Coronary Stent Thrombosis: Current Insights into New Drug-Eluting Stent Designs
10.4068/cmj.2012.48.3.141
- Author:
Hyun Kuk KIM
1
;
Myung Ho JEONG
Author Information
1. The Heart Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Korea. myungho@chollian.net
- Publication Type:Review
- Keywords:
Drug-eluting stents;
Coronary thrombosis;
Blood platelets
- MeSH:
Blood Platelets;
Cardiology;
Coronary Thrombosis;
Drug-Eluting Stents;
Hypersensitivity;
Myocardial Infarction;
Polymers;
Stents;
Thrombosis
- From:Chonnam Medical Journal
2012;48(3):141-149
- CountryRepublic of Korea
- Language:English
-
Abstract:
The advances of interventional cardiology have been achieved by new device development, finding appropriate drug regimes, and understanding of pathomechanism. Drug-eluting stents (DES) implantation with dual anti-platelet therapy reduced revascularization without increasing mortality or myocardial infarction compared with bare-metal stenting. However, late-term stent thrombosis (ST) and restenosis limited its value and raised the safety concern. Main mechanisms of this phenomenon are impaired endothelialization and hypersensitivity reaction with polymer. The second generation DES further improved safety and/or efficacy by using thinner stent strut and biocompatible polymer. Recently, new concept DES with biodegradable polymer, polymer-free and bioabsorbable scaffold are under investigation in the quest to minimize the risk of ST.
