrated that the anticarcinogenic properties of apigenin occur through regulation of cellular response to oxidative stress and DNA damage, suppression of inflammation and angiogenesis, retardation of cell proliferation, and induction of autophagy and apoptosis. One of the most well-recognized mechanisms of apigenin is the capability to promote cell cycle arrest and induction of apoptosis through the p53-related pathway. A further role of apigenin in chemoprevention is the induction of autophagy in several human cancer cell lines. In this review, we discuss the details of apigenin, apoptosis, autophagy, and the role of apigenin in cancer chemoprevention via the induction of apoptosis and autophagy.
